BACKGROUND Diabetic gastrointestinal autonomic neuropathy(DGAN)often affects the patients’quality of life.Thus,research on influencing factors of DGAN may promote DGAN prevention and decrease the incidence rate.This ...BACKGROUND Diabetic gastrointestinal autonomic neuropathy(DGAN)often affects the patients’quality of life.Thus,research on influencing factors of DGAN may promote DGAN prevention and decrease the incidence rate.This study used electrogastrogram(EGG)to assess the relationship between metabolic dysfunction-associated steatotic liver disease(MASLD)and DGAN.AIM To analyze the changes of EGG in patients with MASLD and type 2 diabetes mellitus(T2DM),and to elucidate whether ultrasound-diagnosed MASLD is an independent risk factor for diabetic gastric motility disorders(DGMD).METHODS A total of 272 patients with T2DM hospitalized at the Second Affiliated Hospital of Soochow University from December 2020 to December 2021 and the Affiliated Suqian Hospital of Xuzhou Medical University from November 2023 to June 2024 were included in the cross-sectional study.General information,clinical data,and medical history of all study subjects,including name,age,gender,body mass index,and duration of diabetes were collected.Laboratory tests included biochemical parameters,glycosylated hemoglobin(HbA1c),fasting C-peptide,2h postprandial C-peptide and 25-hydroxyvitamin D[25(OH)D].EGG,fundus examination and carotid artery ultrasonography were performed and results were recorded.According to the results of EGG,the subjects were divided into the DGMD group and non-DGMD group.RESULTS The duration of diabetes,fasting blood glucose(FBG),HbA1c,25(OH)D and the prevalence of MASLD were significantly higher in the DGMD group(P<0.05).Multiple logistic regression analysis showed that the duration,FBG,25(OH)D and the presence of MASLD were independent influencing factors.CONCLUSION MASLD is strongly associated with an increased incidence of DGMD.Timely treatment of MASLD is effective to prevent diabetic gastroparesis.展开更多
In this paper Electrogastrogram (EOG) was recorded in 40 normal subjects and100 patients suffered from gastroduodenal diseases. In 40 normal subjects, the average of amplitudeand frequency of EGG were 150-180 μV and ...In this paper Electrogastrogram (EOG) was recorded in 40 normal subjects and100 patients suffered from gastroduodenal diseases. In 40 normal subjects, the average of amplitudeand frequency of EGG were 150-180 μV and 3 cycles/min respectively before eating, but after eatingthe amplitude was about 236.2 μV and the frequency was about 3.21 cycles/rain. EGG diagnosis of100 patients with gastralgia was conformed to the gastroscopic diagnosis, with the rate 84%. The re-lations between effects of acupuncture and Qigong, the PSC and the differentiation of syndromes ofTCM and EGG were explored.展开更多
It is reported that acupuncture on some acupoints can enhance the regularity of gastric myoelectrical activities, which can be observed from the electrogastrograms (EEGs). In this paper, the electroacupuncture (EA) tr...It is reported that acupuncture on some acupoints can enhance the regularity of gastric myoelectrical activities, which can be observed from the electrogastrograms (EEGs). In this paper, the electroacupuncture (EA) treatments were performed on subjects with slight gastric disorders and the EEGs were monitored in the meanwhile. The EEGs features of baseline, during and after EA treatments were analyzed. The results show that the EA treatments do enhance the regularity of EEGs. And a highly possible pattern for EA to attain the enhancement is to regulate the pacemaker quantity and propagation of slow waves rather than regulating the amplitude of slow waves.展开更多
Not much data are available regarding the electrical activity in the stomachs and intestines of elderly gastrectomized patients The purpose of this study was to determine the feasibility of using a complex dynamic met...Not much data are available regarding the electrical activity in the stomachs and intestines of elderly gastrectomized patients The purpose of this study was to determine the feasibility of using a complex dynamic method to analyze the electrogastrograms （EGGs） of healthy young, healthy elderly, and gastrectomized elderly male individuals. The authors analyzed the EGGs by using the maximum Lyapunov exponent （MLE）, which is one of the indices of the chaotic characteristics of time series. Significant differences were observed between the MLEs estimated from the, EGGs of the young and elderly individuals for most of the temporal intervals. The authors＇ data indicate that the EGGs of elderly gastrectomized subjects might be distinguished from the EGGs of healthy elderly individuals on the basis of the MLE distribution.展开更多
Objective: To investigate the specificity of the effects of electroacupuncture (EA) at different acupoints on gastric functional activity and gastric blood flow after colorectal distension (CRD) in the rat. Methods: F...Objective: To investigate the specificity of the effects of electroacupuncture (EA) at different acupoints on gastric functional activity and gastric blood flow after colorectal distension (CRD) in the rat. Methods: Fifty Wistar rats were randomly divided into 5 groups: a control group, a Zusanli group, a non-point group, a Taichong group and a Neiguan group. Rats were anesthetized after 18 h of fasting, and a rat model of nociceptive blood pressure elevation and abnormal electrogastrogram (EGG) and gastric tension (GT) was prepared by gasbag-induced CRD. EA was given bilaterally, and its effects on gastric blood flow (GBF) of the arcus vasculosi of the greater omentum, blood pressure, EGG fast wave properties, and gastric smooth muscle tension (GT) were quantified. Results: CRD induced an increase in blood pressure that was significantly inhibited by EA at all points (all P<0.05), and the inhibitory effects were greater in the Zusanli and Neiguan groups compared to the non-point group (both P<0.05). CRD also caused reductions in GT and GBF, and in the amplitude, frequency and duration of EGG waves (all P<0.05). These effects were also reversed by EA. The effects of EA on EGG wave amplitude, GT, and GBF were superior in the Zusanli group compared to the Taichong group, Neiguan group, and the non-point group. Conclusion: EA significantly counteracted CRD-induced changes in blood pressure, GBF, EGG, and GT. The effects of stimulation at Zusanli (ST 36) were significantly greater compared to other points, indicating relative specificity of this acupoint.展开更多
目的:观察电针足三里对功能性消化不良(functional dyspepsia,FD)大鼠胃电节律的影响.方法:48只SD大鼠随机分为正常组、模型组、电针组和多潘立酮组,每组12只.采用夹尾刺激的方法造成FD大鼠模型,分别治疗10 d后测定各组大鼠空腹胃电图,...目的:观察电针足三里对功能性消化不良(functional dyspepsia,FD)大鼠胃电节律的影响.方法:48只SD大鼠随机分为正常组、模型组、电针组和多潘立酮组,每组12只.采用夹尾刺激的方法造成FD大鼠模型,分别治疗10 d后测定各组大鼠空腹胃电图,记录时间30 min.结果:与模型组相比,电针组和多潘立酮组大鼠胃电图主频率、主功率及正常慢波百分比均明显升高(胃电图主频率分别为59.89±2.930 vs 40.50±2.317,49.14±3.901 vs 40.50±2.317,P<0.05或P<0.01;主功率分别为0.758±0.101 vs 0.413±0.086,0.612±0.041 vs0.413±0.086,P<0.05或P<0.01;正常慢波百分比分别为66.72±1.573 vs 55.44±2.129,66.35±1.534 vs 55.44±2.129,P<0.05或P<0.01),胃动过缓及胃动过速百分比均明显降低(胃动过缓百分比分别为10.24±0.931 vs 21.07±0.951,9.853±1.057 vs 21.07±0.951,P<0.05或P<0.01;胃动过速百分比分别为12.41±0.503 vs 14.90±0.572,12.88±0.302 vs 14.90±0.572,P<0.05或P<0.01).结论:电针足三里可增加FD大鼠胃电图的主频率、主功率及正常慢波百分比,减少FD大鼠胃动过缓及胃动过速百分比.展开更多
基金Supported by Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0507200The Suqian Sci Tech Program,No.Z2023106+2 种基金National Natural Science Foundation of China,No.82071234,No.31400947 and No.82170836Gusu Talent Program,No.GSWS2022030The Clinical Research Center of Neurological Disease of The Second Affiliated Hospital of Soochow University,No.ND2024A02.
文摘BACKGROUND Diabetic gastrointestinal autonomic neuropathy(DGAN)often affects the patients’quality of life.Thus,research on influencing factors of DGAN may promote DGAN prevention and decrease the incidence rate.This study used electrogastrogram(EGG)to assess the relationship between metabolic dysfunction-associated steatotic liver disease(MASLD)and DGAN.AIM To analyze the changes of EGG in patients with MASLD and type 2 diabetes mellitus(T2DM),and to elucidate whether ultrasound-diagnosed MASLD is an independent risk factor for diabetic gastric motility disorders(DGMD).METHODS A total of 272 patients with T2DM hospitalized at the Second Affiliated Hospital of Soochow University from December 2020 to December 2021 and the Affiliated Suqian Hospital of Xuzhou Medical University from November 2023 to June 2024 were included in the cross-sectional study.General information,clinical data,and medical history of all study subjects,including name,age,gender,body mass index,and duration of diabetes were collected.Laboratory tests included biochemical parameters,glycosylated hemoglobin(HbA1c),fasting C-peptide,2h postprandial C-peptide and 25-hydroxyvitamin D[25(OH)D].EGG,fundus examination and carotid artery ultrasonography were performed and results were recorded.According to the results of EGG,the subjects were divided into the DGMD group and non-DGMD group.RESULTS The duration of diabetes,fasting blood glucose(FBG),HbA1c,25(OH)D and the prevalence of MASLD were significantly higher in the DGMD group(P<0.05).Multiple logistic regression analysis showed that the duration,FBG,25(OH)D and the presence of MASLD were independent influencing factors.CONCLUSION MASLD is strongly associated with an increased incidence of DGMD.Timely treatment of MASLD is effective to prevent diabetic gastroparesis.
文摘In this paper Electrogastrogram (EOG) was recorded in 40 normal subjects and100 patients suffered from gastroduodenal diseases. In 40 normal subjects, the average of amplitudeand frequency of EGG were 150-180 μV and 3 cycles/min respectively before eating, but after eatingthe amplitude was about 236.2 μV and the frequency was about 3.21 cycles/rain. EGG diagnosis of100 patients with gastralgia was conformed to the gastroscopic diagnosis, with the rate 84%. The re-lations between effects of acupuncture and Qigong, the PSC and the differentiation of syndromes ofTCM and EGG were explored.
文摘It is reported that acupuncture on some acupoints can enhance the regularity of gastric myoelectrical activities, which can be observed from the electrogastrograms (EEGs). In this paper, the electroacupuncture (EA) treatments were performed on subjects with slight gastric disorders and the EEGs were monitored in the meanwhile. The EEGs features of baseline, during and after EA treatments were analyzed. The results show that the EA treatments do enhance the regularity of EEGs. And a highly possible pattern for EA to attain the enhancement is to regulate the pacemaker quantity and propagation of slow waves rather than regulating the amplitude of slow waves.
文摘Not much data are available regarding the electrical activity in the stomachs and intestines of elderly gastrectomized patients The purpose of this study was to determine the feasibility of using a complex dynamic method to analyze the electrogastrograms （EGGs） of healthy young, healthy elderly, and gastrectomized elderly male individuals. The authors analyzed the EGGs by using the maximum Lyapunov exponent （MLE）, which is one of the indices of the chaotic characteristics of time series. Significant differences were observed between the MLEs estimated from the, EGGs of the young and elderly individuals for most of the temporal intervals. The authors＇ data indicate that the EGGs of elderly gastrectomized subjects might be distinguished from the EGGs of healthy elderly individuals on the basis of the MLE distribution.
基金supported by TCM Item of National Key Basic Study (2005CB523306, 2006CB504506 2007CB512505)the National Natural Science Foundation of China (30973796, 90709031)
文摘Objective: To investigate the specificity of the effects of electroacupuncture (EA) at different acupoints on gastric functional activity and gastric blood flow after colorectal distension (CRD) in the rat. Methods: Fifty Wistar rats were randomly divided into 5 groups: a control group, a Zusanli group, a non-point group, a Taichong group and a Neiguan group. Rats were anesthetized after 18 h of fasting, and a rat model of nociceptive blood pressure elevation and abnormal electrogastrogram (EGG) and gastric tension (GT) was prepared by gasbag-induced CRD. EA was given bilaterally, and its effects on gastric blood flow (GBF) of the arcus vasculosi of the greater omentum, blood pressure, EGG fast wave properties, and gastric smooth muscle tension (GT) were quantified. Results: CRD induced an increase in blood pressure that was significantly inhibited by EA at all points (all P<0.05), and the inhibitory effects were greater in the Zusanli and Neiguan groups compared to the non-point group (both P<0.05). CRD also caused reductions in GT and GBF, and in the amplitude, frequency and duration of EGG waves (all P<0.05). These effects were also reversed by EA. The effects of EA on EGG wave amplitude, GT, and GBF were superior in the Zusanli group compared to the Taichong group, Neiguan group, and the non-point group. Conclusion: EA significantly counteracted CRD-induced changes in blood pressure, GBF, EGG, and GT. The effects of stimulation at Zusanli (ST 36) were significantly greater compared to other points, indicating relative specificity of this acupoint.
文摘目的:观察电针足三里对功能性消化不良(functional dyspepsia,FD)大鼠胃电节律的影响.方法:48只SD大鼠随机分为正常组、模型组、电针组和多潘立酮组,每组12只.采用夹尾刺激的方法造成FD大鼠模型,分别治疗10 d后测定各组大鼠空腹胃电图,记录时间30 min.结果:与模型组相比,电针组和多潘立酮组大鼠胃电图主频率、主功率及正常慢波百分比均明显升高(胃电图主频率分别为59.89±2.930 vs 40.50±2.317,49.14±3.901 vs 40.50±2.317,P<0.05或P<0.01;主功率分别为0.758±0.101 vs 0.413±0.086,0.612±0.041 vs0.413±0.086,P<0.05或P<0.01;正常慢波百分比分别为66.72±1.573 vs 55.44±2.129,66.35±1.534 vs 55.44±2.129,P<0.05或P<0.01),胃动过缓及胃动过速百分比均明显降低(胃动过缓百分比分别为10.24±0.931 vs 21.07±0.951,9.853±1.057 vs 21.07±0.951,P<0.05或P<0.01;胃动过速百分比分别为12.41±0.503 vs 14.90±0.572,12.88±0.302 vs 14.90±0.572,P<0.05或P<0.01).结论:电针足三里可增加FD大鼠胃电图的主频率、主功率及正常慢波百分比,减少FD大鼠胃动过缓及胃动过速百分比.
