Four different rose hybrid populations were analyzed by ISSR technique with nine polymorphic primers. All of the primers produced 64 bands, of which 59 were polymorphic. The average of polymorphic bands was 6.6 for ea...Four different rose hybrid populations were analyzed by ISSR technique with nine polymorphic primers. All of the primers produced 64 bands, of which 59 were polymorphic. The average of polymorphic bands was 6.6 for each primer. The percentage of polymorphism ranged from 57.1% to 100%, with an average of 92.3%. An UPGMA dendrogram showed five groups. The primer numbered with PI9 and PI11 had relatively high resolution in identifying the F1 offspring in this research.展开更多
In 2021,the relatives of 16 international friends of China jointly sent a letter to Chinese President Xi Jinping,congratulating the Communist Party of China(CPC)on its 100th anniversary.These are the sons and daughter...In 2021,the relatives of 16 international friends of China jointly sent a letter to Chinese President Xi Jinping,congratulating the Communist Party of China(CPC)on its 100th anniversary.These are the sons and daughters and family members of those who helped China in its times of need.Eric Foster,nephew of renowned U.S.journalist Helen Foster-Snow,was one of them.展开更多
ON May 20,2025,eighteen descendants of British prisoners of war(POWs)rescued in the Lisbon Maru incident arrived on Dongji Island in east China’s Zhejiang Province,after a long transoceanic journey.They joined descen...ON May 20,2025,eighteen descendants of British prisoners of war(POWs)rescued in the Lisbon Maru incident arrived on Dongji Island in east China’s Zhejiang Province,after a long transoceanic journey.They joined descendants of the local fishermen who had saved their ancestors 83 years ago,gathering to witness the unveiling of a memorial erected in honor of the fishermen’s extraordinary bravery.At its center,the memorial bears the inscription:“Love knows no boundaries;Friendship transcends time.”展开更多
The subnucleus reticularis dorsalis(SRD),also known as the dorsal reticular nucleus(DRt)or dorsal medullary reticular nucleus(MdD),which resides at the caudal end of the medulla,plays a pivotal role in regulating pain...The subnucleus reticularis dorsalis(SRD),also known as the dorsal reticular nucleus(DRt)or dorsal medullary reticular nucleus(MdD),which resides at the caudal end of the medulla,plays a pivotal role in regulating pain perception.Despite extensive research efforts to unravel its mechanisms,the operational intricacies of SRD remain poorly understood.Advances in experimental methodologies such as brain imaging and chemogenetics have facilitated deeper investigations into the involvement of SRD in various pain disorders.This comprehensive review aims to analyze 36 years(1989–2024)of preclinical research highlighting the critical role of SRD in diffuse noxious inhibitory control(DNIC),also known as conditioned pain modulation(CPM)in humans,and its interconnected neural circuits.Moreover,this review explores the neural circuits related to SRD,including locus coeruleus(LC)-SRD,parabrachial nucleus(PBN)-SRD,rostroventromedial medulla(RVM)-ventrolateral medulla(VLM)-SRD,anterior cingulate cortex(ACC)-SRD,medial medullary reticular formation(mMRF)-SRD,and dorsal striatum(DS)-SRD.Their activation also plays a significant role in analgesia.The pivotal roles of neurotransmitters such asμ-opioid receptor(MOR),noradrenaline,and metabotropic glutamate receptor 7(mGluR7)in modulating SRD responsiveness to pain stimuli are also discussed,as are the influences of SRD on different pain types.This review identified promising avenues for innovative analgesic treatments by shedding light on potential therapeutic strategies targeting SRD.展开更多
BACKGROUND Squamous cell carcinoma(SCC)of the colon is a rare malignant tumor with an unclear pathogenesis.Its clinical presentation is similar to that of adenocarcinoma,and there are no standard treatment guidelines....BACKGROUND Squamous cell carcinoma(SCC)of the colon is a rare malignant tumor with an unclear pathogenesis.Its clinical presentation is similar to that of adenocarcinoma,and there are no standard treatment guidelines.Treatment for SCC of the colon is mainly based on the protocols for colon adenocarcinoma.In advanced stages,colon SCC is highly invasive,prone to distant metastasis,and has a worse prog-nosis than adenocarcinoma.Furthermore,pancreatic metastasis from colon SCC is even rarer.CASE SUMMARY The patient presented with abdominal pain and was diagnosed with SCC of the descending colon following colonoscopy.Preoperative examinations did not reveal any obvious metastasis to other organs,and the patient underwent laparo-scopic radical resection of the descending colon cancer.During surgery,suspi-cious metastases to the pancreatic body and tail,splenic vessels,and splenic hilum were found,leading to combined resection of the pancreatic body and tail along with the spleen.Postoperative pathology confirmed moderately to poorly diffe-rentiated SCC with nerve invasion.The patient developed postoperative compli-cations,including abdominal cavity infection,acute myocardial infarction,and deep vein thrombosis in the lower limbs.Despite active symptomatic treatment and stabilization of the patient’s vital signs,the patient did not undergo adjuvant chemotherapy due to an Eastern Cooperative Oncology Group score of 3.The patient passed away 3 months postoperatively due to multiple organ failure.CONCLUSION This case highlights the aggressive nature of colorectal SCC with atypical meta-stasis and underscores the necessity for multidisciplinary perioperative management.展开更多
BACKGROUND Descending thoracic aortic aneurysms are dangerous and have to be treated quickly.The primary treatment methods are thoracic endovascular aortic repair(TEVAR)and open surgical repair(OSR).The comparative ef...BACKGROUND Descending thoracic aortic aneurysms are dangerous and have to be treated quickly.The primary treatment methods are thoracic endovascular aortic repair(TEVAR)and open surgical repair(OSR).The comparative effectiveness and safety of TEVAR and OSR were evaluated in this meta-analysis,focusing on perioperative and long-term outcomes.AIM To compare and contrast the efficacy and safety of TEVAR vs OSR in the treatment of descending thoracic aortic aneurysms.This study aims to assess both perioperative and long-term outcomes through a systematic review and metaanalysis.METHODS A comprehensive search of PubMed,EMBASE,and Cochrane was conducted from inception to January 2025.Baseline characteristics and outcomes were evaluated.Odds ratios(OR)for dichotomous data and mean differences for continuous data with 95%confidence intervals(CI)were analyzed using random-effects models.RESULTS A meta-analysis of 21 studies involving 29465 patients(8261 TEVAR;21204 OR)showed TEVAR associated with lower operative mortality(OR=0.60,95%CI:0.42-0.85,P=0.004),shorter intensive care unit(-2.94 days,95%CI:-4.76 to-1.12,P=0.002)and hospital stays(-7.35 days,95%CI:-10.54 to-4.17,P<0.00001),and reduced rates of paraplegia(OR=0.44,95%CI:0.27-0.73,P=0.002),spinal ischemia(OR=0.30,95%CI:0.16-0.56,P=0.0002),renal failure(OR=0.29,95%CI:0.14-0.61,P=0.001),and wound infections(OR=0.28,95%CI:0.13-0.61,P=0.001).However,TEVAR had higher rates of vascular complications.No significant differences were noted in 1-year and 5-year mortality rates,the rate of non-elective surgery,neurological complications,or stroke rates.CONCLUSION Compared to EVAR,TEVAR revealed lower operative mortality and better perioperative outcomes across all indicators,including hospital and intensive care unit stays,as well as fewer complications,except for those related to vascular problems.Mortality results were also similar in the long run;consequently,more research is required concerning the long-term durability.展开更多
Neuropathic pain,often featuring allodynia,imposes significant physical and psychological burdens on patients,with limited treatments due to unclear central mechanisms.Addressing this challenge remains a crucial unsol...Neuropathic pain,often featuring allodynia,imposes significant physical and psychological burdens on patients,with limited treatments due to unclear central mechanisms.Addressing this challenge remains a crucial unsolved issue in pain medicine.Our previous study,using protein kinase C gamma(PKCγ)-tdTomato mice,highlights the spinal feedforward inhibitory circuit involving PKCγ neurons in gating neuropathic allodynia.However,the regulatory mechanisms governing this circuit necessitate further elucidation.We used diverse transgenic mice and advanced techniques to uncover the regulatory role of the descending serotonin(5-HT)facilitation system on spinal PKCγ neurons.Our findings revealed that 5-HT neurons from the rostral ventromedial medulla hyperpolarize spinal inhibitory interneurons via 5-HT_(2C) receptors,disinhibiting the feedforward inhibitory circuit involving PKCγ neurons and exacerbating allodynia.Inhibiting spinal 5-HT_(2C) receptors restored the feedforward inhibitory circuit,effectively preventing neuropathic allodynia.These insights offer promising therapeutic targets for neuropathic allodynia management,emphasizing the potential of spinal 5-HT_(2C) receptors as a novel avenue for intervention.展开更多
Perioperative myocardial ischemia(PMI) is mainly caused by increasesin sympathetic nervous system activity due to stress,which results incoronary endothelial dysfunction,hence that it is hypothesized thatcaptopril may...Perioperative myocardial ischemia(PMI) is mainly caused by increasesin sympathetic nervous system activity due to stress,which results incoronary endothelial dysfunction,hence that it is hypothesized thatcaptopril may improve PMI.In our study,twenty mongrel dogs wererandomized for four groups;group Ⅰ:control,group Ⅱ:myocardialinfarction (MI) model,Group Ⅲ:MI+partial gastrectomy,group Ⅳ:MI+captopril+partial gastrectomy.Myocardial infarction wasproduced by ligation of left anterior descending coronary artery exceptthe group Ⅰ.In the group Ⅲ and Ⅳ,the hemodynamics,plasmaendothelin (ET) and nitric oxide (NO) on baseline,pre-andpostoperation were investigated two weeks after MI All animals werekilled by overdose anesthetic and their cardiac samples of non-infarction area taken for examining nitric oxide synthase (NOS)mRNA expression levels in vascular endothelial cells.Results:ingroup Ⅲ,the operation decreased the maximal rate of left ventricularpressure rise (LV+dP/dtmax),cardiac index (CI) and plasma No level,and increased left ventricular end diastolic pressure (LVEDP),time-course of isovolumic pressure fall (T constant),total peripheralresistance (TPR) and the levels of ET.In group Ⅳ,40 minutes afteradminstration of captopril,the TPR was decresed,and the t constantwas incresed significantly.The operation attenuated the TPR and Tconstant,but didn’t affect the other values.In situ hybridization it wasshowed that the expression levels of NOS mRNA was the highest ingroup Ⅰ,lower in groups Ⅱ and Ⅳ,and the lowest in group Ⅲ.Conclusions:1.Partial gastrectomy performed after myocardialinfarction may induce left ventricular systolic and diastolic dysfunction,and may produce coronary endothelial dysfunction;2.captopril canimprove left ventricular dysfuction and endothelial dysfunctioninduced by noncardiac operation.展开更多
Orpheus Descending is written by American famous playwright Tennessee Williams. According to the portrayal of a series marginalized people, this drama presents the solitude in human beings' heart and the estrangem...Orpheus Descending is written by American famous playwright Tennessee Williams. According to the portrayal of a series marginalized people, this drama presents the solitude in human beings' heart and the estrangement in interpersonal relations. This paper tries to analyze the solitude theme in this drama from philosophic aspect and realistic aspect, combining alienation theory and existentialism theory to analyze the reason and the manifestation of solitude.展开更多
Nociceptive signals conveyed to the dorsal horn of the spinal cord by primary nociceptors are subject to extensive modulation by local neurons and by supraspinal descending pathways to the spinal cord before being rel...Nociceptive signals conveyed to the dorsal horn of the spinal cord by primary nociceptors are subject to extensive modulation by local neurons and by supraspinal descending pathways to the spinal cord before being relayed to higher brain centers. Descending modulatory pathways to the spinal cord comprise,among others, noradrenergic, serotonergic, γ-aminobutyric acid(GABA)ergic, and dopaminergic fibers.The contributions of noradrenaline, serotonin, and GABA to pain modulation have been extensively investigated. In contrast, the contributions of dopamine to pain modulation remain poorly understood.The focus of this review is to summarize the current knowledge of the contributions of dopamine to pain modulation. Hypothalamic A11 dopaminergic neurons project to all levels of the spinal cord and provide the main source of spinal dopamine. Dopamine receptors are expressed in primary nociceptors as well as in spinal neurons located in different laminae in the dorsal horn of the spinal cord, suggesting that dopamine can modulate pain signals by acting at both presynaptic and postsynaptic targets. Here, I will review the literature on the effects of dopamine and dopamine receptor agonists/antagonists on the excitability of primary nociceptors, the effects of dopamine on the synaptic transmission between primary nociceptors and dorsal horn neurons, and the effects of dopamine on pain in rodents. Published data support both anti-nociceptive effects of dopamine mediated by D2-like receptors and pro-nociceptive effects mediated by D1-like receptors.展开更多
After the passage of a cold front, spring in northern China, the outbreak of strong wind is often accompanied by dust emissions. Through analyses of data in the atmospheric boundary layer during a typical case, it is ...After the passage of a cold front, spring in northern China, the outbreak of strong wind is often accompanied by dust emissions. Through analyses of data in the atmospheric boundary layer during a typical case, it is revealed there are rather regular gust wave packets superimposed on the basic strong wind flow. The gust-wind wave packets have a period equal to around 3 6 rains and possess coherent structure. As the vertical transport of momentum is decomposed into separate parts by （a） basic flow, （b） gust-wind, and （c） turbulence, they are all in a downwards direction at the lower levels of the atmospheric boundary layer during strong wind periods. However, （a） is the largest, while （b） and （c） are comparable. All these are very different from the case of normal weather. Besides, the friction velocity at the ground surface is also much larger than that of normal weather and should be corrected by taking the contributions of the basic flow and gust-wind into account.The strong basic flow with descending motion is very favorable for soil erosion and sand/dust emissions, but suppresses the entrainment of dust particles by keeping them within the bottom levels of the atmospheric boundary layer. Owing to the coherent structure of gust-wind, dust particles can effectively overcome the systematic descending air motion and penetrate into the middle and upper levels of the atmospheric boundary layer, and then propagate further and diffuse into the troposphere where ascending air motion prevails.展开更多
Background To investigate the effects of collateral coronary circulation on the outcome of the patients with anterior myocardial infarction （MI） with left anterior desending artery occlusion abruptly. Methods Data o...Background To investigate the effects of collateral coronary circulation on the outcome of the patients with anterior myocardial infarction （MI） with left anterior desending artery occlusion abruptly. Methods Data of 189 patients with acute anterior MI who had a primary percutaneous coronary intervention （PCI） in the first 12 h from the onset of symptoms between January 2004 and December 2008 were retrospective analyzed. Left anterior descending arteries （LAD） of all patients were occluded. LADs were reopened with primary PCI. According to the collateral circulation, all patients were classified to two groups： no collateral group （n = 111）, patients without angiographic collateral filling of LAD or side branches （collateral index 0） and collateral group （n = 78）, and patients with angiographic collateral filling of LAD or side branches （collateral index 1, 2 or 3）. At one year＇ s follow-up, the occurrence of death, reinfarctlon, stent thrombosis （ST）, target vessel revascularization and readmission because of heart failure were observed. Results At one year, the mortality was lower in patients with collateral circulation compared with those without collateral circulation （1% vs. 8%, P = 0.049）, whereas there Were no differences in the occurrence of reinfarction, ST, target vessel revascularization and readmission because of heart failure. The occurrence of composite of endpoint was lower in patients with collateral circulation compared with those without collateral circulation （12% vs. 26%; P = 0.014）. Conclusions Pre-exist collateral circulation may prefigure the satisfactory prognosis to the patients with acute anterior MI after primary PCI in the first 12 h of MI onset.展开更多
A high-resolution simulation tool for rotorcraft aerodynamics is developed by coupling CFD with a Vorticity Transport Model（VTM）. An Eulerian-based CFD module is used to model the blade near body flowfield, and a La...A high-resolution simulation tool for rotorcraft aerodynamics is developed by coupling CFD with a Vorticity Transport Model（VTM）. An Eulerian-based CFD module is used to model the blade near body flowfield, and a Lagrangian-based VTM module is employed for vortex tracking in the far wake. The coupling procedure is implemented by transmitting vortex sources to the VTM module and feeding boundary conditions back to the CFD module. The presented CFD/VTM hybrid solver is firstly validated by hover cases of three different rotor configurations. Simulation results, including the blade surface pressure distribution, rotor downwash, and hover figure of merit, exhibit favorable correlations with available experimental data. Then, a rotor operated in vertical descending flight with a fixed collective pitch is investigated. It is shown that the CFD/VTM coupling method is suitable for rotor wake simulation. Wake instabilities（far wake breakdown in hover and toroidal wake pattern in the vortex ring state） are successfully demonstrated with a moderate computational cost.展开更多
This article analyzes the shift factors of the descending node local time for sun-synchronous satellites and proposes a shift control method to keep the local time shift within an allowance range. It is found that the...This article analyzes the shift factors of the descending node local time for sun-synchronous satellites and proposes a shift control method to keep the local time shift within an allowance range. It is found that the satellite orbit design and the orbit injection deviation are the causes for the initial shift velocity, whereas the atmospheric drag and the sun gravitational perturbation produce the shift acceleration. To deal with these shift factors, a shift control method is put forward, through such methods as orbit variation design, orbit altitude, and inclination keeping control. The simulation experiment and practical application have proved the effectiveness of this control method.展开更多
Persistent ascending or descending mesocolon is an embryological anomaly that occurs during the final process of intestinal development in organogenesis.Specifically,the primitive dorsal mesocolon fails to fuse with t...Persistent ascending or descending mesocolon is an embryological anomaly that occurs during the final process of intestinal development in organogenesis.Specifically,the primitive dorsal mesocolon fails to fuse with the parietal peritoneum in the fifth month of gestation.Herein,we describe a case of ascending colon cancer with persistent ascending and descending mesocolon treated by laparoscopic right hemicolectomy.Preoperative computed tomography imaging of the abdomen demonstrated that the descending colon shifted at the midline of the abdomen and the sigmoid colon was located under the ascending colon.The detailed preoperative imaging examination revealed malpositioning of the large intestine and aided in the procedural planning.Because persistent mesocolon may result in the formation of abnormal adhesions,an accurate preoperative diagnosis is essential.We propose that it is important to consider this anomaly when making the preoperative imaging diagnosis to ensure a safe operation.展开更多
Purpose: Descending necrotizing mediastinitis(DNM) is a lethal and acute suppurative disease. This report aimed to summarize our experience in the treatment of DNM with continuous negative pressure catheter drainage a...Purpose: Descending necrotizing mediastinitis(DNM) is a lethal and acute suppurative disease. This report aimed to summarize our experience in the treatment of DNM with continuous negative pressure catheter drainage and transnasal jejunal feeding by interventional techniques. Materials and Methods: We retrospectively analyzed relevant clinical data of patients with DNM who underwent continuous negative pressure catheter drainage and transnasal jejunal feeding. All drainage catheters and jejunal feeding tubes were inserte d by interventional techniques. Results: In total, 21 patients were diagnosed with DNM by esophagography and computed tomography(CT). Catheters for the drainage of mediastinal abscesses as well as transnasal jejunal feeding tubes were successfully placed in all patients, indicating a 100% success rate. Of all patients, 13 underwent insertion of abscess drainage catheters through percutaneous puncture under DynaCT guidance, while eight had drainage catheter insertion through fistula orifices in the posterior nasopharyngeal wall or esophagus under fluoroscopic guidance. In total, 26 drainage tubes were inserted. One patient with diabetes died of sepsis and diabetic ketoacidosis 5 days postoperatively, while the remaining 20 patients showed good recovery with successful removal of the drainage catheters. Durations of catheterization were 45.2±50.44 days. The overall clinical success rate was 95.2%. Conclusion: The above described methods are non-surgical, minimally invasive and efficacious, and may be alternative therapeutic tools for patients who are not eligible for surgical operation, have a high postoperative risk, or are more likely to choose minimally invasive techniques.展开更多
This study was performed to summarize our clinical experience with testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children.This study included 1034 chi...This study was performed to summarize our clinical experience with testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children.This study included 1034 children with palpable cryptorchidism from March 2009 to March 2019.A scrotal stria incision was used to perform testicular descent and fixation.Overall,1020 children successfully underwent surgical testicular descent and fixation through a scrotal stria incision,and 14 patients underwent conversion to inguinal incision surgery.All patients were discharged 1-2 days after the operation.During hospitalization and follow-up,55 patients developed complicationsy including 10 patients with testicular retraction,7 with poor healing of the incision,and 38 with a scrotal hematoma.No patients developed testicular atrophy,an in direct ingui nal hernia,or a hydrocoele.Testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children is safe and feasible in well-selected cases.This method has the advantages of no scarring and a good cosmetic effect.展开更多
基金Supported by the National Natural Science Foundation of China (31171986)Science and Technology Creative Talents of the Special Fund Project of Harbin (RC2012XK002013)Overseas Scholars Research Funding Project of Education Department of Heilongjiang Province (1154h04)
文摘Four different rose hybrid populations were analyzed by ISSR technique with nine polymorphic primers. All of the primers produced 64 bands, of which 59 were polymorphic. The average of polymorphic bands was 6.6 for each primer. The percentage of polymorphism ranged from 57.1% to 100%, with an average of 92.3%. An UPGMA dendrogram showed five groups. The primer numbered with PI9 and PI11 had relatively high resolution in identifying the F1 offspring in this research.
文摘In 2021,the relatives of 16 international friends of China jointly sent a letter to Chinese President Xi Jinping,congratulating the Communist Party of China(CPC)on its 100th anniversary.These are the sons and daughters and family members of those who helped China in its times of need.Eric Foster,nephew of renowned U.S.journalist Helen Foster-Snow,was one of them.
文摘ON May 20,2025,eighteen descendants of British prisoners of war(POWs)rescued in the Lisbon Maru incident arrived on Dongji Island in east China’s Zhejiang Province,after a long transoceanic journey.They joined descendants of the local fishermen who had saved their ancestors 83 years ago,gathering to witness the unveiling of a memorial erected in honor of the fishermen’s extraordinary bravery.At its center,the memorial bears the inscription:“Love knows no boundaries;Friendship transcends time.”
基金funded by the Key Program of the National Natural Science Foundation of China(No.82130122).
文摘The subnucleus reticularis dorsalis(SRD),also known as the dorsal reticular nucleus(DRt)or dorsal medullary reticular nucleus(MdD),which resides at the caudal end of the medulla,plays a pivotal role in regulating pain perception.Despite extensive research efforts to unravel its mechanisms,the operational intricacies of SRD remain poorly understood.Advances in experimental methodologies such as brain imaging and chemogenetics have facilitated deeper investigations into the involvement of SRD in various pain disorders.This comprehensive review aims to analyze 36 years(1989–2024)of preclinical research highlighting the critical role of SRD in diffuse noxious inhibitory control(DNIC),also known as conditioned pain modulation(CPM)in humans,and its interconnected neural circuits.Moreover,this review explores the neural circuits related to SRD,including locus coeruleus(LC)-SRD,parabrachial nucleus(PBN)-SRD,rostroventromedial medulla(RVM)-ventrolateral medulla(VLM)-SRD,anterior cingulate cortex(ACC)-SRD,medial medullary reticular formation(mMRF)-SRD,and dorsal striatum(DS)-SRD.Their activation also plays a significant role in analgesia.The pivotal roles of neurotransmitters such asμ-opioid receptor(MOR),noradrenaline,and metabotropic glutamate receptor 7(mGluR7)in modulating SRD responsiveness to pain stimuli are also discussed,as are the influences of SRD on different pain types.This review identified promising avenues for innovative analgesic treatments by shedding light on potential therapeutic strategies targeting SRD.
文摘BACKGROUND Squamous cell carcinoma(SCC)of the colon is a rare malignant tumor with an unclear pathogenesis.Its clinical presentation is similar to that of adenocarcinoma,and there are no standard treatment guidelines.Treatment for SCC of the colon is mainly based on the protocols for colon adenocarcinoma.In advanced stages,colon SCC is highly invasive,prone to distant metastasis,and has a worse prog-nosis than adenocarcinoma.Furthermore,pancreatic metastasis from colon SCC is even rarer.CASE SUMMARY The patient presented with abdominal pain and was diagnosed with SCC of the descending colon following colonoscopy.Preoperative examinations did not reveal any obvious metastasis to other organs,and the patient underwent laparo-scopic radical resection of the descending colon cancer.During surgery,suspi-cious metastases to the pancreatic body and tail,splenic vessels,and splenic hilum were found,leading to combined resection of the pancreatic body and tail along with the spleen.Postoperative pathology confirmed moderately to poorly diffe-rentiated SCC with nerve invasion.The patient developed postoperative compli-cations,including abdominal cavity infection,acute myocardial infarction,and deep vein thrombosis in the lower limbs.Despite active symptomatic treatment and stabilization of the patient’s vital signs,the patient did not undergo adjuvant chemotherapy due to an Eastern Cooperative Oncology Group score of 3.The patient passed away 3 months postoperatively due to multiple organ failure.CONCLUSION This case highlights the aggressive nature of colorectal SCC with atypical meta-stasis and underscores the necessity for multidisciplinary perioperative management.
文摘BACKGROUND Descending thoracic aortic aneurysms are dangerous and have to be treated quickly.The primary treatment methods are thoracic endovascular aortic repair(TEVAR)and open surgical repair(OSR).The comparative effectiveness and safety of TEVAR and OSR were evaluated in this meta-analysis,focusing on perioperative and long-term outcomes.AIM To compare and contrast the efficacy and safety of TEVAR vs OSR in the treatment of descending thoracic aortic aneurysms.This study aims to assess both perioperative and long-term outcomes through a systematic review and metaanalysis.METHODS A comprehensive search of PubMed,EMBASE,and Cochrane was conducted from inception to January 2025.Baseline characteristics and outcomes were evaluated.Odds ratios(OR)for dichotomous data and mean differences for continuous data with 95%confidence intervals(CI)were analyzed using random-effects models.RESULTS A meta-analysis of 21 studies involving 29465 patients(8261 TEVAR;21204 OR)showed TEVAR associated with lower operative mortality(OR=0.60,95%CI:0.42-0.85,P=0.004),shorter intensive care unit(-2.94 days,95%CI:-4.76 to-1.12,P=0.002)and hospital stays(-7.35 days,95%CI:-10.54 to-4.17,P<0.00001),and reduced rates of paraplegia(OR=0.44,95%CI:0.27-0.73,P=0.002),spinal ischemia(OR=0.30,95%CI:0.16-0.56,P=0.0002),renal failure(OR=0.29,95%CI:0.14-0.61,P=0.001),and wound infections(OR=0.28,95%CI:0.13-0.61,P=0.001).However,TEVAR had higher rates of vascular complications.No significant differences were noted in 1-year and 5-year mortality rates,the rate of non-elective surgery,neurological complications,or stroke rates.CONCLUSION Compared to EVAR,TEVAR revealed lower operative mortality and better perioperative outcomes across all indicators,including hospital and intensive care unit stays,as well as fewer complications,except for those related to vascular problems.Mortality results were also similar in the long run;consequently,more research is required concerning the long-term durability.
基金supported by the National Natural Science Foundation of China(81971058,82371226,82101295,82301398)the National Funded Postdoctoral Researcher Program(GZC20233585)The Boost Plan of Xijing Hospital(XJZT24QN25,XJZT25CX22).
文摘Neuropathic pain,often featuring allodynia,imposes significant physical and psychological burdens on patients,with limited treatments due to unclear central mechanisms.Addressing this challenge remains a crucial unsolved issue in pain medicine.Our previous study,using protein kinase C gamma(PKCγ)-tdTomato mice,highlights the spinal feedforward inhibitory circuit involving PKCγ neurons in gating neuropathic allodynia.However,the regulatory mechanisms governing this circuit necessitate further elucidation.We used diverse transgenic mice and advanced techniques to uncover the regulatory role of the descending serotonin(5-HT)facilitation system on spinal PKCγ neurons.Our findings revealed that 5-HT neurons from the rostral ventromedial medulla hyperpolarize spinal inhibitory interneurons via 5-HT_(2C) receptors,disinhibiting the feedforward inhibitory circuit involving PKCγ neurons and exacerbating allodynia.Inhibiting spinal 5-HT_(2C) receptors restored the feedforward inhibitory circuit,effectively preventing neuropathic allodynia.These insights offer promising therapeutic targets for neuropathic allodynia management,emphasizing the potential of spinal 5-HT_(2C) receptors as a novel avenue for intervention.
文摘Perioperative myocardial ischemia(PMI) is mainly caused by increasesin sympathetic nervous system activity due to stress,which results incoronary endothelial dysfunction,hence that it is hypothesized thatcaptopril may improve PMI.In our study,twenty mongrel dogs wererandomized for four groups;group Ⅰ:control,group Ⅱ:myocardialinfarction (MI) model,Group Ⅲ:MI+partial gastrectomy,group Ⅳ:MI+captopril+partial gastrectomy.Myocardial infarction wasproduced by ligation of left anterior descending coronary artery exceptthe group Ⅰ.In the group Ⅲ and Ⅳ,the hemodynamics,plasmaendothelin (ET) and nitric oxide (NO) on baseline,pre-andpostoperation were investigated two weeks after MI All animals werekilled by overdose anesthetic and their cardiac samples of non-infarction area taken for examining nitric oxide synthase (NOS)mRNA expression levels in vascular endothelial cells.Results:ingroup Ⅲ,the operation decreased the maximal rate of left ventricularpressure rise (LV+dP/dtmax),cardiac index (CI) and plasma No level,and increased left ventricular end diastolic pressure (LVEDP),time-course of isovolumic pressure fall (T constant),total peripheralresistance (TPR) and the levels of ET.In group Ⅳ,40 minutes afteradminstration of captopril,the TPR was decresed,and the t constantwas incresed significantly.The operation attenuated the TPR and Tconstant,but didn’t affect the other values.In situ hybridization it wasshowed that the expression levels of NOS mRNA was the highest ingroup Ⅰ,lower in groups Ⅱ and Ⅳ,and the lowest in group Ⅲ.Conclusions:1.Partial gastrectomy performed after myocardialinfarction may induce left ventricular systolic and diastolic dysfunction,and may produce coronary endothelial dysfunction;2.captopril canimprove left ventricular dysfuction and endothelial dysfunctioninduced by noncardiac operation.
文摘Orpheus Descending is written by American famous playwright Tennessee Williams. According to the portrayal of a series marginalized people, this drama presents the solitude in human beings' heart and the estrangement in interpersonal relations. This paper tries to analyze the solitude theme in this drama from philosophic aspect and realistic aspect, combining alienation theory and existentialism theory to analyze the reason and the manifestation of solitude.
基金supported by internal funds to MP from the Department of Anesthesiology,Stony Brook Medicine,USA
文摘Nociceptive signals conveyed to the dorsal horn of the spinal cord by primary nociceptors are subject to extensive modulation by local neurons and by supraspinal descending pathways to the spinal cord before being relayed to higher brain centers. Descending modulatory pathways to the spinal cord comprise,among others, noradrenergic, serotonergic, γ-aminobutyric acid(GABA)ergic, and dopaminergic fibers.The contributions of noradrenaline, serotonin, and GABA to pain modulation have been extensively investigated. In contrast, the contributions of dopamine to pain modulation remain poorly understood.The focus of this review is to summarize the current knowledge of the contributions of dopamine to pain modulation. Hypothalamic A11 dopaminergic neurons project to all levels of the spinal cord and provide the main source of spinal dopamine. Dopamine receptors are expressed in primary nociceptors as well as in spinal neurons located in different laminae in the dorsal horn of the spinal cord, suggesting that dopamine can modulate pain signals by acting at both presynaptic and postsynaptic targets. Here, I will review the literature on the effects of dopamine and dopamine receptor agonists/antagonists on the excitability of primary nociceptors, the effects of dopamine on the synaptic transmission between primary nociceptors and dorsal horn neurons, and the effects of dopamine on pain in rodents. Published data support both anti-nociceptive effects of dopamine mediated by D2-like receptors and pro-nociceptive effects mediated by D1-like receptors.
基金funded by the National Natural Science Foundation of China under Grant Nos.40830103, 40775018, 40875008 and 40605006the science plan in the Chinese Academy of Sciences (KZCX2-YW210)+2 种基金Chinese Academy of Sciences under Grant No.YZ200708through special finance from the China Meteorological Administration(GYHY200706034)the Urban Meteorological Research Foundation (UMRF200810)
文摘After the passage of a cold front, spring in northern China, the outbreak of strong wind is often accompanied by dust emissions. Through analyses of data in the atmospheric boundary layer during a typical case, it is revealed there are rather regular gust wave packets superimposed on the basic strong wind flow. The gust-wind wave packets have a period equal to around 3 6 rains and possess coherent structure. As the vertical transport of momentum is decomposed into separate parts by （a） basic flow, （b） gust-wind, and （c） turbulence, they are all in a downwards direction at the lower levels of the atmospheric boundary layer during strong wind periods. However, （a） is the largest, while （b） and （c） are comparable. All these are very different from the case of normal weather. Besides, the friction velocity at the ground surface is also much larger than that of normal weather and should be corrected by taking the contributions of the basic flow and gust-wind into account.The strong basic flow with descending motion is very favorable for soil erosion and sand/dust emissions, but suppresses the entrainment of dust particles by keeping them within the bottom levels of the atmospheric boundary layer. Owing to the coherent structure of gust-wind, dust particles can effectively overcome the systematic descending air motion and penetrate into the middle and upper levels of the atmospheric boundary layer, and then propagate further and diffuse into the troposphere where ascending air motion prevails.
文摘Background To investigate the effects of collateral coronary circulation on the outcome of the patients with anterior myocardial infarction （MI） with left anterior desending artery occlusion abruptly. Methods Data of 189 patients with acute anterior MI who had a primary percutaneous coronary intervention （PCI） in the first 12 h from the onset of symptoms between January 2004 and December 2008 were retrospective analyzed. Left anterior descending arteries （LAD） of all patients were occluded. LADs were reopened with primary PCI. According to the collateral circulation, all patients were classified to two groups： no collateral group （n = 111）, patients without angiographic collateral filling of LAD or side branches （collateral index 0） and collateral group （n = 78）, and patients with angiographic collateral filling of LAD or side branches （collateral index 1, 2 or 3）. At one year＇ s follow-up, the occurrence of death, reinfarctlon, stent thrombosis （ST）, target vessel revascularization and readmission because of heart failure were observed. Results At one year, the mortality was lower in patients with collateral circulation compared with those without collateral circulation （1% vs. 8%, P = 0.049）, whereas there Were no differences in the occurrence of reinfarction, ST, target vessel revascularization and readmission because of heart failure. The occurrence of composite of endpoint was lower in patients with collateral circulation compared with those without collateral circulation （12% vs. 26%; P = 0.014）. Conclusions Pre-exist collateral circulation may prefigure the satisfactory prognosis to the patients with acute anterior MI after primary PCI in the first 12 h of MI onset.
基金co-supported by the Funding of Jiangsu Innovation Program for Graduate Education of China(No.KYLX16_0389)the Fundamental Research Funds for the Central Universities of China
文摘A high-resolution simulation tool for rotorcraft aerodynamics is developed by coupling CFD with a Vorticity Transport Model（VTM）. An Eulerian-based CFD module is used to model the blade near body flowfield, and a Lagrangian-based VTM module is employed for vortex tracking in the far wake. The coupling procedure is implemented by transmitting vortex sources to the VTM module and feeding boundary conditions back to the CFD module. The presented CFD/VTM hybrid solver is firstly validated by hover cases of three different rotor configurations. Simulation results, including the blade surface pressure distribution, rotor downwash, and hover figure of merit, exhibit favorable correlations with available experimental data. Then, a rotor operated in vertical descending flight with a fixed collective pitch is investigated. It is shown that the CFD/VTM coupling method is suitable for rotor wake simulation. Wake instabilities（far wake breakdown in hover and toroidal wake pattern in the vortex ring state） are successfully demonstrated with a moderate computational cost.
基金supported by the China Postdotoral Science Foundation(20060401004)
文摘This article analyzes the shift factors of the descending node local time for sun-synchronous satellites and proposes a shift control method to keep the local time shift within an allowance range. It is found that the satellite orbit design and the orbit injection deviation are the causes for the initial shift velocity, whereas the atmospheric drag and the sun gravitational perturbation produce the shift acceleration. To deal with these shift factors, a shift control method is put forward, through such methods as orbit variation design, orbit altitude, and inclination keeping control. The simulation experiment and practical application have proved the effectiveness of this control method.
文摘Persistent ascending or descending mesocolon is an embryological anomaly that occurs during the final process of intestinal development in organogenesis.Specifically,the primitive dorsal mesocolon fails to fuse with the parietal peritoneum in the fifth month of gestation.Herein,we describe a case of ascending colon cancer with persistent ascending and descending mesocolon treated by laparoscopic right hemicolectomy.Preoperative computed tomography imaging of the abdomen demonstrated that the descending colon shifted at the midline of the abdomen and the sigmoid colon was located under the ascending colon.The detailed preoperative imaging examination revealed malpositioning of the large intestine and aided in the procedural planning.Because persistent mesocolon may result in the formation of abnormal adhesions,an accurate preoperative diagnosis is essential.We propose that it is important to consider this anomaly when making the preoperative imaging diagnosis to ensure a safe operation.
文摘Purpose: Descending necrotizing mediastinitis(DNM) is a lethal and acute suppurative disease. This report aimed to summarize our experience in the treatment of DNM with continuous negative pressure catheter drainage and transnasal jejunal feeding by interventional techniques. Materials and Methods: We retrospectively analyzed relevant clinical data of patients with DNM who underwent continuous negative pressure catheter drainage and transnasal jejunal feeding. All drainage catheters and jejunal feeding tubes were inserte d by interventional techniques. Results: In total, 21 patients were diagnosed with DNM by esophagography and computed tomography(CT). Catheters for the drainage of mediastinal abscesses as well as transnasal jejunal feeding tubes were successfully placed in all patients, indicating a 100% success rate. Of all patients, 13 underwent insertion of abscess drainage catheters through percutaneous puncture under DynaCT guidance, while eight had drainage catheter insertion through fistula orifices in the posterior nasopharyngeal wall or esophagus under fluoroscopic guidance. In total, 26 drainage tubes were inserted. One patient with diabetes died of sepsis and diabetic ketoacidosis 5 days postoperatively, while the remaining 20 patients showed good recovery with successful removal of the drainage catheters. Durations of catheterization were 45.2±50.44 days. The overall clinical success rate was 95.2%. Conclusion: The above described methods are non-surgical, minimally invasive and efficacious, and may be alternative therapeutic tools for patients who are not eligible for surgical operation, have a high postoperative risk, or are more likely to choose minimally invasive techniques.
文摘This study was performed to summarize our clinical experience with testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children.This study included 1034 children with palpable cryptorchidism from March 2009 to March 2019.A scrotal stria incision was used to perform testicular descent and fixation.Overall,1020 children successfully underwent surgical testicular descent and fixation through a scrotal stria incision,and 14 patients underwent conversion to inguinal incision surgery.All patients were discharged 1-2 days after the operation.During hospitalization and follow-up,55 patients developed complicationsy including 10 patients with testicular retraction,7 with poor healing of the incision,and 38 with a scrotal hematoma.No patients developed testicular atrophy,an in direct ingui nal hernia,or a hydrocoele.Testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children is safe and feasible in well-selected cases.This method has the advantages of no scarring and a good cosmetic effect.
