Objective To understand the relationships between CDH13（T-cadherin） genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Method...Objective To understand the relationships between CDH13（T-cadherin） genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight（HMW） adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels（per T： Coef =-0.257, P = 0.001）. CDH13 rs7193788 was associated with total adiponectin levels（per A： Coef =-0.221, P = 0.001） and HMW adiponectin levels（per A： Coef =-0.163, P = 0.003）. rs7193788 was significantly associated with ischemic stroke（GA/AA vs. GG： OR = 1.55, 95% CI： 1.07 to 2.24, P = 0.020） after Bonferroni correction（α = 0.025）. There was an interaction between rs7193788 and diabetes（P = 0.036）. Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke（OR = 2.64, 95% CI： 1.58-4.40, P 〈 0.001）. Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.展开更多
Soft computing tools in the form of combination of multiple nonlinear regression and M5′ model tree were used for estimation of overtopping rate at the vertical coastal structures. For reliable and precise estimation...Soft computing tools in the form of combination of multiple nonlinear regression and M5′ model tree were used for estimation of overtopping rate at the vertical coastal structures. For reliable and precise estimation of overtopping rate, the experimental data available in the database CLASH were used. The dimensionless overtopping rate was estimated in terms of conventional dimensionless parameters including the relative crest freeboard Rc/Hs, seabed slope tanθ, deep water wave steepness S（om）, surf similarity ξ（om） and local relative water depth ht/Hs. The accuracy of the new model was compared with other existing models and also evaluated with some field measurements. The results indicated that the model presented in this paper is more accurate than other existing models. With statistical parameters, it is shown that the accuracy of predictions in the new model is better than that of other models.展开更多
With the rapid development of flexible wearable electronic devices,a multifunctional electronic skin with excellent strain sensing performance,satisfactory air permeability,and good self-powered capability for portabi...With the rapid development of flexible wearable electronic devices,a multifunctional electronic skin with excellent strain sensing performance,satisfactory air permeability,and good self-powered capability for portability is urgently desired.Herein,inspired by the“brick-and-mortar”microstructure of natural nacre,an ultra-stretchable and highly sensitive multifunctional e-skin composed of Ti_(3)C_(2)T_(x)(MXene)/Carbon nanotubes(CNTs)/thermoplastic polyurethane films is developed through electrospinning and spraying technology.Benefiting from the tunable multilayer structural design,the multifunctional e-skin synchronously demonstrates a high sensitivity(gauge factor,GF_(max)=5.8×10^(4)),wide sensing range(up to 535%strain),low detection limit(0.15%strain),fast response time(80 ms)and good durability.The sensing mechanism is developed based on the evolution of a two-dimensional(2D)MXene/1D CNTs synergistic conductive network and the expansion of the microcracked structure synchronously.The multifunctional e-skin is also assembled as a single-electrode triboelectric nanogenerator,which shows high triboelectric output and good stability,broadening the application of the multifunctional e-skin in tactile sensing.The nacre-mimetic self-powered e-skin is demonstrated for human physiological signal acquisition,cardiopulmonary resuscitation(CPR),and posture correction training,presenting fascinating application strategies for ergonomics,emergency medical services,and athlete training assessment.展开更多
基金supported by the Key Project of Natural Science Funds of China(81230066)the National Natural Science Fund Projects of China(81473043,81573226)
文摘Objective To understand the relationships between CDH13（T-cadherin） genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight（HMW） adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels（per T： Coef =-0.257, P = 0.001）. CDH13 rs7193788 was associated with total adiponectin levels（per A： Coef =-0.221, P = 0.001） and HMW adiponectin levels（per A： Coef =-0.163, P = 0.003）. rs7193788 was significantly associated with ischemic stroke（GA/AA vs. GG： OR = 1.55, 95% CI： 1.07 to 2.24, P = 0.020） after Bonferroni correction（α = 0.025）. There was an interaction between rs7193788 and diabetes（P = 0.036）. Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke（OR = 2.64, 95% CI： 1.58-4.40, P 〈 0.001）. Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.
文摘Soft computing tools in the form of combination of multiple nonlinear regression and M5′ model tree were used for estimation of overtopping rate at the vertical coastal structures. For reliable and precise estimation of overtopping rate, the experimental data available in the database CLASH were used. The dimensionless overtopping rate was estimated in terms of conventional dimensionless parameters including the relative crest freeboard Rc/Hs, seabed slope tanθ, deep water wave steepness S（om）, surf similarity ξ（om） and local relative water depth ht/Hs. The accuracy of the new model was compared with other existing models and also evaluated with some field measurements. The results indicated that the model presented in this paper is more accurate than other existing models. With statistical parameters, it is shown that the accuracy of predictions in the new model is better than that of other models.
基金supported by the National Natural Science Foundation of China(52303114,52173048)China Postdoctoral Science Foundation(2023M733199,2024T170838)。
文摘With the rapid development of flexible wearable electronic devices,a multifunctional electronic skin with excellent strain sensing performance,satisfactory air permeability,and good self-powered capability for portability is urgently desired.Herein,inspired by the“brick-and-mortar”microstructure of natural nacre,an ultra-stretchable and highly sensitive multifunctional e-skin composed of Ti_(3)C_(2)T_(x)(MXene)/Carbon nanotubes(CNTs)/thermoplastic polyurethane films is developed through electrospinning and spraying technology.Benefiting from the tunable multilayer structural design,the multifunctional e-skin synchronously demonstrates a high sensitivity(gauge factor,GF_(max)=5.8×10^(4)),wide sensing range(up to 535%strain),low detection limit(0.15%strain),fast response time(80 ms)and good durability.The sensing mechanism is developed based on the evolution of a two-dimensional(2D)MXene/1D CNTs synergistic conductive network and the expansion of the microcracked structure synchronously.The multifunctional e-skin is also assembled as a single-electrode triboelectric nanogenerator,which shows high triboelectric output and good stability,broadening the application of the multifunctional e-skin in tactile sensing.The nacre-mimetic self-powered e-skin is demonstrated for human physiological signal acquisition,cardiopulmonary resuscitation(CPR),and posture correction training,presenting fascinating application strategies for ergonomics,emergency medical services,and athlete training assessment.
