Zr and its alloys have excellent mechanical properties as new structural material,but in specific application environment,its corrosion resistance still needs to be further explored.In this work,double glow plasma sur...Zr and its alloys have excellent mechanical properties as new structural material,but in specific application environment,its corrosion resistance still needs to be further explored.In this work,double glow plasma surface alloying technique was used for copperizing on pure Zr surface.Besides,X-ray diffraction（XRD）,scanning electron microscope（SEM） and energy dispersion spectrum（EDS） were employed to characterize the samples.Furthermore,research was also conducted on the polarization curve of the samples in different solutions.Copperizing on surface can improve corrosion resistance of pure Zr in 3.5 % Na Cl and 0.5 moláL-1Na OH solutions.Especially in 0.5 moláL-1Na OH solution,the corrosion resistance can achieve significant improvement.However,copperizing has no influence on the improvement of corrosion resistance of pure Zr in 0.5 moláL-1H2SO4 solution.The results may provide new insight into way for improving the corrosion property of zirconium alloys.展开更多
It is difficult to recover chrysocolla from sulfidation flotation which is closely related to the mineral surface composition.In this study,the effects of fluoride roasting on the surface composition of chrysocolla we...It is difficult to recover chrysocolla from sulfidation flotation which is closely related to the mineral surface composition.In this study,the effects of fluoride roasting on the surface composition of chrysocolla were investigated,its impact on sulfidation flotation was explored,and the mechanisms involved in both fluoride roasting and sulfidation flotation were discussed.With CaF_(2)as the roasting reagent,Na_(2)S·9H_(2)O as the sulfidation reagent,and sodium butyl xanthate(NaBX)as the collector,the results of the flotation experiments showed that fluoride roasting improved the floatability of chrysocolla,and the recovery rate increased from 16.87%to 82.74%.X-ray diffraction analysis revealed that after fluoride roasting,approximately all the Cu on the chrysocolla surface was exposed in the form of CuO,which could provide a basis for subsequent sulfidation flotation.The microscopy and elemental analyses revealed that large quantities of"pagoda-like"grains were observed on the sulfidation surface of the fluoride-roasted chrysocolla,indicating high crystallinity particles of copper sulfide.This suggests that the effect of sulfide formation on the chrysocolla surface was more pronounced.X-ray photoelectron spectroscopy revealed that fluoride roasting increased the relative contents of sulfur and copper on the surface and that both the Cu~+and polysulfide fractions on the surface of the minerals increased.This enhances the effect of sulfidation,which is conducive to flotation recovery.Therefore,fluoride roasting improved the effect of copper species transformation and sulfidation on the surface of chysocolla,promoted the adsorption of collectors,and improved the recovery of chrysocolla from sulfidation flotation.展开更多
Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central ne...Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central nervous system.Central copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B,Menkes disease and Wilson’s disease,respectively,and also in multifactorial neurological disorders such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple sclerosis.This review summarizes current knowledge about the role of copper in central nervous system physiology and pathology,reports about unbalances in copper levels and/or distribution under disease,describes relevant animal models for human disorders where copper metabolism genes are dysregulated,and discusses relevant therapeutic approaches modulating copper availability.Overall,alterations in copper metabolism may contribute to the etiology of central nervous system disorders and represent relevant therapeutic targets to restore tissue homeostasis.展开更多
Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations.Copper homeostasis is...Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations.Copper homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and COX17.Disruptions in copper homeostasis can lead to either the deficiency or accumulation of copper in brain tissue.Emerging evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative disorders.However,the exact mechanisms underlying these processes are not known.Copper is a potent oxidant that increases reactive oxygen species production and promotes oxidative stress.Elevated reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial dysfunction.Reactive oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory pathways.Additionally,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell death.This study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease pathogenesis.By synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of hereditary and neuronal disorders,such as Wilson's disease,Menkes'disease,Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,Huntington's disease,and multiple sclerosis.Potential clinically significant therapeutic targets,including superoxide dismutase 1,D-penicillamine,and 5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline,along with their associated therapeutic agents,are further discussed.Ultimately,we collate evidence that copper homeostasis may function in the underlying etiology of several neurodegenerative diseases and offer novel insights into the potential prevention and treatment of these diseases based on copper homeostasis.展开更多
The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays a...The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.展开更多
To address the lack of systematic studies on heavy metal fluorescent probes in typical buffer solutions,this study developed a Fe^(3+)and Cu^(2+)fluorescent probe,DHU‑NP‑4,based on a naphthalimide fluorophore.Comparat...To address the lack of systematic studies on heavy metal fluorescent probes in typical buffer solutions,this study developed a Fe^(3+)and Cu^(2+)fluorescent probe,DHU‑NP‑4,based on a naphthalimide fluorophore.Comparative analysis of the probe's performance in various buffer systems revealed that buffers with high organic content are unsuitable for evaluating such probes.Furthermore,the pH of the solvent system was found to significantly influence the probe's behavior.Under highly acidic conditions(pH≤2),DHU‑NP‑4 exhibited exceptional specificity for Fe^(3+),while in alkaline conditions,it demonstrated high specificity for Cu^(2+).Leveraging these properties,the probe enabled the quantitative detection of Fe^(3+)and Cu^(2+)in solution.展开更多
Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycli...Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycling,and reuse in different industries.Currently,a large portion of tailings are managed through the tailing storage facilities(TSF)where these tailings undergo hydro-thermal-mechanical stresses with seasonal cycles which are not comprehensively understood.This study presents an investigative study to evaluate the performance of control and cement-stabilized copper MT under the influence of seasonal cycles,freeze-thaw(F-T)and wet-dry(W-D)conditions,representing the seasonal variability in the cold and arid regions.The control and cement-stabilized MT samples were subjected to a maximum of 12 F-T and 12 W-D cycles and corresponding micro-and-macro behavior was investigated through scanning electron microscope(SEM),volumetric strain(εvT,wet density(r),moisture content loss,and unconfined compressive strength(UCS)tests.The results indicated the vulnerability of Copper MT to 67%and 75%strength loss reaching residual states with 12 F-T and 8 W-D cycles,respectively.Whereas the stabilized MT retained 39%-55%and 16%-34%strength with F-T and W-D cycles,demonstrating increased durability.This research highlights the impact of seasonal cycles and corresponding strength-deformation characteristics of control and stabilized Copper MT in cold and arid regions.展开更多
Electrolytic copper foil has gained significant attention as an essential component in lithium-ion batteries(LIBs),printed circuit boards(PCBs),and chip packaging substrates(CPSs)applications.With the advancement of L...Electrolytic copper foil has gained significant attention as an essential component in lithium-ion batteries(LIBs),printed circuit boards(PCBs),and chip packaging substrates(CPSs)applications.With the advancement of LIBs towards higher energy densities and the increasing density of electronic components on circuits,copper foil is required to have demanding properties,such as extremely thin thickness and extremely high tensile strength.This comprehensive review firstly summarizes recent progress on the fabrication of electrolytic copper foil,and the effects of process parameters,cathode substrate,and additives on the electrodeposition behavior,microstructure,and properties of copper foil are discussed in detail.Then the regulation strategies of mechanical properties of electrolytic copper foil are also summarized,including the formation of nanotwins and texture.Furthermore,the recent advances in novel electrolytic copper foils,such as composite foils and extra-thin copper foils,are also overviewed.Lastly,the remaining challenges and perspectives on the further development of electrolytic copper foils are presented.展开更多
Copper and cobalt were recovered from SICOMINES mining waste rock in the Democratic Republic of Congo.The process mineralogy of the samples was analyzed using scanning electron microscopy and energy dispersive spectro...Copper and cobalt were recovered from SICOMINES mining waste rock in the Democratic Republic of Congo.The process mineralogy of the samples was analyzed using scanning electron microscopy and energy dispersive spectroscopy.The results showed that copper minerals exhibited various forms and uneven particle sizes,while cobalt existed in the form of highly dispersed asbolane,and large amounts of easily slimed gangue minerals were filled in the samples,making it difficult to separate copper and cobalt minerals.The particle size range plays a decisive role in selecting the separation method for the copper−cobalt ore.Gravity separation was suitable for particles ranging from 43 to 246μm,while flotation was more effective for particles below 43μm.After ore grinding and particle size classification,applying a combined gravity separation(shaking table)−flotation method yielded concentrated minerals with a copper recovery of 72.83%and a cobalt recovery of 31.13%.展开更多
Exploration of stable metal single-site supported porous graphitic carbon nitride(PCN)nanostructures and the development of maximum atom utilization for enhanced photocatalytic oxidation of antibiotics remains a chall...Exploration of stable metal single-site supported porous graphitic carbon nitride(PCN)nanostructures and the development of maximum atom utilization for enhanced photocatalytic oxidation of antibiotics remains a challenge in current research.This work proposed a one-step thermal copolymerization to obtain Cu(Ⅰ)doping porous carbon nitride(CUCN)through a spontaneously reducing atmosphere by urea in a covered crucible.The obtained CUCN had crumpled ultrathin nanosheets and mesoporous structures,which possessed higher specific surface areas than PCN.From X-ray absorption near edge structure(XANES)and Fourier transform extended X-ray absorption fine structure(FT-EXAFS)spectra analysis,the Cu doping existed in the oxidation state of Cu(Ⅰ)as single atoms anchored on the 2D layers of CN through two N neighbors,thereby facilitating efficient pathways for the transfer of photoexcited charge carriers.Furthermore,the photoluminescence(PL)spectra,electrochemical impedance spectra(EIS)and transient photocurrent response test proved the improved separation and transfer of photoexcited charge carriers for Cu(Ⅰ)introduction.Consequently,the photocatalytic activity of CUCN was much better than that of PCN for antibiotics norfloxacin(NOR),with 4.7-fold higher degradation reaction rate constants.From species-trapping experiments and density function theory(DFT)calculations,the Cu single atoms in Cu-N_(2)served as catalytic sites that could accelerate charge transfer and facilitate the adsorption of molecular oxygen to produce active species.The stable Cu(Ⅰ)embedded in the layer structure led to the excellent recycling test and remained stable after four runs of degradation and even thermal regenerated treatment.The degradation paths of NOR by CUCN under visible light were also demonstrated.Our work sheds light on a sustainable and practical approach for achieving stable metal single-atom doping and enhancing photocatalytic degradation of aqueous pollutants.展开更多
Microscale metallic structures enhanced by additive manufacturing technology have attracted extensive attention especially in microelectronics and electromechanical devices.Meniscus-confined electrodeposition(MCED)adv...Microscale metallic structures enhanced by additive manufacturing technology have attracted extensive attention especially in microelectronics and electromechanical devices.Meniscus-confined electrodeposition(MCED)advances microscale 3D metal printing,enabling simpler fabrication of superior metallic microstructures in air without complex equipment or post-processing.However,accurately predicting growth rates with current MCED techniques remain challenging,which is essential for precise structure fabrication and preventing nozzle clogging.In this work,we present a novel approach to electrochemical 3D printing that utilizes a self-adjusting,voxelated method for fabricating metallic microstructures.Diverging from conventional voxelated printing which focuses on monitoring voxel thickness for structure control,this technique adopts a holistic strategy.It ensures each voxel’s position is in alignment with the final structure by synchronizing the micropipette’s trajectory during deposition with the intended design,thus facilitating self-regulation of voxel position and reducing errors associated with environmental fluctuations in deposition parameters.The method’s ability to print micropillars with various tilt angles,high density,and helical arrays demonstrates its refined control over the deposition process.Transmission electron microscopy analysis reveals that the deposited structures,which are fabricated through layer-by-layer(voxel)printing,contain nanotwins that are widely known to enhance the material’s mechanical and electrical properties.Correspondingly,in situ scanning electron microscopy(SEM)microcompression tests confirm this enhancement,showing these structures exhibit a compressive yield strength exceeding 1 GPa.The indentation tests provided an average hardness of 3.71 GPa,which is the highest value reported in previous work using MCED.The resistivity measured by the four-point probe method was(1.95±0.01)×10^(−7)Ω·m,nearly 11 times that of bulk copper.These findings demonstrate the considerable advantage of this technique in fabricating complex metallic microstructures with enhanced mechanical properties,making it suitable for advanced applications in microsensors,microelectronics,and micro-electromechanical systems.展开更多
Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific capacities.However,the inferior intrinsic conductivity and large volume variation d...Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific capacities.However,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs anode.Herein,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for SIBs.Moreover,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 cycles.This work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.展开更多
BACKGROUND Wilson's disease(WD)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and cornea.Diagnoses and treatments are challenging in settings,where advanced diagnostic tests are ...BACKGROUND Wilson's disease(WD)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and cornea.Diagnoses and treatments are challenging in settings,where advanced diagnostic tests are unavailable,copper chelating agents are frequently scarce,healthcare professionals lack disease awareness,and medical follow-ups are limited.Prompt diagnoses and treatments help prevent complications,improve patients’quality of life,and ensure a normal life expectancy.The clinical presentations and outcomes of WD can vary within a single family.CASE SUMMARY We present the cases of two siblings(19 and 27 years)from a consanguineous family in rural Ecuador,diagnosed as having WD during a family screening.The male patient,diagnosed at age 19 after his brother’s death from acute liver failure,presented with compensated cirrhosis,neurological symptoms,and bilateral Kayser-Fleischer rings.He developed progressive neurological deterioration during an irregular treatment with D-penicillamine due to medication shortages.His condition improved upon switching to trientine tetrahydrochloride,and his neurological symptoms improved over an 8-year period of follow-ups.The female patient,diagnosed at age 10,exhibited only biochemical alterations.Her treatment history was similar;however,she remained asymptomatic without disease progression over the same follow-up period.We discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes,emphasizing the need for research in these areas to optimize therapeutic strategies.CONCLUSION Our patients’medical histories show how early diagnosis and treatment can prevent disease progression;and,how suboptimal treatments impact disease outcomes.展开更多
Copper smelting is the main source of arsenic pollution in the environment,and China is the largest country for copper smelting.Taking 2022 as an example,this study analyzes the distribution and fate of arsenic across...Copper smelting is the main source of arsenic pollution in the environment,and China is the largest country for copper smelting.Taking 2022 as an example,this study analyzes the distribution and fate of arsenic across the copper mining,beneficiation,and smelting processes using a life-cycle approach,providing important insights for arsenic pollution prevention and the resource utilization of arsenic-bearing solid waste.The results show that the amount of As in waste rock,tailing and concentrate are 53483 t,86632 t,76162 t,respectively.After smelting treatment,the amount of arsenic in different types of solid waste,wastewater,waste gas and products are 76128 t,1 t,31 t and 2 t,respectively,and the proportion in arsenic sulfide slag is the highest(55%).The amount of emission to the environment is 32 t,accounting for only 0.04%of total amount.In the future,key considerations are to improve the resource utilization rate of arsenic-containing solid waste(tailing,smelting slag),especially arsenic sulfide slag,and to digest its environmental risk.展开更多
Bovine serum albumin(BSA)and glycine(Gly)dual-ligand-modified copper nanoclusters(BSA-Gly CuNCs)with high fluorescence intensity were synthesized by a one-pot strategy.Based on the competitive fluorescence quenching a...Bovine serum albumin(BSA)and glycine(Gly)dual-ligand-modified copper nanoclusters(BSA-Gly CuNCs)with high fluorescence intensity were synthesized by a one-pot strategy.Based on the competitive fluorescence quenching and dynamic quenching effects of ornidazole(ONZ)on BSA-Gly CuNCs,a simple and sensitive detection method for ONZ was successfully developed.The experimental results demonstrate that the addition of the small molecule Gly can more effectively protect CuNCs,and thus enhance its fluorescence intensity and stability.The proposed assay allowed for the detection of ONZ in a linear range of 0.28 to 52.60μmol·L^(-1)and a detection limit of 0.069μmol·L^(-1).Compared with the single-ligand-modified CuNCs,dual-ligand-modified BSA-Gly CuNCs had higher fluorescence intensity,stability,and sensing ability and were successfully applied to evaluate ONZ in actual ONZ tablets.展开更多
CuS-C50,the cathode materials for magnesium ion batteries,was synthesized by adding the surfactant cetyltrimethyl ammonium bromide(CTAB)and adjusting the percentage of ethylene glycol to 50vol%in hydrothermal synthesi...CuS-C50,the cathode materials for magnesium ion batteries,was synthesized by adding the surfactant cetyltrimethyl ammonium bromide(CTAB)and adjusting the percentage of ethylene glycol to 50vol%in hydrothermal synthesis process.Results show that CuS-C50 has the complete nanoflower structure.In aluminum chloride-pentamethylcydopentodiene/tetrahydrofuran(APC/THF)electrolyte,the CuS-C50 exhibits a high specific capacity of 331.19 mAh/g when the current density is 50 mA/g and still keeps a specific capacity of 136.92 mAh/g over 50 cycles when the current density is 200 mA/g.Results of morphology characterizations indicate that the complete nanoflower structure can provide more active sites and reduce the barriers for Mg^(2+)movement,eventually improving the charge and discharge performance of the CuS cathode materials for magnesium ion batteries.展开更多
The hot deformation behavior of electrolytic copper was investigated using a Gleeble-3500 thermal simulation testing machine at temperatures ranging from 500℃ to 800℃ and strain rates ranging from 0.01 s^(-1) to 10 ...The hot deformation behavior of electrolytic copper was investigated using a Gleeble-3500 thermal simulation testing machine at temperatures ranging from 500℃ to 800℃ and strain rates ranging from 0.01 s^(-1) to 10 s^(-1),under 70% deformation conditions.The true stress-true strain curves were analyzed and a constitutive equation was established at a strain of 0.5.Based on the dynamic material model proposed by Prasad,processing maps were developed under different strain conditions.Microstructure of compressed sample was observed by electron backscatter diffraction.The results reveal that the electrolytic copper demonstrates high sensitivity to deformation temperature and strain rate during high-temperature plastic deformation.The flow stress decreases gradually with raising the temperature and reducing the strain rate.According to the established processing map,the optimal processing conditions are determined as follows:deformation temperatures of 600-650℃ and strain rates of 5-10 s^(-1).Discontinuous dynamic recrystallization of electrolytic copper occurs during high-temperature plastic deformation,and the grains are significantly refined at low temperature and high strain rate conditions.展开更多
A trinuclear copper complex [Cu_(3)(L2)_(2)(SO_(4))_(2)(H_(2)O)_(7)]·8H_(2)O(1)(HL2=1-hydroxy-3-(pyrazin-2-yl)-N-(pyrazin-2-ylmethyl)imidazo[1,5-a]pyrazine-8-carboxamide) with a multi-substituted imidazo[1,5-a]py...A trinuclear copper complex [Cu_(3)(L2)_(2)(SO_(4))_(2)(H_(2)O)_(7)]·8H_(2)O(1)(HL2=1-hydroxy-3-(pyrazin-2-yl)-N-(pyrazin-2-ylmethyl)imidazo[1,5-a]pyrazine-8-carboxamide) with a multi-substituted imidazo[1,5-a]pyrazine scaffold was serendipitously prepared from the reaction of the pro-ligand of H_(2)L1(N,N'-bis(pyrazin-2-ylmethyl)pyrazine-2,3-dicarboxamide) with CuSO_(4)·5H_(2O) in aqueous solution at room temperature.Complex 1 was characterized by IR,single-crystal X-ray analysis,and magnetic susceptibility measurements.Single-crystal X-ray analysis reveals that the complex consists of three Cu(Ⅱ) ions,two in situ transformed L2~-ligands,two coordinated sulfates,seven coordinated water molecules,and eight uncoordinated water molecules.Magnetic susceptibility measurement indicates that there are obvious ferromagnetic coupling interactions between the adjacent Cu(Ⅱ) ions in 1.CCDC:1852713.展开更多
By using a newly developed 4-hydroxy picolinohydrazide as the ligand,Cu-catalyzed coupling of(hetero)aryl chlorides with sodium aryl sulfonates proceeded smoothly at 130℃to give a series of biarylsulfones in 53%~96%y...By using a newly developed 4-hydroxy picolinohydrazide as the ligand,Cu-catalyzed coupling of(hetero)aryl chlorides with sodium aryl sulfonates proceeded smoothly at 130℃to give a series of biarylsulfones in 53%~96%yields.This represents the first metal-catalyzed coupling reaction of(hetero)aryl chlorides with sodium aryl sulfonates.Aryl and heteroaryl chlorides bearing either electron-donating or electron-withdrawing groups were applicable for this coupling reaction.展开更多
Herein,copper nanoclusters(Cu NCs)were synthesized in aqueous solution through a chemical reduction method using polyethyleneimine as reducing agent and protective ligand,with Cu(NO_(3))_(2)as copper source.Subse-quen...Herein,copper nanoclusters(Cu NCs)were synthesized in aqueous solution through a chemical reduction method using polyethyleneimine as reducing agent and protective ligand,with Cu(NO_(3))_(2)as copper source.Subse-quently,composite fluorescent nanoparticles,chitosan-functionalized silica nanoparticles(CSNPs)-coated Cu NCs(Cu NCs/CSNPs),were synthesized via a reverse microemulsion method.Compared with Cu NCs,the composite Cu NCs/CSNPs exhibited an increased quantum yield and enhanced fluorescence sensing performance.Based on the composite Cu NCs/CSNPs,a fluorescence method for the detection of cefixime fluorescence quenching was estab-lished.The technique was simple,sensitive,and selective for detecting cefixime.The fluorescence quenching effi-ciency of Cu NCs/CSNPs was linearly related to the concentration of cefixime in the range of 3.98-38.5µmol·L^(-1)(1.81-17.46 mg·L^(-1)),with a limit of detection of 0.0455µmol·L^(-1)(20.6µg·L^(-1)).展开更多
基金financially supported by the National Basic Research Program of China (No.2013CB733000)the National Natural Science Foundation of China (Nos.51271161,51271162 and 51434008)
文摘Zr and its alloys have excellent mechanical properties as new structural material,but in specific application environment,its corrosion resistance still needs to be further explored.In this work,double glow plasma surface alloying technique was used for copperizing on pure Zr surface.Besides,X-ray diffraction（XRD）,scanning electron microscope（SEM） and energy dispersion spectrum（EDS） were employed to characterize the samples.Furthermore,research was also conducted on the polarization curve of the samples in different solutions.Copperizing on surface can improve corrosion resistance of pure Zr in 3.5 % Na Cl and 0.5 moláL-1Na OH solutions.Especially in 0.5 moláL-1Na OH solution,the corrosion resistance can achieve significant improvement.However,copperizing has no influence on the improvement of corrosion resistance of pure Zr in 0.5 moláL-1H2SO4 solution.The results may provide new insight into way for improving the corrosion property of zirconium alloys.
基金financially supported by the National Natural Science Foundation of China(No.52374259)the Open Fund of the State Key Laboratory of Mineral Processing Science and Technology,China(No.BGRIMM-KJSKL-2023-11)the Major Science and Technology Projects in Yunnan Province,China(No.202302 AF080004)。
文摘It is difficult to recover chrysocolla from sulfidation flotation which is closely related to the mineral surface composition.In this study,the effects of fluoride roasting on the surface composition of chrysocolla were investigated,its impact on sulfidation flotation was explored,and the mechanisms involved in both fluoride roasting and sulfidation flotation were discussed.With CaF_(2)as the roasting reagent,Na_(2)S·9H_(2)O as the sulfidation reagent,and sodium butyl xanthate(NaBX)as the collector,the results of the flotation experiments showed that fluoride roasting improved the floatability of chrysocolla,and the recovery rate increased from 16.87%to 82.74%.X-ray diffraction analysis revealed that after fluoride roasting,approximately all the Cu on the chrysocolla surface was exposed in the form of CuO,which could provide a basis for subsequent sulfidation flotation.The microscopy and elemental analyses revealed that large quantities of"pagoda-like"grains were observed on the sulfidation surface of the fluoride-roasted chrysocolla,indicating high crystallinity particles of copper sulfide.This suggests that the effect of sulfide formation on the chrysocolla surface was more pronounced.X-ray photoelectron spectroscopy revealed that fluoride roasting increased the relative contents of sulfur and copper on the surface and that both the Cu~+and polysulfide fractions on the surface of the minerals increased.This enhances the effect of sulfidation,which is conducive to flotation recovery.Therefore,fluoride roasting improved the effect of copper species transformation and sulfidation on the surface of chysocolla,promoted the adsorption of collectors,and improved the recovery of chrysocolla from sulfidation flotation.
文摘Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central nervous system.Central copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B,Menkes disease and Wilson’s disease,respectively,and also in multifactorial neurological disorders such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple sclerosis.This review summarizes current knowledge about the role of copper in central nervous system physiology and pathology,reports about unbalances in copper levels and/or distribution under disease,describes relevant animal models for human disorders where copper metabolism genes are dysregulated,and discusses relevant therapeutic approaches modulating copper availability.Overall,alterations in copper metabolism may contribute to the etiology of central nervous system disorders and represent relevant therapeutic targets to restore tissue homeostasis.
基金supported by the Notional Natural Science Foundation of Chino,No.82160690Colloborotive Innovation Center of Chinese Ministry of Education,No.2020-39Science and Technology Foundation of Guizhou Province,No.ZK[2021]-014(all to FZ)。
文摘Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations.Copper homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and COX17.Disruptions in copper homeostasis can lead to either the deficiency or accumulation of copper in brain tissue.Emerging evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative disorders.However,the exact mechanisms underlying these processes are not known.Copper is a potent oxidant that increases reactive oxygen species production and promotes oxidative stress.Elevated reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial dysfunction.Reactive oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory pathways.Additionally,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell death.This study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease pathogenesis.By synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of hereditary and neuronal disorders,such as Wilson's disease,Menkes'disease,Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,Huntington's disease,and multiple sclerosis.Potential clinically significant therapeutic targets,including superoxide dismutase 1,D-penicillamine,and 5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline,along with their associated therapeutic agents,are further discussed.Ultimately,we collate evidence that copper homeostasis may function in the underlying etiology of several neurodegenerative diseases and offer novel insights into the potential prevention and treatment of these diseases based on copper homeostasis.
文摘The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.
文摘To address the lack of systematic studies on heavy metal fluorescent probes in typical buffer solutions,this study developed a Fe^(3+)and Cu^(2+)fluorescent probe,DHU‑NP‑4,based on a naphthalimide fluorophore.Comparative analysis of the probe's performance in various buffer systems revealed that buffers with high organic content are unsuitable for evaluating such probes.Furthermore,the pH of the solvent system was found to significantly influence the probe's behavior.Under highly acidic conditions(pH≤2),DHU‑NP‑4 exhibited exceptional specificity for Fe^(3+),while in alkaline conditions,it demonstrated high specificity for Cu^(2+).Leveraging these properties,the probe enabled the quantitative detection of Fe^(3+)and Cu^(2+)in solution.
基金the W.M.Keck Center for Nano-Scale Imaging in the Department of Chemistry and Biochemistry at the University of Arizona(Grant No.RRID:SCR_022884),with funding from the W.M.Keck Foundation Grant.
文摘Approximately 3.44 billion tons of copper mine tailings(MT)were produced globally in 2018 with an increase of 45%from 2010.Significant efforts are being made to manage these tailings through storage facilities,recycling,and reuse in different industries.Currently,a large portion of tailings are managed through the tailing storage facilities(TSF)where these tailings undergo hydro-thermal-mechanical stresses with seasonal cycles which are not comprehensively understood.This study presents an investigative study to evaluate the performance of control and cement-stabilized copper MT under the influence of seasonal cycles,freeze-thaw(F-T)and wet-dry(W-D)conditions,representing the seasonal variability in the cold and arid regions.The control and cement-stabilized MT samples were subjected to a maximum of 12 F-T and 12 W-D cycles and corresponding micro-and-macro behavior was investigated through scanning electron microscope(SEM),volumetric strain(εvT,wet density(r),moisture content loss,and unconfined compressive strength(UCS)tests.The results indicated the vulnerability of Copper MT to 67%and 75%strength loss reaching residual states with 12 F-T and 8 W-D cycles,respectively.Whereas the stabilized MT retained 39%-55%and 16%-34%strength with F-T and W-D cycles,demonstrating increased durability.This research highlights the impact of seasonal cycles and corresponding strength-deformation characteristics of control and stabilized Copper MT in cold and arid regions.
基金supported by the National Key R&D Plan Program of China(No.2021YFB3400800)Henan Key Research and Development Program(No.231111241000)+1 种基金the Joint Fund of Henan Province Science and Technology R&D Program(No.225200810026)Zhongyuan Scholar Workstation Funded Program(No.224400510025).
文摘Electrolytic copper foil has gained significant attention as an essential component in lithium-ion batteries(LIBs),printed circuit boards(PCBs),and chip packaging substrates(CPSs)applications.With the advancement of LIBs towards higher energy densities and the increasing density of electronic components on circuits,copper foil is required to have demanding properties,such as extremely thin thickness and extremely high tensile strength.This comprehensive review firstly summarizes recent progress on the fabrication of electrolytic copper foil,and the effects of process parameters,cathode substrate,and additives on the electrodeposition behavior,microstructure,and properties of copper foil are discussed in detail.Then the regulation strategies of mechanical properties of electrolytic copper foil are also summarized,including the formation of nanotwins and texture.Furthermore,the recent advances in novel electrolytic copper foils,such as composite foils and extra-thin copper foils,are also overviewed.Lastly,the remaining challenges and perspectives on the further development of electrolytic copper foils are presented.
基金National Key Research and Development Program of China(No.2020YFC1909202)Major Science and Technology Program of Yunnan Province,China(No.202202AB080012)for financial support。
文摘Copper and cobalt were recovered from SICOMINES mining waste rock in the Democratic Republic of Congo.The process mineralogy of the samples was analyzed using scanning electron microscopy and energy dispersive spectroscopy.The results showed that copper minerals exhibited various forms and uneven particle sizes,while cobalt existed in the form of highly dispersed asbolane,and large amounts of easily slimed gangue minerals were filled in the samples,making it difficult to separate copper and cobalt minerals.The particle size range plays a decisive role in selecting the separation method for the copper−cobalt ore.Gravity separation was suitable for particles ranging from 43 to 246μm,while flotation was more effective for particles below 43μm.After ore grinding and particle size classification,applying a combined gravity separation(shaking table)−flotation method yielded concentrated minerals with a copper recovery of 72.83%and a cobalt recovery of 31.13%.
基金supported by the National Natural Science Foundation of China(Nos.52070103 and 22102102)Zhejiang Provincial Natural Science Foundation of China(Nos.LY21E090004 and LQ22B050004)+1 种基金Ningbo Public Welfare Science and Technology Program(No.2021S025)Ningbo Youth Leading Talent Project(No.2024QL038).
文摘Exploration of stable metal single-site supported porous graphitic carbon nitride(PCN)nanostructures and the development of maximum atom utilization for enhanced photocatalytic oxidation of antibiotics remains a challenge in current research.This work proposed a one-step thermal copolymerization to obtain Cu(Ⅰ)doping porous carbon nitride(CUCN)through a spontaneously reducing atmosphere by urea in a covered crucible.The obtained CUCN had crumpled ultrathin nanosheets and mesoporous structures,which possessed higher specific surface areas than PCN.From X-ray absorption near edge structure(XANES)and Fourier transform extended X-ray absorption fine structure(FT-EXAFS)spectra analysis,the Cu doping existed in the oxidation state of Cu(Ⅰ)as single atoms anchored on the 2D layers of CN through two N neighbors,thereby facilitating efficient pathways for the transfer of photoexcited charge carriers.Furthermore,the photoluminescence(PL)spectra,electrochemical impedance spectra(EIS)and transient photocurrent response test proved the improved separation and transfer of photoexcited charge carriers for Cu(Ⅰ)introduction.Consequently,the photocatalytic activity of CUCN was much better than that of PCN for antibiotics norfloxacin(NOR),with 4.7-fold higher degradation reaction rate constants.From species-trapping experiments and density function theory(DFT)calculations,the Cu single atoms in Cu-N_(2)served as catalytic sites that could accelerate charge transfer and facilitate the adsorption of molecular oxygen to produce active species.The stable Cu(Ⅰ)embedded in the layer structure led to the excellent recycling test and remained stable after four runs of degradation and even thermal regenerated treatment.The degradation paths of NOR by CUCN under visible light were also demonstrated.Our work sheds light on a sustainable and practical approach for achieving stable metal single-atom doping and enhancing photocatalytic degradation of aqueous pollutants.
基金supported in part by National Key R&D Program of China under Grant 2023YFB4705600in part by the National Natural Science Foundation of China under Grants 61925304,62127810 and 62203138+1 种基金in part by the National Postdoctoral Program for Innovative Talents under Grant BX20200107in part by the Self-Planned Task(No.SKLRS202205C)of State Key Laboratory of Robotics and System(HIT).
文摘Microscale metallic structures enhanced by additive manufacturing technology have attracted extensive attention especially in microelectronics and electromechanical devices.Meniscus-confined electrodeposition(MCED)advances microscale 3D metal printing,enabling simpler fabrication of superior metallic microstructures in air without complex equipment or post-processing.However,accurately predicting growth rates with current MCED techniques remain challenging,which is essential for precise structure fabrication and preventing nozzle clogging.In this work,we present a novel approach to electrochemical 3D printing that utilizes a self-adjusting,voxelated method for fabricating metallic microstructures.Diverging from conventional voxelated printing which focuses on monitoring voxel thickness for structure control,this technique adopts a holistic strategy.It ensures each voxel’s position is in alignment with the final structure by synchronizing the micropipette’s trajectory during deposition with the intended design,thus facilitating self-regulation of voxel position and reducing errors associated with environmental fluctuations in deposition parameters.The method’s ability to print micropillars with various tilt angles,high density,and helical arrays demonstrates its refined control over the deposition process.Transmission electron microscopy analysis reveals that the deposited structures,which are fabricated through layer-by-layer(voxel)printing,contain nanotwins that are widely known to enhance the material’s mechanical and electrical properties.Correspondingly,in situ scanning electron microscopy(SEM)microcompression tests confirm this enhancement,showing these structures exhibit a compressive yield strength exceeding 1 GPa.The indentation tests provided an average hardness of 3.71 GPa,which is the highest value reported in previous work using MCED.The resistivity measured by the four-point probe method was(1.95±0.01)×10^(−7)Ω·m,nearly 11 times that of bulk copper.These findings demonstrate the considerable advantage of this technique in fabricating complex metallic microstructures with enhanced mechanical properties,making it suitable for advanced applications in microsensors,microelectronics,and micro-electromechanical systems.
基金financially supported by the National Natural Science Foundation of China(Nos.U1904173 and 52272219)the Key Research Projects of Henan Provincial Department of Education(No.19A150043)+2 种基金the Natural Science Foundation of Henan Province(Nos.202300410330 and 222300420276)the Nanhu Scholars Program for Young Scholars of Xinyang Normal Universitythe Xinyang Normal University Analysis&Testing Center。
文摘Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific capacities.However,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs anode.Herein,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for SIBs.Moreover,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 cycles.This work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.
文摘BACKGROUND Wilson's disease(WD)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and cornea.Diagnoses and treatments are challenging in settings,where advanced diagnostic tests are unavailable,copper chelating agents are frequently scarce,healthcare professionals lack disease awareness,and medical follow-ups are limited.Prompt diagnoses and treatments help prevent complications,improve patients’quality of life,and ensure a normal life expectancy.The clinical presentations and outcomes of WD can vary within a single family.CASE SUMMARY We present the cases of two siblings(19 and 27 years)from a consanguineous family in rural Ecuador,diagnosed as having WD during a family screening.The male patient,diagnosed at age 19 after his brother’s death from acute liver failure,presented with compensated cirrhosis,neurological symptoms,and bilateral Kayser-Fleischer rings.He developed progressive neurological deterioration during an irregular treatment with D-penicillamine due to medication shortages.His condition improved upon switching to trientine tetrahydrochloride,and his neurological symptoms improved over an 8-year period of follow-ups.The female patient,diagnosed at age 10,exhibited only biochemical alterations.Her treatment history was similar;however,she remained asymptomatic without disease progression over the same follow-up period.We discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes,emphasizing the need for research in these areas to optimize therapeutic strategies.CONCLUSION Our patients’medical histories show how early diagnosis and treatment can prevent disease progression;and,how suboptimal treatments impact disease outcomes.
文摘Copper smelting is the main source of arsenic pollution in the environment,and China is the largest country for copper smelting.Taking 2022 as an example,this study analyzes the distribution and fate of arsenic across the copper mining,beneficiation,and smelting processes using a life-cycle approach,providing important insights for arsenic pollution prevention and the resource utilization of arsenic-bearing solid waste.The results show that the amount of As in waste rock,tailing and concentrate are 53483 t,86632 t,76162 t,respectively.After smelting treatment,the amount of arsenic in different types of solid waste,wastewater,waste gas and products are 76128 t,1 t,31 t and 2 t,respectively,and the proportion in arsenic sulfide slag is the highest(55%).The amount of emission to the environment is 32 t,accounting for only 0.04%of total amount.In the future,key considerations are to improve the resource utilization rate of arsenic-containing solid waste(tailing,smelting slag),especially arsenic sulfide slag,and to digest its environmental risk.
文摘Bovine serum albumin(BSA)and glycine(Gly)dual-ligand-modified copper nanoclusters(BSA-Gly CuNCs)with high fluorescence intensity were synthesized by a one-pot strategy.Based on the competitive fluorescence quenching and dynamic quenching effects of ornidazole(ONZ)on BSA-Gly CuNCs,a simple and sensitive detection method for ONZ was successfully developed.The experimental results demonstrate that the addition of the small molecule Gly can more effectively protect CuNCs,and thus enhance its fluorescence intensity and stability.The proposed assay allowed for the detection of ONZ in a linear range of 0.28 to 52.60μmol·L^(-1)and a detection limit of 0.069μmol·L^(-1).Compared with the single-ligand-modified CuNCs,dual-ligand-modified BSA-Gly CuNCs had higher fluorescence intensity,stability,and sensing ability and were successfully applied to evaluate ONZ in actual ONZ tablets.
基金National Natural Science Foundation of China(52171101)Fundamental Research Funds for the Central Universities(2024IAIS-QN009)National Key R&D Program of China(2021YFB3701100)。
文摘CuS-C50,the cathode materials for magnesium ion batteries,was synthesized by adding the surfactant cetyltrimethyl ammonium bromide(CTAB)and adjusting the percentage of ethylene glycol to 50vol%in hydrothermal synthesis process.Results show that CuS-C50 has the complete nanoflower structure.In aluminum chloride-pentamethylcydopentodiene/tetrahydrofuran(APC/THF)electrolyte,the CuS-C50 exhibits a high specific capacity of 331.19 mAh/g when the current density is 50 mA/g and still keeps a specific capacity of 136.92 mAh/g over 50 cycles when the current density is 200 mA/g.Results of morphology characterizations indicate that the complete nanoflower structure can provide more active sites and reduce the barriers for Mg^(2+)movement,eventually improving the charge and discharge performance of the CuS cathode materials for magnesium ion batteries.
基金Gansu Province Higher Education Institutions Industrial Support Program Project(2022CYZC-19)Gansu Provincial Science and Technology Major Project(22ZD6GA008)。
文摘The hot deformation behavior of electrolytic copper was investigated using a Gleeble-3500 thermal simulation testing machine at temperatures ranging from 500℃ to 800℃ and strain rates ranging from 0.01 s^(-1) to 10 s^(-1),under 70% deformation conditions.The true stress-true strain curves were analyzed and a constitutive equation was established at a strain of 0.5.Based on the dynamic material model proposed by Prasad,processing maps were developed under different strain conditions.Microstructure of compressed sample was observed by electron backscatter diffraction.The results reveal that the electrolytic copper demonstrates high sensitivity to deformation temperature and strain rate during high-temperature plastic deformation.The flow stress decreases gradually with raising the temperature and reducing the strain rate.According to the established processing map,the optimal processing conditions are determined as follows:deformation temperatures of 600-650℃ and strain rates of 5-10 s^(-1).Discontinuous dynamic recrystallization of electrolytic copper occurs during high-temperature plastic deformation,and the grains are significantly refined at low temperature and high strain rate conditions.
文摘A trinuclear copper complex [Cu_(3)(L2)_(2)(SO_(4))_(2)(H_(2)O)_(7)]·8H_(2)O(1)(HL2=1-hydroxy-3-(pyrazin-2-yl)-N-(pyrazin-2-ylmethyl)imidazo[1,5-a]pyrazine-8-carboxamide) with a multi-substituted imidazo[1,5-a]pyrazine scaffold was serendipitously prepared from the reaction of the pro-ligand of H_(2)L1(N,N'-bis(pyrazin-2-ylmethyl)pyrazine-2,3-dicarboxamide) with CuSO_(4)·5H_(2O) in aqueous solution at room temperature.Complex 1 was characterized by IR,single-crystal X-ray analysis,and magnetic susceptibility measurements.Single-crystal X-ray analysis reveals that the complex consists of three Cu(Ⅱ) ions,two in situ transformed L2~-ligands,two coordinated sulfates,seven coordinated water molecules,and eight uncoordinated water molecules.Magnetic susceptibility measurement indicates that there are obvious ferromagnetic coupling interactions between the adjacent Cu(Ⅱ) ions in 1.CCDC:1852713.
文摘By using a newly developed 4-hydroxy picolinohydrazide as the ligand,Cu-catalyzed coupling of(hetero)aryl chlorides with sodium aryl sulfonates proceeded smoothly at 130℃to give a series of biarylsulfones in 53%~96%yields.This represents the first metal-catalyzed coupling reaction of(hetero)aryl chlorides with sodium aryl sulfonates.Aryl and heteroaryl chlorides bearing either electron-donating or electron-withdrawing groups were applicable for this coupling reaction.
文摘Herein,copper nanoclusters(Cu NCs)were synthesized in aqueous solution through a chemical reduction method using polyethyleneimine as reducing agent and protective ligand,with Cu(NO_(3))_(2)as copper source.Subse-quently,composite fluorescent nanoparticles,chitosan-functionalized silica nanoparticles(CSNPs)-coated Cu NCs(Cu NCs/CSNPs),were synthesized via a reverse microemulsion method.Compared with Cu NCs,the composite Cu NCs/CSNPs exhibited an increased quantum yield and enhanced fluorescence sensing performance.Based on the composite Cu NCs/CSNPs,a fluorescence method for the detection of cefixime fluorescence quenching was estab-lished.The technique was simple,sensitive,and selective for detecting cefixime.The fluorescence quenching effi-ciency of Cu NCs/CSNPs was linearly related to the concentration of cefixime in the range of 3.98-38.5µmol·L^(-1)(1.81-17.46 mg·L^(-1)),with a limit of detection of 0.0455µmol·L^(-1)(20.6µg·L^(-1)).
