A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent.The key to the success o...A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent.The key to the success of this transformation is the light-induced generation of active dithioacyl disulfides as thioacyl donors.This green methodology has been successfully employed for the late-stage thioacylation of various amino compounds including drugs,hormones,amino acids and peptides under mild conditions.展开更多
Aim To analyze the fragmentation patterns of diquaternary dipiperaziniumscontaining dithiocarboxyl groups. Methods Positive ion electrospray ionization mass spectrometry inconjunction with tandem mass spectrometry (ES...Aim To analyze the fragmentation patterns of diquaternary dipiperaziniumscontaining dithiocarboxyl groups. Methods Positive ion electrospray ionization mass spectrometry inconjunction with tandem mass spectrometry (ESI-MS^n) was used. Results The fragment ion [M^(2+) Cl^-]^+ showed characteristic double peaks with high intensity instead of the parent molecular ionbeing detected. And [M^(2+) - CH_3^+ ]^+ ion had relatively low intensity. Meanwhile, [M^(2+) Cl^- -Cl^- - PhCH_2^+ ]^+ species had the highest intensity as the base peak, which was originated from[M^(2+) Cl^- ]^+, The detailed fragmentation mechanisms are supported with the tandem massspectrometry.展开更多
基金supported by the National Natural Science Foundation of China(No.21901179)the Natural Science Foundation of Shanxi Province(No.202103021224067)the Scientific Activities of Selected Returned Overseas Professionals of Shanxi Province(No.20200002).
文摘A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent.The key to the success of this transformation is the light-induced generation of active dithioacyl disulfides as thioacyl donors.This green methodology has been successfully employed for the late-stage thioacylation of various amino compounds including drugs,hormones,amino acids and peptides under mild conditions.
文摘Aim To analyze the fragmentation patterns of diquaternary dipiperaziniumscontaining dithiocarboxyl groups. Methods Positive ion electrospray ionization mass spectrometry inconjunction with tandem mass spectrometry (ESI-MS^n) was used. Results The fragment ion [M^(2+) Cl^-]^+ showed characteristic double peaks with high intensity instead of the parent molecular ionbeing detected. And [M^(2+) - CH_3^+ ]^+ ion had relatively low intensity. Meanwhile, [M^(2+) Cl^- -Cl^- - PhCH_2^+ ]^+ species had the highest intensity as the base peak, which was originated from[M^(2+) Cl^- ]^+, The detailed fragmentation mechanisms are supported with the tandem massspectrometry.
