Different forms of programmed cell death have been described to participate in the degeneration of dopaminergic neurons in Parkinson’s disease(PD).Given the critical role that disturbance of mitochondrial homeostasis...Different forms of programmed cell death have been described to participate in the degeneration of dopaminergic neurons in Parkinson’s disease(PD).Given the critical role that disturbance of mitochondrial homeostasis plays in the pathogenesis of PD,apoptosis can be reasonably considered as one of the cell death pathways involved in neuronal loss(Schon and Przedborski,2011).Multiple lines of evidence support that proposal such as the observations in postmortem human brain samples of PD patients including mitochondrial complex I deficiency,reactive oxygen species generation,and oxidative damage to lipids,proteins,and DNA,among others.展开更多
多智能体信息融合(multi-agent information fusion,MAIF)系统主要面向多个智能体之间的信息融合、调节、交流和矛盾处理。研究针对数据高度冲突条件下的D-S证据理论失效问题,提出一种将重构的基本概率分配和信念熵相结合的多智能体系...多智能体信息融合(multi-agent information fusion,MAIF)系统主要面向多个智能体之间的信息融合、调节、交流和矛盾处理。研究针对数据高度冲突条件下的D-S证据理论失效问题,提出一种将重构的基本概率分配和信念熵相结合的多智能体系统冲突数据融合方法。该方法使用重构的基本概率分配和信念熵修正证据的可靠性,获得更合理的证据,使用Dempster组合规则将证据进行融合得到结果,在2个实验中均得到了超过90%的置信度。实验表明了该方法的有效性,提高了MAIF系统辨识过程的精度。展开更多
目的:验证运用有机溶剂/去污剂(S/D)处理法和干热法对C1酯酶抑制剂(C1-INH)中病毒灭活效果。方法:采用S/D处理法灭活含S/D样品中添加的辛德毕斯病毒,噬斑滴定法检测灭活前后的病毒滴度,-干热法灭活脑心肌炎病毒(EMCV)和猪细小病毒(PPV)...目的:验证运用有机溶剂/去污剂(S/D)处理法和干热法对C1酯酶抑制剂(C1-INH)中病毒灭活效果。方法:采用S/D处理法灭活含S/D样品中添加的辛德毕斯病毒,噬斑滴定法检测灭活前后的病毒滴度,-干热法灭活脑心肌炎病毒(EMCV)和猪细小病毒(PPV),细胞病变法检测灭活前后的病毒滴度。结果:经S/D处理法灭活后,3批含S/D样品中辛德毕斯病毒降低量分别为>4.35 lg PFU·mL^(-1)、>4.51 lg PFU·mL^(-1)、>4.64 lg PFU·mL^(-1)。经干热法灭活后,3批不含S/D样品中EMCV降低量分别为≥5.38 lg TCID_(50)/0.1 mL、≥5.12 lg TCID_(50)/0.1 mL、≥5.25 lg TCID_(50)/0.1 mL,PPV降低量分别为4.57 lg TCID_(50)/0.1 mL、4.18 lg TCID_(50)/0.1 mL、4.68 lg TCID_(50)/0.1 mL。结论:通过对指示病毒的验证效果评估,证明S/D法和干热法对C1-INH中的辛德毕斯病毒、EMCV和PPV均有较好的灭活效果。展开更多
基金supported by the Spanish Ministerio de Ciencia e Innovación/Agencia Española de Investigación(PID2021-124096OB-I00)(to JLV)JGR was granted by Demensfonden,The Royal Physiografic Society of Lund,Neurofonden,The Greta och Johan Kocks stiftelser,and Bertil och Ebon Norlins stiftelse.
文摘Different forms of programmed cell death have been described to participate in the degeneration of dopaminergic neurons in Parkinson’s disease(PD).Given the critical role that disturbance of mitochondrial homeostasis plays in the pathogenesis of PD,apoptosis can be reasonably considered as one of the cell death pathways involved in neuronal loss(Schon and Przedborski,2011).Multiple lines of evidence support that proposal such as the observations in postmortem human brain samples of PD patients including mitochondrial complex I deficiency,reactive oxygen species generation,and oxidative damage to lipids,proteins,and DNA,among others.
文摘多智能体信息融合(multi-agent information fusion,MAIF)系统主要面向多个智能体之间的信息融合、调节、交流和矛盾处理。研究针对数据高度冲突条件下的D-S证据理论失效问题,提出一种将重构的基本概率分配和信念熵相结合的多智能体系统冲突数据融合方法。该方法使用重构的基本概率分配和信念熵修正证据的可靠性,获得更合理的证据,使用Dempster组合规则将证据进行融合得到结果,在2个实验中均得到了超过90%的置信度。实验表明了该方法的有效性,提高了MAIF系统辨识过程的精度。
文摘目的:验证运用有机溶剂/去污剂(S/D)处理法和干热法对C1酯酶抑制剂(C1-INH)中病毒灭活效果。方法:采用S/D处理法灭活含S/D样品中添加的辛德毕斯病毒,噬斑滴定法检测灭活前后的病毒滴度,-干热法灭活脑心肌炎病毒(EMCV)和猪细小病毒(PPV),细胞病变法检测灭活前后的病毒滴度。结果:经S/D处理法灭活后,3批含S/D样品中辛德毕斯病毒降低量分别为>4.35 lg PFU·mL^(-1)、>4.51 lg PFU·mL^(-1)、>4.64 lg PFU·mL^(-1)。经干热法灭活后,3批不含S/D样品中EMCV降低量分别为≥5.38 lg TCID_(50)/0.1 mL、≥5.12 lg TCID_(50)/0.1 mL、≥5.25 lg TCID_(50)/0.1 mL,PPV降低量分别为4.57 lg TCID_(50)/0.1 mL、4.18 lg TCID_(50)/0.1 mL、4.68 lg TCID_(50)/0.1 mL。结论:通过对指示病毒的验证效果评估,证明S/D法和干热法对C1-INH中的辛德毕斯病毒、EMCV和PPV均有较好的灭活效果。
