It is proposed that where sexually selected vocal communication is an honest signal, the call production rate is predicted to change throughout the breeding season. Male leopard seals call underwater for many hours ea...It is proposed that where sexually selected vocal communication is an honest signal, the call production rate is predicted to change throughout the breeding season. Male leopard seals call underwater for many hours each day over their three- to four-month breeding season, and it is hypothesized that a decrease in calling rate would be associated with the declining body condition of smaller males. The calling rates of leopard seals were measured （N= 49 recordings） and com- pared between seals of different size classes throughout the breeding season. Male leopard seals produce their calls at more stable rates as they become larger. In this study, larger male leopard seals adopted a strategy of consistent underwater calling throughout the breeding season, whereas there was a breakdown in the calling stereotypy of the smaller males at its height. Toward the end of the breeding season, the smaller seals produced fewer calls in shortened calling bouts, and they took more rest periods. Therefore, underwater calling may represent an honest signal in the leopard seal. For marine mammals that call underwater, the production of repetitive sequences advertises the breath-holding ability of the caller to the listeners, and this ability may be related to male stamina and endurance, thus representing an honest signal that could be widespread in other species.展开更多
AIM To investigate whether adductor canal nerve block(ACB) reduces patient falls when compared to femoral nerve block(FNB) after total knee arthroplasty(TKA). METHODS We conducted an institutional review of all-cause ...AIM To investigate whether adductor canal nerve block(ACB) reduces patient falls when compared to femoral nerve block(FNB) after total knee arthroplasty(TKA). METHODS We conducted an institutional review of all-cause falls after TKA from January 2013 to August 2016 using a quality improvement database. Our inclusion criteria were patients with diagnosis of primary knee osteoarthritis who underwent primary unilateral TKA with either a FNB or an ACB and sustained a fall during their hospitalization. We excluded patients who had revision TKA and extensor mechanism reconstruction. We also excluded patients with a history of post-traumatic arthritis, prior history of lower extremity fracture, history of neurological disease, or cerebrovascular disease. RESULTS A total of 834 patients had TKA with femoral nerve block and knee immobilizer(FNB + KI). Of those patients, 11(1.3%) experienced a fall during their hospital stay. In contrast, 791 patients had TKA with ACB. Of those patients, only one(0.13%) patient fall was recorded within this group. We used the Fisher's exact test to compare the differences between the two groups. The difference between the two groups achieves statistical significance(P = 0.006). We also found that 11 out of the 12 patients that fell had a right TKA procedure while one patient had a left TKA procedure. Nine out of twelve patients that fell were female, while only three patients were male.CONCLUSION Given the reduction in the number of falls with ACB, it is recommended that ACB be considered the preferred analgesia for patients undergoing a TKA procedure.展开更多
DEAR EDITOR,Recent studies have examined the cost of raising parasitic cuckoos and highlighted the importance of "no extra cost" in explaining the low levels of defense in hosts. To clarify the reasons for p...DEAR EDITOR,Recent studies have examined the cost of raising parasitic cuckoos and highlighted the importance of "no extra cost" in explaining the low levels of defense in hosts. To clarify the reasons for parasitization in typical hosts, we present a simple model to explore the immediate and future costs of parasitism in shaping the evolution of defense behavior in hosts.展开更多
Background: It was the intention of the authors to generate a list of the top diseases responsible for the greatest financial expense in the United States. This listing would then inform policymakers as to the highest...Background: It was the intention of the authors to generate a list of the top diseases responsible for the greatest financial expense in the United States. This listing would then inform policymakers as to the highest priority target conditions. With such information available, funding for the NIH could be accomplished based upon factual criteria rather than political clout or uninformed consensus. Method: The first step was a literature review to explore articles and reports which were published about the cost of illness (COI) up to December 2009. Therefore the source of the data used in this investigation was obtained from this retrospective search approach. Results: With reference to total cost for disease, first was HCVD with 475.3 billion US dollars, followed by alcohol abuse and substance at 300.6 billion US dollars, digestive diseases at 259.6 billion US dollars, cancer at 239.5 billion US dollars and mental disease at 216,6 billion US dollars. Conclusion: As has been seen, the total societal costs of the diseases do not synch with the degree of attention paid to these various disease states. Several of the diseases have very powerful and vocal support organizations that encourage attention and clinical research support. On the other hand we hear very little about efforts against allergic rhinitis or infectious and parasitic diseases.展开更多
In this paper,we present a stochastic adaptive algorithm using radial basis function models for global optimization of costly black-box functions.The exploration radii in local searches are generated adaptively.Each i...In this paper,we present a stochastic adaptive algorithm using radial basis function models for global optimization of costly black-box functions.The exploration radii in local searches are generated adaptively.Each iteration point is selected from some randomly generated trial points according to certain criteria.A restarting strategy is adopted to build the restarting version of the algorithm.The performance of the presented algorithm and its restarting version are tested on 13 standard numerical examples.The numerical results suggest that the algorithm and its restarting version are very effective.展开更多
BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Resear...BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.展开更多
Ambient fine particulate matter(PM_(2.5))pollution causes the largest environmental health risk globally,yet ex-posure levels and the resulting health risks vary across countries with different income levels.Global we...Ambient fine particulate matter(PM_(2.5))pollution causes the largest environmental health risk globally,yet ex-posure levels and the resulting health risks vary across countries with different income levels.Global wealth inequality has intensified in recent years,yet the relationship between wealth inequality and health risks related to PM_(2.5) pollution remains poorly understood.In this study,we evaluated the global mortality and health cost at-tributable to PM_(2.5) exposure from 2017 to 2021,and analyzed the relationship between wealth inequality,PM_(2.5) pollution,and the associated health risks across regions with varying economic levels.We found a consistent decline in mortalities and health costs attributable to PM_(2.5) exposure from 2017 to 2020,followed by a rebound after 2020,driven primarily by the resurgence of PM_(2.5) concentrations and a deceleration in the reduction of baseline mortality rates.We also found that the average PM_(2.5) concentration and associated risks decrease as domestic wealth inequality decreases and national income level increases.However,regions with extremely high levels of wealth inequality consistently show lower national average PM_(2.5) concentrations and health risks.These findings highlight the need to consider healthcare security during emergencies,as well as policy fairness across economic regions,in the formulation of global PM_(2.5) pollution control measures to promote sustainable,more equitable economic growth and coordinated air pollution management.展开更多
Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people...Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people are diagnosed with SCI annually(Singh et al.,2014),and while this number appears quite low,the effect that an SCI has on the patient’s quality of life is drastic,due to the current difficulties to comprehensively treat this illness.The cost of patient care can also be quite costly,amounting to an estimated$1.69 billion in healthcare costs in the USA alone(Mahabaleshwarkar and Khanna,2014).展开更多
Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This st...Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This study evaluates the carbon footprint(CF)and economic viability of a liquefied natural gas(LNG)-fueled fishing vessel,using real engine operation simulations to provide precise and dynamic evaluation of fuel consumption and GHG emissions.Operational profiles are obtained through the utilization of onboard monitoring systems,whereas engine performance is simulated using the 1D/0D AVL Boost^(TM)model.Life cycle assessment(LCA)is conducted to quantify the environmental impact,whereas life cycle cost assessment(LCCA)is performed to analyze the profitability of LNG as an alternative fuel.The potential impact of the future fuel price uncertainties is addressed using Monte Carlo simulations.The LCA findings indicate that LNG has the potential to reduce the CF of the vessel by 14%to 16%,in comparison to a diesel power system configuration that serves as the baseline scenario.The LCCA results further indicate that the total cost of an LNG-powered ship is lower by 9.5%-13.8%,depending on the share of LNG and pilot fuels.This finding highlights the potential of LNG to produce considerable environmental benefits while addressing economic challenges under diverse operational and fuel price conditions.展开更多
Construction on the Wuhan Greenland Center began on December 8, 2010. The 606-meter-tall building, which will cos 30 billion yuan ($4.5 billion), will be
人工智能技术的迅猛发展为教育领域注入了新的活力,但其融入教学仍面临技术适配性不强、理论框架缺失及学习者认知发展关注不足等问题。本文以基于“浙大先生”的某国家级教学名师的“计算机体系结构”课程为例,基于领域学习模型MDL(Mod...人工智能技术的迅猛发展为教育领域注入了新的活力,但其融入教学仍面临技术适配性不强、理论框架缺失及学习者认知发展关注不足等问题。本文以基于“浙大先生”的某国家级教学名师的“计算机体系结构”课程为例,基于领域学习模型MDL(Model of Domain Learning)和COST(Content-Others-Self-Task)教学设计框架,系统探讨人工智能深度融入教学的理论与实践路径。通过整合多模态数字资源与知识图谱、数字教师与虚拟学伴等人工智能工具,课程设计旨在促进学习者系统化知识的构建、个人专业兴趣的形成以及深度学习策略的掌握。研究指出,未来研究应进一步探索情感支持机制与复杂工程场景模拟,以推动人工智能与教育的深度融合与创新发展。展开更多
为了规避网络广告延时效应带来的不确定性风险,企业往往会采用效果付费(cost per action, CPA)方式进行网络推广。本文在CPA模式下研究考虑延时效应的供应链网络广告决策与协调问题。首先,建立含有时间延迟的品牌信誉动态模型和效果依...为了规避网络广告延时效应带来的不确定性风险,企业往往会采用效果付费(cost per action, CPA)方式进行网络推广。本文在CPA模式下研究考虑延时效应的供应链网络广告决策与协调问题。首先,建立含有时间延迟的品牌信誉动态模型和效果依赖的网络广告投入成本模型,并构建CPA模式下供应链网络广告微分博弈模型,再利用最优控制理论求解得到分散式决策与集中式决策下供应链系统的最优网络广告策略、定价策略、品牌信誉以及利润。其次,对决策结果进行综合比较分析,明确供应链系统的最佳决策机制,参照最佳决策供应链系统,设计一种动态批发价格契约,使供应链实现完美协调。最后,通过数值算例验证研究结果的有效性,对网络广告投入、品牌信誉、利润以及协调参数进行灵敏度分析。研究发现,与传统广告研究结论不同,CPA模式下制造商的最优网络广告投入高度依赖于时间,且遵循“逐降-早停”原则;CPA模式下短暂的网络广告延时效应和良好的销售效果可以增加双方合作的积极性,进而企业倾向于整体获利最大的集中式决策机制。本文研究成果为供应链企业网络推广实践提供了重要的理论指导。展开更多
The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,th...The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,there is a lack of empirical assessments of early opportunities for CCUS implementation in the cement sector.In this study,a comprehensive onshore and offshore source–sink matching optimization assessment framework for CCUS retrofitting in the cement industry,called the SSM-Cement framework,is proposed.The framework comprises four main modules:the cement plant suitability screening module,the storage site assessment module,the source–sink matching optimization model module,and the economic assessment module.By applying this framework to China,919 candidates are initially screened from 1132 existing cement plants.Further,603 CCUS-ready cement plants are identified,and are found to achieve a cumulative emission reduction of 18.5 Gt CO_(2) from 2030 to 2060 by meeting the CCUS feasibility conditions for constructing both onshore and offshore CO_(2) transportation routes.The levelized cost of cement(LCOC)is found to range from 30 to 96(mean 73)USD·(t cement)^(-1),while the levelized carbon avoidance cost(LCAC)ranges from^(-5) to 140(mean 88)USD·(t CO_(2))^(-1).The northeastern and northwestern regions of China are considered priority areas for CCUS implementation,with the LCAC concentrated in the range of 35 to 70 USD·(t CO_(2))^(-1).In addition to onshore storage of 15.8 Gt CO_(2) from 2030 to 2060,offshore storage would contribute 2.7 Gt of decarbonization for coastal cement plants,with comparable LCACs around 90 USD·(t CO_(2))^(-1).展开更多
The release of a new artificial intelligence(AI)model,ironically,evokes a biblical memory.What has transpired in the past few days echoes the biblical story of David versus Goliath,in which the massive and wellarmed G...The release of a new artificial intelligence(AI)model,ironically,evokes a biblical memory.What has transpired in the past few days echoes the biblical story of David versus Goliath,in which the massive and wellarmed Goliath is defeated by the comparatively puny David,who comes to the battle with only his staff and sling.展开更多
By systematically reviewing the development status of global carbon dioxide capture,utilization and storage(CCUS)cluster,and comparing domestic and international CCUS industrial models and successful experiences,this ...By systematically reviewing the development status of global carbon dioxide capture,utilization and storage(CCUS)cluster,and comparing domestic and international CCUS industrial models and successful experiences,this study explores the challenges and strategies for the scaled development of the CCUS industry of China.Globally,the CCUS industry has entered a phase of scaled and clustered development.North America has established a system of key technologies in large-scale CO_(2) capture,long-distance pipeline transmission,pipeline network optimization,and large-scale CO_(2) flooding for enhanced oil recovery(CO_(2)-EOR),with relatively mature cluster development and a gradual shift in industrial model from CO_(2)-EOR to geological storage.The CCUS industry of China has developed rapidly across all segments but remains in the early stage of cluster development,facing challenges such as absent business model,insufficient policy support,and technological gaps in core areas.China needs to improve the policy support system to boost enterprises participation across the entire industrial chain,strengthen top-level design and medium-to long-term planning to accelerate demonstration projects construction for whole-process CCUS clusters,advance for a full-chain technological system,including low-cost capture,pipeline optimization and EOR/storage integration technologies,and strengthen personnel training,strengthen discipline construction and university-enterprise research cooperation.展开更多
Ultra-low emission of nitrogen oxide(NO_(x))is an irreversible trend for the development of waste-to-energy industry.But traditional approaches to remove NO_(x) face significant challenge s,such as low denitration eff...Ultra-low emission of nitrogen oxide(NO_(x))is an irreversible trend for the development of waste-to-energy industry.But traditional approaches to remove NO_(x) face significant challenge s,such as low denitration efficiency,complex denitration system,and high investment and operating cost.Here we put forward a novel polymer non-catalytic reduction(PNCR)technology that utilized a new type of polymer agent to remove NO_(x),and the proposed PNCR technology was applied to the existing waste-to-energy plant to test the denitration performance.The PNCR technology demonstrated excellent denitration performance with a NO_(x) emission concentration of<100 mg/Nm^(3) and high denitration efficiency of>75%at the temperature range of 800-900℃,which showed the application feasibility even on the complex and unstable industrial operating conditions.In addition,PNCR and hybrid polymer/selective non-catalytic reduction(PNCR/SNCR)technology possessed remarkable economic advantages including low investment fee and low operating cost of<10 CNY per ton of municipal solid waste(MSW)compared with selective catalytic reduction(SCR)technology.The excellent denitration performance of PNCR technology forebodes a broad industrial application prospect in the field of flue gas cleaning for waste-to-energy plants.展开更多
The rapid advent in artificial intelligence and big data has revolutionized the dynamic requirement in the demands of the computing resource for executing specific tasks in the cloud environment.The process of achievi...The rapid advent in artificial intelligence and big data has revolutionized the dynamic requirement in the demands of the computing resource for executing specific tasks in the cloud environment.The process of achieving autonomic resource management is identified to be a herculean task due to its huge distributed and heterogeneous environment.Moreover,the cloud network needs to provide autonomic resource management and deliver potential services to the clients by complying with the requirements of Quality-of-Service(QoS)without impacting the Service Level Agreements(SLAs).However,the existing autonomic cloud resource managing frameworks are not capable in handling the resources of the cloud with its dynamic requirements.In this paper,Coot Bird Behavior Model-based Workload Aware Autonomic Resource Management Scheme(CBBM-WARMS)is proposed for handling the dynamic requirements of cloud resources through the estimation of workload that need to be policed by the cloud environment.This CBBM-WARMS initially adopted the algorithm of adaptive density peak clustering for workloads clustering of the cloud.Then,it utilized the fuzzy logic during the process of workload scheduling for achieving the determining the availability of cloud resources.It further used CBBM for potential Virtual Machine(VM)deployment that attributes towards the provision of optimal resources.It is proposed with the capability of achieving optimal QoS with minimized time,energy consumption,SLA cost and SLA violation.The experimental validation of the proposed CBBMWARMS confirms minimized SLA cost of 19.21%and reduced SLA violation rate of 18.74%,better than the compared autonomic cloud resource managing frameworks.展开更多
Accuracy allocation is crucial in the accuracy design of machining tools.Current accuracy allocation methods primarily focus on positional deviation,with little consideration for tool direction deviation.To address th...Accuracy allocation is crucial in the accuracy design of machining tools.Current accuracy allocation methods primarily focus on positional deviation,with little consideration for tool direction deviation.To address this issue,we propose a geometric error cost sensitivity-based accuracy allocation method for five-axis machine tools.A geometric error model consisting of 4l error components is constructed based on homogeneous transformation matrices.Volumetric points with positional and tool direction deviations are randomly sampled to evaluate the accuracy of the machine tool.The sensitivity of each error component at these sampling points is analyzed using the Sobol method.To balance the needs of geometric precision and manufacturing cost,a geometric error cost sensitivity function is developed to estimate the required cost.By allocating error components affecting tool direction deviation first and the remaining components second,this allocation scheme ensures that both deviations meet the requirements.We also perform numerical simulation of a BC-type(B-axis and C-axis type)five-axis machine tool to validate the method.The results show that the new allocation scheme reduces the total geometric error cost by 27.8%compared to a uniform allocation scheme,and yields the same positional and tool direction machining accuracies.展开更多
文摘It is proposed that where sexually selected vocal communication is an honest signal, the call production rate is predicted to change throughout the breeding season. Male leopard seals call underwater for many hours each day over their three- to four-month breeding season, and it is hypothesized that a decrease in calling rate would be associated with the declining body condition of smaller males. The calling rates of leopard seals were measured （N= 49 recordings） and com- pared between seals of different size classes throughout the breeding season. Male leopard seals produce their calls at more stable rates as they become larger. In this study, larger male leopard seals adopted a strategy of consistent underwater calling throughout the breeding season, whereas there was a breakdown in the calling stereotypy of the smaller males at its height. Toward the end of the breeding season, the smaller seals produced fewer calls in shortened calling bouts, and they took more rest periods. Therefore, underwater calling may represent an honest signal in the leopard seal. For marine mammals that call underwater, the production of repetitive sequences advertises the breath-holding ability of the caller to the listeners, and this ability may be related to male stamina and endurance, thus representing an honest signal that could be widespread in other species.
文摘AIM To investigate whether adductor canal nerve block(ACB) reduces patient falls when compared to femoral nerve block(FNB) after total knee arthroplasty(TKA). METHODS We conducted an institutional review of all-cause falls after TKA from January 2013 to August 2016 using a quality improvement database. Our inclusion criteria were patients with diagnosis of primary knee osteoarthritis who underwent primary unilateral TKA with either a FNB or an ACB and sustained a fall during their hospitalization. We excluded patients who had revision TKA and extensor mechanism reconstruction. We also excluded patients with a history of post-traumatic arthritis, prior history of lower extremity fracture, history of neurological disease, or cerebrovascular disease. RESULTS A total of 834 patients had TKA with femoral nerve block and knee immobilizer(FNB + KI). Of those patients, 11(1.3%) experienced a fall during their hospital stay. In contrast, 791 patients had TKA with ACB. Of those patients, only one(0.13%) patient fall was recorded within this group. We used the Fisher's exact test to compare the differences between the two groups. The difference between the two groups achieves statistical significance(P = 0.006). We also found that 11 out of the 12 patients that fell had a right TKA procedure while one patient had a left TKA procedure. Nine out of twelve patients that fell were female, while only three patients were male.CONCLUSION Given the reduction in the number of falls with ACB, it is recommended that ACB be considered the preferred analgesia for patients undergoing a TKA procedure.
基金supported by the National Natural Science Foundation of China (31672298 to N.L., 31772453 and31970427 to W.L.)。
文摘DEAR EDITOR,Recent studies have examined the cost of raising parasitic cuckoos and highlighted the importance of "no extra cost" in explaining the low levels of defense in hosts. To clarify the reasons for parasitization in typical hosts, we present a simple model to explore the immediate and future costs of parasitism in shaping the evolution of defense behavior in hosts.
文摘Background: It was the intention of the authors to generate a list of the top diseases responsible for the greatest financial expense in the United States. This listing would then inform policymakers as to the highest priority target conditions. With such information available, funding for the NIH could be accomplished based upon factual criteria rather than political clout or uninformed consensus. Method: The first step was a literature review to explore articles and reports which were published about the cost of illness (COI) up to December 2009. Therefore the source of the data used in this investigation was obtained from this retrospective search approach. Results: With reference to total cost for disease, first was HCVD with 475.3 billion US dollars, followed by alcohol abuse and substance at 300.6 billion US dollars, digestive diseases at 259.6 billion US dollars, cancer at 239.5 billion US dollars and mental disease at 216,6 billion US dollars. Conclusion: As has been seen, the total societal costs of the diseases do not synch with the degree of attention paid to these various disease states. Several of the diseases have very powerful and vocal support organizations that encourage attention and clinical research support. On the other hand we hear very little about efforts against allergic rhinitis or infectious and parasitic diseases.
文摘In this paper,we present a stochastic adaptive algorithm using radial basis function models for global optimization of costly black-box functions.The exploration radii in local searches are generated adaptively.Each iteration point is selected from some randomly generated trial points according to certain criteria.A restarting strategy is adopted to build the restarting version of the algorithm.The performance of the presented algorithm and its restarting version are tested on 13 standard numerical examples.The numerical results suggest that the algorithm and its restarting version are very effective.
文摘BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.
基金supported by the National Natural Science Foundation of China(Nos.42305089 and 42175106)the Self-supporting Program of Guangzhou Laboratory(No.SRPG22-007)+1 种基金the Youth Science and Technology Fund Project of Gansu(No.22JR5RA512)the Fundamental Research Funds for the Central Universities(No.lzujbky-2022-pd05).
文摘Ambient fine particulate matter(PM_(2.5))pollution causes the largest environmental health risk globally,yet ex-posure levels and the resulting health risks vary across countries with different income levels.Global wealth inequality has intensified in recent years,yet the relationship between wealth inequality and health risks related to PM_(2.5) pollution remains poorly understood.In this study,we evaluated the global mortality and health cost at-tributable to PM_(2.5) exposure from 2017 to 2021,and analyzed the relationship between wealth inequality,PM_(2.5) pollution,and the associated health risks across regions with varying economic levels.We found a consistent decline in mortalities and health costs attributable to PM_(2.5) exposure from 2017 to 2020,followed by a rebound after 2020,driven primarily by the resurgence of PM_(2.5) concentrations and a deceleration in the reduction of baseline mortality rates.We also found that the average PM_(2.5) concentration and associated risks decrease as domestic wealth inequality decreases and national income level increases.However,regions with extremely high levels of wealth inequality consistently show lower national average PM_(2.5) concentrations and health risks.These findings highlight the need to consider healthcare security during emergencies,as well as policy fairness across economic regions,in the formulation of global PM_(2.5) pollution control measures to promote sustainable,more equitable economic growth and coordinated air pollution management.
基金supported by the Irish Research Council under the Government of Ireland Postdoctoral Fellowship Project ID-GOIPD/2023/1431(to AS).
文摘Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people are diagnosed with SCI annually(Singh et al.,2014),and while this number appears quite low,the effect that an SCI has on the patient’s quality of life is drastic,due to the current difficulties to comprehensively treat this illness.The cost of patient care can also be quite costly,amounting to an estimated$1.69 billion in healthcare costs in the USA alone(Mahabaleshwarkar and Khanna,2014).
文摘Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This study evaluates the carbon footprint(CF)and economic viability of a liquefied natural gas(LNG)-fueled fishing vessel,using real engine operation simulations to provide precise and dynamic evaluation of fuel consumption and GHG emissions.Operational profiles are obtained through the utilization of onboard monitoring systems,whereas engine performance is simulated using the 1D/0D AVL Boost^(TM)model.Life cycle assessment(LCA)is conducted to quantify the environmental impact,whereas life cycle cost assessment(LCCA)is performed to analyze the profitability of LNG as an alternative fuel.The potential impact of the future fuel price uncertainties is addressed using Monte Carlo simulations.The LCA findings indicate that LNG has the potential to reduce the CF of the vessel by 14%to 16%,in comparison to a diesel power system configuration that serves as the baseline scenario.The LCCA results further indicate that the total cost of an LNG-powered ship is lower by 9.5%-13.8%,depending on the share of LNG and pilot fuels.This finding highlights the potential of LNG to produce considerable environmental benefits while addressing economic challenges under diverse operational and fuel price conditions.
文摘Construction on the Wuhan Greenland Center began on December 8, 2010. The 606-meter-tall building, which will cos 30 billion yuan ($4.5 billion), will be
文摘人工智能技术的迅猛发展为教育领域注入了新的活力,但其融入教学仍面临技术适配性不强、理论框架缺失及学习者认知发展关注不足等问题。本文以基于“浙大先生”的某国家级教学名师的“计算机体系结构”课程为例,基于领域学习模型MDL(Model of Domain Learning)和COST(Content-Others-Self-Task)教学设计框架,系统探讨人工智能深度融入教学的理论与实践路径。通过整合多模态数字资源与知识图谱、数字教师与虚拟学伴等人工智能工具,课程设计旨在促进学习者系统化知识的构建、个人专业兴趣的形成以及深度学习策略的掌握。研究指出,未来研究应进一步探索情感支持机制与复杂工程场景模拟,以推动人工智能与教育的深度融合与创新发展。
文摘为了规避网络广告延时效应带来的不确定性风险,企业往往会采用效果付费(cost per action, CPA)方式进行网络推广。本文在CPA模式下研究考虑延时效应的供应链网络广告决策与协调问题。首先,建立含有时间延迟的品牌信誉动态模型和效果依赖的网络广告投入成本模型,并构建CPA模式下供应链网络广告微分博弈模型,再利用最优控制理论求解得到分散式决策与集中式决策下供应链系统的最优网络广告策略、定价策略、品牌信誉以及利润。其次,对决策结果进行综合比较分析,明确供应链系统的最佳决策机制,参照最佳决策供应链系统,设计一种动态批发价格契约,使供应链实现完美协调。最后,通过数值算例验证研究结果的有效性,对网络广告投入、品牌信誉、利润以及协调参数进行灵敏度分析。研究发现,与传统广告研究结论不同,CPA模式下制造商的最优网络广告投入高度依赖于时间,且遵循“逐降-早停”原则;CPA模式下短暂的网络广告延时效应和良好的销售效果可以增加双方合作的积极性,进而企业倾向于整体获利最大的集中式决策机制。本文研究成果为供应链企业网络推广实践提供了重要的理论指导。
基金financial support of National Natural Science Foundation of China(72174196 and 71874193)the Open Fund of State Key Laboratory of Coal Resources and Safe Mining(SKLCRSM21KFA05)National Program for Support of Top-Notch Young Professionals.
文摘The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,there is a lack of empirical assessments of early opportunities for CCUS implementation in the cement sector.In this study,a comprehensive onshore and offshore source–sink matching optimization assessment framework for CCUS retrofitting in the cement industry,called the SSM-Cement framework,is proposed.The framework comprises four main modules:the cement plant suitability screening module,the storage site assessment module,the source–sink matching optimization model module,and the economic assessment module.By applying this framework to China,919 candidates are initially screened from 1132 existing cement plants.Further,603 CCUS-ready cement plants are identified,and are found to achieve a cumulative emission reduction of 18.5 Gt CO_(2) from 2030 to 2060 by meeting the CCUS feasibility conditions for constructing both onshore and offshore CO_(2) transportation routes.The levelized cost of cement(LCOC)is found to range from 30 to 96(mean 73)USD·(t cement)^(-1),while the levelized carbon avoidance cost(LCAC)ranges from^(-5) to 140(mean 88)USD·(t CO_(2))^(-1).The northeastern and northwestern regions of China are considered priority areas for CCUS implementation,with the LCAC concentrated in the range of 35 to 70 USD·(t CO_(2))^(-1).In addition to onshore storage of 15.8 Gt CO_(2) from 2030 to 2060,offshore storage would contribute 2.7 Gt of decarbonization for coastal cement plants,with comparable LCACs around 90 USD·(t CO_(2))^(-1).
文摘The release of a new artificial intelligence(AI)model,ironically,evokes a biblical memory.What has transpired in the past few days echoes the biblical story of David versus Goliath,in which the massive and wellarmed Goliath is defeated by the comparatively puny David,who comes to the battle with only his staff and sling.
基金Supported by the PetroChina Science and Technology Major Project(2021ZZ01-05)Hainan Merit-based Recruitment Project(ZDYF2024SHFZ147)National Natural Science Foundation of China(NNSC)Project(52474033)。
文摘By systematically reviewing the development status of global carbon dioxide capture,utilization and storage(CCUS)cluster,and comparing domestic and international CCUS industrial models and successful experiences,this study explores the challenges and strategies for the scaled development of the CCUS industry of China.Globally,the CCUS industry has entered a phase of scaled and clustered development.North America has established a system of key technologies in large-scale CO_(2) capture,long-distance pipeline transmission,pipeline network optimization,and large-scale CO_(2) flooding for enhanced oil recovery(CO_(2)-EOR),with relatively mature cluster development and a gradual shift in industrial model from CO_(2)-EOR to geological storage.The CCUS industry of China has developed rapidly across all segments but remains in the early stage of cluster development,facing challenges such as absent business model,insufficient policy support,and technological gaps in core areas.China needs to improve the policy support system to boost enterprises participation across the entire industrial chain,strengthen top-level design and medium-to long-term planning to accelerate demonstration projects construction for whole-process CCUS clusters,advance for a full-chain technological system,including low-cost capture,pipeline optimization and EOR/storage integration technologies,and strengthen personnel training,strengthen discipline construction and university-enterprise research cooperation.
基金supported by the National Natural Science Foundation of China(No.92367107)。
文摘Ultra-low emission of nitrogen oxide(NO_(x))is an irreversible trend for the development of waste-to-energy industry.But traditional approaches to remove NO_(x) face significant challenge s,such as low denitration efficiency,complex denitration system,and high investment and operating cost.Here we put forward a novel polymer non-catalytic reduction(PNCR)technology that utilized a new type of polymer agent to remove NO_(x),and the proposed PNCR technology was applied to the existing waste-to-energy plant to test the denitration performance.The PNCR technology demonstrated excellent denitration performance with a NO_(x) emission concentration of<100 mg/Nm^(3) and high denitration efficiency of>75%at the temperature range of 800-900℃,which showed the application feasibility even on the complex and unstable industrial operating conditions.In addition,PNCR and hybrid polymer/selective non-catalytic reduction(PNCR/SNCR)technology possessed remarkable economic advantages including low investment fee and low operating cost of<10 CNY per ton of municipal solid waste(MSW)compared with selective catalytic reduction(SCR)technology.The excellent denitration performance of PNCR technology forebodes a broad industrial application prospect in the field of flue gas cleaning for waste-to-energy plants.
文摘The rapid advent in artificial intelligence and big data has revolutionized the dynamic requirement in the demands of the computing resource for executing specific tasks in the cloud environment.The process of achieving autonomic resource management is identified to be a herculean task due to its huge distributed and heterogeneous environment.Moreover,the cloud network needs to provide autonomic resource management and deliver potential services to the clients by complying with the requirements of Quality-of-Service(QoS)without impacting the Service Level Agreements(SLAs).However,the existing autonomic cloud resource managing frameworks are not capable in handling the resources of the cloud with its dynamic requirements.In this paper,Coot Bird Behavior Model-based Workload Aware Autonomic Resource Management Scheme(CBBM-WARMS)is proposed for handling the dynamic requirements of cloud resources through the estimation of workload that need to be policed by the cloud environment.This CBBM-WARMS initially adopted the algorithm of adaptive density peak clustering for workloads clustering of the cloud.Then,it utilized the fuzzy logic during the process of workload scheduling for achieving the determining the availability of cloud resources.It further used CBBM for potential Virtual Machine(VM)deployment that attributes towards the provision of optimal resources.It is proposed with the capability of achieving optimal QoS with minimized time,energy consumption,SLA cost and SLA violation.The experimental validation of the proposed CBBMWARMS confirms minimized SLA cost of 19.21%and reduced SLA violation rate of 18.74%,better than the compared autonomic cloud resource managing frameworks.
基金supported by the Key R&D Program of Zhejiang Province(Nos.2023C01166 and 2024SJCZX0046)the Zhejiang Provincial Natural Science Foundation of China(Nos.LDT23E05013E05 and LD24E050009)the Natural Science Foundation of Ningbo(No.2021J150),China.
文摘Accuracy allocation is crucial in the accuracy design of machining tools.Current accuracy allocation methods primarily focus on positional deviation,with little consideration for tool direction deviation.To address this issue,we propose a geometric error cost sensitivity-based accuracy allocation method for five-axis machine tools.A geometric error model consisting of 4l error components is constructed based on homogeneous transformation matrices.Volumetric points with positional and tool direction deviations are randomly sampled to evaluate the accuracy of the machine tool.The sensitivity of each error component at these sampling points is analyzed using the Sobol method.To balance the needs of geometric precision and manufacturing cost,a geometric error cost sensitivity function is developed to estimate the required cost.By allocating error components affecting tool direction deviation first and the remaining components second,this allocation scheme ensures that both deviations meet the requirements.We also perform numerical simulation of a BC-type(B-axis and C-axis type)five-axis machine tool to validate the method.The results show that the new allocation scheme reduces the total geometric error cost by 27.8%compared to a uniform allocation scheme,and yields the same positional and tool direction machining accuracies.
