Four new cyathane-type diterpenoids,nigernins C-F(1-4),together with four known compounds,were isolated from the fruiting bodies of the basidiomycete Phellodon niger.The structures of these new compounds were establis...Four new cyathane-type diterpenoids,nigernins C-F(1-4),together with four known compounds,were isolated from the fruiting bodies of the basidiomycete Phellodon niger.The structures of these new compounds were established on the basis of spectroscopic analysis,including 1D and 2D NMR experiments.In addition,nigernin F(4)with an unusual 3,4-seco cyathane diterpenoid skeleton was found to occur in nature for the first time.It was suggested to be as an oxidation product of C-3-C-4 bond cleavage of nigernin E(3).展开更多
Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural diversity and activity variation of natural products.Glucosylation is the most common type of gly...Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural diversity and activity variation of natural products.Glucosylation is the most common type of glycosylation,whereas xylosylation is relatively rare.Despite their unique chemical structures and beneficial activities,xylosylated natural products from microorganisms have received little attention.This review provides,for the first time,a comprehensive summary of 126 microbial-derived xylosylated natural products,including xylosyl-cyathane diterpenes,xylosylated triterpenes,xylosyl aromatic compounds,and others.Among these compounds,xylosyl-cyathane diterpenes represent the highest number of derivatives,followed by xylosylated triterpenes.Xylosyl compounds from bacterial sources have less defined structural profiles compared to those from fungi.The characterization of xylosyltransferase EriJ from Basidiomycota extended the structural diversity of xylosyl cyathane diterpenes.This work provides a valuable reference for the research and use of xylosyltransferase for drug discovery and synthetic chemistry.Further work is needed to explore the potential applications of microbial derived xylosyl compounds and to develop novel xylosyl transferases.With the deepening of genomic sequencing of medicinal fungi,more biosynthesis of bioactive xylosyl compounds is expected to be elucidated in the future.展开更多
基金This project was supported by the National Basic Research Program of China(973 Program,2009CB522300)the National Natural Sciences Foundation of China(30830113)MOST(2009ZX09501-029).
文摘Four new cyathane-type diterpenoids,nigernins C-F(1-4),together with four known compounds,were isolated from the fruiting bodies of the basidiomycete Phellodon niger.The structures of these new compounds were established on the basis of spectroscopic analysis,including 1D and 2D NMR experiments.In addition,nigernin F(4)with an unusual 3,4-seco cyathane diterpenoid skeleton was found to occur in nature for the first time.It was suggested to be as an oxidation product of C-3-C-4 bond cleavage of nigernin E(3).
基金supported by the Key R&D Projects in Shaanxi Province of China(No.2023-YBSF-164)the National Natural Science Foundation of China(No.31800031 and No.32370069)+1 种基金the Fundamental Research Funds for the Central Universities(2572023AW40)the Natural Science Foundation of Heilongjiang Province of China(No.LH2023C035).
文摘Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural diversity and activity variation of natural products.Glucosylation is the most common type of glycosylation,whereas xylosylation is relatively rare.Despite their unique chemical structures and beneficial activities,xylosylated natural products from microorganisms have received little attention.This review provides,for the first time,a comprehensive summary of 126 microbial-derived xylosylated natural products,including xylosyl-cyathane diterpenes,xylosylated triterpenes,xylosyl aromatic compounds,and others.Among these compounds,xylosyl-cyathane diterpenes represent the highest number of derivatives,followed by xylosylated triterpenes.Xylosyl compounds from bacterial sources have less defined structural profiles compared to those from fungi.The characterization of xylosyltransferase EriJ from Basidiomycota extended the structural diversity of xylosyl cyathane diterpenes.This work provides a valuable reference for the research and use of xylosyltransferase for drug discovery and synthetic chemistry.Further work is needed to explore the potential applications of microbial derived xylosyl compounds and to develop novel xylosyl transferases.With the deepening of genomic sequencing of medicinal fungi,more biosynthesis of bioactive xylosyl compounds is expected to be elucidated in the future.
