Herein,the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO)complex catalyze asymmetric formal[3+2]cycloaddition between quinones and ynamides is explored,producing ...Herein,the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO)complex catalyze asymmetric formal[3+2]cycloaddition between quinones and ynamides is explored,producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities.Furthermore,density functional theory calculations were applied to explain the possible reaction mechanism.展开更多
基金supported by the National Natural Science Foundation of China(22278200,21971095,21502080,21772019,21772076,21871117,91956203)the National Key R&D Program of China(2023YFA1506400)+3 种基金the Science and Technology Major Program of Gansu Province of China(22ZD6FA006,23ZDFA015)the“111”Program of Ministry of Education of Chinathe Major Project of the Ministry of Science and Technology of China(2018ZX09711001-005-002)the Science and Technology Commission of Shanghai Municipality(19JC1430100)。
文摘Herein,the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO)complex catalyze asymmetric formal[3+2]cycloaddition between quinones and ynamides is explored,producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities.Furthermore,density functional theory calculations were applied to explain the possible reaction mechanism.
