The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design ...The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated molecular patterns （DAMPs） can activate immune cells, including dendritic cells （DCs）, via Toll-like receptors （TLRs）; however, the role of DAMPs released from chemical drug-treated tumor cells in the activation of the immune response needs to be further elucidated. Here, we found that colorectal cancer （CRC） cells treated with oxaliplatin （OXA） and/or 5-fluorouracil （5-Fu） released high levels of high-mobility group box 1 （HMGB1） and heat shock protein 70 （HSP70）. After OXA/5-Fu therapy, the sera of CRC patients also exhibited increased levels of HMGB1 and HSP70, both of which are well-known DAMPs. The supernatants of dying CRC cells treated with OXA/5-Fu promoted mouse and human DC maturation, with upregulation of HLA-DR, CD80 and CD86 expression and enhancement of IL-lp, TNF-a, MIP-la, MIP-lp, RANTES and IP-IO production. Vaccines composed of DCs pulsed with the supernatants of chemically stressed CRC cells induced a more significant IFN-y-producing Thl response both in vitroand in vivo. However, the supernatants of chemically stressed CRC cells failed to induce phenotypic maturation and cytokine production in TLR4-deficient DCs, indicating an essential role of TLR4 in DAMP-induced DC maturation and activation. Furthermore, pulsing with the supernatants of chemically stressed CRC cells did not efficiently induce an IFN-y-producing Thl response in TLR4-deficient DCs. Collectively, these results demonstrate that DAMPs released from chemically stressed cancer cells can activate DCs viaTLR4 and enhance the induction of an anti-tumor T-cell immune response, delineating a clinically relevant immuno-adjuvant pathway triggered by DAMPs.展开更多
The inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis,are chronic,relapsing immune mediated disorders of the gastrointestinal homeostasis and intestinal inflammation[1].Failure to re...The inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis,are chronic,relapsing immune mediated disorders of the gastrointestinal homeostasis and intestinal inflammation[1].Failure to resolve mucosal inflammation and maintain gut barrier are notable shared clinical challenges in IBD,in particular when they activate immune cells within the gut lamia propria.Clinical trials and animal model studies aiming towards DAMPs have demonstrated that they can be effective therapeutic targets in mucosal inflammation of IBD.展开更多
To ensure the compatibility between rolling stock and infrastructure when dynamically assessing railway bridges under high-speed traffic,the damping properties considered in the calculation model significantly influen...To ensure the compatibility between rolling stock and infrastructure when dynamically assessing railway bridges under high-speed traffic,the damping properties considered in the calculation model significantly influence the predicted acceleration amplitude at resonance.However,due to the normative specifications of EN 1991-2,which are considered to be overly conservative,damping factors that are far below the actual damping have to be used when predicting vibrations of railway bridges,which means that accelerations at resonance tend to be overestimated to an uneconomical extent.Comparisons between damping factors prescribed by the standard and those identified based on in situ structure measurements always reveal a large discrepancy between reality and regulation.Given this background,this contribution presents a novel approach for defining the damping factor of railway bridges with ballasted tracks,where the damping factor for bridges is mathematically determined based on three different two-dimensional mechanical models.The basic principle of the approach for mathematically determining the damping factor is to separately define and superimpose the dissipative contributions of the supporting structure(including the substructure)and the superstructure.Using the results of a measurement campaign on 15 existing steel railway bridges in the Austrian rail network,the presented mechanical models are calibrated,and by analysing the energy dissipation in the ballasted track,guiding principles for practical application are defined.This guideline is intended to establish an alternative to the currently valid specifications of EN 1991-2,enabling the damping factor of railway bridges to be assessed in a realistic range by mathematical calculation and thus without the need for extensive in situ measurements on the individual structure.In this way,the existing potential of the infrastructure with regard to the damping properties of bridges can be utilised.This contribution focuses on steel bridges,but the mathematical approach for determining the damping factor applies equally to other bridge types(concrete,composite,or filler beam).展开更多
The existence of a global attractor is established for generalized Navier-Stokes equations incorporating damping term within the periodic domainΩ=[−π,π]^(n).Initially,we show the existence and uniqueness of strong ...The existence of a global attractor is established for generalized Navier-Stokes equations incorporating damping term within the periodic domainΩ=[−π,π]^(n).Initially,we show the existence and uniqueness of strong solutions.Subsequently,we verify the continuity of the associated semigroup when max{2n+1/n-1,5n+2/3n-2} < β <3n+2/n-2.Finally,we establish the existence of both H^(α)-global attractor and H^(2α)-global attractor.展开更多
As environmental concerns drive shifts in construction materials,rock is increasingly considered as an alternative to sand,reinforcing the importance of understanding its dynamic properties.This study investigates the...As environmental concerns drive shifts in construction materials,rock is increasingly considered as an alternative to sand,reinforcing the importance of understanding its dynamic properties.This study investigates the effect of water content on the small-strain dynamic properties of basalt samples using free-free laboratory testing.Free-free testing,which requires minimal equipment and preparation,provides an efficient and low-cost method for determining key dynamic properties,including three wave velocities(V_(s),V_(p),and V_(c)),material damping ratios,and Poisson's ratios.These properties are crucial for numerical modeling in earthquake analyses and geotechnical site characterization.The test consists of three components:(1)direct travel-time measurement,(2)torsional resonance testing,and(3)compressional resonance testing.A total of 20 rock samples were tested under systematically controlled water contents,ranging from fully dried to saturated,to quantify the effects on Poisson's ratio and material damping ratios.The results showed significant increases in both parameters with rising water content.The Poisson's ratio increased by up to 320%for aphanitic basalt and 150%for vesicular basalt,while the damping ratio rose up to 30-fold(D_(c,min))and 16-fold(D_(s,min)).These findings highlight the critical need to incorporate consideration of water content when characterizing dynamic rock properties for seismic and geotechnical analyses.The practical applicability of this research lies in improving in situ property interpretation and enhancing seismic design reliability by providing engineers with precise relationships between water content and dynamic rock behavior.展开更多
The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and e...The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and existence of uniform attractor under some suitable assumptions on the nonlinear term g(u),the nonlinear damping f(u_(t))and the external force h(x,t).Specifically,the asymptotic compactness of the semigroup is verified by the energy reconstruction method.展开更多
We investigate the three-dimensional(3D)generalized magnetohydrodynamic(MHD)-Boussinesq system with fractional dissipation and damping terms,aiming to establish the well-posedness theory for the 3D incompressible temp...We investigate the three-dimensional(3D)generalized magnetohydrodynamic(MHD)-Boussinesq system with fractional dissipation and damping terms,aiming to establish the well-posedness theory for the 3D incompressible temperature-dependent MHD-Boussinesq equations with damping.By exploiting the structural properties of the system and performing refined a priori estimates,we address the global well-posedness of solutions under the weakest possible dissipation conditions.展开更多
Under the condition of frequent replacement of wind tunnel models,multiple types of wind tunnel models are fixed by a slender support sting with low stiffness damping.When excited by wind load,various models produce r...Under the condition of frequent replacement of wind tunnel models,multiple types of wind tunnel models are fixed by a slender support sting with low stiffness damping.When excited by wind load,various models produce random multi-dimensional vibration with different characteristics,which makes it impossible to obtain accurate and efficient aerodynamic data.Therefore,in order to ensure the reliable and efficient conduction of wind tunnel test,a wind-tunnel-modeladaptive vibration control method is proposed in this paper.First,the split type adaptive vibration suppression structure is designed.Second,the multi-dimensional vibration characteristic characterization method is derived and the vibration characteristic identification method of the system is designed.Then,a vibration state estimation model is established according to the identification results of vibration characteristics,and a multi-actuator cooperative control method based on vibration state estimation is constructed.Finally,a model-adaptive vibration control system is built,and vibration characteristics identification and hammer experiments are carried out for two types of typical models.The results show that the proposed model-adaptive vibration control method increases the equivalent damping ratio of pitch and yaw dimensions of the high-aspect-ratio class model by 8.19 times and 48.81 times,respectively.The equivalent damping ratio of pitch and yaw dimensions of the highslenderness-ratio class model is increased by 16.44 and 5.43 times,respectively.It provides a strong guarantee for the reliable and efficient development of multi-type wind tunnel test tasks.展开更多
The wide-area damping controllers(WADCs),which are essential for mitigating regional low-frequency oscillations,face cyber-physical security threats due to the vulnerability of wide-area measurement system to cyber at...The wide-area damping controllers(WADCs),which are essential for mitigating regional low-frequency oscillations,face cyber-physical security threats due to the vulnerability of wide-area measurement system to cyber attacks and wind power uncertainties.This paper introduces reachability analysis method to quantify the impact of varying-amplitude attacks and uncertain wind fluctuations on the performance of WADC.Firstly,considering wind farm integration and attack injection,a nonlinear power system model with multiple buses is constructed based on Kron reduction method to improve computational efficiency and mitigate the constraints imposed by algebraic constraints.Then,a zonotope-based polytope construction method is employed to effectively model the range of attack amplitudes and wind uncertainties.By conducting reachability analysis,the reachable set preserving the nonlinear characteristics of studied system is computed,which enables the quantification of the maximum fluctuation range of regional oscillations under the dual disturbances.Case studies are undertaken on two multi-machine power systems with wind farm integration.The obtained results emphasize the efficacy of designed method,providing valuable insights into the magnitude of the impact that attacks exert on the operational characteristics of power system under various uncertain factors.展开更多
This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite-epoxy(G-E)composites reinforced with cast ...This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite-epoxy(G-E)composites reinforced with cast iron(CI)filler particles.Hybrid G-E composite with added cast iron(CI)filler particles enhances stiffness,strength,and vibration damping,offering enhanced performance for vibration-sensitive engineering applications.Unlike conventional approaches,this work simultaneously employs Artificial Neural Networks(ANN)for highaccuracy property prediction and Response Surface Methodology(RSM)for in-depth analysis of factor interactions and optimization.A total of 24 experimental test data sets of varying input factors(granite weight%,epoxy weight%,and CI filler weight%)were utilized to train and test the prediction models using an ANN approach and further analyze the interaction effects using RSM.Mechanical properties,including tensile,compressive,and flexural strength,elastic modulus,density and damping properties measured under various testing conditions,were set as output parameters for prediction.This study analyzed and optimized the performance of the ANN model using Bayesian Regularization and Levenberg-Marquardt algorithms to identify the best performing number of neurons in the hidden layer for achieving the highest prediction accuracy.The proposed ANN framework achieved an exceptional average determination coefficient(R2)exceeding 99%,with Bayesian Regularization demonstrating remarkable stability in the 22-neuron range and minimal variation across all properties.RSM and ANN form a powerful framework for predicting and optimizing hybrid G-E composite properties,enabling efficient design for vibration-critical applications with reduced experimental effort and performance optimization.展开更多
This study explores the dynamic contact response of a viscoelastic functionally graded material(FGM)-coated half-plane under a rigid flat punch subjected to a time-harmonic vertical force.The elastic modulus and mass ...This study explores the dynamic contact response of a viscoelastic functionally graded material(FGM)-coated half-plane under a rigid flat punch subjected to a time-harmonic vertical force.The elastic modulus and mass density of the FGM coating vary exponentially along the thickness direction.The FGM coating and the homogeneous half-plane possess viscoelastic properties,which are described by a linearly hysteretic damping model.By applying the asymptotic method and the Fourier integral transform technique,the contact problem is converted into a Cauchy singular integral equation.The effects of excitation frequency,gradient index,damping factor ratio,and punch width on the vertical impedance and dynamic contact stress are analyzed.The results indicate that adjusting the gradient index of the FGM coating can significantly affect the contact stress and vertical impedance.展开更多
This work is devoted to the study of initial boundary value problem for k-component system of semilinear wave equations with several fundamental boundary conditions(namely,the Dirichlet,Neumann,and Robin boundary cond...This work is devoted to the study of initial boundary value problem for k-component system of semilinear wave equations with several fundamental boundary conditions(namely,the Dirichlet,Neumann,and Robin boundary conditions).Blow-up results and lifespan estimates of solutions to the problem with two different types of weak damping terms and power nonlinearities in the sub-critical and critical cases on exterior domain are obtained.The test function technique is performed in the proofs.It is worth observing that our results in Theorem 1.1 in this article contain the results in[6]as a special case whenθ=0.To the best of our knowledge,the results in Theorems 1.1-1.2 are new.展开更多
With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided b...With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided by synchronous generators.To address this critical issue,Virtual Synchronous Generator(VSG)technology has emerged as a highly promising solution by emulating the inertia and damping characteristics of conventional synchronous generators.To enhance the operational efficiency of virtual synchronous generators(VSGs),this study employs smallsignal modeling analysis,root locus methods,and synchronous generator power-angle characteristic analysis to comprehensively evaluate how virtual inertia and damping coefficients affect frequency stability and power output during transient processes.Based on these analyses,an adaptive control strategy is proposed:increasing the virtual inertia when the rotor angular velocity undergoes rapid changes,while strengthening the damping coefficient when the speed deviation exceeds a certain threshold to suppress angular velocity oscillations.To validate the effectiveness of the proposed method,a grid-connected VSG simulation platform was developed inMATLAB/Simulink.Comparative simulations demonstrate that the proposed adaptive control strategy outperforms conventional VSGmethods by significantly reducing grid frequency deviations and shortening active power response time during active power command changes and load disturbances.This approach enhances microgrid stability and dynamic performance,confirming its viability for renewable-dominant power systems.Future work should focus on experimental validation and real-world parameter optimization,while further exploring the strategy’s effectiveness in improvingVSG low-voltage ride-through(LVRT)capability and power-sharing applications in multi-parallel configurations.展开更多
In this study,three specific scenarios of a novel accelerator light source mechanism called steady-state microbunching(SSMB)were studied:longitudinal weak focusing,longitudinal strong focusing,and generalized longitud...In this study,three specific scenarios of a novel accelerator light source mechanism called steady-state microbunching(SSMB)were studied:longitudinal weak focusing,longitudinal strong focusing,and generalized longitudinal strong focusing(GLSF).At present,GLSF is the most promising method for realizing high-power short-wavelength coherent radiation with mild requirements on modulation laser power.Its essence is to exploit the ultrasmall natural vertical emittance of an electron beam in a planar storage ring for efficient microbunching formation,like a partial transverse-longitudinal emittance exchange in the optical laser wavelength range.Based on an in-depth investigation of related beam physics,a solution for a GLSF SSMB storage ring that can deliver 1 kW average-power EUV light is presented.The work in this paper,such as the generalized Courant–Snyder formalism,analysis of theoretical minimum emittances,transverse-longitudinal coupling dynamics,and derivation of the bunching factor and modulation strengths for laser-induced microbunching schemes,is expected to be useful not only for the development of SSMB but also for future accelerator light sources in general that demand increasingly precise electron beam phase space manipulations.展开更多
文摘The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated molecular patterns （DAMPs） can activate immune cells, including dendritic cells （DCs）, via Toll-like receptors （TLRs）; however, the role of DAMPs released from chemical drug-treated tumor cells in the activation of the immune response needs to be further elucidated. Here, we found that colorectal cancer （CRC） cells treated with oxaliplatin （OXA） and/or 5-fluorouracil （5-Fu） released high levels of high-mobility group box 1 （HMGB1） and heat shock protein 70 （HSP70）. After OXA/5-Fu therapy, the sera of CRC patients also exhibited increased levels of HMGB1 and HSP70, both of which are well-known DAMPs. The supernatants of dying CRC cells treated with OXA/5-Fu promoted mouse and human DC maturation, with upregulation of HLA-DR, CD80 and CD86 expression and enhancement of IL-lp, TNF-a, MIP-la, MIP-lp, RANTES and IP-IO production. Vaccines composed of DCs pulsed with the supernatants of chemically stressed CRC cells induced a more significant IFN-y-producing Thl response both in vitroand in vivo. However, the supernatants of chemically stressed CRC cells failed to induce phenotypic maturation and cytokine production in TLR4-deficient DCs, indicating an essential role of TLR4 in DAMP-induced DC maturation and activation. Furthermore, pulsing with the supernatants of chemically stressed CRC cells did not efficiently induce an IFN-y-producing Thl response in TLR4-deficient DCs. Collectively, these results demonstrate that DAMPs released from chemically stressed cancer cells can activate DCs viaTLR4 and enhance the induction of an anti-tumor T-cell immune response, delineating a clinically relevant immuno-adjuvant pathway triggered by DAMPs.
基金supported by the National Natural Science Foundation of China(81571881,81772052,and 81801971)Medical Research Program of Jiangsu Commission of Health(H2018058)+1 种基金Key Project of Science Foundation of the 12th Five-Year Plan(BNJ13J002)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX19＿0052)
文摘The inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis,are chronic,relapsing immune mediated disorders of the gastrointestinal homeostasis and intestinal inflammation[1].Failure to resolve mucosal inflammation and maintain gut barrier are notable shared clinical challenges in IBD,in particular when they activate immune cells within the gut lamia propria.Clinical trials and animal model studies aiming towards DAMPs have demonstrated that they can be effective therapeutic targets in mucosal inflammation of IBD.
基金funded by the Austrian Federal Railways(ÖBB Infrastruktur AG)in the context of the research project‘VeMoDiss’(acronym)。
文摘To ensure the compatibility between rolling stock and infrastructure when dynamically assessing railway bridges under high-speed traffic,the damping properties considered in the calculation model significantly influence the predicted acceleration amplitude at resonance.However,due to the normative specifications of EN 1991-2,which are considered to be overly conservative,damping factors that are far below the actual damping have to be used when predicting vibrations of railway bridges,which means that accelerations at resonance tend to be overestimated to an uneconomical extent.Comparisons between damping factors prescribed by the standard and those identified based on in situ structure measurements always reveal a large discrepancy between reality and regulation.Given this background,this contribution presents a novel approach for defining the damping factor of railway bridges with ballasted tracks,where the damping factor for bridges is mathematically determined based on three different two-dimensional mechanical models.The basic principle of the approach for mathematically determining the damping factor is to separately define and superimpose the dissipative contributions of the supporting structure(including the substructure)and the superstructure.Using the results of a measurement campaign on 15 existing steel railway bridges in the Austrian rail network,the presented mechanical models are calibrated,and by analysing the energy dissipation in the ballasted track,guiding principles for practical application are defined.This guideline is intended to establish an alternative to the currently valid specifications of EN 1991-2,enabling the damping factor of railway bridges to be assessed in a realistic range by mathematical calculation and thus without the need for extensive in situ measurements on the individual structure.In this way,the existing potential of the infrastructure with regard to the damping properties of bridges can be utilised.This contribution focuses on steel bridges,but the mathematical approach for determining the damping factor applies equally to other bridge types(concrete,composite,or filler beam).
文摘The existence of a global attractor is established for generalized Navier-Stokes equations incorporating damping term within the periodic domainΩ=[−π,π]^(n).Initially,we show the existence and uniqueness of strong solutions.Subsequently,we verify the continuity of the associated semigroup when max{2n+1/n-1,5n+2/3n-2} < β <3n+2/n-2.Finally,we establish the existence of both H^(α)-global attractor and H^(2α)-global attractor.
文摘As environmental concerns drive shifts in construction materials,rock is increasingly considered as an alternative to sand,reinforcing the importance of understanding its dynamic properties.This study investigates the effect of water content on the small-strain dynamic properties of basalt samples using free-free laboratory testing.Free-free testing,which requires minimal equipment and preparation,provides an efficient and low-cost method for determining key dynamic properties,including three wave velocities(V_(s),V_(p),and V_(c)),material damping ratios,and Poisson's ratios.These properties are crucial for numerical modeling in earthquake analyses and geotechnical site characterization.The test consists of three components:(1)direct travel-time measurement,(2)torsional resonance testing,and(3)compressional resonance testing.A total of 20 rock samples were tested under systematically controlled water contents,ranging from fully dried to saturated,to quantify the effects on Poisson's ratio and material damping ratios.The results showed significant increases in both parameters with rising water content.The Poisson's ratio increased by up to 320%for aphanitic basalt and 150%for vesicular basalt,while the damping ratio rose up to 30-fold(D_(c,min))and 16-fold(D_(s,min)).These findings highlight the critical need to incorporate consideration of water content when characterizing dynamic rock properties for seismic and geotechnical analyses.The practical applicability of this research lies in improving in situ property interpretation and enhancing seismic design reliability by providing engineers with precise relationships between water content and dynamic rock behavior.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11961059,1210502)the University Innovation Project of Gansu Province(Grant No.2023B-062)the Gansu Province Basic Research Innovation Group Project(Grant No.23JRRA684).
文摘The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and existence of uniform attractor under some suitable assumptions on the nonlinear term g(u),the nonlinear damping f(u_(t))and the external force h(x,t).Specifically,the asymptotic compactness of the semigroup is verified by the energy reconstruction method.
文摘We investigate the three-dimensional(3D)generalized magnetohydrodynamic(MHD)-Boussinesq system with fractional dissipation and damping terms,aiming to establish the well-posedness theory for the 3D incompressible temperature-dependent MHD-Boussinesq equations with damping.By exploiting the structural properties of the system and performing refined a priori estimates,we address the global well-posedness of solutions under the weakest possible dissipation conditions.
基金supported in part by the National Natural Science Foundation of China(Nos.52475550,52305095)in part by the Key R&D Project of Liaoning Province,China(No.2023JH2/101800026)。
文摘Under the condition of frequent replacement of wind tunnel models,multiple types of wind tunnel models are fixed by a slender support sting with low stiffness damping.When excited by wind load,various models produce random multi-dimensional vibration with different characteristics,which makes it impossible to obtain accurate and efficient aerodynamic data.Therefore,in order to ensure the reliable and efficient conduction of wind tunnel test,a wind-tunnel-modeladaptive vibration control method is proposed in this paper.First,the split type adaptive vibration suppression structure is designed.Second,the multi-dimensional vibration characteristic characterization method is derived and the vibration characteristic identification method of the system is designed.Then,a vibration state estimation model is established according to the identification results of vibration characteristics,and a multi-actuator cooperative control method based on vibration state estimation is constructed.Finally,a model-adaptive vibration control system is built,and vibration characteristics identification and hammer experiments are carried out for two types of typical models.The results show that the proposed model-adaptive vibration control method increases the equivalent damping ratio of pitch and yaw dimensions of the high-aspect-ratio class model by 8.19 times and 48.81 times,respectively.The equivalent damping ratio of pitch and yaw dimensions of the highslenderness-ratio class model is increased by 16.44 and 5.43 times,respectively.It provides a strong guarantee for the reliable and efficient development of multi-type wind tunnel test tasks.
基金supported in part by the Young Elite Scientists Sponsorship Program by the Chinese Society for Electrical Engineering under Grant CSEE-YESS-2022019in part by the Guangzhou Basic and Applied Basic Research Foundation under Grand 2024A04J3672in part by the National Natural Science Foundation of China under Grant 52207106.
文摘The wide-area damping controllers(WADCs),which are essential for mitigating regional low-frequency oscillations,face cyber-physical security threats due to the vulnerability of wide-area measurement system to cyber attacks and wind power uncertainties.This paper introduces reachability analysis method to quantify the impact of varying-amplitude attacks and uncertain wind fluctuations on the performance of WADC.Firstly,considering wind farm integration and attack injection,a nonlinear power system model with multiple buses is constructed based on Kron reduction method to improve computational efficiency and mitigate the constraints imposed by algebraic constraints.Then,a zonotope-based polytope construction method is employed to effectively model the range of attack amplitudes and wind uncertainties.By conducting reachability analysis,the reachable set preserving the nonlinear characteristics of studied system is computed,which enables the quantification of the maximum fluctuation range of regional oscillations under the dual disturbances.Case studies are undertaken on two multi-machine power systems with wind farm integration.The obtained results emphasize the efficacy of designed method,providing valuable insights into the magnitude of the impact that attacks exert on the operational characteristics of power system under various uncertain factors.
文摘This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite-epoxy(G-E)composites reinforced with cast iron(CI)filler particles.Hybrid G-E composite with added cast iron(CI)filler particles enhances stiffness,strength,and vibration damping,offering enhanced performance for vibration-sensitive engineering applications.Unlike conventional approaches,this work simultaneously employs Artificial Neural Networks(ANN)for highaccuracy property prediction and Response Surface Methodology(RSM)for in-depth analysis of factor interactions and optimization.A total of 24 experimental test data sets of varying input factors(granite weight%,epoxy weight%,and CI filler weight%)were utilized to train and test the prediction models using an ANN approach and further analyze the interaction effects using RSM.Mechanical properties,including tensile,compressive,and flexural strength,elastic modulus,density and damping properties measured under various testing conditions,were set as output parameters for prediction.This study analyzed and optimized the performance of the ANN model using Bayesian Regularization and Levenberg-Marquardt algorithms to identify the best performing number of neurons in the hidden layer for achieving the highest prediction accuracy.The proposed ANN framework achieved an exceptional average determination coefficient(R2)exceeding 99%,with Bayesian Regularization demonstrating remarkable stability in the 22-neuron range and minimal variation across all properties.RSM and ANN form a powerful framework for predicting and optimizing hybrid G-E composite properties,enabling efficient design for vibration-critical applications with reduced experimental effort and performance optimization.
基金Project supported by the National Natural Science Foundation of China(Nos.12021002,12192212,and 12462007)。
文摘This study explores the dynamic contact response of a viscoelastic functionally graded material(FGM)-coated half-plane under a rigid flat punch subjected to a time-harmonic vertical force.The elastic modulus and mass density of the FGM coating vary exponentially along the thickness direction.The FGM coating and the homogeneous half-plane possess viscoelastic properties,which are described by a linearly hysteretic damping model.By applying the asymptotic method and the Fourier integral transform technique,the contact problem is converted into a Cauchy singular integral equation.The effects of excitation frequency,gradient index,damping factor ratio,and punch width on the vertical impedance and dynamic contact stress are analyzed.The results indicate that adjusting the gradient index of the FGM coating can significantly affect the contact stress and vertical impedance.
基金Supported by Fundamental Research Program of Shanxi Province(20210302123045,20210302123182)National Natural Science Foundation of China(11601446)。
文摘This work is devoted to the study of initial boundary value problem for k-component system of semilinear wave equations with several fundamental boundary conditions(namely,the Dirichlet,Neumann,and Robin boundary conditions).Blow-up results and lifespan estimates of solutions to the problem with two different types of weak damping terms and power nonlinearities in the sub-critical and critical cases on exterior domain are obtained.The test function technique is performed in the proofs.It is worth observing that our results in Theorem 1.1 in this article contain the results in[6]as a special case whenθ=0.To the best of our knowledge,the results in Theorems 1.1-1.2 are new.
基金financially supported by the Talent Initiation Fund of Wuxi University(550220008).
文摘With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided by synchronous generators.To address this critical issue,Virtual Synchronous Generator(VSG)technology has emerged as a highly promising solution by emulating the inertia and damping characteristics of conventional synchronous generators.To enhance the operational efficiency of virtual synchronous generators(VSGs),this study employs smallsignal modeling analysis,root locus methods,and synchronous generator power-angle characteristic analysis to comprehensively evaluate how virtual inertia and damping coefficients affect frequency stability and power output during transient processes.Based on these analyses,an adaptive control strategy is proposed:increasing the virtual inertia when the rotor angular velocity undergoes rapid changes,while strengthening the damping coefficient when the speed deviation exceeds a certain threshold to suppress angular velocity oscillations.To validate the effectiveness of the proposed method,a grid-connected VSG simulation platform was developed inMATLAB/Simulink.Comparative simulations demonstrate that the proposed adaptive control strategy outperforms conventional VSGmethods by significantly reducing grid frequency deviations and shortening active power response time during active power command changes and load disturbances.This approach enhances microgrid stability and dynamic performance,confirming its viability for renewable-dominant power systems.Future work should focus on experimental validation and real-world parameter optimization,while further exploring the strategy’s effectiveness in improvingVSG low-voltage ride-through(LVRT)capability and power-sharing applications in multi-parallel configurations.
基金supported by the National Key Research and Development Program of China(No.2022YFA1603401)National Natural Science Foundation of China(Nos.12035010 and 12342501)+1 种基金Beijing Outstanding Young Scientist Program(No.JWZQ20240101006)the Tsinghua University Dushi Program.
文摘In this study,three specific scenarios of a novel accelerator light source mechanism called steady-state microbunching(SSMB)were studied:longitudinal weak focusing,longitudinal strong focusing,and generalized longitudinal strong focusing(GLSF).At present,GLSF is the most promising method for realizing high-power short-wavelength coherent radiation with mild requirements on modulation laser power.Its essence is to exploit the ultrasmall natural vertical emittance of an electron beam in a planar storage ring for efficient microbunching formation,like a partial transverse-longitudinal emittance exchange in the optical laser wavelength range.Based on an in-depth investigation of related beam physics,a solution for a GLSF SSMB storage ring that can deliver 1 kW average-power EUV light is presented.The work in this paper,such as the generalized Courant–Snyder formalism,analysis of theoretical minimum emittances,transverse-longitudinal coupling dynamics,and derivation of the bunching factor and modulation strengths for laser-induced microbunching schemes,is expected to be useful not only for the development of SSMB but also for future accelerator light sources in general that demand increasingly precise electron beam phase space manipulations.
