Diabetic patients who underwent long-term dialysis may increase the prevalence of foot ulceration. In addition, diabetic foot ulcer (DFUs) patients with end-stage renal disease (ESRD) do not heal well, and the amputat...Diabetic patients who underwent long-term dialysis may increase the prevalence of foot ulceration. In addition, diabetic foot ulcer (DFUs) patients with end-stage renal disease (ESRD) do not heal well, and the amputation rate is 6.5 - 10 times higher compared to the non-nephropathic diabetic population. Thus, a suitable therapeutic agent was needed. ON101 is a topical cream that promotes diabetic wound healing through a unique macrophage-regulating ability. In this case series, we included 5 diabetes patients (mean age 54.6 ± 8.7 years, 4 mal) with ESRD (mean eGFR 7.4 ± 3.35 mL/min/1.73m<sup>2</sup>) and had experienced dialysis for at least 4.5 years. These patients also have UT (University of Texas) grade 2A DFUs that have existed for at least 1.5 months (mean ulcer duration 8.3 ± 8.97 months). These subjects were applied ON101 twice daily for up to 20 weeks, and wound size was recorded during treatment. Among these subjects, three ulcers (patient No. 1, 2, and 3) completely healed within 10 weeks upon ON101 application, and one ulcer was 99% reduced at 20<sup>th</sup> weeks (patient No. 4). Only one ulcer didn’t show an obvious response that may due to poor compliance in wound care and glucose control. In summary, the overall healing rate was 60%, suggesting ON101 performed equivalence healing efficacy in dialysis patients compared with those who did not have dialysis.展开更多
Objective:This paper presents an analysis of the concept of patient outcomes.Methods:The present study conducted searches on various databases,including Wanfang,Sinomed,CNKI,Pub Med,Cochrane Library,Embase,Web of Scie...Objective:This paper presents an analysis of the concept of patient outcomes.Methods:The present study conducted searches on various databases,including Wanfang,Sinomed,CNKI,Pub Med,Cochrane Library,Embase,Web of Science,and Ovid.The paper followed the Walker and Avant concept-analysis approach.Results:Initially,899 pieces of literature were identified through the search process,and after screening,41 of them were ultimately included in the analysis.The identified attributes of the concept included(1)capability,(2)decision making,and(3)action.These antecedents were shaped by factors such as illness perception,self-efficacy,and family and social.The consequences included(1)physiological effects,(2)psychological effects,and(3)social influence.Conclusions:The concept analysis of self-management in patients with diabetic foot ulcers(DFUs)not only aids in clinical practice and suppor ts interventions,but also contributes to the development of self-management theory.The common goal of clinical medical staff is to assist DFU patients in improving cognitive ability,making correct self-management decisions,and enhancing self-management behavior.展开更多
Objectives:To develop the List of Clinical Needs for New Chinese Materia Medica Development(Second Batch),aiming to identify and highlight specific diseases with pressing,unmet therapeutic needs.The objective is to gu...Objectives:To develop the List of Clinical Needs for New Chinese Materia Medica Development(Second Batch),aiming to identify and highlight specific diseases with pressing,unmet therapeutic needs.The objective is to guide pharmaceutical research and development(R&D)by establishing development priorities based on clinical gaps,epidemiological burden,and the shortcomings of existing treatments.Methods:The list was developed by the China Association of Chinese Medicine using a methodology grounded in evidence and expert consensus.Results:The list identifies 8 diseases with significant clinical gaps:Myelodysplastic syndromes(MDS),fibromyalgia(FM),atrophic gastritis and its precancerous lesions,adenomyosis(AM),diabetes related foot ulcers(DFU),granulomatous mastitis(GLM),diabetic kidney disease(DKD),and metabolic-associated fatty liver disease(MAFLD).For each disease,the list provides a systematic analysis of epidemiological burden,limitations of current treatments,and specific clinical needs.It also proposes a strategic research framework focused on multi-target mechanisms,disease-modifying potential,and optimized combination therapies.Conclusions:The list provides a strategically structured framework to guide the development of new Chinese materia medica.It aligns traditional Chinese medicine(TCM)development with national public health priorities,emphasizes TCM's holistic and multi-target advantages,and promotes a patient-centered approach.By bridging clinical needs with TCM principles,the list aims to foster the creation of clinically valuable medicines to address chronic and complex diseases where current western medical approaches are insufficient.展开更多
文摘Diabetic patients who underwent long-term dialysis may increase the prevalence of foot ulceration. In addition, diabetic foot ulcer (DFUs) patients with end-stage renal disease (ESRD) do not heal well, and the amputation rate is 6.5 - 10 times higher compared to the non-nephropathic diabetic population. Thus, a suitable therapeutic agent was needed. ON101 is a topical cream that promotes diabetic wound healing through a unique macrophage-regulating ability. In this case series, we included 5 diabetes patients (mean age 54.6 ± 8.7 years, 4 mal) with ESRD (mean eGFR 7.4 ± 3.35 mL/min/1.73m<sup>2</sup>) and had experienced dialysis for at least 4.5 years. These patients also have UT (University of Texas) grade 2A DFUs that have existed for at least 1.5 months (mean ulcer duration 8.3 ± 8.97 months). These subjects were applied ON101 twice daily for up to 20 weeks, and wound size was recorded during treatment. Among these subjects, three ulcers (patient No. 1, 2, and 3) completely healed within 10 weeks upon ON101 application, and one ulcer was 99% reduced at 20<sup>th</sup> weeks (patient No. 4). Only one ulcer didn’t show an obvious response that may due to poor compliance in wound care and glucose control. In summary, the overall healing rate was 60%, suggesting ON101 performed equivalence healing efficacy in dialysis patients compared with those who did not have dialysis.
基金supported by the Health Science and Technology Project of Pudong New Area Health Commission(No.PW2023A-09)the Academic Leaders Training Program of Pudong Health Bureau of Shanghai(No.PWRd2022-16)+1 种基金Tongji University“Third Year Action Plan for Discipline Construction of School of Nursing”(No.JS2210328)Important Weak Subject Construction Project of Shanghai Pudong New Area Health Commission(No.PWZbr2022-04)。
文摘Objective:This paper presents an analysis of the concept of patient outcomes.Methods:The present study conducted searches on various databases,including Wanfang,Sinomed,CNKI,Pub Med,Cochrane Library,Embase,Web of Science,and Ovid.The paper followed the Walker and Avant concept-analysis approach.Results:Initially,899 pieces of literature were identified through the search process,and after screening,41 of them were ultimately included in the analysis.The identified attributes of the concept included(1)capability,(2)decision making,and(3)action.These antecedents were shaped by factors such as illness perception,self-efficacy,and family and social.The consequences included(1)physiological effects,(2)psychological effects,and(3)social influence.Conclusions:The concept analysis of self-management in patients with diabetic foot ulcers(DFUs)not only aids in clinical practice and suppor ts interventions,but also contributes to the development of self-management theory.The common goal of clinical medical staff is to assist DFU patients in improving cognitive ability,making correct self-management decisions,and enhancing self-management behavior.
文摘Objectives:To develop the List of Clinical Needs for New Chinese Materia Medica Development(Second Batch),aiming to identify and highlight specific diseases with pressing,unmet therapeutic needs.The objective is to guide pharmaceutical research and development(R&D)by establishing development priorities based on clinical gaps,epidemiological burden,and the shortcomings of existing treatments.Methods:The list was developed by the China Association of Chinese Medicine using a methodology grounded in evidence and expert consensus.Results:The list identifies 8 diseases with significant clinical gaps:Myelodysplastic syndromes(MDS),fibromyalgia(FM),atrophic gastritis and its precancerous lesions,adenomyosis(AM),diabetes related foot ulcers(DFU),granulomatous mastitis(GLM),diabetic kidney disease(DKD),and metabolic-associated fatty liver disease(MAFLD).For each disease,the list provides a systematic analysis of epidemiological burden,limitations of current treatments,and specific clinical needs.It also proposes a strategic research framework focused on multi-target mechanisms,disease-modifying potential,and optimized combination therapies.Conclusions:The list provides a strategically structured framework to guide the development of new Chinese materia medica.It aligns traditional Chinese medicine(TCM)development with national public health priorities,emphasizes TCM's holistic and multi-target advantages,and promotes a patient-centered approach.By bridging clinical needs with TCM principles,the list aims to foster the creation of clinically valuable medicines to address chronic and complex diseases where current western medical approaches are insufficient.
