To assess the side effects and the continuation rate of combined oral contraceptive （COC） containing desogestrel （Marvelon） during 12 months. Methods This was a post-marketing surveillance study on Marvelon COC am...To assess the side effects and the continuation rate of combined oral contraceptive （COC） containing desogestrel （Marvelon） during 12 months. Methods This was a post-marketing surveillance study on Marvelon COC among 870 healthy rural women in 5 different counties of Jiangsu Province during 12 months. Results About 24.02% of the women who used Marvelon COC experienced side effects during 12 months. Gastrointestinal disorder, bleeding/spotting and chloasma were ranked the first three in the side effects. The rate of side effects of Marvelon COC users during the first 3 months in southern area of Jiangsu was significantly higher than that of users in northern area of Jiangsu. Most of the users did not experience obvious weight changes i.e., loss or increase in weight of more than 5 kg during 12 months. Blood pressure and biochemical indicators of almost 99% among users were within the normal range. The gross cumulative continuation rate for 12 months was 83.14%; the most common medical reason for discontinuation was gastrointestinal disorder. There was an increased risk of discontinuation use among women with lower educational level. Conclusion Marvelon COC brought fewer side effects and was well accepted when applied in Chinese rural women.展开更多
目的研究不同剂量米非司酮联合去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血(dysfunctional uterine bleeding during perimenopause,P-DUB)的临床疗效。方法选择2015年3月至2016年2月于河南省中医院接受治疗的P-DUB患者158例,按照随...目的研究不同剂量米非司酮联合去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血(dysfunctional uterine bleeding during perimenopause,P-DUB)的临床疗效。方法选择2015年3月至2016年2月于河南省中医院接受治疗的P-DUB患者158例,按照随机数字表法分为A、B、C组,每组53例。3组均给予去氧孕烯炔雌醇治疗。A组给予米非司酮10mg,B组给予米非司酮15mg,C组给予米非司酮20mg。观察3组子宫出血控制时间、停止时间,治疗前后子宫内膜厚度、月经量、血红蛋白水平、性激素水平和不良反应。结果 A组子宫出血控制时间、子宫出血停止时间长于B、C组(P<0.05)。B、C组子宫出血控制时间、子宫出血停止时间差异无统计学意义(P>0.05)。治疗后,A组子宫内膜厚度及促黄体激素(LH)、雌二醇(E_2)、孕酮(P)、促卵泡生成素(FSH)大于B、C组,血红蛋白小于B、C组(P<0.05)。治疗后,B、C组子宫内膜厚度、血红蛋白及LH、E_2、P和FSH差异无统计学意义(P>0.05)。A组总有效率(69.81%)低于B组(92.45%)、C组(96.23%)(P<0.05)。B、C组总有效率差异无统计学意义(P>0.05)。A组不良反应发生率(5.66%)低于B组(9.43%)(P>0.05)。A组不良反应发生率低于C组(22.64%)(P<0.05)。B、C组不良反应发生率差异无统计学意义(P>0.05)。结论15mg剂量米非司酮联合去氧孕烯炔雌醇治疗P-DUB疗效显著,安全可靠,值得临床推广应用。展开更多
总结7种含有不同生物活性的常用甾体激素避孕药(Marvelon,Microgynon,中国Ⅰ号片,Mercilon,LNG事后药,Mesigyna,Cyclofem)对中国妇女脂代谢的影响。191例需要避孕的健康志愿者分别服用以上不同的避孕药,并依次在用药前、用药期间及停药...总结7种含有不同生物活性的常用甾体激素避孕药(Marvelon,Microgynon,中国Ⅰ号片,Mercilon,LNG事后药,Mesigyna,Cyclofem)对中国妇女脂代谢的影响。191例需要避孕的健康志愿者分别服用以上不同的避孕药,并依次在用药前、用药期间及停药后采空腹静脉血,观察血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白A Ⅰ(apo A Ⅰ)、载脂蛋白AⅡ(apo AⅡ)、载脂蛋白B(apo B)水平变化及TC/HDL-C、apo A Ⅰ/apo B比值改变。共观察1665个周期。结果显示,以上7种避孕药均有升高或降低某些脂质水平的作用,但停药后均能恢复,而且无论在用药期间或停药后,以上两项比值无显著改变。结果提示短期服用以上7种避孕药(一年内),对脂代谢无不良影响,并发现由于各种甾体激素类避孕药的配伍各异,因而产生的生物活性不同,对人体脂代谢的影响亦不一致。因此建议如能交替使用不同种类的避孕药,也许可减少长期服药者副作用的发生。展开更多
基金funded by the National Tenth Five-year Key Project (2002BA709B06)
文摘To assess the side effects and the continuation rate of combined oral contraceptive （COC） containing desogestrel （Marvelon） during 12 months. Methods This was a post-marketing surveillance study on Marvelon COC among 870 healthy rural women in 5 different counties of Jiangsu Province during 12 months. Results About 24.02% of the women who used Marvelon COC experienced side effects during 12 months. Gastrointestinal disorder, bleeding/spotting and chloasma were ranked the first three in the side effects. The rate of side effects of Marvelon COC users during the first 3 months in southern area of Jiangsu was significantly higher than that of users in northern area of Jiangsu. Most of the users did not experience obvious weight changes i.e., loss or increase in weight of more than 5 kg during 12 months. Blood pressure and biochemical indicators of almost 99% among users were within the normal range. The gross cumulative continuation rate for 12 months was 83.14%; the most common medical reason for discontinuation was gastrointestinal disorder. There was an increased risk of discontinuation use among women with lower educational level. Conclusion Marvelon COC brought fewer side effects and was well accepted when applied in Chinese rural women.
文摘总结7种含有不同生物活性的常用甾体激素避孕药(Marvelon,Microgynon,中国Ⅰ号片,Mercilon,LNG事后药,Mesigyna,Cyclofem)对中国妇女脂代谢的影响。191例需要避孕的健康志愿者分别服用以上不同的避孕药,并依次在用药前、用药期间及停药后采空腹静脉血,观察血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白A Ⅰ(apo A Ⅰ)、载脂蛋白AⅡ(apo AⅡ)、载脂蛋白B(apo B)水平变化及TC/HDL-C、apo A Ⅰ/apo B比值改变。共观察1665个周期。结果显示,以上7种避孕药均有升高或降低某些脂质水平的作用,但停药后均能恢复,而且无论在用药期间或停药后,以上两项比值无显著改变。结果提示短期服用以上7种避孕药(一年内),对脂代谢无不良影响,并发现由于各种甾体激素类避孕药的配伍各异,因而产生的生物活性不同,对人体脂代谢的影响亦不一致。因此建议如能交替使用不同种类的避孕药,也许可减少长期服药者副作用的发生。
