Chiral bisoxazoline(box)ligands with indene groups at C4 and C5 are highly potent in asymmetric catalysis,but face challenges in terms of cost and recyclability.To address this,we have designed polystyrene-supported b...Chiral bisoxazoline(box)ligands with indene groups at C4 and C5 are highly potent in asymmetric catalysis,but face challenges in terms of cost and recyclability.To address this,we have designed polystyrene-supported box ligands by modifying the indene moiety instead of the traditional methylene bridge.This design preserves the necessary steric environment for copper coordination,enabling high efficiency and excellent enantioselectivity as examined in photoinduced asymmetric cyanation reactions.The resulting copper complexes are robust and recyclable,maintaining performance over five cycles.This approach provides a sustainable and practical solution for asymmetric catalysis with chiral box ligands.展开更多
基金the National Natural Science Foundation of China(Nos.92256301,22371085,22271113,22471089)the National Key R&D Program of China(Nos.2023YFA1507203,2024YFA1509700)+4 种基金the Fundamental Research Funds for the Central Universities(No.CCNU24JCPT018)the Wuhan Natural Science Foundation(No.2024040801020303)the Postdoctor Project of Hubei Province under Grant Number 2024HBBHCXB039the China Postdoctoral Science Foundation(No.2024M751614)First Batch of Postdoctoral Overseas Talent Program of China for support of this research.
文摘Chiral bisoxazoline(box)ligands with indene groups at C4 and C5 are highly potent in asymmetric catalysis,but face challenges in terms of cost and recyclability.To address this,we have designed polystyrene-supported box ligands by modifying the indene moiety instead of the traditional methylene bridge.This design preserves the necessary steric environment for copper coordination,enabling high efficiency and excellent enantioselectivity as examined in photoinduced asymmetric cyanation reactions.The resulting copper complexes are robust and recyclable,maintaining performance over five cycles.This approach provides a sustainable and practical solution for asymmetric catalysis with chiral box ligands.
