In conventional cross-coupled controller design,the method usually ignored the inherent characteristic of time-vary-ing parameters and model uncertainties in system.In this paper,a cross-coupled controller(CCC)using a...In conventional cross-coupled controller design,the method usually ignored the inherent characteristic of time-vary-ing parameters and model uncertainties in system.In this paper,a cross-coupled controller(CCC)using an H~∞control scheme has been proposed to reduce the contouring error for an X-Y table.Furthermore,the proposed CCC design,which is a typical Multi-Input Multi-Output(MIMO)system with linear time varying(LTV)characteristics,has been verified as being internally stable.The simulations are carried on Matlab simulink to verify the proposed method,and the results showed that the proposed method can reduce the contouring error significantly compared with the conventional one.展开更多
By analyzing the principle of process variations, a lightweight Physical Unclonable Function （PUF） circuit based on selectable cross-coupled inverters is proposed in this paper. Firstly, selectable cross-coupled inv...By analyzing the principle of process variations, a lightweight Physical Unclonable Function （PUF） circuit based on selectable cross-coupled inverters is proposed in this paper. Firstly, selectable cross-coupled inverters are chosen for two delay paths. Simultaneously, the circuit takes challenge signal to control each delay path. The PUF cell circuit is implemented in Semiconductor Manufacturing International Corporation （SMIC） 65 nm CMOS technology and the layout area is 2.94μm × 1.68μm. Then the 64-bit PUF circuit is achieved with the cascade connection of cell circuits. The simulation results show that the randomness is 49.4% and the reliability is 96.5%. Compared to the other works, this PUF circuit improves the encrypt performance and greatly reduces the area.展开更多
A design approach for online pre-compensation of three-axis cross-coupled contour errors with mismatched dynamics is proposed.In the context of cross-coupled contour control design,online pre-compensation of contour e...A design approach for online pre-compensation of three-axis cross-coupled contour errors with mismatched dynamics is proposed.In the context of cross-coupled contour control design,online pre-compensation of contour errors is commonly employed.However,establishing a specific relationship between contour errors is challenging for mismatched computer numerical control(CNC)systems.Therefore,the design of interpolation methods for mismatched systems remains crucial,as most existing systems struggle to be adjusted to match seamlessly.This study introduces an online pre-compensation scheme for cross-coupled contour errors in three-axis motion,which constitutes a compensation system for real-time correction of contour error estimation.The coupling control structure,based on a speed loop,comprises a proportion integration differentiation(PID)control feedback controller,a feedforward controller,and an online pre-compensation cross-coupled contour controller.The experimental results demonstrate that the proposed three-axis cross-coupled contour error pre-compensation scheme significantly enhances the contour accuracy compared to traditional cross-coupled control systems.Moreover,the proposed cross-coupled contour error pre-compensation controller exhibits superior contour performance over conventional cross-coupled controllers when tracking high-order curvature bending paths.展开更多
The synthesis method of propargylamines has always been the focus of research in organic synthetic methodology.A method of alkynylation of tertiary aliphatic amines with alkynes in the presence of copper doped zeolite...The synthesis method of propargylamines has always been the focus of research in organic synthetic methodology.A method of alkynylation of tertiary aliphatic amines with alkynes in the presence of copper doped zeolite Y as a catalyst and oxygen in the air as an oxidant has been developed.The most important feature of this reaction is that copper molecular siolite is used as catalyst,which avoids the intermolecular self-coupling of alkynes,and thus realizes the high efficiency propargylization of alkyl tertiary amines.展开更多
The cross-coupled control(CCC)is widely applied to reduce contour errors in contour-following applications.In such situation,the contour error estimation plays an important role.Traditionally,the linear or second-orde...The cross-coupled control(CCC)is widely applied to reduce contour errors in contour-following applications.In such situation,the contour error estimation plays an important role.Traditionally,the linear or second-order estimation approach is adopted for biaxial motion systems,whereas only linear approach is available for triaxial systems.In this paper,the second-order contour error estimation,which was presented in our previous work,is utilized to determine the variable CCC gains for motion control systems with three axes.An integrated stable motion control strategy,which combines the feedforward,feedback and CCC controllers,is developed for multiaxis CNC systems.Experimental results on a triaxial platform indicate that the CCC scheme based on the second-order estimation,compared with that based on the linear one,significantly reduces the contour error even in the conditions of high tracking feedrate and small radius of curvature.展开更多
An innovative, thermally-insensitive phenomenon of cascaded cross-coupled structures is found. And a novel CMOS temperature sensor based on a cross-coupled structure is proposed. This sensor consists of two different ...An innovative, thermally-insensitive phenomenon of cascaded cross-coupled structures is found. And a novel CMOS temperature sensor based on a cross-coupled structure is proposed. This sensor consists of two different ring oscillators. The first ring oscillator generates pulses that have a period, changing linearly with temperature. Instead of using the system clock like in traditional sensors, the second oscillator utilizes a cascaded cross-coupled structure to generate temperature independent pulses to capture the result from the first oscillator. Due to the compensation between the two ring oscillators, errors caused by supply voltage variations and systematic process variations are reduced. The layout design of the sensor is based on the TSMC13G process standard cell library. Only three inverters are modified for proper channel width tuning without any other custom design. This allows for an easy integration of the sensor into cell-based chips. Post-layout simulations results show that an error lower than ±1.1 °C can be achieved in the full temperature range from 40 to 120 °C. As shown by SPICE simulations, the thermal insensitivity of the cross-coupled inverters can be realized for various TSMC technologies： 0.25 μm, 0.18 μm, 0.13 μm, and 65 nm.展开更多
This paper proposes an efficient PSP-based model for cross-coupled metal-oxide-semiconductor field-effect transistors(MOSFETs) with optimized layout in the voltage controlled oscillator(VCO).The model employs a PSP ch...This paper proposes an efficient PSP-based model for cross-coupled metal-oxide-semiconductor field-effect transistors(MOSFETs) with optimized layout in the voltage controlled oscillator(VCO).The model employs a PSP charge model to characterize the bias-dependent extrinsic capacitance instead of numerical functions with strong non-linearity.The simulation convergence is greatly improved by this method.An original scheme is developed to extract the parameters of the PSP charge model based on S-parameters measurement.The interconnection parasitics of the cross-coupled MOSFETs are modeled based on vector fitting.The model is verified with an LC VCO design,and exhibits excellent convergence during simulation.The results show improvements as high as 60.5% and 61.8% in simulation efficiency and accuracy,respectively,indicating that the proposed model better characterizes optimized cross-coupled MOSFETs in advanced radio frequency(RF) circuit design.展开更多
A low-power,high-speed dynamic comparator with the addition of a cross-coupled pair in the pre-amplifier stage,followed by a strong-arm latch,is presented.The proposed modification increases the pre-amplifier’s diffe...A low-power,high-speed dynamic comparator with the addition of a cross-coupled pair in the pre-amplifier stage,followed by a strong-arm latch,is presented.The proposed modification increases the pre-amplifier’s differential and common-mode gains,improving the latch’s differential and common-mode input voltage,resulting in faster regeneration with 22%speed improvement as compared to conventional comparator at small input differential voltages(V_(i,id)).The proposed technique boosts the comparator’s speed and helps achieve 21%lower energy per conversion delay product(EDP)compared to the literature.Analytical modeling of the delay that proves the improvement in the speed of the proposed comparator is also presented and verified with the simulation results.The proposed comparator’s delay is insensitive to the common-mode voltage(V_(i,cm)).The proposed comparator is fabricated in 180-nm CMOS technology and measurement shows less than 160 ps relative CLK-Q delay with 81 fJ.ns EDP and 0.8 mV input-referred rms noise with 1.8 V supply.To demonstrate the scalability of the proposed technique to advanced technology nodes,the proposed design is also simulated in 65-nm CMOS technology with a 1.1 V supply for 5 GHz frequency.For V_(i,cm) of 0.3 V and V_(i,id) of 1 mV and 10 mV,the proposed comparator exhibits a 40.69 ps and 32.41 ps delay and has 3.74 fJ.ns and 2.78 fJ.ns EDP respectively.展开更多
Chiral carbonyl compounds frequently occur in natural products and pharmaceuticals. Additionally, they serve as important intermediates in organic synthesis. Transition metal-catalyzed asymmetric carbonylative cross-c...Chiral carbonyl compounds frequently occur in natural products and pharmaceuticals. Additionally, they serve as important intermediates in organic synthesis. Transition metal-catalyzed asymmetric carbonylative cross-coupling reactions are among the most straightforward and effective methods for synthesizing chiral carbonyl compounds, including esters, amides, and ketones. The advances in asymmetric carbonylative cross-coupling reactions using various O-, N-, C-, and S-containing nucleophiles or electrophiles over the past decade are summarized.展开更多
A chromium(II)-catalyzed reduction cross coupling reaction was reported.This reaction utilizes inexpensive and readily available chromium dichloride as a catalyst and 4,4'-di-tert-butyl-bipyridine as a ligand to a...A chromium(II)-catalyzed reduction cross coupling reaction was reported.This reaction utilizes inexpensive and readily available chromium dichloride as a catalyst and 4,4'-di-tert-butyl-bipyridine as a ligand to achieve reduction cross coupling between trifluoromethyl olefins and alkyl bromides under mild conditions,effectively synthesizing difluoroalkene derivatives.This reaction exhibits good substrate universality and is compatible with multiple important functional groups,providing a concise synthetic pathway for constructing conjugated difluoroalkenes containing allyl difluoromethylene structural units.Preliminary mechanistic experiments indicate that alkyl bromides first undergo a reduction process to generate corresponding alkyl radicals,followed by addition to trifluoromethyl olefins.After binding with Cr(II),they undergo aβ-fluorine elimination process to generate difluoroalkenes.展开更多
Selective defluorinative functionalization of trifluoromethylarenes(ArCF3)to obtain the pharmaceutically commonα,α-difluorobenzylic motif is an attractive and elegant synthetic route.Over the past decade,although C(...Selective defluorinative functionalization of trifluoromethylarenes(ArCF3)to obtain the pharmaceutically commonα,α-difluorobenzylic motif is an attractive and elegant synthetic route.Over the past decade,although C(sp^(3))-F bonds functionalization have been greatly developed,catalytic cross-coupling of trifluoromethylarenes with C-H of terminal alkynes remains a challenge.Here,we report an approach to achieve Sonogashira-type cross-coupling of trifluoromethylarenes with terminal alkynes C(sp)-H bonds via photoredox and Cu/L dual catalysis.Tridentate anionic ligand is pivotal to realize this C-H sp-sp^(3) cross-coupling.Moreover,this unique catalytic system is also suitable for cross-coupling of C(sp^(3))-F bonds with azoles C(sp^(2))-H bonds.A series of trifluoromethylarenes,terminal alkynes and azoles with various functional groups are compatible with this protocol affording a variety of defluoroalkynylation or defluoroazolation products.Preliminary mechanistic studies indicated that deprotonated BINOL involved as a photocatalyst to activate ArCF3 rather than a ligand to the metal.展开更多
In most Suzuki–Miyaura carbon-carbon cross-coupling reactions,the borabicyclo[3.3.1]nonane scaffold(9-BBN)only serves as an auxiliary facilitating the transmetalation step and thus is transformed into by-products.The...In most Suzuki–Miyaura carbon-carbon cross-coupling reactions,the borabicyclo[3.3.1]nonane scaffold(9-BBN)only serves as an auxiliary facilitating the transmetalation step and thus is transformed into by-products.There are rare examples where the 9-BBN derivatives serve as the potentially diverse C8 building blocks in cross-coupling reactions.Herein,we report a cobalt-catalyzed migratory carboncarbon cross-coupling reaction of the in situ formed 9-BBN ate complexes to afford diverse aryl-and alkyl-functionalized cyclooctenes.Preliminary mechanistic studies suggest the oxidation-induced cisbicyclo[3.3.0]oct-1-ylborane is the key intermediate in this migratory cross-coupling reaction,which promotes the development of other diverse migratory cross-coupling of borate complexes.展开更多
The switchable cross-coupling of indoles and pyridotriazoles through carbene insertion at C_(2)-or C_(3)-positon has been developed in this paper.This highly site-selective C-H carbenoid functionalization is determine...The switchable cross-coupling of indoles and pyridotriazoles through carbene insertion at C_(2)-or C_(3)-positon has been developed in this paper.This highly site-selective C-H carbenoid functionalization is determined by both the Rh-catalyst species and auxiliary groups.[Cp∗RhCl_(2)]_(2) and coordinating pyrimidyl group direct the C-H carbenoid functionalization to occur at the C_(2)-position,while Rh2OAc4 and noncoordinating benzyl group lead the reaction to occur at the C_(3)-position of the indoles.This regioselective C−H functionalization strategy is of significant importance for the discovery of indole drugs.展开更多
An N-heterocyclic carbene(NHC)catalyzed enantioselective cyclisation and trifluoromethylation of olefins with cinnamaldehydes via radical relay cross-coupling in the presence of Togni reagent is reported andδ-lactone...An N-heterocyclic carbene(NHC)catalyzed enantioselective cyclisation and trifluoromethylation of olefins with cinnamaldehydes via radical relay cross-coupling in the presence of Togni reagent is reported andδ-lactones tolerated with stereogenic centers atβ-andγ-positions are obtained in moderate to high yields and with high enantioselectivities.Further computational studies explain that the radical crosscoupling step is the key to determining the enantioselectivity.Energy analysis of key transition states and intermediates also provides a reasonable explanation for the difficulty of diastereoselective control.DFT calculations also reveal that the hydrogen-bonding interaction plays a vital role in the promotion of this chemistry.展开更多
The Pd-catalyzed Suzuki-Miyaura coupling reaction is a crucial tool for constructing C-C bonds.Currently,the organic solvents employed during reaction may cause serious environmental problems.Moreover,the low solubili...The Pd-catalyzed Suzuki-Miyaura coupling reaction is a crucial tool for constructing C-C bonds.Currently,the organic solvents employed during reaction may cause serious environmental problems.Moreover,the low solubility of inorganic bases in organic solvents leads to enormous mass transfer resistance.To address this issue,the Pickering droplets reactor stabilized by Pd/g-C_(3)N_(4)at substrate-water two-phase interface is reported.Benefiting from the hydrophobic conjugated framework and hydrophilic terminal groups,Pd/g-C_(3)N_(4)can configure stable Pickering emulsion without additional functionalization.The Pd loaded catalysts exhibits excellent performance(TOF=21852 h^(-1))for the Suzuki-Miyaura coupling reaction,which is deriving from unique electronic structure of g-C_(3)N_(4)and high interfacial area of emulsion.Moreover,there is no clear decrease in reactivity after six cycles(conversion>86%).In this study,the organic solvent was replaced by reaction substrate,and the high activity can be achieved for various halogenated aromatic hydrocarbons and their derivatives.展开更多
In order to improve the yield and reduce the cost in the synthesis of antitumor drug vismodegib the key intermediates are prepared and the Negishi reaction step is examined.The effects of different molar ratios of rea...In order to improve the yield and reduce the cost in the synthesis of antitumor drug vismodegib the key intermediates are prepared and the Negishi reaction step is examined.The effects of different molar ratios of reactants dosages of catalyst and time for refluxing are investigated by using single factor tests.The results demonstrate that when the molar ratios of 2-bromopyridine 2-chloro-N-4-chloro-3-iodophenyl -4-methylsulfonyl benzamide zinc chloride n-butyllithium and tetrakis triphenyl phosphine palladium are changed to 1.0∶0.5∶1.5∶1.1∶0.05 and the mixture is refluxed for 24 h the production yield is improved to 72%.This reaction condition significantly enhances the synthetic efficiency avoids consuming excessive raw materials/catalysts and meanwhile prevents a prolonged reaction time.The optimization of the proportion of reactants and the heating time is proved to be important for the efficiency and economy in cross-coupling reaction to synthesize vismodegib.展开更多
Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on im...Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on improving the controllability and efficiency of SynRM.Accurate rotor position information is essential for the controller to generate appropriate current and voltage references corresponding to the desired speed and load torque.Shaft-mounted position sensors are generally undesirable because of their high cost,sensitivity to harsh operating conditions,maintenance requirements,and reduced reliability in environments characterized by high vibration.Consequently,sensorless control techniques that estimate rotor position using measured stator currents and voltages have attracted increasing attention.However,magnetic saturation,parameter nonlinearities,and cross-coupling effects significantly degrade position estimation accuracy and may compromise the stability of sensorless SynRM drives.In this paper,a nonlinear SynRM model is developed using finite element analysis(FEA)to accurately capture magnetic saturation and cross-coupling effects,thereby providing a precise representation of the machine’s electromagnetic behavior under varying load and flux conditions.A series of magnetostatic FEA simulations is performed.To reduce computational complexity,only one motor pole is analyzed by applying anti-periodic boundary conditions along the domain sides and enforcing a zero magnetic vector potential on the external stator boundary.Nonlinear iron material properties are modeled using the appropriate B-H curve.The simulations are carried out by imposing d-and q-axis current components and computing the corresponding flux linkages and electromagnetic torque.Based on these results,both apparent and incremental inductances are extracted and incorporated into the control algorithm.An advanced fictitious flux linkage method combined with a phase-locked loop(PLL)is employed for accurate rotor position estimation.Simulation results confirm that the proposed sensorless control strategy ensures stable operation and high position estimation accuracy over the entire speed range.展开更多
A simple Cu（OAc）2 catalyzed Sonogashira coupling protocol is presented. It was found that the couplings of a variety of aryl halides with terminal alkynes were conducted smoothly to afford the corresponding desired ...A simple Cu（OAc）2 catalyzed Sonogashira coupling protocol is presented. It was found that the couplings of a variety of aryl halides with terminal alkynes were conducted smoothly to afford the corresponding desired products in moderate to excellent yields, using Cu（OAc）2 as the catalyst and Et3N as the solvent.展开更多
Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis（RA）.In a continuous research aiming at discovery of sinomenine derivates with better bioactivity,a cross-coupling reaction of sinom...Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis（RA）.In a continuous research aiming at discovery of sinomenine derivates with better bioactivity,a cross-coupling reaction of sinomenine and 1,2-dihydroxybenzene catalyzed by a fungus Coriolus unicolor afforded an unique C-C cross-coupled compound 2,together with（S）-disinomenine and （R）-disinomenine.The structure of 2 was elucidated by MS and NMR spectroscopy.Compound 2 was further assayed for the inhibitory activity on IL-6 overproduction in SW982 cells and exhibited a much more potent activity on IL-6（96%inhibition） compared with those of（S）-disinomenine and sinomenine（17%and 12%inhibition,respectively）.展开更多
We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） wit...We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） with Grignard reagent （1.3 mmol） mediated by NiCl2 （4 mol%） and （p-CH3Ph）3P （8 mol%） in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.展开更多
文摘In conventional cross-coupled controller design,the method usually ignored the inherent characteristic of time-vary-ing parameters and model uncertainties in system.In this paper,a cross-coupled controller(CCC)using an H~∞control scheme has been proposed to reduce the contouring error for an X-Y table.Furthermore,the proposed CCC design,which is a typical Multi-Input Multi-Output(MIMO)system with linear time varying(LTV)characteristics,has been verified as being internally stable.The simulations are carried on Matlab simulink to verify the proposed method,and the results showed that the proposed method can reduce the contouring error significantly compared with the conventional one.
基金Supported by the National Natural Science Foundation of China(Nos.61474068,61404076,61274132)the Zhejiang Provincial Natural Science Foundation of China(No.LQ14F040001)the Doctoral Program of Higher Education of China(No.20113305110005)
文摘By analyzing the principle of process variations, a lightweight Physical Unclonable Function （PUF） circuit based on selectable cross-coupled inverters is proposed in this paper. Firstly, selectable cross-coupled inverters are chosen for two delay paths. Simultaneously, the circuit takes challenge signal to control each delay path. The PUF cell circuit is implemented in Semiconductor Manufacturing International Corporation （SMIC） 65 nm CMOS technology and the layout area is 2.94μm × 1.68μm. Then the 64-bit PUF circuit is achieved with the cascade connection of cell circuits. The simulation results show that the randomness is 49.4% and the reliability is 96.5%. Compared to the other works, this PUF circuit improves the encrypt performance and greatly reduces the area.
文摘A design approach for online pre-compensation of three-axis cross-coupled contour errors with mismatched dynamics is proposed.In the context of cross-coupled contour control design,online pre-compensation of contour errors is commonly employed.However,establishing a specific relationship between contour errors is challenging for mismatched computer numerical control(CNC)systems.Therefore,the design of interpolation methods for mismatched systems remains crucial,as most existing systems struggle to be adjusted to match seamlessly.This study introduces an online pre-compensation scheme for cross-coupled contour errors in three-axis motion,which constitutes a compensation system for real-time correction of contour error estimation.The coupling control structure,based on a speed loop,comprises a proportion integration differentiation(PID)control feedback controller,a feedforward controller,and an online pre-compensation cross-coupled contour controller.The experimental results demonstrate that the proposed three-axis cross-coupled contour error pre-compensation scheme significantly enhances the contour accuracy compared to traditional cross-coupled control systems.Moreover,the proposed cross-coupled contour error pre-compensation controller exhibits superior contour performance over conventional cross-coupled controllers when tracking high-order curvature bending paths.
文摘The synthesis method of propargylamines has always been the focus of research in organic synthetic methodology.A method of alkynylation of tertiary aliphatic amines with alkynes in the presence of copper doped zeolite Y as a catalyst and oxygen in the air as an oxidant has been developed.The most important feature of this reaction is that copper molecular siolite is used as catalyst,which avoids the intermolecular self-coupling of alkynes,and thus realizes the high efficiency propargylization of alkyl tertiary amines.
基金supported by the National Natural Science Foundation of China(Grant Nos.51325502 and 51405175)the National Basic Research Program of China("973"Project)(Grant No.2011CB706804)the National Science and Technology Major Projects of China(Grant No.2012ZX04001-012-01-05)
文摘The cross-coupled control(CCC)is widely applied to reduce contour errors in contour-following applications.In such situation,the contour error estimation plays an important role.Traditionally,the linear or second-order estimation approach is adopted for biaxial motion systems,whereas only linear approach is available for triaxial systems.In this paper,the second-order contour error estimation,which was presented in our previous work,is utilized to determine the variable CCC gains for motion control systems with three axes.An integrated stable motion control strategy,which combines the feedforward,feedback and CCC controllers,is developed for multiaxis CNC systems.Experimental results on a triaxial platform indicate that the CCC scheme based on the second-order estimation,compared with that based on the linear one,significantly reduces the contour error even in the conditions of high tracking feedrate and small radius of curvature.
基金supported by the National High Technology Research and Development Program of China (No. 2006AA010202)
文摘An innovative, thermally-insensitive phenomenon of cascaded cross-coupled structures is found. And a novel CMOS temperature sensor based on a cross-coupled structure is proposed. This sensor consists of two different ring oscillators. The first ring oscillator generates pulses that have a period, changing linearly with temperature. Instead of using the system clock like in traditional sensors, the second oscillator utilizes a cascaded cross-coupled structure to generate temperature independent pulses to capture the result from the first oscillator. Due to the compensation between the two ring oscillators, errors caused by supply voltage variations and systematic process variations are reduced. The layout design of the sensor is based on the TSMC13G process standard cell library. Only three inverters are modified for proper channel width tuning without any other custom design. This allows for an easy integration of the sensor into cell-based chips. Post-layout simulations results show that an error lower than ±1.1 °C can be achieved in the full temperature range from 40 to 120 °C. As shown by SPICE simulations, the thermal insensitivity of the cross-coupled inverters can be realized for various TSMC technologies： 0.25 μm, 0.18 μm, 0.13 μm, and 65 nm.
基金Project supported by the National Basic Research Program (973) of China (No. 2010CB327403)the National Natural Science Foundation of China (Nos. 61001066 and 61102027)
文摘This paper proposes an efficient PSP-based model for cross-coupled metal-oxide-semiconductor field-effect transistors(MOSFETs) with optimized layout in the voltage controlled oscillator(VCO).The model employs a PSP charge model to characterize the bias-dependent extrinsic capacitance instead of numerical functions with strong non-linearity.The simulation convergence is greatly improved by this method.An original scheme is developed to extract the parameters of the PSP charge model based on S-parameters measurement.The interconnection parasitics of the cross-coupled MOSFETs are modeled based on vector fitting.The model is verified with an LC VCO design,and exhibits excellent convergence during simulation.The results show improvements as high as 60.5% and 61.8% in simulation efficiency and accuracy,respectively,indicating that the proposed model better characterizes optimized cross-coupled MOSFETs in advanced radio frequency(RF) circuit design.
基金supported by the Anusandhan National Research Foundation of India under Grant CRG/2021/007283 for Tapeout and MeitY(C2S programme).
文摘A low-power,high-speed dynamic comparator with the addition of a cross-coupled pair in the pre-amplifier stage,followed by a strong-arm latch,is presented.The proposed modification increases the pre-amplifier’s differential and common-mode gains,improving the latch’s differential and common-mode input voltage,resulting in faster regeneration with 22%speed improvement as compared to conventional comparator at small input differential voltages(V_(i,id)).The proposed technique boosts the comparator’s speed and helps achieve 21%lower energy per conversion delay product(EDP)compared to the literature.Analytical modeling of the delay that proves the improvement in the speed of the proposed comparator is also presented and verified with the simulation results.The proposed comparator’s delay is insensitive to the common-mode voltage(V_(i,cm)).The proposed comparator is fabricated in 180-nm CMOS technology and measurement shows less than 160 ps relative CLK-Q delay with 81 fJ.ns EDP and 0.8 mV input-referred rms noise with 1.8 V supply.To demonstrate the scalability of the proposed technique to advanced technology nodes,the proposed design is also simulated in 65-nm CMOS technology with a 1.1 V supply for 5 GHz frequency.For V_(i,cm) of 0.3 V and V_(i,id) of 1 mV and 10 mV,the proposed comparator exhibits a 40.69 ps and 32.41 ps delay and has 3.74 fJ.ns and 2.78 fJ.ns EDP respectively.
文摘Chiral carbonyl compounds frequently occur in natural products and pharmaceuticals. Additionally, they serve as important intermediates in organic synthesis. Transition metal-catalyzed asymmetric carbonylative cross-coupling reactions are among the most straightforward and effective methods for synthesizing chiral carbonyl compounds, including esters, amides, and ketones. The advances in asymmetric carbonylative cross-coupling reactions using various O-, N-, C-, and S-containing nucleophiles or electrophiles over the past decade are summarized.
文摘A chromium(II)-catalyzed reduction cross coupling reaction was reported.This reaction utilizes inexpensive and readily available chromium dichloride as a catalyst and 4,4'-di-tert-butyl-bipyridine as a ligand to achieve reduction cross coupling between trifluoromethyl olefins and alkyl bromides under mild conditions,effectively synthesizing difluoroalkene derivatives.This reaction exhibits good substrate universality and is compatible with multiple important functional groups,providing a concise synthetic pathway for constructing conjugated difluoroalkenes containing allyl difluoromethylene structural units.Preliminary mechanistic experiments indicate that alkyl bromides first undergo a reduction process to generate corresponding alkyl radicals,followed by addition to trifluoromethyl olefins.After binding with Cr(II),they undergo aβ-fluorine elimination process to generate difluoroalkenes.
基金support of this work by the National Natural Science Foundation of China(Nos.22371307,21971267)the program for Guangdong Introducing Innovative and Entrepreneurial Teams(No.2017ZT07C069).
文摘Selective defluorinative functionalization of trifluoromethylarenes(ArCF3)to obtain the pharmaceutically commonα,α-difluorobenzylic motif is an attractive and elegant synthetic route.Over the past decade,although C(sp^(3))-F bonds functionalization have been greatly developed,catalytic cross-coupling of trifluoromethylarenes with C-H of terminal alkynes remains a challenge.Here,we report an approach to achieve Sonogashira-type cross-coupling of trifluoromethylarenes with terminal alkynes C(sp)-H bonds via photoredox and Cu/L dual catalysis.Tridentate anionic ligand is pivotal to realize this C-H sp-sp^(3) cross-coupling.Moreover,this unique catalytic system is also suitable for cross-coupling of C(sp^(3))-F bonds with azoles C(sp^(2))-H bonds.A series of trifluoromethylarenes,terminal alkynes and azoles with various functional groups are compatible with this protocol affording a variety of defluoroalkynylation or defluoroazolation products.Preliminary mechanistic studies indicated that deprotonated BINOL involved as a photocatalyst to activate ArCF3 rather than a ligand to the metal.
基金supported by the National Natural Science Foundation of China(No.22171046)the Hundred-Talent Project of Fujian(No.50021113)Fuzhou University(No.0480-00489503)。
文摘In most Suzuki–Miyaura carbon-carbon cross-coupling reactions,the borabicyclo[3.3.1]nonane scaffold(9-BBN)only serves as an auxiliary facilitating the transmetalation step and thus is transformed into by-products.There are rare examples where the 9-BBN derivatives serve as the potentially diverse C8 building blocks in cross-coupling reactions.Herein,we report a cobalt-catalyzed migratory carboncarbon cross-coupling reaction of the in situ formed 9-BBN ate complexes to afford diverse aryl-and alkyl-functionalized cyclooctenes.Preliminary mechanistic studies suggest the oxidation-induced cisbicyclo[3.3.0]oct-1-ylborane is the key intermediate in this migratory cross-coupling reaction,which promotes the development of other diverse migratory cross-coupling of borate complexes.
基金CAMS Innovation Fund for Medical Sciences(CIFMS)(Nos.2022-I2M-1-013,2022-I2M-1-014,2022-I2M-2-002).
文摘The switchable cross-coupling of indoles and pyridotriazoles through carbene insertion at C_(2)-or C_(3)-positon has been developed in this paper.This highly site-selective C-H carbenoid functionalization is determined by both the Rh-catalyst species and auxiliary groups.[Cp∗RhCl_(2)]_(2) and coordinating pyrimidyl group direct the C-H carbenoid functionalization to occur at the C_(2)-position,while Rh2OAc4 and noncoordinating benzyl group lead the reaction to occur at the C_(3)-position of the indoles.This regioselective C−H functionalization strategy is of significant importance for the discovery of indole drugs.
基金financial supports for this work are provided by the National Natural Science Foundation of China(Nos.21871160,21672121,22071130)。
文摘An N-heterocyclic carbene(NHC)catalyzed enantioselective cyclisation and trifluoromethylation of olefins with cinnamaldehydes via radical relay cross-coupling in the presence of Togni reagent is reported andδ-lactones tolerated with stereogenic centers atβ-andγ-positions are obtained in moderate to high yields and with high enantioselectivities.Further computational studies explain that the radical crosscoupling step is the key to determining the enantioselectivity.Energy analysis of key transition states and intermediates also provides a reasonable explanation for the difficulty of diastereoselective control.DFT calculations also reveal that the hydrogen-bonding interaction plays a vital role in the promotion of this chemistry.
基金the National Natural Science Foundation of China(22178243).
文摘The Pd-catalyzed Suzuki-Miyaura coupling reaction is a crucial tool for constructing C-C bonds.Currently,the organic solvents employed during reaction may cause serious environmental problems.Moreover,the low solubility of inorganic bases in organic solvents leads to enormous mass transfer resistance.To address this issue,the Pickering droplets reactor stabilized by Pd/g-C_(3)N_(4)at substrate-water two-phase interface is reported.Benefiting from the hydrophobic conjugated framework and hydrophilic terminal groups,Pd/g-C_(3)N_(4)can configure stable Pickering emulsion without additional functionalization.The Pd loaded catalysts exhibits excellent performance(TOF=21852 h^(-1))for the Suzuki-Miyaura coupling reaction,which is deriving from unique electronic structure of g-C_(3)N_(4)and high interfacial area of emulsion.Moreover,there is no clear decrease in reactivity after six cycles(conversion>86%).In this study,the organic solvent was replaced by reaction substrate,and the high activity can be achieved for various halogenated aromatic hydrocarbons and their derivatives.
基金The National Basic Research Program of China(973Program)(No.2011CB933503)China Postdoctoral Science Foundation(No.2013M541592)
文摘In order to improve the yield and reduce the cost in the synthesis of antitumor drug vismodegib the key intermediates are prepared and the Negishi reaction step is examined.The effects of different molar ratios of reactants dosages of catalyst and time for refluxing are investigated by using single factor tests.The results demonstrate that when the molar ratios of 2-bromopyridine 2-chloro-N-4-chloro-3-iodophenyl -4-methylsulfonyl benzamide zinc chloride n-butyllithium and tetrakis triphenyl phosphine palladium are changed to 1.0∶0.5∶1.5∶1.1∶0.05 and the mixture is refluxed for 24 h the production yield is improved to 72%.This reaction condition significantly enhances the synthetic efficiency avoids consuming excessive raw materials/catalysts and meanwhile prevents a prolonged reaction time.The optimization of the proportion of reactants and the heating time is proved to be important for the efficiency and economy in cross-coupling reaction to synthesize vismodegib.
文摘Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on improving the controllability and efficiency of SynRM.Accurate rotor position information is essential for the controller to generate appropriate current and voltage references corresponding to the desired speed and load torque.Shaft-mounted position sensors are generally undesirable because of their high cost,sensitivity to harsh operating conditions,maintenance requirements,and reduced reliability in environments characterized by high vibration.Consequently,sensorless control techniques that estimate rotor position using measured stator currents and voltages have attracted increasing attention.However,magnetic saturation,parameter nonlinearities,and cross-coupling effects significantly degrade position estimation accuracy and may compromise the stability of sensorless SynRM drives.In this paper,a nonlinear SynRM model is developed using finite element analysis(FEA)to accurately capture magnetic saturation and cross-coupling effects,thereby providing a precise representation of the machine’s electromagnetic behavior under varying load and flux conditions.A series of magnetostatic FEA simulations is performed.To reduce computational complexity,only one motor pole is analyzed by applying anti-periodic boundary conditions along the domain sides and enforcing a zero magnetic vector potential on the external stator boundary.Nonlinear iron material properties are modeled using the appropriate B-H curve.The simulations are carried out by imposing d-and q-axis current components and computing the corresponding flux linkages and electromagnetic torque.Based on these results,both apparent and incremental inductances are extracted and incorporated into the control algorithm.An advanced fictitious flux linkage method combined with a phase-locked loop(PLL)is employed for accurate rotor position estimation.Simulation results confirm that the proposed sensorless control strategy ensures stable operation and high position estimation accuracy over the entire speed range.
文摘A simple Cu（OAc）2 catalyzed Sonogashira coupling protocol is presented. It was found that the couplings of a variety of aryl halides with terminal alkynes were conducted smoothly to afford the corresponding desired products in moderate to excellent yields, using Cu（OAc）2 as the catalyst and Et3N as the solvent.
基金supported by National Natural Science Foundation of China(Nos20872060,20936002 and 31100080)the Fundamental Research Funds for Central University(No1082020502)
文摘Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis（RA）.In a continuous research aiming at discovery of sinomenine derivates with better bioactivity,a cross-coupling reaction of sinomenine and 1,2-dihydroxybenzene catalyzed by a fungus Coriolus unicolor afforded an unique C-C cross-coupled compound 2,together with（S）-disinomenine and （R）-disinomenine.The structure of 2 was elucidated by MS and NMR spectroscopy.Compound 2 was further assayed for the inhibitory activity on IL-6 overproduction in SW982 cells and exhibited a much more potent activity on IL-6（96%inhibition） compared with those of（S）-disinomenine and sinomenine（17%and 12%inhibition,respectively）.
基金financially supported by the Fundamental Research Funds for the Central Universities,Southwest University for Nationalities (No.12NZYTH03)the Natural Science Foundation of Southwest University for Nationalities (No.381010)+1 种基金the Project of Postgraduate Degree Construction,Southwest University for Nationalities (No.2013XWD-S0703)the State Administration of Foreign Experts Affairs project (No.2012-10)
文摘We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） with Grignard reagent （1.3 mmol） mediated by NiCl2 （4 mol%） and （p-CH3Ph）3P （8 mol%） in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.
