Combined with the content of the five responsible parties system, this paper probes into the core function of the owners project management and analyzes its existing problems with engineering cases. Taking phase II pr...Combined with the content of the five responsible parties system, this paper probes into the core function of the owners project management and analyzes its existing problems with engineering cases. Taking phase II project construction of Changzhou Institute of Technology as an example, this paper briefly describes the project overview, analyzes the authorization of the owners representative and the core functions of the owner and proposes that the supervision and assessment of the owner to the PM should be strengthened when the PM is introduced to achieve the balance of responsibilities and rights.展开更多
Tibetan Qula,a traditional fermented food processed from yak milk,is valued for its high nutritional content and distinctive flavor,but the vast territory of Xizang often results in quality heterogeneity.To identify t...Tibetan Qula,a traditional fermented food processed from yak milk,is valued for its high nutritional content and distinctive flavor,but the vast territory of Xizang often results in quality heterogeneity.To identify the core microorganisms with metabolic activities in Qula,we conducted a comprehensive investigation of 10 samples from 7 regions of Xizang using integrated multi-omics techniques and multivariate statistical analysis.All samples were higher in protein content(36.43-60.25%),acidity(86.72-216.52°T)and lactic acid bacteria count(3.69-6.14 logCFU/g),while lower in fat(2.40-11.35%)and moisture contents(5.84-12.02%).High-throughput sequencing showed significant differences in microbial diversity and community composition among samples,but Lactococcus,Lactobacillus,Leuconostoc,Acetobacter,Penicillium and Aspergillus were core microorganisms due to their high abundance and wide distribution.Notably,they also played an important role in maintaining community interactions,especially Acetobacter.Of the 60 volatiles detected by GC-MS,23 compounds such as hexanal,heptanal,butanoic acid,hexanoic acid and ethyl octanoate were identified as the dominant flavors.In contrast,the 62 non-volatiles obtained from metabolomics were primarily composed of carbohydrates,organic acids,fatty acids and amino acids,with lactose,lactic acid,palmitic acid and alanine being the most abundant metabolites in their respective categories.Correlation analysis indicated that core microorganisms were predominantly involved in the formation and transformation of metabolites,while Lactococcus,Rhodotorula and Trichothecium facilitated the accumulation of various flavors.This study provides a comprehensive analysis of the microbial and metabolic characteristics of Tibetan Qula,offering a scientific foundation for quality enhancement through biofortification technology.展开更多
In the present work,free vibration and buckling analyses of sandwich plates with various functionally graded foam cores are carried out.Foam cores are assumed to be made of metal,and three different configurations of ...In the present work,free vibration and buckling analyses of sandwich plates with various functionally graded foam cores are carried out.Foam cores are assumed to be made of metal,and three different configurations of the porous distribution in the core layer are taken into consideration.To carry out a comparative study between the distributions of pores in the core foam,the mass of foam in all three cases is kept the same.The vibration and buckling behaviors of skew plates are also analyzed as a part of the current investigation.The principle of minimization of potential energy and Hamilton’s principle are used for the derivation of the governing equations,while a C-0 finite element-based higher-order zigzag formulation is developed to solve the free vibration and buckling problems.The influences of gradation laws,boundary conditions,skew angle and geometry of plates are studied in detail for the dynamic and stability characteristics.It is found that both the non-dimensional natural frequency and buckling load decrease with the increase in the thickness of the metal foam cores,while they show an increasing trend as the skew angle of the plate increases.展开更多
首先分析Chirp函数在频域上的一般特性,并且分析Altrea公司提供的数控振荡器知识产权核(NCO IP core)的输入/输出特性,通过MegaCore环境确定其输入控制字,通过外围逻辑电路实时向NCO IP core调入控制频率控制字以达到改变输出频率的目的...首先分析Chirp函数在频域上的一般特性,并且分析Altrea公司提供的数控振荡器知识产权核(NCO IP core)的输入/输出特性,通过MegaCore环境确定其输入控制字,通过外围逻辑电路实时向NCO IP core调入控制频率控制字以达到改变输出频率的目的,并通过在示波器上观测FPGA的运行情况,验证了该设计具有很好的输出效果。展开更多
Carbosilane dendrimers with p-bromophenyl core were synthesized by alternating Grignard and hydrosilylation reaction. And the α-naphthalenyl was connected to the core by the Suzuki coupling reaction. A new carbosilan...Carbosilane dendrimers with p-bromophenyl core were synthesized by alternating Grignard and hydrosilylation reaction. And the α-naphthalenyl was connected to the core by the Suzuki coupling reaction. A new carbosilane dendrimer with big π-conjugated structure [4-（naphthalen-l-yl）phenyl core] was given. It shows Suzuki coupling reaction is an effective and powerful core-functionalization method and the satisfactory result can be obtained through prolonging the reaction time with the increase of the generation of dendrimer.展开更多
目的:采用复杂网络技术探讨针灸治疗卵巢功能减退类疾病的腧穴配伍规律,运用网络针灸学方法分析核心腧穴的作用机制。方法:检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普网(VIP)、中国生物医学文献服务系统(Sino ...目的:采用复杂网络技术探讨针灸治疗卵巢功能减退类疾病的腧穴配伍规律,运用网络针灸学方法分析核心腧穴的作用机制。方法:检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普网(VIP)、中国生物医学文献服务系统(Sino Med)、PubMed、EMbase、Cochrane Library、Web of Science数据库建库至2024年4月8日收录的针灸治疗卵巢功能减退类疾病的文献,对选用腧穴进行频次分析、关联规则分析及复杂网络分析,筛选出核心腧穴处方。在检索到的文献中进行核心腧穴靶点挖掘,在GeneCards数据库、Therapeutic Target数据库和Dis Ge NET数据库中挖掘卵巢功能减退类疾病靶点。利用STRING数据库对交集靶点进行蛋白互作网络构建,使用R语言进行基因本体(GO)富集分析和京都百科全书基因与基因组(KEGG)通路富集分析,通过Cytoscape软件构建针灸治疗卵巢功能减退类疾病的“核心腧穴-靶点-通路”网络图。结果:最终纳入文献133篇,共提取186条腧穴处方,包括101个腧穴。核心穴方由15个腧穴组成,挖掘得到73个腧穴靶点,涉及13个核心腧穴,包括关元、三阴交、肾俞、中脘、足三里、中极、气海、百会、太冲、太溪、次髎、子宫和归来。核心腧穴与卵巢功能减退类疾病的交集靶点有40个,其中肿瘤蛋白53、蛋白激酶Bα、白细胞介素1beta、白细胞介素6、白细胞介素10、肿瘤坏死因子、核因子kappa B亚基1是关键靶点,涉及辅助性T细胞(Th)17细胞分化、炎症性肠病、乙型肝炎、甲型流感、人类免疫缺陷病毒1感染等多条信号通路,调控细胞凋亡、炎性反应、免疫应答等生物过程。结论:针灸干预卵巢功能减退类疾病的核心腧穴通过作用于多靶点、多通路共同发挥延缓卵巢衰老作用,为腧穴处方的机制研究提供理论基础。展开更多
Commercial sterility does not guarantee the sustained stability of ultrahigh temperature(UHT)milk over 6 months shelf life.We explore the microbiota presented in normal(SZ)and quality deteriorated UHT milk(QY and WY)p...Commercial sterility does not guarantee the sustained stability of ultrahigh temperature(UHT)milk over 6 months shelf life.We explore the microbiota presented in normal(SZ)and quality deteriorated UHT milk(QY and WY)products from the same brand.Based on high-throughput sequencing research results,11 phyla and 54 genera were identified as dominant microbiota.Pseudomonas,Streptococcus,and Acinetobacter as core functional microbiota significantly influenced the UHT milk quality properties.Moreover,principal component analysis(PCA)and multivariate analyses were used to examine the quality characteristics,including 11 physicochemical parameters,10 fatty acids,and 2 enzyme activities,in normal and quality deteriorated UHT milk.We found that the abundance of Pseudomonas increased in quality deteriorated milk(WY)and showed a significant positive correlation with heat-resistant protease content.Acinetobacter in quality deteriorated milk(QY)also considerably contributed to the content of heat-resistant lipase,which resulted in spoilage deterioration of UHT milk.展开更多
Functional zoning is a critical phase in the planning of parks.Through summarizing and analyzing the functional zoning modes of different urban park types in China,as well as comparing to the functional zoning modes o...Functional zoning is a critical phase in the planning of parks.Through summarizing and analyzing the functional zoning modes of different urban park types in China,as well as comparing to the functional zoning modes of nature reserves,famous scenic areas and overseas national parks,the functional zoning modes of urban wetland parks in China were elaborated in this study,the assumption of further sectorization were put forward,and theoretical supports were sought for more scientific and operable functional zoning of urban wetland parks.展开更多
文摘Combined with the content of the five responsible parties system, this paper probes into the core function of the owners project management and analyzes its existing problems with engineering cases. Taking phase II project construction of Changzhou Institute of Technology as an example, this paper briefly describes the project overview, analyzes the authorization of the owners representative and the core functions of the owner and proposes that the supervision and assessment of the owner to the PM should be strengthened when the PM is introduced to achieve the balance of responsibilities and rights.
基金supported by Guizhou Provincial Science and Technology Projects(Qiankehe Jichu[2024]Youth 196,197)Youth Science and Technology Talent Development Project(Qianjiaoji[2024]265).
文摘Tibetan Qula,a traditional fermented food processed from yak milk,is valued for its high nutritional content and distinctive flavor,but the vast territory of Xizang often results in quality heterogeneity.To identify the core microorganisms with metabolic activities in Qula,we conducted a comprehensive investigation of 10 samples from 7 regions of Xizang using integrated multi-omics techniques and multivariate statistical analysis.All samples were higher in protein content(36.43-60.25%),acidity(86.72-216.52°T)and lactic acid bacteria count(3.69-6.14 logCFU/g),while lower in fat(2.40-11.35%)and moisture contents(5.84-12.02%).High-throughput sequencing showed significant differences in microbial diversity and community composition among samples,but Lactococcus,Lactobacillus,Leuconostoc,Acetobacter,Penicillium and Aspergillus were core microorganisms due to their high abundance and wide distribution.Notably,they also played an important role in maintaining community interactions,especially Acetobacter.Of the 60 volatiles detected by GC-MS,23 compounds such as hexanal,heptanal,butanoic acid,hexanoic acid and ethyl octanoate were identified as the dominant flavors.In contrast,the 62 non-volatiles obtained from metabolomics were primarily composed of carbohydrates,organic acids,fatty acids and amino acids,with lactose,lactic acid,palmitic acid and alanine being the most abundant metabolites in their respective categories.Correlation analysis indicated that core microorganisms were predominantly involved in the formation and transformation of metabolites,while Lactococcus,Rhodotorula and Trichothecium facilitated the accumulation of various flavors.This study provides a comprehensive analysis of the microbial and metabolic characteristics of Tibetan Qula,offering a scientific foundation for quality enhancement through biofortification technology.
基金supporting the present work through Ph.D.scholarship grant(2K17/NITK/PHD/6170004).Tanmoy Mukhopadhyay acknowledges SERB,India,for providing research support through the grant SERB/AE/2020316.
文摘In the present work,free vibration and buckling analyses of sandwich plates with various functionally graded foam cores are carried out.Foam cores are assumed to be made of metal,and three different configurations of the porous distribution in the core layer are taken into consideration.To carry out a comparative study between the distributions of pores in the core foam,the mass of foam in all three cases is kept the same.The vibration and buckling behaviors of skew plates are also analyzed as a part of the current investigation.The principle of minimization of potential energy and Hamilton’s principle are used for the derivation of the governing equations,while a C-0 finite element-based higher-order zigzag formulation is developed to solve the free vibration and buckling problems.The influences of gradation laws,boundary conditions,skew angle and geometry of plates are studied in detail for the dynamic and stability characteristics.It is found that both the non-dimensional natural frequency and buckling load decrease with the increase in the thickness of the metal foam cores,while they show an increasing trend as the skew angle of the plate increases.
文摘首先分析Chirp函数在频域上的一般特性,并且分析Altrea公司提供的数控振荡器知识产权核(NCO IP core)的输入/输出特性,通过MegaCore环境确定其输入控制字,通过外围逻辑电路实时向NCO IP core调入控制频率控制字以达到改变输出频率的目的,并通过在示波器上观测FPGA的运行情况,验证了该设计具有很好的输出效果。
文摘Carbosilane dendrimers with p-bromophenyl core were synthesized by alternating Grignard and hydrosilylation reaction. And the α-naphthalenyl was connected to the core by the Suzuki coupling reaction. A new carbosilane dendrimer with big π-conjugated structure [4-（naphthalen-l-yl）phenyl core] was given. It shows Suzuki coupling reaction is an effective and powerful core-functionalization method and the satisfactory result can be obtained through prolonging the reaction time with the increase of the generation of dendrimer.
文摘目的:采用复杂网络技术探讨针灸治疗卵巢功能减退类疾病的腧穴配伍规律,运用网络针灸学方法分析核心腧穴的作用机制。方法:检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普网(VIP)、中国生物医学文献服务系统(Sino Med)、PubMed、EMbase、Cochrane Library、Web of Science数据库建库至2024年4月8日收录的针灸治疗卵巢功能减退类疾病的文献,对选用腧穴进行频次分析、关联规则分析及复杂网络分析,筛选出核心腧穴处方。在检索到的文献中进行核心腧穴靶点挖掘,在GeneCards数据库、Therapeutic Target数据库和Dis Ge NET数据库中挖掘卵巢功能减退类疾病靶点。利用STRING数据库对交集靶点进行蛋白互作网络构建,使用R语言进行基因本体(GO)富集分析和京都百科全书基因与基因组(KEGG)通路富集分析,通过Cytoscape软件构建针灸治疗卵巢功能减退类疾病的“核心腧穴-靶点-通路”网络图。结果:最终纳入文献133篇,共提取186条腧穴处方,包括101个腧穴。核心穴方由15个腧穴组成,挖掘得到73个腧穴靶点,涉及13个核心腧穴,包括关元、三阴交、肾俞、中脘、足三里、中极、气海、百会、太冲、太溪、次髎、子宫和归来。核心腧穴与卵巢功能减退类疾病的交集靶点有40个,其中肿瘤蛋白53、蛋白激酶Bα、白细胞介素1beta、白细胞介素6、白细胞介素10、肿瘤坏死因子、核因子kappa B亚基1是关键靶点,涉及辅助性T细胞(Th)17细胞分化、炎症性肠病、乙型肝炎、甲型流感、人类免疫缺陷病毒1感染等多条信号通路,调控细胞凋亡、炎性反应、免疫应答等生物过程。结论:针灸干预卵巢功能减退类疾病的核心腧穴通过作用于多靶点、多通路共同发挥延缓卵巢衰老作用,为腧穴处方的机制研究提供理论基础。
基金supported by the National Natural Science Foundation of China(32172279,31871831)Shenyang Science and Technology Innovation Platform Project(21-103-0-14,21-104-0-28)Shenyang City Youth Science and Technology Innovation Leading Talent Project(RC200495).
文摘Commercial sterility does not guarantee the sustained stability of ultrahigh temperature(UHT)milk over 6 months shelf life.We explore the microbiota presented in normal(SZ)and quality deteriorated UHT milk(QY and WY)products from the same brand.Based on high-throughput sequencing research results,11 phyla and 54 genera were identified as dominant microbiota.Pseudomonas,Streptococcus,and Acinetobacter as core functional microbiota significantly influenced the UHT milk quality properties.Moreover,principal component analysis(PCA)and multivariate analyses were used to examine the quality characteristics,including 11 physicochemical parameters,10 fatty acids,and 2 enzyme activities,in normal and quality deteriorated UHT milk.We found that the abundance of Pseudomonas increased in quality deteriorated milk(WY)and showed a significant positive correlation with heat-resistant protease content.Acinetobacter in quality deteriorated milk(QY)also considerably contributed to the content of heat-resistant lipase,which resulted in spoilage deterioration of UHT milk.
文摘Functional zoning is a critical phase in the planning of parks.Through summarizing and analyzing the functional zoning modes of different urban park types in China,as well as comparing to the functional zoning modes of nature reserves,famous scenic areas and overseas national parks,the functional zoning modes of urban wetland parks in China were elaborated in this study,the assumption of further sectorization were put forward,and theoretical supports were sought for more scientific and operable functional zoning of urban wetland parks.
