We study the electronic and magnetic properties of an oxygen-deficient perovskite Ca2Mn2O5 based on the first principle calculations. The calculations show that the ground state of Ca2Mn2O5 is a D-type anti-ferromagne...We study the electronic and magnetic properties of an oxygen-deficient perovskite Ca2Mn2O5 based on the first principle calculations. The calculations show that the ground state of Ca2Mn2O5 is a D-type anti-ferromagnetic structure with the anti-ferromagnetic spin coupling along the c-direction. The corresponding electronic structure of the D-type state is investigated, and the results display that Ca2Mn2O5 is an insulator with an indirect energy gap of -2.08eV. By the partiM density-of-state analysis, the valence band maximum is mainly contributed to by the 0-213 orbitMs and the conduction band minimum is contributed to by the 0-213 and Mn-3d orbitals. Due to the Coulomb repulsion interaction between electrons, the density of state of Mn-3d is pulled to -6--4.5eV.展开更多
This paper deals with the optimality conditions and dual theory of multi-objective programming problems involving generalized convexity. New classes of generalized type-I functions are introduced for arcwise connected...This paper deals with the optimality conditions and dual theory of multi-objective programming problems involving generalized convexity. New classes of generalized type-I functions are introduced for arcwise connected functions, and examples are given to show the existence of these functions. By utilizing the new concepts, several sufficient optimality conditions and Mond-Weir type duality results are proposed for non-differentiable multi-objective programming problem.展开更多
The classical D-type iterative learning control law depends crucially on the relative degreeof the controlled system, high order di?erential iterative learning law must be taken for systems withhigh order relative deg...The classical D-type iterative learning control law depends crucially on the relative degreeof the controlled system, high order di?erential iterative learning law must be taken for systems withhigh order relative degree. It is very di?cult to ascertain the relative degree of the controlled systemfor uncertain nonlinear systems. A first-order D-type iterative learning control design method ispresented for a class of nonlinear systems with unknown relative degree based on dummy model inthis paper. A dummy model with relative degree 1 is constructed for a class of nonlinear systemswith unknown relative degree. A first-order D-type iterative learning control law is designed basedon the dummy model, so that the dummy model can track the desired trajectory perfectly, and thecontrolled system can track the desired trajectory within a certain error. The simulation exampledemonstrates the feasibility and e?ectiveness of the presented method.展开更多
目的研究昆明地区RhD初筛阴性献血者RHD基因的多态性及其分子机制,为建立区域性献血者RHD基因数据库提供数据支持。方法选择昆明地区2023年11月-2024年8月初筛RhD阴性标本218例,采用间接抗球蛋白试验法(IAT)进行RhD阴性确认,采用盐水试...目的研究昆明地区RhD初筛阴性献血者RHD基因的多态性及其分子机制,为建立区域性献血者RHD基因数据库提供数据支持。方法选择昆明地区2023年11月-2024年8月初筛RhD阴性标本218例,采用间接抗球蛋白试验法(IAT)进行RhD阴性确认,采用盐水试管法进行RhCE表型鉴定。提取全血基因组DNA,采用PCR-SSP法/SSP荧光PCR染料法进行RHD基因分型,对无法确定基因型的标本进行RHD基因1~10外显子Sanger测序分析。结果检出RhD真阴性表型179例(82.11%),其中RHD*01N.01(RHD全缺失)型154例(86.03%),表型以ccee为主(87.01%);携带非功能性RHD等位基因25例(13.97%),包括RHD*01N.0320例、RHD*01N.163例、RHD*01N.051例、RHD*01N.591例,表型以Ccee为主(64%)。检出D变异型39例(15.89%),其中RHD*DEL1(c.1227G>A)型34例,表型均为C抗原阳性(Ccee 27例,CCee 7例);弱D/部分D型4例,包括RHD*DVI.32例、RHD*weak D type 711例、RHD*weak D type1081例;另检出1例RHD*01/RHD*01N.01,基因型与血清学表型结果不一致。RHD*01N.01女性献血者不规则抗体(主要为抗-D)阳性率9.84%。结论昆明地区RhD初筛阴性献血者RHD基因多态性显著,RhD真阴性比例高于国内部分地区,D变异型以“亚洲型”DEL为主,比例低于国内部分地区。研究结果为本地区RhD阴性和D变异型个体精准输血提供了理论和数据支持。展开更多
Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in human.Aggregation-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a p...Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in human.Aggregation-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)laser.Unfortunately,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor treatment.In this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion luminescence.The theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting glioma.Under the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in situ.These results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.展开更多
In this paper,a novel D-type iterative learning control(ILC)law is proposed for discrete-time antilinear systems.This D-type control law is different from the previous linear(nonlinear)D-type ILC law.The main feature ...In this paper,a novel D-type iterative learning control(ILC)law is proposed for discrete-time antilinear systems.This D-type control law is different from the previous linear(nonlinear)D-type ILC law.The main feature is that we take the conjugate of the(t+1)-th error to construct the proposed controller.The convergence proofs are given for their corresponding ILC schemes.展开更多
基金Supported by the National Basic Research Program of China under Grant No 2014CB931703the National Natural Science Foundation of China under Grant Nos 11404172,51101088,and 51171082the Fundamental Research Funds for the Central Universities
文摘We study the electronic and magnetic properties of an oxygen-deficient perovskite Ca2Mn2O5 based on the first principle calculations. The calculations show that the ground state of Ca2Mn2O5 is a D-type anti-ferromagnetic structure with the anti-ferromagnetic spin coupling along the c-direction. The corresponding electronic structure of the D-type state is investigated, and the results display that Ca2Mn2O5 is an insulator with an indirect energy gap of -2.08eV. By the partiM density-of-state analysis, the valence band maximum is mainly contributed to by the 0-213 orbitMs and the conduction band minimum is contributed to by the 0-213 and Mn-3d orbitals. Due to the Coulomb repulsion interaction between electrons, the density of state of Mn-3d is pulled to -6--4.5eV.
文摘This paper deals with the optimality conditions and dual theory of multi-objective programming problems involving generalized convexity. New classes of generalized type-I functions are introduced for arcwise connected functions, and examples are given to show the existence of these functions. By utilizing the new concepts, several sufficient optimality conditions and Mond-Weir type duality results are proposed for non-differentiable multi-objective programming problem.
文摘The classical D-type iterative learning control law depends crucially on the relative degreeof the controlled system, high order di?erential iterative learning law must be taken for systems withhigh order relative degree. It is very di?cult to ascertain the relative degree of the controlled systemfor uncertain nonlinear systems. A first-order D-type iterative learning control design method ispresented for a class of nonlinear systems with unknown relative degree based on dummy model inthis paper. A dummy model with relative degree 1 is constructed for a class of nonlinear systemswith unknown relative degree. A first-order D-type iterative learning control law is designed basedon the dummy model, so that the dummy model can track the desired trajectory perfectly, and thecontrolled system can track the desired trajectory within a certain error. The simulation exampledemonstrates the feasibility and e?ectiveness of the presented method.
文摘目的研究昆明地区RhD初筛阴性献血者RHD基因的多态性及其分子机制,为建立区域性献血者RHD基因数据库提供数据支持。方法选择昆明地区2023年11月-2024年8月初筛RhD阴性标本218例,采用间接抗球蛋白试验法(IAT)进行RhD阴性确认,采用盐水试管法进行RhCE表型鉴定。提取全血基因组DNA,采用PCR-SSP法/SSP荧光PCR染料法进行RHD基因分型,对无法确定基因型的标本进行RHD基因1~10外显子Sanger测序分析。结果检出RhD真阴性表型179例(82.11%),其中RHD*01N.01(RHD全缺失)型154例(86.03%),表型以ccee为主(87.01%);携带非功能性RHD等位基因25例(13.97%),包括RHD*01N.0320例、RHD*01N.163例、RHD*01N.051例、RHD*01N.591例,表型以Ccee为主(64%)。检出D变异型39例(15.89%),其中RHD*DEL1(c.1227G>A)型34例,表型均为C抗原阳性(Ccee 27例,CCee 7例);弱D/部分D型4例,包括RHD*DVI.32例、RHD*weak D type 711例、RHD*weak D type1081例;另检出1例RHD*01/RHD*01N.01,基因型与血清学表型结果不一致。RHD*01N.01女性献血者不规则抗体(主要为抗-D)阳性率9.84%。结论昆明地区RhD初筛阴性献血者RHD基因多态性显著,RhD真阴性比例高于国内部分地区,D变异型以“亚洲型”DEL为主,比例低于国内部分地区。研究结果为本地区RhD阴性和D变异型个体精准输血提供了理论和数据支持。
基金Natural Science Foundation of China,Grant/Award Numbers:T2222021,32011530115,32025021National Key R&D Programs,Grant/Award Number:2019YFE0198700+2 种基金Science and Technology Bureau of Ningbo City,Grant/Award Numbers:2020Z094,2021Z072Excellent Member of Youth Innovation Promotion Association Foundation of CAS,Grant/Award Number:Y2021079Innovation and Technology Commission,Grant/Award Number:MHP/047/19。
文摘Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in human.Aggregation-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)laser.Unfortunately,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor treatment.In this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion luminescence.The theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting glioma.Under the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in situ.These results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.
文摘In this paper,a novel D-type iterative learning control(ILC)law is proposed for discrete-time antilinear systems.This D-type control law is different from the previous linear(nonlinear)D-type ILC law.The main feature is that we take the conjugate of the(t+1)-th error to construct the proposed controller.The convergence proofs are given for their corresponding ILC schemes.
