Engleromyces goetzii is a traditional medicinal mushroom that is widely used to treat infection,inflammation and cancer in Tibet,Sichuan and Yunnan provinces of China.Two new trichothecenes,engleromycones A and B(1 an...Engleromyces goetzii is a traditional medicinal mushroom that is widely used to treat infection,inflammation and cancer in Tibet,Sichuan and Yunnan provinces of China.Two new trichothecenes,engleromycones A and B(1 and 2),one new cuparane-type sesquiterpenoid named infuscol F(11),eight known trichothecene analogs,sambucinol(3),3-deoxysambucinol(4),trichothecolone(5),trichodermol(6),8-deoxytrichothecin(7),trichothecin(8),trichothecinol B(9)and trichothecinol A(10),and one known cyclopentanoid sesquiterpene cyclonerodiol(12)were isolated from the cultures of E.goetzii.The new compounds were elucidated through spectroscopic analyses.The anticancer effects of trichothecenes 1–10 were examined in the HL-60,SMMC-7721,A549,MCF-7,and SW-480 human cancer cell lines using an MTT assay.Trichothecinol A(10)significantly inhibited the growth of MCF-7 cells,with an IC50 value of 0.006 lM,which was comparable to the cytotoxic activity of the positive control,paclitaxel,indicating that trichothecinol A(10)represents a potential anticancer agent.展开更多
基金the National Natural Sciences Foundation of China(U1132607,21302194)the National Science&Technology Pillar Program of China(2012BAD23B0305 and 2013BAI11B02).
文摘Engleromyces goetzii is a traditional medicinal mushroom that is widely used to treat infection,inflammation and cancer in Tibet,Sichuan and Yunnan provinces of China.Two new trichothecenes,engleromycones A and B(1 and 2),one new cuparane-type sesquiterpenoid named infuscol F(11),eight known trichothecene analogs,sambucinol(3),3-deoxysambucinol(4),trichothecolone(5),trichodermol(6),8-deoxytrichothecin(7),trichothecin(8),trichothecinol B(9)and trichothecinol A(10),and one known cyclopentanoid sesquiterpene cyclonerodiol(12)were isolated from the cultures of E.goetzii.The new compounds were elucidated through spectroscopic analyses.The anticancer effects of trichothecenes 1–10 were examined in the HL-60,SMMC-7721,A549,MCF-7,and SW-480 human cancer cell lines using an MTT assay.Trichothecinol A(10)significantly inhibited the growth of MCF-7 cells,with an IC50 value of 0.006 lM,which was comparable to the cytotoxic activity of the positive control,paclitaxel,indicating that trichothecinol A(10)represents a potential anticancer agent.
