COVID-19 placed increased pressure and urgency for effective cost management,resulting in unprecedented financial strains for hospitals.The pandemic also became a catalyst for accelerating digital transformation to im...COVID-19 placed increased pressure and urgency for effective cost management,resulting in unprecedented financial strains for hospitals.The pandemic also became a catalyst for accelerating digital transformation to improve operations and services in the healthcare industry.Morningdale Hospital is a large and reputable general hospital with a long history in the U.K.You are an intern in the Finance Department of the Hospital.The CEO has asked you to complete a patient-level cost analysis of endoscopic procedures in the Gastrointestinal Department.In your final report,you plan to include a SWOT analysis and a cost analysis using Activity-Based Costing accounting method.展开更多
The paper studies the historical development of costing systems. The changes of costing systems are proposed to be caused by the changes in product market, production technology and demand for control. The result of t...The paper studies the historical development of costing systems. The changes of costing systems are proposed to be caused by the changes in product market, production technology and demand for control. The result of this research provides historical evidence to support the proposition.展开更多
A hybrid energy system is built for the power demand of a community in Xinjiang of China,and pumped storage and lithium batteries are used as energy storage devices.The feasibility of different configurations is evalu...A hybrid energy system is built for the power demand of a community in Xinjiang of China,and pumped storage and lithium batteries are used as energy storage devices.The feasibility of different configurations is evaluated through technoeconomic analysis.Technical-economic parameters are set in the HOMER Pro software to obtain optimal configuration and techno-economic evaluation and sensitivity analysis.The study also explores the impact of different types of PV tracking systems and module costs on system performance.The results show that the lowest levelized cost of energy(LCOE)(0.135$/kWh)can be achieved with pumped hydro,which is more economical than lithium batteries.PV tracking systems can improve solar efficiency.Compared with diesel systems,renewable energy has economic advantages and environmental benefits.In most regions of Xinjiang,solar energy is more competitive than wind power.In areas with abundant wind resources,the integration of wind and solar energy can reduce costs.展开更多
The advent of microgrids in modern energy systems heralds a promising era of resilience,sustainability,and efficiency.Within the realm of grid-tied microgrids,the selection of an optimal optimization algorithm is crit...The advent of microgrids in modern energy systems heralds a promising era of resilience,sustainability,and efficiency.Within the realm of grid-tied microgrids,the selection of an optimal optimization algorithm is critical for effective energy management,particularly in economic dispatching.This study compares the performance of Particle Swarm Optimization(PSO)and Genetic Algorithms(GA)in microgrid energy management systems,implemented using MATLAB tools.Through a comprehensive review of the literature and sim-ulations conducted in MATLAB,the study analyzes performance metrics,convergence speed,and the overall efficacy of GA and PSO,with a focus on economic dispatching tasks.Notably,a significant distinction emerges between the cost curves generated by the two algo-rithms for microgrid operation,with the PSO algorithm consistently resulting in lower costs due to its effective economic dispatching capabilities.Specifically,the utilization of the PSO approach could potentially lead to substantial savings on the power bill,amounting to approximately$15.30 in this evaluation.Thefindings provide insights into the strengths and limitations of each algorithm within the complex dynamics of grid-tied microgrids,thereby assisting stakeholders and researchers in arriving at informed decisions.This study contributes to the discourse on sustainable energy management by offering actionable guidance for the advancement of grid-tied micro-grid technologies through MATLAB-implemented optimization algorithms.展开更多
With the gradual development of smart power plants and large-scale centralized control,there is a need to exchange a large number of signals between different DCS systems and between DCS and PLC systems.Different cont...With the gradual development of smart power plants and large-scale centralized control,there is a need to exchange a large number of signals between different DCS systems and between DCS and PLC systems.Different control systems have different brands and cannot communicate directly via networks.Moreover,due to network security concerns,the main control of unit units and the auxiliary control system of the entire plant cannot communicate directly via networks either.The commonly adopted methods for signal exchange between control systems are hardwiring and 485 communications.Both have obvious drawbacks,where hardwiring requires a large number of channels and cable laying;485 configuration is difficult,not easy to maintain,and faults are hard to locate.This paper studies how to strike a balance between the two,using a minimal amount of hardwiring to transmit a large number of signals,which is safe,reliable,cost-effective,and can be maintained by any control personnel without network security risks.展开更多
Plants are continuously exposed to abiotic and biotic stresses that threaten their growth,reproduction,and survival.Adaptation to these stresses requires complex regulatory networks that coordinate physiological,molec...Plants are continuously exposed to abiotic and biotic stresses that threaten their growth,reproduction,and survival.Adaptation to these stresses requires complex regulatory networks that coordinate physiological,molecular,and ecological responses.However,such adaptation often incurs significant costs,including reduced growth,yield penalties,and altered ecological interactions.This review systematically synthesizes recent advances published between 2018 and 2025,following PRISMA criteria,on plant responses to abiotic and biotic stressors,with an emphasis on the trade-offs between adaptation and productivity.It also highlights major discrepancies in the literature and discusses strategies for enhancing plant stress tolerance in agriculture.By integrating findings from genomics,transcriptomics,proteomics,and metabolomics,the review categorizes both mechanistic insights and ecological consequences.The findings underscore the need for multi-stress,systems-level,field-based research that connects molecular processes to ecological and agricultural outcomes.Accordingly,critical gaps are identified—particularly the scarcity of multi-stress and field-based studies—and future directions that integrate omics approaches,systems biology,and eco-physiological frameworks are proposed.Understanding the costs of adaptation is essential not only for breeding resilient,high-yielding crops but also for ensuring their successful incorporation into sustainable agricultural practices under changing climate conditions.展开更多
Stroke,which is the second leading cause of mortality worldwide and the third leading cause of death and disability combined,[1]necessitates cost-effective rehabilitation interventions.Acupuncture is a traditional Chi...Stroke,which is the second leading cause of mortality worldwide and the third leading cause of death and disability combined,[1]necessitates cost-effective rehabilitation interventions.Acupuncture is a traditional Chinese medicine therapy that is increasingly recognized as a complementary stroke therapy.展开更多
BACKGROUND The clinical necessity of routine abdominal drainage following radical gastrectomy remains controversial,particularly under the enhanced recovery after surgery(ERAS)protocol.ERAS advocates a multimodal peri...BACKGROUND The clinical necessity of routine abdominal drainage following radical gastrectomy remains controversial,particularly under the enhanced recovery after surgery(ERAS)protocol.ERAS advocates a multimodal perioperative strategy designed to attenuate surgical stress and optimize postoperative convalescence.AIM To evaluate the necessity of abdominal drainage tube placement following radical gastrectomy in the context of ERAS protocols.METHODS A systematic review and meta-analysis were conducted by searching PubMed,EMBASE,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang,VIP Information,and SinoMed databases for randomized controlled trials comparing outcomes of abdominal drainage vs no drainage after gastrectomy under ERAS protocols.Primary outcomes included time to gastrointestinal function recovery,drainage tube removal time,postoperative complication rates,and length of hospital stay.Review Manager 5.4 was used for statistical analysis,and heterogeneity was assessed using the I2 statistic.RESULTS A total of 21 randomized controlled trials involving 1652 patients were included.Compared with routine abdominal drainage,the ERAS group without drainage showed significantly faster gastrointestinal recovery[standardized mean difference=-1.30,95%confidence interval(CI):-1.66 to-0.94,P<0.00001]and shorter hospital stay(standardized mean difference=-1.37,95%CI:-1.86 to-0.88,P<0.00001).The incidence of total postoperative complications was also significantly lower(odds ratio=0.53,95%CI:0.40-0.70,P<0.00001),particularly for anastomotic leakage and pulmonary infection.No significant differences were observed in surgical site infections or urinary tract infections.Sensitivity and subgroup analyses indicated stability of results,although some heterogeneity was noted.CONCLUSION Avoiding routine abdominal drainage under ERAS could lead to faster recovery,reduced complications,and shorter hospital stay following radical gastrectomy,supporting the selective use of drainage rather than routine.展开更多
In the context of the Diagnosis Related Groups(DRGs)system,the orthopedic hospital implemented refined drug control to provide a pharmacological reference for promoting rational clinical drug use.A statistical analysi...In the context of the Diagnosis Related Groups(DRGs)system,the orthopedic hospital implemented refined drug control to provide a pharmacological reference for promoting rational clinical drug use.A statistical analysis was conducted on the hospital’s data from January to December 2021(prior to the implementation of control),focusing on the types of unreasonable prescriptions.A multi-dimensional analysis was also conducted to identify the underlying causes of inappropriate medication practices.Following this,refined drug control measures were introduced,and data from January to December 2022(post-control)were compared,examining factors such as the average drug cost,drug expenses for the IC29 diagnosis group,and the drug cost ratio.An interrupted time-series analysis was employed to evaluate the effects of these interventions.The results showed that after the implementation of refined drug control in the orthopedic department,significant reductions were observed in the average cost per patient,average drug cost per patient,drug cost ratio,cost consumption index,average length of hospital stay,and allocation ratio(P<0.05).In particular,the first month of control(January 2022)saw a marked decrease in average drug costs per patient by 1272.90 yuan(P<0.01),a reduction in the drug cost ratio by 0.98%,and a decline in drug costs for the IC29 diagnosis group by 616.79 yuan(P>0.05).Moreover,the rate of unreasonable inappropriate prescribing dropped dramatically from 40.48%in 2021 to 3.57%by December 2022.The refined control of drug use within the orthopedic hospital significantly improved the rationality of clinical prescribing practices,reduced the occurrence of adverse drug reactions,and enhanced patient adherence to prescribed treatments.These findings demonstrated considerable clinical value in promoting efficient and safe drug use.展开更多
Dear Editor,This letter addresses the robust predefined-time control challenge for leaderless optimal formation in networked mobile vehicle(NMV)systems.The aim is to minimize a composite global cost function derived f...Dear Editor,This letter addresses the robust predefined-time control challenge for leaderless optimal formation in networked mobile vehicle(NMV)systems.The aim is to minimize a composite global cost function derived from individual strongly convex functions of each agent,considering both input disturbances and network communication constraints.A novel predefined-time optimal formation control(PTOFC)algorithm is presented,ensuring agent state convergence to optimal formation positions within an adjustable settling time.Through the integration of an integral sliding mode technique,disturbances are effectively countered.A representative numerical example highlights the effectiveness and robustness of the developed approach.展开更多
Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the...Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.展开更多
Activity based costing (ABC) is a method which can solve many limitations of the traditional cost systems in manufacturing management. In this paper, we investigate how to integrate ABC with workflow technology, and ...Activity based costing (ABC) is a method which can solve many limitations of the traditional cost systems in manufacturing management. In this paper, we investigate how to integrate ABC with workflow technology, and build a workflow meta model supporting ABC. Firstly, the concept and concept model of activity based costing (ABC) are introduced. Next, the meta model of P -PROCE (Process, Product, Resource, Organization, and Cost & Evaluation) is presented. Then the cost meta model is defined by adding ABC to P -PROCE model. Object constraint language (OCL) is used to express meta model and constraints. Finally, we show an enterprise modeling and simulation tool based on the workflow meta model. We can systematically construct an enterprise model and easily and efficiently conduct simulation. Moreover it enables us to analyze and evaluate business processes and its costs.展开更多
Hainan’s special customs operations are expected to significantly reduce the institutional costs of foreign goods flowing into Hainan,enabling the island to function as a gateway for global goods.DAVID Adrian Janke,a...Hainan’s special customs operations are expected to significantly reduce the institutional costs of foreign goods flowing into Hainan,enabling the island to function as a gateway for global goods.DAVID Adrian Janke,a British citizen operating a translation company in Haikou,capital of Hainan Province in south China,witnessed surging orders as special customs operations got underway in the island province on December 18.展开更多
BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Resear...BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.展开更多
Ambient fine particulate matter(PM_(2.5))pollution causes the largest environmental health risk globally,yet ex-posure levels and the resulting health risks vary across countries with different income levels.Global we...Ambient fine particulate matter(PM_(2.5))pollution causes the largest environmental health risk globally,yet ex-posure levels and the resulting health risks vary across countries with different income levels.Global wealth inequality has intensified in recent years,yet the relationship between wealth inequality and health risks related to PM_(2.5) pollution remains poorly understood.In this study,we evaluated the global mortality and health cost at-tributable to PM_(2.5) exposure from 2017 to 2021,and analyzed the relationship between wealth inequality,PM_(2.5) pollution,and the associated health risks across regions with varying economic levels.We found a consistent decline in mortalities and health costs attributable to PM_(2.5) exposure from 2017 to 2020,followed by a rebound after 2020,driven primarily by the resurgence of PM_(2.5) concentrations and a deceleration in the reduction of baseline mortality rates.We also found that the average PM_(2.5) concentration and associated risks decrease as domestic wealth inequality decreases and national income level increases.However,regions with extremely high levels of wealth inequality consistently show lower national average PM_(2.5) concentrations and health risks.These findings highlight the need to consider healthcare security during emergencies,as well as policy fairness across economic regions,in the formulation of global PM_(2.5) pollution control measures to promote sustainable,more equitable economic growth and coordinated air pollution management.展开更多
Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people...Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people are diagnosed with SCI annually(Singh et al.,2014),and while this number appears quite low,the effect that an SCI has on the patient’s quality of life is drastic,due to the current difficulties to comprehensively treat this illness.The cost of patient care can also be quite costly,amounting to an estimated$1.69 billion in healthcare costs in the USA alone(Mahabaleshwarkar and Khanna,2014).展开更多
Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This st...Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This study evaluates the carbon footprint(CF)and economic viability of a liquefied natural gas(LNG)-fueled fishing vessel,using real engine operation simulations to provide precise and dynamic evaluation of fuel consumption and GHG emissions.Operational profiles are obtained through the utilization of onboard monitoring systems,whereas engine performance is simulated using the 1D/0D AVL Boost^(TM)model.Life cycle assessment(LCA)is conducted to quantify the environmental impact,whereas life cycle cost assessment(LCCA)is performed to analyze the profitability of LNG as an alternative fuel.The potential impact of the future fuel price uncertainties is addressed using Monte Carlo simulations.The LCA findings indicate that LNG has the potential to reduce the CF of the vessel by 14%to 16%,in comparison to a diesel power system configuration that serves as the baseline scenario.The LCCA results further indicate that the total cost of an LNG-powered ship is lower by 9.5%-13.8%,depending on the share of LNG and pilot fuels.This finding highlights the potential of LNG to produce considerable environmental benefits while addressing economic challenges under diverse operational and fuel price conditions.展开更多
文摘COVID-19 placed increased pressure and urgency for effective cost management,resulting in unprecedented financial strains for hospitals.The pandemic also became a catalyst for accelerating digital transformation to improve operations and services in the healthcare industry.Morningdale Hospital is a large and reputable general hospital with a long history in the U.K.You are an intern in the Finance Department of the Hospital.The CEO has asked you to complete a patient-level cost analysis of endoscopic procedures in the Gastrointestinal Department.In your final report,you plan to include a SWOT analysis and a cost analysis using Activity-Based Costing accounting method.
文摘The paper studies the historical development of costing systems. The changes of costing systems are proposed to be caused by the changes in product market, production technology and demand for control. The result of this research provides historical evidence to support the proposition.
基金supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region of China“Research on photoelectric thermal conversion mechanism and optimization design of photovoltaic building envelope structure”(2022D01C87)。
文摘A hybrid energy system is built for the power demand of a community in Xinjiang of China,and pumped storage and lithium batteries are used as energy storage devices.The feasibility of different configurations is evaluated through technoeconomic analysis.Technical-economic parameters are set in the HOMER Pro software to obtain optimal configuration and techno-economic evaluation and sensitivity analysis.The study also explores the impact of different types of PV tracking systems and module costs on system performance.The results show that the lowest levelized cost of energy(LCOE)(0.135$/kWh)can be achieved with pumped hydro,which is more economical than lithium batteries.PV tracking systems can improve solar efficiency.Compared with diesel systems,renewable energy has economic advantages and environmental benefits.In most regions of Xinjiang,solar energy is more competitive than wind power.In areas with abundant wind resources,the integration of wind and solar energy can reduce costs.
文摘The advent of microgrids in modern energy systems heralds a promising era of resilience,sustainability,and efficiency.Within the realm of grid-tied microgrids,the selection of an optimal optimization algorithm is critical for effective energy management,particularly in economic dispatching.This study compares the performance of Particle Swarm Optimization(PSO)and Genetic Algorithms(GA)in microgrid energy management systems,implemented using MATLAB tools.Through a comprehensive review of the literature and sim-ulations conducted in MATLAB,the study analyzes performance metrics,convergence speed,and the overall efficacy of GA and PSO,with a focus on economic dispatching tasks.Notably,a significant distinction emerges between the cost curves generated by the two algo-rithms for microgrid operation,with the PSO algorithm consistently resulting in lower costs due to its effective economic dispatching capabilities.Specifically,the utilization of the PSO approach could potentially lead to substantial savings on the power bill,amounting to approximately$15.30 in this evaluation.Thefindings provide insights into the strengths and limitations of each algorithm within the complex dynamics of grid-tied microgrids,thereby assisting stakeholders and researchers in arriving at informed decisions.This study contributes to the discourse on sustainable energy management by offering actionable guidance for the advancement of grid-tied micro-grid technologies through MATLAB-implemented optimization algorithms.
文摘With the gradual development of smart power plants and large-scale centralized control,there is a need to exchange a large number of signals between different DCS systems and between DCS and PLC systems.Different control systems have different brands and cannot communicate directly via networks.Moreover,due to network security concerns,the main control of unit units and the auxiliary control system of the entire plant cannot communicate directly via networks either.The commonly adopted methods for signal exchange between control systems are hardwiring and 485 communications.Both have obvious drawbacks,where hardwiring requires a large number of channels and cable laying;485 configuration is difficult,not easy to maintain,and faults are hard to locate.This paper studies how to strike a balance between the two,using a minimal amount of hardwiring to transmit a large number of signals,which is safe,reliable,cost-effective,and can be maintained by any control personnel without network security risks.
文摘Plants are continuously exposed to abiotic and biotic stresses that threaten their growth,reproduction,and survival.Adaptation to these stresses requires complex regulatory networks that coordinate physiological,molecular,and ecological responses.However,such adaptation often incurs significant costs,including reduced growth,yield penalties,and altered ecological interactions.This review systematically synthesizes recent advances published between 2018 and 2025,following PRISMA criteria,on plant responses to abiotic and biotic stressors,with an emphasis on the trade-offs between adaptation and productivity.It also highlights major discrepancies in the literature and discusses strategies for enhancing plant stress tolerance in agriculture.By integrating findings from genomics,transcriptomics,proteomics,and metabolomics,the review categorizes both mechanistic insights and ecological consequences.The findings underscore the need for multi-stress,systems-level,field-based research that connects molecular processes to ecological and agricultural outcomes.Accordingly,critical gaps are identified—particularly the scarcity of multi-stress and field-based studies—and future directions that integrate omics approaches,systems biology,and eco-physiological frameworks are proposed.Understanding the costs of adaptation is essential not only for breeding resilient,high-yielding crops but also for ensuring their successful incorporation into sustainable agricultural practices under changing climate conditions.
基金supported by the social development project of the National Social Science Fund Project(No.17BTQ063)National Natural Science Foundation of China(72174094).
文摘Stroke,which is the second leading cause of mortality worldwide and the third leading cause of death and disability combined,[1]necessitates cost-effective rehabilitation interventions.Acupuncture is a traditional Chinese medicine therapy that is increasingly recognized as a complementary stroke therapy.
文摘BACKGROUND The clinical necessity of routine abdominal drainage following radical gastrectomy remains controversial,particularly under the enhanced recovery after surgery(ERAS)protocol.ERAS advocates a multimodal perioperative strategy designed to attenuate surgical stress and optimize postoperative convalescence.AIM To evaluate the necessity of abdominal drainage tube placement following radical gastrectomy in the context of ERAS protocols.METHODS A systematic review and meta-analysis were conducted by searching PubMed,EMBASE,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang,VIP Information,and SinoMed databases for randomized controlled trials comparing outcomes of abdominal drainage vs no drainage after gastrectomy under ERAS protocols.Primary outcomes included time to gastrointestinal function recovery,drainage tube removal time,postoperative complication rates,and length of hospital stay.Review Manager 5.4 was used for statistical analysis,and heterogeneity was assessed using the I2 statistic.RESULTS A total of 21 randomized controlled trials involving 1652 patients were included.Compared with routine abdominal drainage,the ERAS group without drainage showed significantly faster gastrointestinal recovery[standardized mean difference=-1.30,95%confidence interval(CI):-1.66 to-0.94,P<0.00001]and shorter hospital stay(standardized mean difference=-1.37,95%CI:-1.86 to-0.88,P<0.00001).The incidence of total postoperative complications was also significantly lower(odds ratio=0.53,95%CI:0.40-0.70,P<0.00001),particularly for anastomotic leakage and pulmonary infection.No significant differences were observed in surgical site infections or urinary tract infections.Sensitivity and subgroup analyses indicated stability of results,although some heterogeneity was noted.CONCLUSION Avoiding routine abdominal drainage under ERAS could lead to faster recovery,reduced complications,and shorter hospital stay following radical gastrectomy,supporting the selective use of drainage rather than routine.
基金Jiangxi Provincial Hospital Pharmacy Special Research Fund Project(Grant No.2024-ZXYJ02).
文摘In the context of the Diagnosis Related Groups(DRGs)system,the orthopedic hospital implemented refined drug control to provide a pharmacological reference for promoting rational clinical drug use.A statistical analysis was conducted on the hospital’s data from January to December 2021(prior to the implementation of control),focusing on the types of unreasonable prescriptions.A multi-dimensional analysis was also conducted to identify the underlying causes of inappropriate medication practices.Following this,refined drug control measures were introduced,and data from January to December 2022(post-control)were compared,examining factors such as the average drug cost,drug expenses for the IC29 diagnosis group,and the drug cost ratio.An interrupted time-series analysis was employed to evaluate the effects of these interventions.The results showed that after the implementation of refined drug control in the orthopedic department,significant reductions were observed in the average cost per patient,average drug cost per patient,drug cost ratio,cost consumption index,average length of hospital stay,and allocation ratio(P<0.05).In particular,the first month of control(January 2022)saw a marked decrease in average drug costs per patient by 1272.90 yuan(P<0.01),a reduction in the drug cost ratio by 0.98%,and a decline in drug costs for the IC29 diagnosis group by 616.79 yuan(P>0.05).Moreover,the rate of unreasonable inappropriate prescribing dropped dramatically from 40.48%in 2021 to 3.57%by December 2022.The refined control of drug use within the orthopedic hospital significantly improved the rationality of clinical prescribing practices,reduced the occurrence of adverse drug reactions,and enhanced patient adherence to prescribed treatments.These findings demonstrated considerable clinical value in promoting efficient and safe drug use.
基金supported by the National Natural Science Foundation of China(62373162,U24A20268,624B2055)the Shenzhen Science and Technology Program(JCYJ 20240813114007010)the Knowledge Innovation Program of Wuhan-Basic Research(2023010201010100).
文摘Dear Editor,This letter addresses the robust predefined-time control challenge for leaderless optimal formation in networked mobile vehicle(NMV)systems.The aim is to minimize a composite global cost function derived from individual strongly convex functions of each agent,considering both input disturbances and network communication constraints.A novel predefined-time optimal formation control(PTOFC)algorithm is presented,ensuring agent state convergence to optimal formation positions within an adjustable settling time.Through the integration of an integral sliding mode technique,disturbances are effectively countered.A representative numerical example highlights the effectiveness and robustness of the developed approach.
基金supported by the Liaoning Revitalization Talents Program(XLYC2203148)
文摘Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.
文摘Activity based costing (ABC) is a method which can solve many limitations of the traditional cost systems in manufacturing management. In this paper, we investigate how to integrate ABC with workflow technology, and build a workflow meta model supporting ABC. Firstly, the concept and concept model of activity based costing (ABC) are introduced. Next, the meta model of P -PROCE (Process, Product, Resource, Organization, and Cost & Evaluation) is presented. Then the cost meta model is defined by adding ABC to P -PROCE model. Object constraint language (OCL) is used to express meta model and constraints. Finally, we show an enterprise modeling and simulation tool based on the workflow meta model. We can systematically construct an enterprise model and easily and efficiently conduct simulation. Moreover it enables us to analyze and evaluate business processes and its costs.
文摘Hainan’s special customs operations are expected to significantly reduce the institutional costs of foreign goods flowing into Hainan,enabling the island to function as a gateway for global goods.DAVID Adrian Janke,a British citizen operating a translation company in Haikou,capital of Hainan Province in south China,witnessed surging orders as special customs operations got underway in the island province on December 18.
文摘BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.
基金supported by the National Natural Science Foundation of China(Nos.42305089 and 42175106)the Self-supporting Program of Guangzhou Laboratory(No.SRPG22-007)+1 种基金the Youth Science and Technology Fund Project of Gansu(No.22JR5RA512)the Fundamental Research Funds for the Central Universities(No.lzujbky-2022-pd05).
文摘Ambient fine particulate matter(PM_(2.5))pollution causes the largest environmental health risk globally,yet ex-posure levels and the resulting health risks vary across countries with different income levels.Global wealth inequality has intensified in recent years,yet the relationship between wealth inequality and health risks related to PM_(2.5) pollution remains poorly understood.In this study,we evaluated the global mortality and health cost at-tributable to PM_(2.5) exposure from 2017 to 2021,and analyzed the relationship between wealth inequality,PM_(2.5) pollution,and the associated health risks across regions with varying economic levels.We found a consistent decline in mortalities and health costs attributable to PM_(2.5) exposure from 2017 to 2020,followed by a rebound after 2020,driven primarily by the resurgence of PM_(2.5) concentrations and a deceleration in the reduction of baseline mortality rates.We also found that the average PM_(2.5) concentration and associated risks decrease as domestic wealth inequality decreases and national income level increases.However,regions with extremely high levels of wealth inequality consistently show lower national average PM_(2.5) concentrations and health risks.These findings highlight the need to consider healthcare security during emergencies,as well as policy fairness across economic regions,in the formulation of global PM_(2.5) pollution control measures to promote sustainable,more equitable economic growth and coordinated air pollution management.
基金supported by the Irish Research Council under the Government of Ireland Postdoctoral Fellowship Project ID-GOIPD/2023/1431(to AS).
文摘Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people are diagnosed with SCI annually(Singh et al.,2014),and while this number appears quite low,the effect that an SCI has on the patient’s quality of life is drastic,due to the current difficulties to comprehensively treat this illness.The cost of patient care can also be quite costly,amounting to an estimated$1.69 billion in healthcare costs in the USA alone(Mahabaleshwarkar and Khanna,2014).
文摘Analysis of the environmental and economic performance of fishing vessels has received limited attention compared with other ship types despite their notable contribution to global greenhouse gas(GHG)emissions.This study evaluates the carbon footprint(CF)and economic viability of a liquefied natural gas(LNG)-fueled fishing vessel,using real engine operation simulations to provide precise and dynamic evaluation of fuel consumption and GHG emissions.Operational profiles are obtained through the utilization of onboard monitoring systems,whereas engine performance is simulated using the 1D/0D AVL Boost^(TM)model.Life cycle assessment(LCA)is conducted to quantify the environmental impact,whereas life cycle cost assessment(LCCA)is performed to analyze the profitability of LNG as an alternative fuel.The potential impact of the future fuel price uncertainties is addressed using Monte Carlo simulations.The LCA findings indicate that LNG has the potential to reduce the CF of the vessel by 14%to 16%,in comparison to a diesel power system configuration that serves as the baseline scenario.The LCCA results further indicate that the total cost of an LNG-powered ship is lower by 9.5%-13.8%,depending on the share of LNG and pilot fuels.This finding highlights the potential of LNG to produce considerable environmental benefits while addressing economic challenges under diverse operational and fuel price conditions.
