The mathematical model of stem cells is discussed with its motivation to describe the tissue relationship by technically introducing a two compartments model. The clear link between the proliferation phase of stem cel...The mathematical model of stem cells is discussed with its motivation to describe the tissue relationship by technically introducing a two compartments model. The clear link between the proliferation phase of stem cells and the circulating neutrophil phase is set forth after delay feedback control of the state variable of stem cells. Hopf bifurcation is discussed with varying free parameters and time delays. Based on the center manifold theory, the normal form near the critical point is computed and the stability of bifurcating periodical solution is rigorously discussed. With the aids of the artificial tool on-hand which implies how much tedious work doing by DDE-Biftool software, the bifurcating periodic solution after Hopf point is continued by varying time delay.展开更多
The DDE-Biftool software is applied to solve the dynamical stability and bifurcation problem of the neutrophil cells model. Based on Hopf point finding with the stability property of the equilibrium solution loss, the...The DDE-Biftool software is applied to solve the dynamical stability and bifurcation problem of the neutrophil cells model. Based on Hopf point finding with the stability property of the equilibrium solution loss, the continuation of the bifurcating periodical solution starting from Hopf point is exploited. The generalized Hopf point is tracked by seeking for the critical value of free parameter of the switching phenomena of the open loop, which describes the lineup of bifurcating periodical solutions from Hopf point. The normal form near the generalized Hopf point is computed by Lyapunov-Schimdt reduction scheme combined with the center manifold analytical technique. The near dynamics is classified by geometrically different topological phase portraits.展开更多
文摘The mathematical model of stem cells is discussed with its motivation to describe the tissue relationship by technically introducing a two compartments model. The clear link between the proliferation phase of stem cells and the circulating neutrophil phase is set forth after delay feedback control of the state variable of stem cells. Hopf bifurcation is discussed with varying free parameters and time delays. Based on the center manifold theory, the normal form near the critical point is computed and the stability of bifurcating periodical solution is rigorously discussed. With the aids of the artificial tool on-hand which implies how much tedious work doing by DDE-Biftool software, the bifurcating periodic solution after Hopf point is continued by varying time delay.
文摘The DDE-Biftool software is applied to solve the dynamical stability and bifurcation problem of the neutrophil cells model. Based on Hopf point finding with the stability property of the equilibrium solution loss, the continuation of the bifurcating periodical solution starting from Hopf point is exploited. The generalized Hopf point is tracked by seeking for the critical value of free parameter of the switching phenomena of the open loop, which describes the lineup of bifurcating periodical solutions from Hopf point. The normal form near the generalized Hopf point is computed by Lyapunov-Schimdt reduction scheme combined with the center manifold analytical technique. The near dynamics is classified by geometrically different topological phase portraits.
