The karst geothermal reservoir in Xiong'an New Area is a representative example of an ancient buried hill geothermal system.However,published heat flow data are predominantly derived from the Cenozoic sedimentary ...The karst geothermal reservoir in Xiong'an New Area is a representative example of an ancient buried hill geothermal system.However,published heat flow data are predominantly derived from the Cenozoic sedimentary cap.Due to the limited depth of borehole exploration,heat flow measurements and analyses of the Archean crystalline base-ment in the study area are rare.Further investigation of the heat flow and temperature field characteristics within the Archean crystalline basement beneath the karst geothermal reservoir is necessary to understand the vertical distribution of heat flow and improve the geothermal genetic mechanism in the area.The D01 deep geothermal scientific drilling param-eter well was implemented in the Niutuozhen geothermal field of Xiong'an New Area.The well exposed the entire Gaoyuzhaung Formation karst geotheremal reservoir of the Jixian system and drilled 1,723.67 m into the Archean crys-talline basement,providing the necessary conditions for determining its heat flow.This study involved borehole tempera-ture measurements and thermophysical property testing of core samples from the D01 well to analyze the vertical distri-bution of heat flow.The findings revealed distinct segmentation in the geothermal gradient and rock thermophysical prop-erties.The geothermal reservoir of Gaoyuzhuang Formation is dominated by convection,with significant temperature inversions corresponding to karst fracture developments.In contrast,the Archean crystalline basement exhibits conduc-tive heat transfer.After 233 days of static equilibrium,the average geothermal gradients of the Gaoyuzhuang Formation and the Archean crystalline basement were determined to be 1.5°C/km and 18.3°C/km,respectively.These values adjusted to-0.8°C/km and 18.2°C/km after 551 days,with the longer static time curve approaching steady-state condi-tions.The average thermal conductivity of dolomite in Gaoyuzhuang Formation was measured as 4.37±0.82 W/(K·m),3 and that of Archean gneiss as 2.41±0.40 W/(K·m).The average radioactive heat generation rate were 0.30±0.32μW/m 3 for dolomite and 1.32±0.69μW/m for gneiss.Using the temperature curve after 551 days and thermal conductivity data,the Archean heat flow at the D01 well was calculated as(43.9±7.0)mW/m2,While the heat flow for the Neogene sedi-mentary cap was estimated at 88.6mW/m2.The heat flow of Neogene sedimentary caprock is significantly higher than 2 that of Archean crystalline basement at the D01 well,with an excess of 44.7 mW/m accounting for approximately 50%of the total heat flow in the Neogene sedimentary caprock.This is primarily attributed to lateral thermal convection within the high-porosity and high-permeability karst dolomite layer,and vertical thermal convection facilitated by the Niudong fault,which collectively contribute to the heat supply of the Neogene sedimentary caprock.Thermal convection in karst fissure and fault zone contribute approximately 50%of the heat flow in the Neogene sedimentary caprock.This study quantitatively revealed the vertical distribution of heat flow,providing empirical evidence for the genetic mechanism of the convection-conduction geothermal system in sedimentary basins.展开更多
Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving cognition.In this study,we report a novel dual se...Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving cognition.In this study,we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01(a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative)that exhibits both anti-depression effects and improvements in cognition.D01 inhibits serotonin transporters(K_(i)=30.1±6.9 nmol/L)and M channels(IC_(50)=10.1±2.4μmol/L).D01 also reduces the immobility duration in the mouse FST and TST assays in a dose-dependent manner without a stimulatory effect on locomotion.Intragastric administrations of D01(20 and 40 mg/kg)can significantly shorten the immobility time in a mouse model of chronic restraint stress(CRS)-induced depression-like behavior.Additionally,D01 dose-dependently improves the cognitive deficit induced by CRS in Morris water maze test and increases the exploration time with novel objects in normal or scopolamine-induced cognitive deficits in mice,but not fluoxetine.Furthermore,D01 reverses the long-term potentiation(LTP)inhibition induced by scopolamine.Taken together,our findings demonstrate that D01,a dual-target serotonin reuptake and M channel inhibitor,is highly effective in the treatment-resistant depression and cognitive deficits,thus holding potential for development as therapy of depression with cognitive deficits.展开更多
基金funded by the National Key Research and Development Program(Grant Nos.2021YFB1507404 and 2018YFC0604305)the Project of China Geological Survey(Grant Nos.DD20221680,DD20189113,and DD20190127).
文摘The karst geothermal reservoir in Xiong'an New Area is a representative example of an ancient buried hill geothermal system.However,published heat flow data are predominantly derived from the Cenozoic sedimentary cap.Due to the limited depth of borehole exploration,heat flow measurements and analyses of the Archean crystalline base-ment in the study area are rare.Further investigation of the heat flow and temperature field characteristics within the Archean crystalline basement beneath the karst geothermal reservoir is necessary to understand the vertical distribution of heat flow and improve the geothermal genetic mechanism in the area.The D01 deep geothermal scientific drilling param-eter well was implemented in the Niutuozhen geothermal field of Xiong'an New Area.The well exposed the entire Gaoyuzhaung Formation karst geotheremal reservoir of the Jixian system and drilled 1,723.67 m into the Archean crys-talline basement,providing the necessary conditions for determining its heat flow.This study involved borehole tempera-ture measurements and thermophysical property testing of core samples from the D01 well to analyze the vertical distri-bution of heat flow.The findings revealed distinct segmentation in the geothermal gradient and rock thermophysical prop-erties.The geothermal reservoir of Gaoyuzhuang Formation is dominated by convection,with significant temperature inversions corresponding to karst fracture developments.In contrast,the Archean crystalline basement exhibits conduc-tive heat transfer.After 233 days of static equilibrium,the average geothermal gradients of the Gaoyuzhuang Formation and the Archean crystalline basement were determined to be 1.5°C/km and 18.3°C/km,respectively.These values adjusted to-0.8°C/km and 18.2°C/km after 551 days,with the longer static time curve approaching steady-state condi-tions.The average thermal conductivity of dolomite in Gaoyuzhuang Formation was measured as 4.37±0.82 W/(K·m),3 and that of Archean gneiss as 2.41±0.40 W/(K·m).The average radioactive heat generation rate were 0.30±0.32μW/m 3 for dolomite and 1.32±0.69μW/m for gneiss.Using the temperature curve after 551 days and thermal conductivity data,the Archean heat flow at the D01 well was calculated as(43.9±7.0)mW/m2,While the heat flow for the Neogene sedi-mentary cap was estimated at 88.6mW/m2.The heat flow of Neogene sedimentary caprock is significantly higher than 2 that of Archean crystalline basement at the D01 well,with an excess of 44.7 mW/m accounting for approximately 50%of the total heat flow in the Neogene sedimentary caprock.This is primarily attributed to lateral thermal convection within the high-porosity and high-permeability karst dolomite layer,and vertical thermal convection facilitated by the Niudong fault,which collectively contribute to the heat supply of the Neogene sedimentary caprock.Thermal convection in karst fissure and fault zone contribute approximately 50%of the heat flow in the Neogene sedimentary caprock.This study quantitatively revealed the vertical distribution of heat flow,providing empirical evidence for the genetic mechanism of the convection-conduction geothermal system in sedimentary basins.
基金supported by research grants from Science and Technology Program of Guangdong(2018B030334001,China)the Ministry of Science and Technology of China(2018ZX09711001004-006)awarded to Ke Wei Wang。
文摘Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving cognition.In this study,we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01(a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative)that exhibits both anti-depression effects and improvements in cognition.D01 inhibits serotonin transporters(K_(i)=30.1±6.9 nmol/L)and M channels(IC_(50)=10.1±2.4μmol/L).D01 also reduces the immobility duration in the mouse FST and TST assays in a dose-dependent manner without a stimulatory effect on locomotion.Intragastric administrations of D01(20 and 40 mg/kg)can significantly shorten the immobility time in a mouse model of chronic restraint stress(CRS)-induced depression-like behavior.Additionally,D01 dose-dependently improves the cognitive deficit induced by CRS in Morris water maze test and increases the exploration time with novel objects in normal or scopolamine-induced cognitive deficits in mice,but not fluoxetine.Furthermore,D01 reverses the long-term potentiation(LTP)inhibition induced by scopolamine.Taken together,our findings demonstrate that D01,a dual-target serotonin reuptake and M channel inhibitor,is highly effective in the treatment-resistant depression and cognitive deficits,thus holding potential for development as therapy of depression with cognitive deficits.
