传统的功率分配算法由于复杂的矩阵运算与迭代所造成的高时延,在实际通信中实时获取信道信息十分困难,当前重要的研究方向是在系统性能和计算复杂度之间找到有效平衡。针对终端直通(Device-to-Device,D2D)用户与蜂窝用户的联合功率分配...传统的功率分配算法由于复杂的矩阵运算与迭代所造成的高时延,在实际通信中实时获取信道信息十分困难,当前重要的研究方向是在系统性能和计算复杂度之间找到有效平衡。针对终端直通(Device-to-Device,D2D)用户与蜂窝用户的联合功率分配问题,提出一种异构功率控制图神经网络(Heterogeneous Power Control Graph Neural Network,HPCGNN)算法,旨在最大化所有用户的加权和速率。首先通过构建干扰的异构图,将信道和噪声等信息嵌入到图的节点和边;再由HPCGNN完成消息传递和更新,采用无监督学习方式优化深度神经网络(Deep Neural Network,DNN)参数,最终得到最佳的功率分配。仿真结果表明,相较于其他深度学习算法,所提算法能够有效提高系统性能,且在损失5%性能下相较分式规划(Fractional Programming,FP)能降低82%~98%的时间复杂度。展开更多
对D2D(Device to Device)通信系统的隐蔽通信问题进行研究,提出了一种基于智能反射面(Intelligent Reflecting Surfaces,IRS)的D2D通信系统,该系统采用双IRS模式。首先分析了各信号的信干噪比(SINR)和各自的期望值,并据此推导出系统遍...对D2D(Device to Device)通信系统的隐蔽通信问题进行研究,提出了一种基于智能反射面(Intelligent Reflecting Surfaces,IRS)的D2D通信系统,该系统采用双IRS模式。首先分析了各信号的信干噪比(SINR)和各自的期望值,并据此推导出系统遍历总容量的解形式,接着针对隐蔽通信建立了二元假设问题,推导出误检测率的解形式,并据此计算出平均最小误检测率。除此之外,还分析了无IRS系统的遍历总容量和平均最小误检测率,与双IRS系统进行对比。仿真结果表明,双IRS系统的遍历总容量和平均最小误检测率优于无IRS系统,双IRS系统能够比传统的无IRS系统获得更高的容量和更低的误检测率。展开更多
BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acu...BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute pancreatitis.AIM To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute pan-creatitis.METHODS The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)groups.Relevant data was collected for each group.Western blot analysis assessed PLD2 protein expression in patient serum.Real-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil migration.Serum levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent assay.Transwell migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil migration.RESULTS Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumor necrosis factor-α,interleukin-1β,and interleukin-6 in the severe group were higher than those in the moderate and mild groups(P<0.05),and the levels in the moderate group were also higher than those in the mild group(P<0.05).The number of migrating neutrophils in the severe group was higher than that in the moderate and mild groups(P<0.05),and the moderate group was also higher than the mild group(P<0.05).In addition,the number of migrating neutrophils in the mild group combined with PLD2 inhibitor was higher than that in the mild group(P<0.05),and the number of migrating neutrophils in the moderate group combined with PLD2 inhibitor was higher than that in the moderate group(P<0.05).The number of migrating neutrophils in the severe group+PLD2 inhibitor group was significantly higher than that in the severe group(P<0.05),indicating that PLD2 inhibitors significantly stimulated neutrophil migration.CONCLUSION PLD2 exerted a crucial regulatory role in the pathological progression of acute pancreatitis.Its protein expression varied among patients based on the severity of the disease,and a negative correlation existed between PLD2 expression and disease severity.Additionally,PLD2 appeared to impede acute pancreatitis progression by limiting neutrophil migration.展开更多
目的:探究GLI锌指3(GLI3)基因5个位点(rs77640775、rs2051935、rs3823720、rs1125413、rs846266)单核苷酸多态性(SNP)与指长比的关联性。方法:选取宁夏807名汉族大学生(女性405人,男性402人)为研究对象,以数码相机及Image-Pro Plus 6.0...目的:探究GLI锌指3(GLI3)基因5个位点(rs77640775、rs2051935、rs3823720、rs1125413、rs846266)单核苷酸多态性(SNP)与指长比的关联性。方法:选取宁夏807名汉族大学生(女性405人,男性402人)为研究对象,以数码相机及Image-Pro Plus 6.0图像软件分别采集双手照片,并测量示指(2D)和环指(4D)指长,多重PCR法检测GLI3基因5个SNP位点的基因型,单因素方差分析评估示-环指长比(D_(2/4))与GLI3基因多态性的关系。结果:宁夏女大学生左手D_(2/4)(LD_(2/4))、右手D_(2/4)(RD_(2/4))均显著高于男性;男性和女性间GLI3基因5个位点基因型和等位基因频率分布差异均无统计学意义;不同性别GLI3基因5个位点SNPs与双手D_(2/4)间均无显著关联。结论:D_(2/4)在宁夏大学生的分布具有显著性别二态性,暂未发现GLI3基因位点多态性与其形成有关。展开更多
文摘传统的功率分配算法由于复杂的矩阵运算与迭代所造成的高时延,在实际通信中实时获取信道信息十分困难,当前重要的研究方向是在系统性能和计算复杂度之间找到有效平衡。针对终端直通(Device-to-Device,D2D)用户与蜂窝用户的联合功率分配问题,提出一种异构功率控制图神经网络(Heterogeneous Power Control Graph Neural Network,HPCGNN)算法,旨在最大化所有用户的加权和速率。首先通过构建干扰的异构图,将信道和噪声等信息嵌入到图的节点和边;再由HPCGNN完成消息传递和更新,采用无监督学习方式优化深度神经网络(Deep Neural Network,DNN)参数,最终得到最佳的功率分配。仿真结果表明,相较于其他深度学习算法,所提算法能够有效提高系统性能,且在损失5%性能下相较分式规划(Fractional Programming,FP)能降低82%~98%的时间复杂度。
文摘对D2D(Device to Device)通信系统的隐蔽通信问题进行研究,提出了一种基于智能反射面(Intelligent Reflecting Surfaces,IRS)的D2D通信系统,该系统采用双IRS模式。首先分析了各信号的信干噪比(SINR)和各自的期望值,并据此推导出系统遍历总容量的解形式,接着针对隐蔽通信建立了二元假设问题,推导出误检测率的解形式,并据此计算出平均最小误检测率。除此之外,还分析了无IRS系统的遍历总容量和平均最小误检测率,与双IRS系统进行对比。仿真结果表明,双IRS系统的遍历总容量和平均最小误检测率优于无IRS系统,双IRS系统能够比传统的无IRS系统获得更高的容量和更低的误检测率。
文摘BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute pancreatitis.AIM To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute pan-creatitis.METHODS The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)groups.Relevant data was collected for each group.Western blot analysis assessed PLD2 protein expression in patient serum.Real-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil migration.Serum levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent assay.Transwell migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil migration.RESULTS Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumor necrosis factor-α,interleukin-1β,and interleukin-6 in the severe group were higher than those in the moderate and mild groups(P<0.05),and the levels in the moderate group were also higher than those in the mild group(P<0.05).The number of migrating neutrophils in the severe group was higher than that in the moderate and mild groups(P<0.05),and the moderate group was also higher than the mild group(P<0.05).In addition,the number of migrating neutrophils in the mild group combined with PLD2 inhibitor was higher than that in the mild group(P<0.05),and the number of migrating neutrophils in the moderate group combined with PLD2 inhibitor was higher than that in the moderate group(P<0.05).The number of migrating neutrophils in the severe group+PLD2 inhibitor group was significantly higher than that in the severe group(P<0.05),indicating that PLD2 inhibitors significantly stimulated neutrophil migration.CONCLUSION PLD2 exerted a crucial regulatory role in the pathological progression of acute pancreatitis.Its protein expression varied among patients based on the severity of the disease,and a negative correlation existed between PLD2 expression and disease severity.Additionally,PLD2 appeared to impede acute pancreatitis progression by limiting neutrophil migration.
文摘目的:探究GLI锌指3(GLI3)基因5个位点(rs77640775、rs2051935、rs3823720、rs1125413、rs846266)单核苷酸多态性(SNP)与指长比的关联性。方法:选取宁夏807名汉族大学生(女性405人,男性402人)为研究对象,以数码相机及Image-Pro Plus 6.0图像软件分别采集双手照片,并测量示指(2D)和环指(4D)指长,多重PCR法检测GLI3基因5个SNP位点的基因型,单因素方差分析评估示-环指长比(D_(2/4))与GLI3基因多态性的关系。结果:宁夏女大学生左手D_(2/4)(LD_(2/4))、右手D_(2/4)(RD_(2/4))均显著高于男性;男性和女性间GLI3基因5个位点基因型和等位基因频率分布差异均无统计学意义;不同性别GLI3基因5个位点SNPs与双手D_(2/4)间均无显著关联。结论:D_(2/4)在宁夏大学生的分布具有显著性别二态性,暂未发现GLI3基因位点多态性与其形成有关。
