Background/Aim: Dandruff is a common scalp problem associated with flaky and inflamed skin. In this study, we investigated the efficacy of a shampoo containing piroctone olamine and climbazole and the combination of t...Background/Aim: Dandruff is a common scalp problem associated with flaky and inflamed skin. In this study, we investigated the efficacy of a shampoo containing piroctone olamine and climbazole and the combination of this shampoo with a scalp tonic containing piroctone olamine and licochalcone A, derived from Glycyrrhiza inflata root extract, to reduce dandruff. Study Design/Methods: After conditioning, 102 subjects (♂ 56 and 46 ♀) with moderate to very strong dandruff affection underwent a randomized half head study for 4 weeks. The volunteers’ heads were washed regularly either with a placebo or the anti-dandruff shampoo, followed by the anti-dandruff tonic application or no treatment. In a 2-week post-treatment phase, subjects only applied placebo shampoo. Every two weeks, trained experts assessed dandruff affection based on a scale of 1 to 6. At study start and after every 2 weeks, cytokine concentrations and anti-fungal activity of test products were determined in scalp wash-ups by enzyme-linked immunosorbant assays or a Malassezia colony-forming assay, respectively. Results: Results of expert grading and anti-fungal activity revealed a significant reduction in dandruff affection and Malassezia colony-forming units after treatment with the anti-dandruff shampoo or its combination with the tonic. Dandruff affection even remained reduced in the post-treatment phase when levels of Malassezia colony-forming units had returned to baseline. Cytokine analyses proved a significant decrease in pro-inflammatory dandruff markers after treatment with both anti-dandruff products. For the shampoo/tonic combination, a superior reduction of one scalp inflammatory marker was determined even after the post-treatment phase. Conclusion: Both the rinse-off shampoo as well as its combination with the leave-on tonic excellently alleviated dandruff and its associated micro-inflammation. Both treatments showed anti-fungal activity. The superior benefit, exerted by the combination, is primarily based on the known anti-inflammatory effect of licochalcone A and the improved scalp substantivity of the leave-on application.展开更多
The human scalp harbors a diverse range of microbiome,much like other skin surfaces,where both beneficial and harmful microorganisms coexist.This study explores the possibility of balancing key scalp microorganisms,pa...The human scalp harbors a diverse range of microbiome,much like other skin surfaces,where both beneficial and harmful microorganisms coexist.This study explores the possibility of balancing key scalp microorganisms,particularly Staphylococcus epidermidis,Staphylococcus aureus and Malassezia species.While Staphylococcus epidermidis plays a beneficial role in maintaining scalp health by producing antimicrobial proteins and supporting the skin barrier,Staphylococcus aureus is identified as a pathogen linked to skin infections and dandruff formation.Malassezia fungi degrade triglycerides in sebum into unsaturated fatty acids,exacerbating scalp conditions like dandruff.In order to promote the beneficial microbe while inhibit the harmful ones,we investigated the combination of 1.0 mM pyrrolidone carboxylate-zinc(PCA-Zn),0.2%malt oligosaccharides(MT:corn-derived oligosaccharide mainly containing maltotetraose)and 0.05 mM Hinokitiol on its microbial activity,which significantly enhanced the growth of Staphylococcus epidermidis while inhibiting both Staphylococcus aureus and Malassezia,offering insights into promising strategies for scalp care.展开更多
文摘Background/Aim: Dandruff is a common scalp problem associated with flaky and inflamed skin. In this study, we investigated the efficacy of a shampoo containing piroctone olamine and climbazole and the combination of this shampoo with a scalp tonic containing piroctone olamine and licochalcone A, derived from Glycyrrhiza inflata root extract, to reduce dandruff. Study Design/Methods: After conditioning, 102 subjects (♂ 56 and 46 ♀) with moderate to very strong dandruff affection underwent a randomized half head study for 4 weeks. The volunteers’ heads were washed regularly either with a placebo or the anti-dandruff shampoo, followed by the anti-dandruff tonic application or no treatment. In a 2-week post-treatment phase, subjects only applied placebo shampoo. Every two weeks, trained experts assessed dandruff affection based on a scale of 1 to 6. At study start and after every 2 weeks, cytokine concentrations and anti-fungal activity of test products were determined in scalp wash-ups by enzyme-linked immunosorbant assays or a Malassezia colony-forming assay, respectively. Results: Results of expert grading and anti-fungal activity revealed a significant reduction in dandruff affection and Malassezia colony-forming units after treatment with the anti-dandruff shampoo or its combination with the tonic. Dandruff affection even remained reduced in the post-treatment phase when levels of Malassezia colony-forming units had returned to baseline. Cytokine analyses proved a significant decrease in pro-inflammatory dandruff markers after treatment with both anti-dandruff products. For the shampoo/tonic combination, a superior reduction of one scalp inflammatory marker was determined even after the post-treatment phase. Conclusion: Both the rinse-off shampoo as well as its combination with the leave-on tonic excellently alleviated dandruff and its associated micro-inflammation. Both treatments showed anti-fungal activity. The superior benefit, exerted by the combination, is primarily based on the known anti-inflammatory effect of licochalcone A and the improved scalp substantivity of the leave-on application.
文摘The human scalp harbors a diverse range of microbiome,much like other skin surfaces,where both beneficial and harmful microorganisms coexist.This study explores the possibility of balancing key scalp microorganisms,particularly Staphylococcus epidermidis,Staphylococcus aureus and Malassezia species.While Staphylococcus epidermidis plays a beneficial role in maintaining scalp health by producing antimicrobial proteins and supporting the skin barrier,Staphylococcus aureus is identified as a pathogen linked to skin infections and dandruff formation.Malassezia fungi degrade triglycerides in sebum into unsaturated fatty acids,exacerbating scalp conditions like dandruff.In order to promote the beneficial microbe while inhibit the harmful ones,we investigated the combination of 1.0 mM pyrrolidone carboxylate-zinc(PCA-Zn),0.2%malt oligosaccharides(MT:corn-derived oligosaccharide mainly containing maltotetraose)and 0.05 mM Hinokitiol on its microbial activity,which significantly enhanced the growth of Staphylococcus epidermidis while inhibiting both Staphylococcus aureus and Malassezia,offering insights into promising strategies for scalp care.
