Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol...Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.展开更多
Time delay and integration （TDI） charge coupled device （CCD） noise sets a fundamental limit on image sensor performance, especially under low illumination in remote sensing applications. After introducing the comp...Time delay and integration （TDI） charge coupled device （CCD） noise sets a fundamental limit on image sensor performance, especially under low illumination in remote sensing applications. After introducing the complete sources of CCD noise, we study the effects of TDI operation mode on noise, and the relationship between different types of noise and number of the TDI stage. Then we propose a new technique to identify and measure sources of TDI CCD noise employing mathematical statistics theory, where theoretical analysis shows that noise estimated formulation converges well. Finally, we establish a testing platform to carry out experiments, and a standard TDI CCD is calibrated by using the proposed method. The experimental results show that the noise analysis and measurement methods presented in this paper are useful for modeling TDI CCDs.展开更多
The Laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space.However,it fails to obtain the correct stress at the interfaces in a layered half-space,especially when th...The Laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space.However,it fails to obtain the correct stress at the interfaces in a layered half-space,especially when there are significant differences in material properties.Therefore,a coupled Legendre-Laguerre polynomial method with analytical integration is proposed.The Rayleigh waves in a one-dimensional(1D)hexagonal quasicrystal(QC)layered half-space with an imperfect interface are investigated.The correctness is validated by comparison with available results.Its computation efficiency is analyzed.The dispersion curves of the phase velocity,displacement distributions,and stress distributions are illustrated.The effects of the phonon-phason coupling and imperfect interface coefficients on the wave characteristics are investigated.Some novel findings reveal that the proposed method is highly efficient for addressing the Rayleigh waves in a QC layered half-space.It can save over 99%of the computation time.This method can be expanded to investigate waves in various layered half-spaces,including earth-layered media and surface acoustic wave(SAW)devices.展开更多
In the realm of nonlinear integrable systems,the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrabilit...In the realm of nonlinear integrable systems,the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrability.By focusing on single-component decompositions within the potential BKP hierarchy,it has been observed that specific linear superpositions of decomposition solutions remain consistent with the underlying equations.Moreover,through the implementation of multi-component decompositions within the potential BKP hierarchy,successful endeavors have been undertaken to formulate linear superposition solutions and novel coupled Kd V-type systems that resist decoupling via alterations in dependent variables.展开更多
To address problems in surface integrity and machining allowance distribution during combined electric arc-mechanical milling,this paper takes TC4 as the research object,examines the influence of electric arc milling(...To address problems in surface integrity and machining allowance distribution during combined electric arc-mechanical milling,this paper takes TC4 as the research object,examines the influence of electric arc milling(EAM)depth on recast layer thickness and surface roughness,alongside an analysis of the recast layer’s organization characteristics and sur-face morphology.A comparative evaluation of cutting forces,surface roughness,and surface hardening is conducted between combined milling and conventional mechanical milling.Key findings reveal that electric arc machining produces a recast layer with a hardness of 313.21 HV.As the EAM depth increases,the localized recast layer thickness and peak-to-valley(PV)differ-ences also rise.To ensure effective surface defect removal,the machining allowance for subsequent mechanical milling must exceed the combined thickness of the recast layer and the PV difference.Under identical parameters,combined milling yields higher surface roughness(0.584μm)and greater surface hardening(10.4%)compared to mechanical milling alone,alongside an 18.716 N increase in cutting force.Response surface methodology(RSM)analysis identifies feed per tooth as the most significant factor affecting surface roughness,followed by spindle speed,with milling depth having the least influence.展开更多
This paper provides a comparative analysis of the performance of a high-resolution regional ocean-atmosphere coupled model in predicting tropical cyclone(TC)gales over the northern South China Sea.The atmosphere and o...This paper provides a comparative analysis of the performance of a high-resolution regional ocean-atmosphere coupled model in predicting tropical cyclone(TC)gales over the northern South China Sea.The atmosphere and ocean components of the coupled system are represented by the China Meteorological Administration’s Tropical Regional Atmosphere Model for the South China Sea(CMA-TRAMS)and the LASG/IAP Climate system Ocean Model(LICOM),respectively.The Ocean Atmosphere Sea Ice Soil VersionH 3(OASIS3)software has been utilized for the exchange of momentum,heat,and freshwater fluxes between these two components.An assessment of the coupled model’s three-day predictions for five TCs’gales was conducted.Preliminary findings indicate that the predicted TC tracks show less sensitivity to oceanic influences than the predicted TC intensities.Significant improvement in predicting the surface TC gales has been achieved through coupling the ocean model.This improvement is attributed to the impact of the warmer ocean’s effect on TC intensification,counteracting the cooling effect of the cold wake.In summary,coupling has enhanced the model’s predictive capabilities for TC gales.A detailed assessment of the coupled model’s performance in predicting other tropical weather phenomena is forthcoming.展开更多
A new type strongly gain coupled (GC) DFB laser and a new type self alignment spot size converter (SA SSC) are proposed and successfully fabricated.The strongly GC DFB laser is monolithically integrated with the ...A new type strongly gain coupled (GC) DFB laser and a new type self alignment spot size converter (SA SSC) are proposed and successfully fabricated.The strongly GC DFB laser is monolithically integrated with the SA SSC with three step epitaxies.A high single mode yield and large side mode suppression ratio is obtained from the strongly GC DFB laser.A near circle far field pattern is obtained by using the SA SSC.展开更多
随着分布式新能源和电动汽车等虚拟储能的广泛接入,电力系统的不确定性和低惯量特性变得更加显著,系统的频率运行风险增加,并且主动配电网内部的供需关系呈现出更加灵活多样的特征,导致其与输电网之间的功率交互关系也更加复杂。为此,...随着分布式新能源和电动汽车等虚拟储能的广泛接入,电力系统的不确定性和低惯量特性变得更加显著,系统的频率运行风险增加,并且主动配电网内部的供需关系呈现出更加灵活多样的特征,导致其与输电网之间的功率交互关系也更加复杂。为此,构建了一种基于主动配电网灵活性支撑机制的电-碳-绿证分布式协同优化方法,以充分挖掘输配系统中分布式资源的支撑能力及其碳减排效益。首先,建立了与输配协同系统匹配的动态频率安全约束和基于双向调节模型的主动配电网灵活性支撑机制,提出了输配系统间的电-碳-绿证协同交互框架。为应对新能源出力的不确定性,将两侧子系统中涉及不确定变量的约束建模为联合机会约束。采用交替方向乘子法(alternating direction of multipliers algorithm,ADMM)进行输配系统的分布式协同。仿真结果表明,所提模型能够有效挖掘配电网中分布式资源的支撑潜力,灵活体现主动配电网的向外支撑能力或被支撑需求。与传统方法相比,系统动态频率安全性和输配协同调节灵活性显著提升,总运行成本较输电网单独调度模型降低13.42%,新能源减载量较忽略多市场耦合模型减少16.76%,系统运行经济性和低碳性明显改善。此外,所提出的求解方法比基于传统的样本平均近似方法减少约98%的计算时间,能够实现输配系统的快速分布式协同优化。展开更多
A mesoscale coupled atmosphere–ocean model has been developed based on the GRAPES（Global and Regional Assimilation and Prediction System） regional typhoon model（GRAPES_TYM） and ECOM-si（estuary, coast and ocean m...A mesoscale coupled atmosphere–ocean model has been developed based on the GRAPES（Global and Regional Assimilation and Prediction System） regional typhoon model（GRAPES_TYM） and ECOM-si（estuary, coast and ocean model（semi-implicit））. Coupling between the typhoon and ocean models was conducted by exchanging wind stress, heat, moisture fluxes, and sea surface temperatures（SSTs） using the coupler OASIS3.0. Numerical prediction experiments were run with and without coupling for the case of Typhoon Muifa in the western North Pacific. To investigate the impact of using more accurate SST information on the simulation of the track and the intensity of Typhoon Muifa, experiments were also conducted using increased SST resolution in the initial condition field of the control test. The results indicate that increasing SST resolution in the initial condition field somewhat improved the intensity forecast, and use of the coupled model improved the intensity forecast significantly, with mean absolute errors in maximum wind speed within 48 and 72 h reduced by 32% and 20%, respectively. Use of the coupled model also resulted in less pronounced over-prediction of the intensity of Typhoon Muifa by the GRAPES_TYM. Moreover, the effects of using the coupled model on the intensity varied throughout the different stages of the development of Muifa owing to changes in the oceanic mixed layer depth. The coupled model had pronounced effects during the later stage of Muifa but had no obvious effects during the earlier stage. The SSTs predicted by the coupled model decreased by about 5–6℃ at most after the typhoon passed, in agreement with satellite data. Furthermore, based on analysis on the sea surface heat flux, wet static energy of the boundary layer, atmospheric temperature, and precipitation forecasted by the coupled model and the control test, the simulation results of this coupled atmosphere–ocean model can be considered to reasonably reflect the primary mechanisms underlying the interactions between tropical cyclones and oceans.展开更多
基金supported by the Shenzhen Medical Research Fund(Grant No.A2303049)Guangdong Basic and Applied Basic Research(Grant No.2023A1515010647)+1 种基金National Natural Science Foundation of China(Grant No.22004135)Shenzhen Science and Technology Program(Grant No.RCBS20210706092409020,GXWD20201231165807008,20200824162253002).
文摘Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.
基金Project supported by the National High Technology Research and Development Program of China (Grant No. 2006AA06A208)
文摘Time delay and integration （TDI） charge coupled device （CCD） noise sets a fundamental limit on image sensor performance, especially under low illumination in remote sensing applications. After introducing the complete sources of CCD noise, we study the effects of TDI operation mode on noise, and the relationship between different types of noise and number of the TDI stage. Then we propose a new technique to identify and measure sources of TDI CCD noise employing mathematical statistics theory, where theoretical analysis shows that noise estimated formulation converges well. Finally, we establish a testing platform to carry out experiments, and a standard TDI CCD is calibrated by using the proposed method. The experimental results show that the noise analysis and measurement methods presented in this paper are useful for modeling TDI CCDs.
基金Project supported by the National Natural Science Foundation of China(No.12102131)the Natural Science Foundation of Henan Province of China(No.242300420248)the International Science and Technology Cooperation Project of Henan Province of China(No.242102521010)。
文摘The Laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space.However,it fails to obtain the correct stress at the interfaces in a layered half-space,especially when there are significant differences in material properties.Therefore,a coupled Legendre-Laguerre polynomial method with analytical integration is proposed.The Rayleigh waves in a one-dimensional(1D)hexagonal quasicrystal(QC)layered half-space with an imperfect interface are investigated.The correctness is validated by comparison with available results.Its computation efficiency is analyzed.The dispersion curves of the phase velocity,displacement distributions,and stress distributions are illustrated.The effects of the phonon-phason coupling and imperfect interface coefficients on the wave characteristics are investigated.Some novel findings reveal that the proposed method is highly efficient for addressing the Rayleigh waves in a QC layered half-space.It can save over 99%of the computation time.This method can be expanded to investigate waves in various layered half-spaces,including earth-layered media and surface acoustic wave(SAW)devices.
基金sponsored by the National Natural Science Foundations of China under Grant Nos.12301315,12235007,11975131the Zhejiang Provincial Natural Science Foundation of China under Grant No.LQ20A010009。
文摘In the realm of nonlinear integrable systems,the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrability.By focusing on single-component decompositions within the potential BKP hierarchy,it has been observed that specific linear superpositions of decomposition solutions remain consistent with the underlying equations.Moreover,through the implementation of multi-component decompositions within the potential BKP hierarchy,successful endeavors have been undertaken to formulate linear superposition solutions and novel coupled Kd V-type systems that resist decoupling via alterations in dependent variables.
基金supported by the National Natural Science Foundation of China“Study on the evolution law of discharge channel and deformation suppression method for low-pressure micro-arc milling machining of aerospace thin-walled parts”(52265061)The Tianshan Innovation Team“Robotics and intelligent equipment technology science and technology innovation team”(2022D14002).
文摘To address problems in surface integrity and machining allowance distribution during combined electric arc-mechanical milling,this paper takes TC4 as the research object,examines the influence of electric arc milling(EAM)depth on recast layer thickness and surface roughness,alongside an analysis of the recast layer’s organization characteristics and sur-face morphology.A comparative evaluation of cutting forces,surface roughness,and surface hardening is conducted between combined milling and conventional mechanical milling.Key findings reveal that electric arc machining produces a recast layer with a hardness of 313.21 HV.As the EAM depth increases,the localized recast layer thickness and peak-to-valley(PV)differ-ences also rise.To ensure effective surface defect removal,the machining allowance for subsequent mechanical milling must exceed the combined thickness of the recast layer and the PV difference.Under identical parameters,combined milling yields higher surface roughness(0.584μm)and greater surface hardening(10.4%)compared to mechanical milling alone,alongside an 18.716 N increase in cutting force.Response surface methodology(RSM)analysis identifies feed per tooth as the most significant factor affecting surface roughness,followed by spindle speed,with milling depth having the least influence.
基金supported by the National Key R&D Program of China [grant number 2023YFC3008005]the Guangdong Basic and Applied Basic Research Foundation [grant numbers 2022A1515011288 and 2024A1515030210]+1 种基金the Key Innovation Team of the China Meteorological Administration [grant number CMA2023ZD08]the Guangdong Provincial Marine Meteorology Science Data Center [grant number 2024B1212070014]。
文摘This paper provides a comparative analysis of the performance of a high-resolution regional ocean-atmosphere coupled model in predicting tropical cyclone(TC)gales over the northern South China Sea.The atmosphere and ocean components of the coupled system are represented by the China Meteorological Administration’s Tropical Regional Atmosphere Model for the South China Sea(CMA-TRAMS)and the LASG/IAP Climate system Ocean Model(LICOM),respectively.The Ocean Atmosphere Sea Ice Soil VersionH 3(OASIS3)software has been utilized for the exchange of momentum,heat,and freshwater fluxes between these two components.An assessment of the coupled model’s three-day predictions for five TCs’gales was conducted.Preliminary findings indicate that the predicted TC tracks show less sensitivity to oceanic influences than the predicted TC intensities.Significant improvement in predicting the surface TC gales has been achieved through coupling the ocean model.This improvement is attributed to the impact of the warmer ocean’s effect on TC intensification,counteracting the cooling effect of the cold wake.In summary,coupling has enhanced the model’s predictive capabilities for TC gales.A detailed assessment of the coupled model’s performance in predicting other tropical weather phenomena is forthcoming.
文摘A new type strongly gain coupled (GC) DFB laser and a new type self alignment spot size converter (SA SSC) are proposed and successfully fabricated.The strongly GC DFB laser is monolithically integrated with the SA SSC with three step epitaxies.A high single mode yield and large side mode suppression ratio is obtained from the strongly GC DFB laser.A near circle far field pattern is obtained by using the SA SSC.
文摘随着分布式新能源和电动汽车等虚拟储能的广泛接入,电力系统的不确定性和低惯量特性变得更加显著,系统的频率运行风险增加,并且主动配电网内部的供需关系呈现出更加灵活多样的特征,导致其与输电网之间的功率交互关系也更加复杂。为此,构建了一种基于主动配电网灵活性支撑机制的电-碳-绿证分布式协同优化方法,以充分挖掘输配系统中分布式资源的支撑能力及其碳减排效益。首先,建立了与输配协同系统匹配的动态频率安全约束和基于双向调节模型的主动配电网灵活性支撑机制,提出了输配系统间的电-碳-绿证协同交互框架。为应对新能源出力的不确定性,将两侧子系统中涉及不确定变量的约束建模为联合机会约束。采用交替方向乘子法(alternating direction of multipliers algorithm,ADMM)进行输配系统的分布式协同。仿真结果表明,所提模型能够有效挖掘配电网中分布式资源的支撑潜力,灵活体现主动配电网的向外支撑能力或被支撑需求。与传统方法相比,系统动态频率安全性和输配协同调节灵活性显著提升,总运行成本较输电网单独调度模型降低13.42%,新能源减载量较忽略多市场耦合模型减少16.76%,系统运行经济性和低碳性明显改善。此外,所提出的求解方法比基于传统的样本平均近似方法减少约98%的计算时间,能够实现输配系统的快速分布式协同优化。
基金The National Basic Research and Development Program(973 Program)of China under contract No.2009CB421506the National Natural Science Foundation of China under contract No.40975035China Meteorological Administration GRAPES Research Fund
文摘A mesoscale coupled atmosphere–ocean model has been developed based on the GRAPES（Global and Regional Assimilation and Prediction System） regional typhoon model（GRAPES_TYM） and ECOM-si（estuary, coast and ocean model（semi-implicit））. Coupling between the typhoon and ocean models was conducted by exchanging wind stress, heat, moisture fluxes, and sea surface temperatures（SSTs） using the coupler OASIS3.0. Numerical prediction experiments were run with and without coupling for the case of Typhoon Muifa in the western North Pacific. To investigate the impact of using more accurate SST information on the simulation of the track and the intensity of Typhoon Muifa, experiments were also conducted using increased SST resolution in the initial condition field of the control test. The results indicate that increasing SST resolution in the initial condition field somewhat improved the intensity forecast, and use of the coupled model improved the intensity forecast significantly, with mean absolute errors in maximum wind speed within 48 and 72 h reduced by 32% and 20%, respectively. Use of the coupled model also resulted in less pronounced over-prediction of the intensity of Typhoon Muifa by the GRAPES_TYM. Moreover, the effects of using the coupled model on the intensity varied throughout the different stages of the development of Muifa owing to changes in the oceanic mixed layer depth. The coupled model had pronounced effects during the later stage of Muifa but had no obvious effects during the earlier stage. The SSTs predicted by the coupled model decreased by about 5–6℃ at most after the typhoon passed, in agreement with satellite data. Furthermore, based on analysis on the sea surface heat flux, wet static energy of the boundary layer, atmospheric temperature, and precipitation forecasted by the coupled model and the control test, the simulation results of this coupled atmosphere–ocean model can be considered to reasonably reflect the primary mechanisms underlying the interactions between tropical cyclones and oceans.
