The past several decades witnessed tremendous success in controlling global plastic pollution,but most of these achievements do not involve recycling the plastic waste.Herein,we propose a recycling strategy of using p...The past several decades witnessed tremendous success in controlling global plastic pollution,but most of these achievements do not involve recycling the plastic waste.Herein,we propose a recycling strategy of using polyvinyl chloride(PVC) wastes to remove copper ions(Cu_(2+)) from electroplating wastewater for microbial control during wound healing and food preservation.The PVC wastes were recovered and crosslinked by the assistance of diethylenetriamine(DETA),which offered multiple active sites to extract Cu_(2+)ions from electroplating wastewater and in situ reduce to copper nanoparticles(CuNPs) containing crystalline Cu and Cu_(2)O.The obtained composites(i.e.,PVC-DETA@CuNPs) performed excellent antibacterial efficacies(99.999%) against Escherichia coli(E.coli) by disrupting bacterial cell membranes through contact-killing action and oxidative stress.After a series of biological evaluations on wound mice,PVC-DETA@-CuNPs exhibited promising potential in resisting wound bacterial infection,accelerating the healing process,and promoting epithelial regeneration.Interestingly,PVCDETA@CuNPs film was evidenced to delay the spoilage process of strawberries and extend their shelf life by combating with food-borne pathogens.This study presents a recycling approach towards waste reuse and the development of innovative antibacterial materials for microbial control.展开更多
Waterborne pathogens pose a lifelong threat, necessitating advanced disinfection systemswith state-of-the-art materials. Laser-Induced Graphene (LIG), a 3-dimensional form ofgraphene, is a widely known electrode mater...Waterborne pathogens pose a lifelong threat, necessitating advanced disinfection systemswith state-of-the-art materials. Laser-Induced Graphene (LIG), a 3-dimensional form ofgraphene, is a widely known electrode material for its electrically-induced antimicrobialproperties. However, LIG surfaces exhibit antimicrobial properties exclusively in the presenceof electricity. In this work, copper-doped LIG (Cu-LIG) composite electrodes and filterswere developed with enhanced antimicrobial properties in single-step laser scribing. Thework emphasizes the optimization of copper doping with LIG for both electrical and nonelectrical-based disinfection. The copper doping was optimized to a minimal concentration(∼1%) just to enhance the electrochemical properties of LIG. Furthermore, the excess additionof copper was helpful towards non-electricity-based treatment without significantleaching. The prepared surfaces were tested in both electrodes and filter configuration andshowed excellent antibacterial and antiviral activity against mixed bacterial culture and amodel enteric virus, MS2 bacteriophage. On the application of 2.5 V with Cu-LIG electrodes,6-log removal of bacteria and virus was achieved. Furthermore, the membrane-based electroconductivefilters were tested in a flow-through configuration and demonstrated 6-logremoval at 2.5 V with a flux of ∼ 500 (L·m^(2))/h with both bacteria and viruses at minimumenergy expense. Additionally, reactive oxygen species scavenging and hydrogen peroxidegeneration experiments have confirmed the role of electrical effects and indirect oxidationon the inactivation mechanism. The prepared Cu-LIG composite surfaces showed potentialfor environmental remediation applications.展开更多
The synthesis and catalytic properties of copper nanoparticles（Cunps） were reported using L-ascorbic acid as reducing and capping agent in aqueous medium. The effect of different concentrations of L-ascorbic acid on...The synthesis and catalytic properties of copper nanoparticles（Cunps） were reported using L-ascorbic acid as reducing and capping agent in aqueous medium. The effect of different concentrations of L-ascorbic acid on the particle size of Cunps was investigated. The synthesized Cunps were characterized by UV-Visible spectrophotometer, scanning electron microscopy（SEM）, transmission electron microscopy（TEM） and Fourier transform infrared（FTIR） spectrophotometer. The result indicates that the size of copper nanoparticles decreases with the increase in concentration of L-ascorbic acid. L-Ascorbic acid plays an important role to protect the copper nanoparticles from oxidation and agglomeration which helps nanoparticles to get better stability for the application. The synthesized Cunps show excellent catalytic activity in the oxidation of serine（Ser） by peroxomonosulphate（PMS）. The catalytic activity of Cunps increases with the decrease in size of Cunps. The Cunps are expected to be suitable alternative and play an imperative role in the fields of catalysis and environmental remediation.展开更多
A genuine neurotic condition is experienced when some blood constituents accumulate on the wall of the artery get withdrew from the wall, again join the circulatory system and coagulation occur. Role of copper nanopar...A genuine neurotic condition is experienced when some blood constituents accumulate on the wall of the artery get withdrew from the wall, again join the circulatory system and coagulation occur. Role of copper nanoparticles and inclined magnetic field on the peristaltic flow of a nanofluid in an annular region of inclined annulus is investigated.We represent the clot model by considering the small artery as an annulus whose outer tube has a wave of sinusoidal nature and inner tube has a clot on its walls. Lubrication approach is used to simplify the problem. Close form solutions are determined for temperature and velocity profile. Impact of related parameters on pressure rise, pressure gradient,velocity and streamlines are interpreted graphically. Comparison among the pure blood and copper blood is presented and analyzed. One main finding of the considered analysis is that the inclusion of copper nanoparticles enlarges the amplitude of the velocity. Therefore, the considered study plays a dominant role in biomedical applications.展开更多
We demonstrate a passively Q-switched erbium-doped fiber laser （EDFL） using a copper nanoparticle （CuNP） thin film as the saturable absorber in a ring cavity. A stable Q-switched pulse operation is observed as the...We demonstrate a passively Q-switched erbium-doped fiber laser （EDFL） using a copper nanoparticle （CuNP） thin film as the saturable absorber in a ring cavity. A stable Q-switched pulse operation is observed as the CuNP saturable absorber （SA） is introduced in the cavity. The pulse repetition rate of the EDFL is observed to be proportional to the pump power, and is limited to 101.2kHz by the maximum pump power of 113.7mW. On the other hand, the pulse width reduces from 10.19μs to 4.28μs as the pump power is varied from 26.1 mW to 113.7mW. The findings suggest that CuNP SA could be useful as a potential saturable absorber for the development of the robust, compact, efficient and low cost Q-switched fiber laser operating at 1.5-μm region.展开更多
The multiwalled carbon nanotubes thin-film-based electrode was fabricated by electrophoretic deposition and modified with copper （Cu） nanoparticles to fabricate Cu/CNTs nanocomposite sensor for nonenzymatic glucose ...The multiwalled carbon nanotubes thin-film-based electrode was fabricated by electrophoretic deposition and modified with copper （Cu） nanoparticles to fabricate Cu/CNTs nanocomposite sensor for nonenzymatic glucose detection. The expensive glassy carbon electrode was replaced by fluorine-doped tin oxide glass containing CNTs film to confine the Cu nanoparticles growth by electrodeposition through cyclic voltammetry （CV）. The ultraviolet visible and X-ray diffraction analysis revealed the successful deposition of Cu nanoparticles on the CNTs-modified electrode. The atomic force microscopy images confirrqed the morphology of electrodeposited Cu on CNTs film as uniformly dispersed particles. The electrocatalytic activity of electrode to the glucose oxidation was investigated in alkaline medium by CV and amperometric measurements. The fabricated sensor exhibited a fast response time of less than 5 s and the sensitivity of 314 μA rnM^-1 cm^-2 with linear concentration range （0.02-3.0 mM） having detection limit 10.0 μM. Due to simple preparation of sensor, Cu/CNTs nanocomposite electrodes are a suitable candidate for reliable determination of glucose with good stability.展开更多
Copper nanoparticle is a new material widely used in biological medicine, animal husbandry and industrial areas, but its potential toxicity to human health and environment remains unclear. In order to study the hepato...Copper nanoparticle is a new material widely used in biological medicine, animal husbandry and industrial areas, but its potential toxicity to human health and environment remains unclear. In order to study the hepatotoxic mechanisms of nanoparticles copper, two-dimensional gel electrophoresis （2-DE） and matrix-assisted laser desorption/ionization time of flight mass spectrometry （MALDI/TOF MS） of proteomics technology were used to isolate and identify the differentially expressed proteins from liver, which associated with hepatotoxicity induced by copper nanoparticle in rats. In this study, we have screened 15 kinds of proteins related with hepatotoxicity, of which spot8212 was identified as Malate dehydrogenase （Mdhl）. The mRNA expression trend of Mdhl was consistent with the result of 2-DE by RT-PCR validation. Bioinformatics analysis showed that Mdhl was stable and no signal peptides, subcellular location was in endoplasmic reticulum; it contained many functional sites such as malate dehydrogenase activity signal sites 155LTRLDHNRAKSQI167; a helixes and random coils were the two main elements. Homologous analysis demonstrated high homologous of Mdhl in rats with mouse and human, and the phylogenetic tree of Mdhl was constructed. The result indicated that copper nanoparticle could regulate up the Mdhl protein expression so as to compensate the energy deficit. Energy metabolic disturbance may be a pathway for copper nanoparticle particles to exert the hepatotoxic effects in rats.展开更多
A novel method for the detection of PDGF-BB has been developed using double-strand DNA-copper nanoparticles （dsDNA-CuNPs） as fluorescent markers. This assay relies on the premise that the aptamer- based probe underg...A novel method for the detection of PDGF-BB has been developed using double-strand DNA-copper nanoparticles （dsDNA-CuNPs） as fluorescent markers. This assay relies on the premise that the aptamer- based probe undergoes a conformational change upon binding with target protein, and subsequently triggers polymerization reaction to generate dsDNA. Then, the resultant dsDNA can be used as a template for the formation of CuNPs with high fluorescence. Under the optimized conditions, the proposed assay allowed sensitive and selective detection of PDGF-BB with a detection limit of 4 nmol/L. This possibly makes it an attractive platform for the detection of a variety of biomolecules whose aptamers undergo similar conformational change.展开更多
Copper nanoparticle was synthesized in the presence of heptadecafluorononanoic acid by the conventional solution immersion method at room temperature from the copper plate, as a resource material. The bulk etching rat...Copper nanoparticle was synthesized in the presence of heptadecafluorononanoic acid by the conventional solution immersion method at room temperature from the copper plate, as a resource material. The bulk etching rate was calculated by the weight loss method. The pale green colored Cu-HDFN was characterized by Fourier transform infrared spectroscopy, UV-Visible spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy and contact angle measurements and the results are critically analyzed.展开更多
Heat-treated wood has good dimensional stability,durability,and color,but its susceptibility to fungal growth affects its commercial value.In this study,lumber harvested from mature Masson’s pine(Pinus massoniana Lam...Heat-treated wood has good dimensional stability,durability,and color,but its susceptibility to fungal growth affects its commercial value.In this study,lumber harvested from mature Masson’s pine(Pinus massoniana Lamb.)was vacuum impregnated with a basic copper salt solution(copper hydroxide,diethanolamine,and polyethylene glycol 200)prior to heat-treatment at 220℃ for 3 h.Antifungal properties,surface chemistry,crystal structure and sugar contents were tested,compared with heat treatment alone.The results showed that the samples treated by heating without copper salt treatment showed poor suppression of fungal growth,the copperimpregnated heat-treated wood suppressed(100%)the growth of Botryodiplodia theobromae Pat.,Aspergillus niger V.Tiegh.,Penicillium citrinum Thom,and Trichoderma viride Pers.The combined results of X-ray photoelectron spectroscopy,X-ray diffraction and sugars analysis suggested that fungal inhibition by the heat-treated copper-bearing Masson’s pine was mainly due to the reduction of the metal salt by PEG200 at high temperature to generate copper nanoparticles.In addition,the reduced sugar content of the treated timber,and hence the nutrient substrate for spoilage microbes,reduced in the presence of the metal salts at high-temperature.This study has demonstrated an effective method of increasing low-grade wood’s utility and commercial value.展开更多
Copper nanoparticles(CuNPs)have emerged as a promising alternative due to their unique antimicrobial properties.The synthesis of CuNPs using Asparagus racemosus,commonly known as Shatavari,offers a sustainable and env...Copper nanoparticles(CuNPs)have emerged as a promising alternative due to their unique antimicrobial properties.The synthesis of CuNPs using Asparagus racemosus,commonly known as Shatavari,offers a sustainable and environmentally friendly approach to producing nanomaterials.Moreover,the resulting CuNPs have been found to possess excellent antibacterial,and antioxidant properties,which further expands their potential applications in medicine and environmental remediation.In this article,we discussed the in vitro characterization of the CuNPs.In vitro studies revealed that CuNPs have the potential for biomedical applications and as a base nanomaterial for the construction of drug delivery and targeting vehicles.展开更多
Neurokinin-1 receptor(NK1R),a member of the G protein-coupled receptor(GPCR)family,contributes to multiple pathological processes,including pain,chronic inflammation,and cancer(Gutierrez et al.,2019;Robinson et al.,20...Neurokinin-1 receptor(NK1R),a member of the G protein-coupled receptor(GPCR)family,contributes to multiple pathological processes,including pain,chronic inflammation,and cancer(Gutierrez et al.,2019;Robinson et al.,2023).Current reports and our previous work have proven that NK1R is highly expressed in many cancer cells,such as colorectal cancer and leukemia,and that targeted blocking of NK1R can effectively inhibit tumor cell proliferation(Li XQ et al.,2013;Li JY et al.,2016;Ge et al.,2019;Shi et al.,2021).展开更多
Nanotechnology holds immense importance in the biomedical field due to its ability to revolutionize healthcare on a molecular scale.Motivated by the imperative of enhancing patient outcomes,a comprehensive numerical s...Nanotechnology holds immense importance in the biomedical field due to its ability to revolutionize healthcare on a molecular scale.Motivated by the imperative of enhancing patient outcomes,a comprehensive numerical simulation study on the dynamics of blood flow in a stenosed artery,focusing on the effects of copper and alumina nanoparticles,is conducted.The study employs a 2-dimensional Newtonian blood flow model infused with copper and alumina nanoparticles,considering the influence of a magnetic field,thermal radiation,and various flow parameters.The governing differential equations are first non-dimensionalized to facilitate analysis and subsequently solved using the 4th order collocation method,bvp4c module in MATLAB.This approach obtains velocity and temperature profiles,revealing the impact of relevant parameters crucial in the biomedical field.The findings of this study underscore the significance of understanding blood flow dynamics in stenosed arteries and the potential benefits of utilizing copper and alumina nanoparticles in treatment strategies.The incorporation of nanoparticles introduces novel avenues for enhancing therapeutic interventions,particularly in mitigating the effects of stenosis.The elucidation of velocity and temperature profiles provides valuable insights into the behavior of blood flow under different conditions,thereby informing the development of targeted biomedical applications.The arterial curvature flow parameter influences temperature profiles,with increased parameters promoting more efficient heat dissipation.The elevated values of Prandtl number and thermal radiation parameter showcase the diminished temperature profiles,indicating stronger dominance of momentum diffusion over thermal diffusion and radiative heat transfer mechanism.Sensitivity analysis of the pertinent physical parameters reveals that the Prandtl number has the most significant impact on blood flow dynamics.A statistical analysis of the present results and existing literature has also been included in the study.Overall,this research contributes to advancing our understanding of vascular health and lays the groundwork for innovative approaches in stenosis treatment and related biomedical fields.展开更多
Tamarind fruit shell powder(TFSP)with particle size of<50μm(obtained from cleaned tamarind fruit shells)was modified with in situ generated copper nanoparticles(CuNPs)by simple one step hydrothermal method.The mod...Tamarind fruit shell powder(TFSP)with particle size of<50μm(obtained from cleaned tamarind fruit shells)was modified with in situ generated copper nanoparticles(CuNPs)by simple one step hydrothermal method.The modified TFSP was characterized by scanning electron microscope(SEM),Fourier transform infrared(FT-IR)spectroscopy,X-ray diffraction(XRD),thermogravi-metric analysis(TGA)and antibacterial tests.The generated stable CuNPs on the surface of the modified TFSP were spherical in shape with an average size of 88 nm.The FT-IR spectroscopy analysis indicated the involvement of the functional groups of the TFSP in the generation and stabilization of the CuNPs.The XRD analysis indicated the presence of both CuNPs and Cu 2 O nanoparticles in the modified TFSP.The thermal analysis indicated the presence of 5.6 wt%of copper nanoparticles as calculated from the difference of residual char content between the un-modified and modified TFSP.The modified TFSP with in situ generated CuNPs exhibited obvious antibacterial activity against both the Gram negative and Gram positive bacteria and hence can be considered as low cost filler in the preparation of antibacterial polymer hybrid nanocomposites for packaging and medical applications.展开更多
Copper nanoparticles-decorated polyaniline- derived mesoporous carbon that can serve as noble metal-free electrocatalyst for the hydrazine oxidation reaction （HzOR） is synthesized via a facile synthetic route. The m...Copper nanoparticles-decorated polyaniline- derived mesoporous carbon that can serve as noble metal-free electrocatalyst for the hydrazine oxidation reaction （HzOR） is synthesized via a facile synthetic route. The material exhibits excellent electrocatalytic activity toward HzOR with low overpotential and high current density. The material also remains stable during the electrocatalytic reaction for long time. Its good electro- catalytic performance makes this material a promising alternative to conventional noble metal-based catalysts （e.g., Pt） that are commonly used in HzOR-based fuel cells.展开更多
In this paper, highly dispersive nanosized copper particles with a mean particle size of less than 6 nm are prepared by an environmentally friendly chemical reduction method. Non-toxic L-ascorbic acid acts as both red...In this paper, highly dispersive nanosized copper particles with a mean particle size of less than 6 nm are prepared by an environmentally friendly chemical reduction method. Non-toxic L-ascorbic acid acts as both reducing agent and antioxidant in ethylene glycol in the absence of any other capping agent. Transmission electron microscopy （TEM） is used to characterize the size and morphology of Cu nanoparticles. The results of UV-Vis spectroscopy （UV-Vis）, energy dispersive spectroscopy （EDS） and high resolution TEM （HRTEM） illustrate that the resultant product is pure Cu nanocrystals. The size of Cu nanoparticles is remarkably impacted by the order of reagent addition, and the investigation reveals the reaction procedure of Cu^2＋ ions and L-ascorbic acid.展开更多
The employing of organophosphorus pesticides(OPs),especially,the abusing of OPs,leads to residue accumulation,which causes immense effect to human health and environment.So,it is an urgent task to develop highly sensi...The employing of organophosphorus pesticides(OPs),especially,the abusing of OPs,leads to residue accumulation,which causes immense effect to human health and environment.So,it is an urgent task to develop highly sensitive OPs’detection platforms.A novel enzyme modulated fluorescence-on sensor for sensitive detection of omethoate was successfully constructed,using AT-rich double-stranded DNA(dsDNA)templated copper nanoparticles(CuNPs)as the fluorescent signal and covalently combined magnetic Fe_(3)O_(4)and graphene oxide(GO)as the single-stranded DNA(ssDNA)adsorbent.The assay just associates acetylcholinesterase(AChE),one strand of dsDNA,acetylcholinein(ATCh),Fe_(3)O_(4)@GO and ascorbic acid(AA)/Cu^(2+).T6-1 and T6-2 are two strands single-stranded DNA(ssDNA)with the AT-rich sequence and continuous T bases at their two ends,respectively.In the aid of Hg^(^(2+)),they can hybridize into a blunt-ended dsDNA with one AT-rich end and one T-Hg^(^(2+))-T base pairs end.Once omethoate exists,it can inhibit AChE from transducing acetylcholinein(ATCh)into thiocholine(TCh).So,no TCh can snatch Hg^(^(2+))from T-Hg^(^(2+))-T base pairs in blunt-ended T6-1/T6-2.T6-1/T6-2 still keeps its integrity in blunt-ended dsDNA configuration,and hence the subsequently added Fe_(3)O_(4)@GO cannot absorb it.The remained blunt-ended T6-1/T6-2 in supernatant can act as the template of CuNPs to produce strong luminescence.The developed detection offers a signal-on omethoate detection,which can sensitively detect omethoate in the linear range of 5-200 nmol/L with a detection limit of 2.48 nmol/L.More importantly,it can detect omethoate in food and environmental samples,demonstrating high potential in real sample detection.展开更多
Elimination of hazardous chemicals in the process of synthesis,which guarantees the safety of the nanoparticles(NPs)for therapeutic utilization,could be obtained by using the phyto-synthesis method.The present project...Elimination of hazardous chemicals in the process of synthesis,which guarantees the safety of the nanoparticles(NPs)for therapeutic utilization,could be obtained by using the phyto-synthesis method.The present project is a multidimensional survey that aimed to optimize the phyto-synthesis conditions of copper nanoparticles(Cu NPs)using the microwave and ultrasound-assisted methods and facilitate approaching the dilemma of choosing between these two methods by characterizing the final products of each method.Based on the transmission electron microscopy(TEM),the obtained NPs were sub 10 nm in both methods.The optimized NPs were achieved in 5 min using 6 mL of phytoextract at 95℃ in a microwave oven,and amplitude 100%and cycle 0.8 in an ultrasonic processor.In addition to the antibacterial property and molecular wound healing stimulation of Cu NPs,these amorphous nanoscale particles could provide desirable absorption and distribution over the wounds to be suggested as an effective transdermal drug delivery system.The ultrasound-assisted method was the most appropriate way to obtain an amorphous mixture of Cu NPs with a majority of copper oxide while the microwave-assisted method was more suitable for synthesis procedures using plant extracts with heat-sensitive and volatile components.展开更多
Molecular dynamics （MD） computer simulations have been carried out to study the structures, properties and crystal nucleation of nanoparticles with 453 Cu atoms. Structure information was analyzed from the MD simula...Molecular dynamics （MD） computer simulations have been carried out to study the structures, properties and crystal nucleation of nanoparticles with 453 Cu atoms. Structure information was analyzed from the MD simulations, while properties of nanoparticles of Cu453, such as melting point, freezing temperature, heat capacity and mo- lar volumes, have been estimated. The face center cubic （FCC） phase and icosahedron （Ih） phase were observed during the quenching process, and nucleation rates of crystallization to FCC crystal of Cu453 at temperatures of 650, 700, 750, and 800 K were analyzed. Both classical nucleation theory （CNT） and diffuse interface theory （DIT） were used to interpret our observed nucleation rates. The free energy and diffuse interface thickness between the liquid and the FCC crystal phases were estimated by the CNT and DIT respectively, and the results show that the DIT does not work properly to the system.展开更多
The selective oxidation of methane under mild conditions remains the“Holy Grail of Catalysis”.The key to activating methane and inhibiting over-oxidation of target oxygenates lies in designing active centers.Copper ...The selective oxidation of methane under mild conditions remains the“Holy Grail of Catalysis”.The key to activating methane and inhibiting over-oxidation of target oxygenates lies in designing active centers.Copper nanoparticles were loaded onto TiO_(2)nanofibers using the photo-deposition method.The resulting catalysts were found to effectively convert methane into C1 oxygenated products under mild conditions.Compared with previously reported catalysts,it delivers a superior performance of up to 2510.7 mmol·g_(Cu)^(-1)·h^(-1)productivity with a selectivity of around 100%at 80℃for 5 min.Microstructure characterizations and density functional theory(DFT)calculations indicate that TiO_(2)in the mixed phase of anatase and rutile significantly increases the Cu^(+)/CuO ratio of the supported Cu species,and this ratio is linearly related to the formation rate of oxygen-containing species.The CuI site promotes the generation of active O species from H_(2)O_(2)dissociation on Cu_(2)O(111).These active O species reduce the energy barrier for breaking the C-H bond of CH_(4),thus boosting the catalytic activity.The methane conversion mechanism was proposed as a methyl radical pathway to form CH_(3)OH and CH_(3)OOH,and then the generated CH_(3)OH is further oxidized to HOCH_(2)OOH.展开更多
基金financially supported by the National Energy R&D Center of Petroleum Refining Technology (RIPP,SINOPEC)the National Natural Science Foundation of China (Nos.22062017 and 22164015)+2 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region (Nos.2024ZD10 and 2023QN02011)the Program of Higher-Level Talents of Inner Mongolia University (No.10000-22311201/035)the Research Program of science and technology at Universities of Inner Mongolia Autonomous Region (No.NJZZ23091)
文摘The past several decades witnessed tremendous success in controlling global plastic pollution,but most of these achievements do not involve recycling the plastic waste.Herein,we propose a recycling strategy of using polyvinyl chloride(PVC) wastes to remove copper ions(Cu_(2+)) from electroplating wastewater for microbial control during wound healing and food preservation.The PVC wastes were recovered and crosslinked by the assistance of diethylenetriamine(DETA),which offered multiple active sites to extract Cu_(2+)ions from electroplating wastewater and in situ reduce to copper nanoparticles(CuNPs) containing crystalline Cu and Cu_(2)O.The obtained composites(i.e.,PVC-DETA@CuNPs) performed excellent antibacterial efficacies(99.999%) against Escherichia coli(E.coli) by disrupting bacterial cell membranes through contact-killing action and oxidative stress.After a series of biological evaluations on wound mice,PVC-DETA@-CuNPs exhibited promising potential in resisting wound bacterial infection,accelerating the healing process,and promoting epithelial regeneration.Interestingly,PVCDETA@CuNPs film was evidenced to delay the spoilage process of strawberries and extend their shelf life by combating with food-borne pathogens.This study presents a recycling approach towards waste reuse and the development of innovative antibacterial materials for microbial control.
基金supported by the DST(DST-WTIDST/TMD/EWO/WTI/DM/2021/283,DST-SYST,and DSTinspire faculty award)and Science and Engineering Research Board(SERB+1 种基金No.CRG/2019/005280)the Indian Institute of Technology Bombay(IITB)for their funding support for this work.ND and AMN acknowledge the Ministry of Education,India,for their doctoral fellowship support.We thank Prof.Suparna Mukherjee at IIT Bombay for kindly providing us with the host E.coli C3000(No.ATCC 15597).
文摘Waterborne pathogens pose a lifelong threat, necessitating advanced disinfection systemswith state-of-the-art materials. Laser-Induced Graphene (LIG), a 3-dimensional form ofgraphene, is a widely known electrode material for its electrically-induced antimicrobialproperties. However, LIG surfaces exhibit antimicrobial properties exclusively in the presenceof electricity. In this work, copper-doped LIG (Cu-LIG) composite electrodes and filterswere developed with enhanced antimicrobial properties in single-step laser scribing. Thework emphasizes the optimization of copper doping with LIG for both electrical and nonelectrical-based disinfection. The copper doping was optimized to a minimal concentration(∼1%) just to enhance the electrochemical properties of LIG. Furthermore, the excess additionof copper was helpful towards non-electricity-based treatment without significantleaching. The prepared surfaces were tested in both electrodes and filter configuration andshowed excellent antibacterial and antiviral activity against mixed bacterial culture and amodel enteric virus, MS2 bacteriophage. On the application of 2.5 V with Cu-LIG electrodes,6-log removal of bacteria and virus was achieved. Furthermore, the membrane-based electroconductivefilters were tested in a flow-through configuration and demonstrated 6-logremoval at 2.5 V with a flux of ∼ 500 (L·m^(2))/h with both bacteria and viruses at minimumenergy expense. Additionally, reactive oxygen species scavenging and hydrogen peroxidegeneration experiments have confirmed the role of electrical effects and indirect oxidationon the inactivation mechanism. The prepared Cu-LIG composite surfaces showed potentialfor environmental remediation applications.
文摘The synthesis and catalytic properties of copper nanoparticles（Cunps） were reported using L-ascorbic acid as reducing and capping agent in aqueous medium. The effect of different concentrations of L-ascorbic acid on the particle size of Cunps was investigated. The synthesized Cunps were characterized by UV-Visible spectrophotometer, scanning electron microscopy（SEM）, transmission electron microscopy（TEM） and Fourier transform infrared（FTIR） spectrophotometer. The result indicates that the size of copper nanoparticles decreases with the increase in concentration of L-ascorbic acid. L-Ascorbic acid plays an important role to protect the copper nanoparticles from oxidation and agglomeration which helps nanoparticles to get better stability for the application. The synthesized Cunps show excellent catalytic activity in the oxidation of serine（Ser） by peroxomonosulphate（PMS）. The catalytic activity of Cunps increases with the decrease in size of Cunps. The Cunps are expected to be suitable alternative and play an imperative role in the fields of catalysis and environmental remediation.
文摘A genuine neurotic condition is experienced when some blood constituents accumulate on the wall of the artery get withdrew from the wall, again join the circulatory system and coagulation occur. Role of copper nanoparticles and inclined magnetic field on the peristaltic flow of a nanofluid in an annular region of inclined annulus is investigated.We represent the clot model by considering the small artery as an annulus whose outer tube has a wave of sinusoidal nature and inner tube has a clot on its walls. Lubrication approach is used to simplify the problem. Close form solutions are determined for temperature and velocity profile. Impact of related parameters on pressure rise, pressure gradient,velocity and streamlines are interpreted graphically. Comparison among the pure blood and copper blood is presented and analyzed. One main finding of the considered analysis is that the inclusion of copper nanoparticles enlarges the amplitude of the velocity. Therefore, the considered study plays a dominant role in biomedical applications.
基金Supported by the University of Malaya under Grant Nos PG173-2015B and PG004-2016A
文摘We demonstrate a passively Q-switched erbium-doped fiber laser （EDFL） using a copper nanoparticle （CuNP） thin film as the saturable absorber in a ring cavity. A stable Q-switched pulse operation is observed as the CuNP saturable absorber （SA） is introduced in the cavity. The pulse repetition rate of the EDFL is observed to be proportional to the pump power, and is limited to 101.2kHz by the maximum pump power of 113.7mW. On the other hand, the pulse width reduces from 10.19μs to 4.28μs as the pump power is varied from 26.1 mW to 113.7mW. The findings suggest that CuNP SA could be useful as a potential saturable absorber for the development of the robust, compact, efficient and low cost Q-switched fiber laser operating at 1.5-μm region.
基金supported by the University of Engineering and Technology, Lahore, Pakistan
文摘The multiwalled carbon nanotubes thin-film-based electrode was fabricated by electrophoretic deposition and modified with copper （Cu） nanoparticles to fabricate Cu/CNTs nanocomposite sensor for nonenzymatic glucose detection. The expensive glassy carbon electrode was replaced by fluorine-doped tin oxide glass containing CNTs film to confine the Cu nanoparticles growth by electrodeposition through cyclic voltammetry （CV）. The ultraviolet visible and X-ray diffraction analysis revealed the successful deposition of Cu nanoparticles on the CNTs-modified electrode. The atomic force microscopy images confirrqed the morphology of electrodeposited Cu on CNTs film as uniformly dispersed particles. The electrocatalytic activity of electrode to the glucose oxidation was investigated in alkaline medium by CV and amperometric measurements. The fabricated sensor exhibited a fast response time of less than 5 s and the sensitivity of 314 μA rnM^-1 cm^-2 with linear concentration range （0.02-3.0 mM） having detection limit 10.0 μM. Due to simple preparation of sensor, Cu/CNTs nanocomposite electrodes are a suitable candidate for reliable determination of glucose with good stability.
基金supported by the Project of China Agriculture Research System (CARS-40-30)
文摘Copper nanoparticle is a new material widely used in biological medicine, animal husbandry and industrial areas, but its potential toxicity to human health and environment remains unclear. In order to study the hepatotoxic mechanisms of nanoparticles copper, two-dimensional gel electrophoresis （2-DE） and matrix-assisted laser desorption/ionization time of flight mass spectrometry （MALDI/TOF MS） of proteomics technology were used to isolate and identify the differentially expressed proteins from liver, which associated with hepatotoxicity induced by copper nanoparticle in rats. In this study, we have screened 15 kinds of proteins related with hepatotoxicity, of which spot8212 was identified as Malate dehydrogenase （Mdhl）. The mRNA expression trend of Mdhl was consistent with the result of 2-DE by RT-PCR validation. Bioinformatics analysis showed that Mdhl was stable and no signal peptides, subcellular location was in endoplasmic reticulum; it contained many functional sites such as malate dehydrogenase activity signal sites 155LTRLDHNRAKSQI167; a helixes and random coils were the two main elements. Homologous analysis demonstrated high homologous of Mdhl in rats with mouse and human, and the phylogenetic tree of Mdhl was constructed. The result indicated that copper nanoparticle could regulate up the Mdhl protein expression so as to compensate the energy deficit. Energy metabolic disturbance may be a pathway for copper nanoparticle particles to exert the hepatotoxic effects in rats.
基金supported by the National Natural Science Foundation of China(Nos.21190041,21190044,21175035)National Basic Research Program(No.2011CB911002)Interna-tional Science&Technology operation Program of China(No.2010DFB30300)
文摘A novel method for the detection of PDGF-BB has been developed using double-strand DNA-copper nanoparticles （dsDNA-CuNPs） as fluorescent markers. This assay relies on the premise that the aptamer- based probe undergoes a conformational change upon binding with target protein, and subsequently triggers polymerization reaction to generate dsDNA. Then, the resultant dsDNA can be used as a template for the formation of CuNPs with high fluorescence. Under the optimized conditions, the proposed assay allowed sensitive and selective detection of PDGF-BB with a detection limit of 4 nmol/L. This possibly makes it an attractive platform for the detection of a variety of biomolecules whose aptamers undergo similar conformational change.
文摘Copper nanoparticle was synthesized in the presence of heptadecafluorononanoic acid by the conventional solution immersion method at room temperature from the copper plate, as a resource material. The bulk etching rate was calculated by the weight loss method. The pale green colored Cu-HDFN was characterized by Fourier transform infrared spectroscopy, UV-Visible spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy and contact angle measurements and the results are critically analyzed.
基金This research was sponsored by the Guangdong Forestry Science and Technology Innovation Project“Research on the Thermal Modification of Eucalyptus and Spingbract Chinkapin Wood and the Key Technologies of Their Wood Flooring Preparation”(No.2018KJCX006).
文摘Heat-treated wood has good dimensional stability,durability,and color,but its susceptibility to fungal growth affects its commercial value.In this study,lumber harvested from mature Masson’s pine(Pinus massoniana Lamb.)was vacuum impregnated with a basic copper salt solution(copper hydroxide,diethanolamine,and polyethylene glycol 200)prior to heat-treatment at 220℃ for 3 h.Antifungal properties,surface chemistry,crystal structure and sugar contents were tested,compared with heat treatment alone.The results showed that the samples treated by heating without copper salt treatment showed poor suppression of fungal growth,the copperimpregnated heat-treated wood suppressed(100%)the growth of Botryodiplodia theobromae Pat.,Aspergillus niger V.Tiegh.,Penicillium citrinum Thom,and Trichoderma viride Pers.The combined results of X-ray photoelectron spectroscopy,X-ray diffraction and sugars analysis suggested that fungal inhibition by the heat-treated copper-bearing Masson’s pine was mainly due to the reduction of the metal salt by PEG200 at high temperature to generate copper nanoparticles.In addition,the reduced sugar content of the treated timber,and hence the nutrient substrate for spoilage microbes,reduced in the presence of the metal salts at high-temperature.This study has demonstrated an effective method of increasing low-grade wood’s utility and commercial value.
文摘Copper nanoparticles(CuNPs)have emerged as a promising alternative due to their unique antimicrobial properties.The synthesis of CuNPs using Asparagus racemosus,commonly known as Shatavari,offers a sustainable and environmentally friendly approach to producing nanomaterials.Moreover,the resulting CuNPs have been found to possess excellent antibacterial,and antioxidant properties,which further expands their potential applications in medicine and environmental remediation.In this article,we discussed the in vitro characterization of the CuNPs.In vitro studies revealed that CuNPs have the potential for biomedical applications and as a base nanomaterial for the construction of drug delivery and targeting vehicles.
基金supported by the National Natural Science Foundation of China(No.32201092)the Zhejiang Provincial Natural Science Foundation of China(No.LTGY24H180008).
文摘Neurokinin-1 receptor(NK1R),a member of the G protein-coupled receptor(GPCR)family,contributes to multiple pathological processes,including pain,chronic inflammation,and cancer(Gutierrez et al.,2019;Robinson et al.,2023).Current reports and our previous work have proven that NK1R is highly expressed in many cancer cells,such as colorectal cancer and leukemia,and that targeted blocking of NK1R can effectively inhibit tumor cell proliferation(Li XQ et al.,2013;Li JY et al.,2016;Ge et al.,2019;Shi et al.,2021).
基金funded by Universiti Teknikal Malaysia Melaka and Ministry of Higher Education(MoHE)Malaysia,grant number FRGS/1/2024/FTKM/F00586.
文摘Nanotechnology holds immense importance in the biomedical field due to its ability to revolutionize healthcare on a molecular scale.Motivated by the imperative of enhancing patient outcomes,a comprehensive numerical simulation study on the dynamics of blood flow in a stenosed artery,focusing on the effects of copper and alumina nanoparticles,is conducted.The study employs a 2-dimensional Newtonian blood flow model infused with copper and alumina nanoparticles,considering the influence of a magnetic field,thermal radiation,and various flow parameters.The governing differential equations are first non-dimensionalized to facilitate analysis and subsequently solved using the 4th order collocation method,bvp4c module in MATLAB.This approach obtains velocity and temperature profiles,revealing the impact of relevant parameters crucial in the biomedical field.The findings of this study underscore the significance of understanding blood flow dynamics in stenosed arteries and the potential benefits of utilizing copper and alumina nanoparticles in treatment strategies.The incorporation of nanoparticles introduces novel avenues for enhancing therapeutic interventions,particularly in mitigating the effects of stenosis.The elucidation of velocity and temperature profiles provides valuable insights into the behavior of blood flow under different conditions,thereby informing the development of targeted biomedical applications.The arterial curvature flow parameter influences temperature profiles,with increased parameters promoting more efficient heat dissipation.The elevated values of Prandtl number and thermal radiation parameter showcase the diminished temperature profiles,indicating stronger dominance of momentum diffusion over thermal diffusion and radiative heat transfer mechanism.Sensitivity analysis of the pertinent physical parameters reveals that the Prandtl number has the most significant impact on blood flow dynamics.A statistical analysis of the present results and existing literature has also been included in the study.Overall,this research contributes to advancing our understanding of vascular health and lays the groundwork for innovative approaches in stenosis treatment and related biomedical fields.
文摘Tamarind fruit shell powder(TFSP)with particle size of<50μm(obtained from cleaned tamarind fruit shells)was modified with in situ generated copper nanoparticles(CuNPs)by simple one step hydrothermal method.The modified TFSP was characterized by scanning electron microscope(SEM),Fourier transform infrared(FT-IR)spectroscopy,X-ray diffraction(XRD),thermogravi-metric analysis(TGA)and antibacterial tests.The generated stable CuNPs on the surface of the modified TFSP were spherical in shape with an average size of 88 nm.The FT-IR spectroscopy analysis indicated the involvement of the functional groups of the TFSP in the generation and stabilization of the CuNPs.The XRD analysis indicated the presence of both CuNPs and Cu 2 O nanoparticles in the modified TFSP.The thermal analysis indicated the presence of 5.6 wt%of copper nanoparticles as calculated from the difference of residual char content between the un-modified and modified TFSP.The modified TFSP with in situ generated CuNPs exhibited obvious antibacterial activity against both the Gram negative and Gram positive bacteria and hence can be considered as low cost filler in the preparation of antibacterial polymer hybrid nanocomposites for packaging and medical applications.
文摘Copper nanoparticles-decorated polyaniline- derived mesoporous carbon that can serve as noble metal-free electrocatalyst for the hydrazine oxidation reaction （HzOR） is synthesized via a facile synthetic route. The material exhibits excellent electrocatalytic activity toward HzOR with low overpotential and high current density. The material also remains stable during the electrocatalytic reaction for long time. Its good electro- catalytic performance makes this material a promising alternative to conventional noble metal-based catalysts （e.g., Pt） that are commonly used in HzOR-based fuel cells.
基金Acknowledgement This work is sponsored by the National Natural Science Foundation of China （No. 51202175） and the Natural Science Foundation of Hubei Province （No. 2011 CDB245）.
文摘In this paper, highly dispersive nanosized copper particles with a mean particle size of less than 6 nm are prepared by an environmentally friendly chemical reduction method. Non-toxic L-ascorbic acid acts as both reducing agent and antioxidant in ethylene glycol in the absence of any other capping agent. Transmission electron microscopy （TEM） is used to characterize the size and morphology of Cu nanoparticles. The results of UV-Vis spectroscopy （UV-Vis）, energy dispersive spectroscopy （EDS） and high resolution TEM （HRTEM） illustrate that the resultant product is pure Cu nanocrystals. The size of Cu nanoparticles is remarkably impacted by the order of reagent addition, and the investigation reveals the reaction procedure of Cu^2＋ ions and L-ascorbic acid.
基金funded by the National Natural Science Foundation of China (21705089)the Natural Science Foundation of Shandong Province (ZR2017MB064)the Research Foundation for Distinguished Scholars of Qingdao Agricultural University (663-1116010)
文摘The employing of organophosphorus pesticides(OPs),especially,the abusing of OPs,leads to residue accumulation,which causes immense effect to human health and environment.So,it is an urgent task to develop highly sensitive OPs’detection platforms.A novel enzyme modulated fluorescence-on sensor for sensitive detection of omethoate was successfully constructed,using AT-rich double-stranded DNA(dsDNA)templated copper nanoparticles(CuNPs)as the fluorescent signal and covalently combined magnetic Fe_(3)O_(4)and graphene oxide(GO)as the single-stranded DNA(ssDNA)adsorbent.The assay just associates acetylcholinesterase(AChE),one strand of dsDNA,acetylcholinein(ATCh),Fe_(3)O_(4)@GO and ascorbic acid(AA)/Cu^(2+).T6-1 and T6-2 are two strands single-stranded DNA(ssDNA)with the AT-rich sequence and continuous T bases at their two ends,respectively.In the aid of Hg^(^(2+)),they can hybridize into a blunt-ended dsDNA with one AT-rich end and one T-Hg^(^(2+))-T base pairs end.Once omethoate exists,it can inhibit AChE from transducing acetylcholinein(ATCh)into thiocholine(TCh).So,no TCh can snatch Hg^(^(2+))from T-Hg^(^(2+))-T base pairs in blunt-ended T6-1/T6-2.T6-1/T6-2 still keeps its integrity in blunt-ended dsDNA configuration,and hence the subsequently added Fe_(3)O_(4)@GO cannot absorb it.The remained blunt-ended T6-1/T6-2 in supernatant can act as the template of CuNPs to produce strong luminescence.The developed detection offers a signal-on omethoate detection,which can sensitively detect omethoate in the linear range of 5-200 nmol/L with a detection limit of 2.48 nmol/L.More importantly,it can detect omethoate in food and environmental samples,demonstrating high potential in real sample detection.
文摘Elimination of hazardous chemicals in the process of synthesis,which guarantees the safety of the nanoparticles(NPs)for therapeutic utilization,could be obtained by using the phyto-synthesis method.The present project is a multidimensional survey that aimed to optimize the phyto-synthesis conditions of copper nanoparticles(Cu NPs)using the microwave and ultrasound-assisted methods and facilitate approaching the dilemma of choosing between these two methods by characterizing the final products of each method.Based on the transmission electron microscopy(TEM),the obtained NPs were sub 10 nm in both methods.The optimized NPs were achieved in 5 min using 6 mL of phytoextract at 95℃ in a microwave oven,and amplitude 100%and cycle 0.8 in an ultrasonic processor.In addition to the antibacterial property and molecular wound healing stimulation of Cu NPs,these amorphous nanoscale particles could provide desirable absorption and distribution over the wounds to be suggested as an effective transdermal drug delivery system.The ultrasound-assisted method was the most appropriate way to obtain an amorphous mixture of Cu NPs with a majority of copper oxide while the microwave-assisted method was more suitable for synthesis procedures using plant extracts with heat-sensitive and volatile components.
文摘Molecular dynamics （MD） computer simulations have been carried out to study the structures, properties and crystal nucleation of nanoparticles with 453 Cu atoms. Structure information was analyzed from the MD simulations, while properties of nanoparticles of Cu453, such as melting point, freezing temperature, heat capacity and mo- lar volumes, have been estimated. The face center cubic （FCC） phase and icosahedron （Ih） phase were observed during the quenching process, and nucleation rates of crystallization to FCC crystal of Cu453 at temperatures of 650, 700, 750, and 800 K were analyzed. Both classical nucleation theory （CNT） and diffuse interface theory （DIT） were used to interpret our observed nucleation rates. The free energy and diffuse interface thickness between the liquid and the FCC crystal phases were estimated by the CNT and DIT respectively, and the results show that the DIT does not work properly to the system.
基金supported by the National Natural Science Foundation of China(Nos.92145301,91845201,22002094,22102106,22309061)the Natural Science Foundation of Jilin Province(No.YDZJ202201ZYTS360).
文摘The selective oxidation of methane under mild conditions remains the“Holy Grail of Catalysis”.The key to activating methane and inhibiting over-oxidation of target oxygenates lies in designing active centers.Copper nanoparticles were loaded onto TiO_(2)nanofibers using the photo-deposition method.The resulting catalysts were found to effectively convert methane into C1 oxygenated products under mild conditions.Compared with previously reported catalysts,it delivers a superior performance of up to 2510.7 mmol·g_(Cu)^(-1)·h^(-1)productivity with a selectivity of around 100%at 80℃for 5 min.Microstructure characterizations and density functional theory(DFT)calculations indicate that TiO_(2)in the mixed phase of anatase and rutile significantly increases the Cu^(+)/CuO ratio of the supported Cu species,and this ratio is linearly related to the formation rate of oxygen-containing species.The CuI site promotes the generation of active O species from H_(2)O_(2)dissociation on Cu_(2)O(111).These active O species reduce the energy barrier for breaking the C-H bond of CH_(4),thus boosting the catalytic activity.The methane conversion mechanism was proposed as a methyl radical pathway to form CH_(3)OH and CH_(3)OOH,and then the generated CH_(3)OH is further oxidized to HOCH_(2)OOH.
