To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VB...To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VBIV were randomly divided into two groups; 45 patients （the treated group） were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients （control group） were treated with Xueshuantong （血栓通） and BHI intravenous dripping, once daily for 14 days. The clinical syndromes and the index of the transcranial Doppler （TCD） and hemorheology were observed. Results： The total effective rate was 100% in the treated group, which was better than that in the control group 90.5%, （P〈0. 05）. The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, （P〈0.01）. Conclusion： YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.展开更多
目的利用网状Meta分析比较不同中药注射液治疗卒中后认知障碍(PSCI)的有效性和安全性。方法检索中国学术期刊全文数据库(CNKI)、维普生物医学数据库(VIP)、万方数据库(Wanfang)、PubMed、Web of Science、Cochrane Library数据库建库至2...目的利用网状Meta分析比较不同中药注射液治疗卒中后认知障碍(PSCI)的有效性和安全性。方法检索中国学术期刊全文数据库(CNKI)、维普生物医学数据库(VIP)、万方数据库(Wanfang)、PubMed、Web of Science、Cochrane Library数据库建库至2024年3月中药注射液治疗PSCI的随机对照试验(RCT)文献,根据纳入与排除标准筛选文献,采用Cochrane偏倚风险评估工具评价文献质量,采用Stata 16.0软件进行统计分析。结果最终纳入文献28篇,涉及患者2942例,治疗方法包括西医常规和10种中药注射液:丹参多酚酸盐注射液(DSDF)、复方丹参注射液(FFDS)、银杏达莫注射液(YXDM)、醒脑静注射液(XNJ)、银杏叶注射液(YXY)、舒血宁注射液(SXN)、血塞通注射液(XST)、疏血通注射液(SXT)、丹红注射液(DH)、天麻素注射液(TMS)。网状Meta分析结果显示,在临床总有效率方面,累积概率排序为:YXY+西医常规治疗组(73.1%)>SXN+西医常规治疗组(62.9%)>TMS+西医常规治疗组(61.8%)>YXDM+西医常规治疗组(59.4%)>DSDF+西医常规治疗组(58.7%)>XNJ+西医常规治疗组(58.2%)>SXT+西医常规治疗组(39.3%)>DH+西医常规治疗组(36.0%)>西医常规治疗组(0.6%);在简易智力状态检查量表(MMSE)评分方面,累积概率排序为:TMS+西医常规治疗组(80.2%)>YXY+西医常规治疗组(70.4%)>YXDM+西医常规治疗组(60.7%)>XNJ+西医常规治疗组(58.8%)>XST+西医常规治疗组(51.8%)>SXN+西医常规治疗组(50.2%)>DSDF+西医常规治疗组(48.2%)>FFDS+西医常规治疗组(43.5%)>SXT+西医常规治疗组(41.6%)>DH+西医常规治疗组(34.6%)>西医常规治疗组(10.0%);在蒙特利尔认知评估量表(Mo CA)方面,累积概率排序为:SXT+西医常规治疗组(86.0%)>YXY+西医常规治疗组(83.4%)>SXN+西医常规治疗组(74.9%)>TMS+西医常规治疗组(65.1%)>XNJ+西医常规治疗组(53.9%)>FFDS+西医常规治疗组(51.0%)>YXDM+西医常规治疗组(49.1%)>XST+西医常规治疗组(42.0%)>DH+西医常规治疗组(23.2%)>DSDF+西医常规治疗组(18.5%)>西医常规治疗组(2.9%)。在日常生活能力量表(ADL)评分方面,累积概率排序为:TMS+西医常规治疗组(85.4%)>YXDM+西医常规治疗组(63.7%)>DH+西医常规治疗组(59.7%)>SXT+西医常规治疗组(59.5%)>XNJ+西医常规治疗组(59.3%)>XST+西医常规治疗组(52.3%)>DSDF+西医常规治疗组(46.4%)>西医常规治疗组(14.9%)>SXN+西医常规治疗组(8.8%)。10项研究报道了不良反应,主要涉及消化系统。结论中药注射液联合西医常规治疗可提高PSCI的临床疗效,MMSE评分、MoCA评分和ADL评分表明YXY和TMS优势显著,然而,由于纳入研究的质量受限且存在发表偏倚,当前结论仍需通过更为严谨的高质量研究加以验证。此举将有助于为制定中药注射液干预PSCI的诊疗方案提供更为坚实的循证医学依据。展开更多
文摘To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VBIV were randomly divided into two groups; 45 patients （the treated group） were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients （control group） were treated with Xueshuantong （血栓通） and BHI intravenous dripping, once daily for 14 days. The clinical syndromes and the index of the transcranial Doppler （TCD） and hemorheology were observed. Results： The total effective rate was 100% in the treated group, which was better than that in the control group 90.5%, （P〈0. 05）. The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, （P〈0.01）. Conclusion： YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.
