In this study, we investigate the cross-frequency coupling and functional brain networks in the subjects with temporal lobe epilepsy(TLE) using interictal EEG signals. The phase to phase synchronization within and acr...In this study, we investigate the cross-frequency coupling and functional brain networks in the subjects with temporal lobe epilepsy(TLE) using interictal EEG signals. The phase to phase synchronization within and across frequency bands is calculated and a significant difference between the epilepsy and control groups is observed. Compared with the controls,the epilepsy patients exhibit a stronger within-frequency coupling(WFC) within theta and beta bands, and shows a stronger cross-frequency coupling(CFC) in the delta–alpha and theta–alpha band pairs, but a weakened CFC in alpha–beta band pairs. The weakened coupling between alpha and high frequency band reflects a suppression of phase modulation between the brain regions related to epilepsy. Moreover, WFC and CFC are positively correlated, which is higher in the patients relative to controls. We further reconstruct functional brain connectivity and find that both WFC and CFC networks show small-world properties. For the epilepsy, the small-world efficiency is enhanced in the CFC networks in delta–alpha and theta–alpha band pairs, whereas weakened between alpha and beta bands, which suggests a shift away from the optimal operating point in the epileptic brain with a new balance between WFC and CFC. Our results may help us to understand the important role of information communication across different frequency bands and shed new light on the study of pathology of epilepsy.展开更多
Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation.Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of ne...Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation.Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of neurons.Although hemorrhagic shock and resuscitation(HSR)injury can impair cognition,it remains unclear how this insult directly affects astrocytes.In this study,we established an HSR model by bleeding and re-transfusion in mice.The social interaction test and new object recognition test were applied to evaluate post-operative cognitive changes,and the results suggest that mice experience cognitive impairment following exposure to HSR.In the HSR group,the power spectral density ofβandγoscillations decreased,and the coupling of theθoscillation phase andγoscillation amplitude was abnormal,which indicated abnormal neuronal oscillation and cognitive impairment after HSR exposure.In brief,cognitive impairment in mice is strongly correlated with Ca^(2+)signal strength in lateral septum astrocytes following HSR.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.61302002)
文摘In this study, we investigate the cross-frequency coupling and functional brain networks in the subjects with temporal lobe epilepsy(TLE) using interictal EEG signals. The phase to phase synchronization within and across frequency bands is calculated and a significant difference between the epilepsy and control groups is observed. Compared with the controls,the epilepsy patients exhibit a stronger within-frequency coupling(WFC) within theta and beta bands, and shows a stronger cross-frequency coupling(CFC) in the delta–alpha and theta–alpha band pairs, but a weakened CFC in alpha–beta band pairs. The weakened coupling between alpha and high frequency band reflects a suppression of phase modulation between the brain regions related to epilepsy. Moreover, WFC and CFC are positively correlated, which is higher in the patients relative to controls. We further reconstruct functional brain connectivity and find that both WFC and CFC networks show small-world properties. For the epilepsy, the small-world efficiency is enhanced in the CFC networks in delta–alpha and theta–alpha band pairs, whereas weakened between alpha and beta bands, which suggests a shift away from the optimal operating point in the epileptic brain with a new balance between WFC and CFC. Our results may help us to understand the important role of information communication across different frequency bands and shed new light on the study of pathology of epilepsy.
基金supported by the National Natural Science Foundation of China(82171455).
文摘Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation.Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of neurons.Although hemorrhagic shock and resuscitation(HSR)injury can impair cognition,it remains unclear how this insult directly affects astrocytes.In this study,we established an HSR model by bleeding and re-transfusion in mice.The social interaction test and new object recognition test were applied to evaluate post-operative cognitive changes,and the results suggest that mice experience cognitive impairment following exposure to HSR.In the HSR group,the power spectral density ofβandγoscillations decreased,and the coupling of theθoscillation phase andγoscillation amplitude was abnormal,which indicated abnormal neuronal oscillation and cognitive impairment after HSR exposure.In brief,cognitive impairment in mice is strongly correlated with Ca^(2+)signal strength in lateral septum astrocytes following HSR.
