Engineering a versatile nanoplatform integrating imaging and therapeutic functions for efficient cancer treatment remains a grand challenge.Herein,a type of metal–organic framework(MOF)-based hybrid material for fluo...Engineering a versatile nanoplatform integrating imaging and therapeutic functions for efficient cancer treatment remains a grand challenge.Herein,a type of metal–organic framework(MOF)-based hybrid material for fluorescence imaging-guided synergistic phototherapy was prepared by in situ polymerization of a pyrrole(Py)monomer in the pores of a porphyrinic MOF.The resultant material(named PPy@MOF-525@HA)has a suitable size for cellular uptake,high degree of thermal stability and efficient photothermal conversion ability(η=62.1%)upon near-infrared light irradiation,showing great potential for photothermal therapy.In addition,the porphyrinic MOF can trigger the generation of singlet oxygen(^(1)O_(2))under the irradiation of visible light giving in vitro photodynamic therapy outcomes.Simultaneously,PPy@MOF-525@HA can also act as a contrast agent for cancer cell-specific targeting and fluorescence imaging to provide accurate guidance for cancer treatment.This work provides a promising platform for fluorescence imaging-guided synergistic phototherapy.展开更多
Ultrashort laser pulses can serve as fast probes to record instant events.The isolated attosecond pulses(IAPs)generated from high-order harmonic generation(HHG)have been shortened down to about 2 atomic units in time,...Ultrashort laser pulses can serve as fast probes to record instant events.The isolated attosecond pulses(IAPs)generated from high-order harmonic generation(HHG)have been shortened down to about 2 atomic units in time,empowering us to study quantum behaviors of electrons in atoms,molecules,and solids with unprecedented time resolution.Following the cutoff energy law of HHG,the shortest IAP reported so far is driven with short-wavelength infrared(SWIR)pulses,which require additional broadband frequency conversion techniques and raise the bar for attosecond researches.Here,we show that with fewcycle near-infrared(NIR)laser pulses,IAP with pulse duration of 51±4 as is generated during 1-fs linear polarization gate formed by generalized double optical gating(GDOG)technique.The characterization is done with attosecond streak camera,and phase reconstruction is performed with quick phase retrieval by omega oscillation filtering(qPROOF).Furthermore,we show that the IAP generation favors certain carrier envelope phases(CEPs)in the narrow gate,i.e.,IAP is only efficiently produced for certain CEPs,which eliminates the requirement of CEP stabilization.The demonstrated scheme for IAP generation in principle has much higher conversion efficiency than the long-wave driver scheme according to the wavelength scaling law of HHG.Our work suggests an alternative way to generate ultrashort IAPs by applying GDOG on few-cycle free-CEP NIR driving pulses,and is thereby of great importance to facilitate the development of attosecond science and technology.展开更多
基金supported by a grant from the National Natural Science Foundation of China(22171001 and 21701160)the Doctor Startup Fund(S020118002/026)the Natural Science Foundation of Anhui Province of China(2108085MB49 and 1908085MB30).
文摘Engineering a versatile nanoplatform integrating imaging and therapeutic functions for efficient cancer treatment remains a grand challenge.Herein,a type of metal–organic framework(MOF)-based hybrid material for fluorescence imaging-guided synergistic phototherapy was prepared by in situ polymerization of a pyrrole(Py)monomer in the pores of a porphyrinic MOF.The resultant material(named PPy@MOF-525@HA)has a suitable size for cellular uptake,high degree of thermal stability and efficient photothermal conversion ability(η=62.1%)upon near-infrared light irradiation,showing great potential for photothermal therapy.In addition,the porphyrinic MOF can trigger the generation of singlet oxygen(^(1)O_(2))under the irradiation of visible light giving in vitro photodynamic therapy outcomes.Simultaneously,PPy@MOF-525@HA can also act as a contrast agent for cancer cell-specific targeting and fluorescence imaging to provide accurate guidance for cancer treatment.This work provides a promising platform for fluorescence imaging-guided synergistic phototherapy.
基金supported by the National Key Research and Development Program of China(grant no.2019YFA0307703)the Major Research Plan of the National Natural Science Foundation of China(grant no.91850201)the National Natural Science Foundation of China(grant nos.12234020 and 11974426).
文摘Ultrashort laser pulses can serve as fast probes to record instant events.The isolated attosecond pulses(IAPs)generated from high-order harmonic generation(HHG)have been shortened down to about 2 atomic units in time,empowering us to study quantum behaviors of electrons in atoms,molecules,and solids with unprecedented time resolution.Following the cutoff energy law of HHG,the shortest IAP reported so far is driven with short-wavelength infrared(SWIR)pulses,which require additional broadband frequency conversion techniques and raise the bar for attosecond researches.Here,we show that with fewcycle near-infrared(NIR)laser pulses,IAP with pulse duration of 51±4 as is generated during 1-fs linear polarization gate formed by generalized double optical gating(GDOG)technique.The characterization is done with attosecond streak camera,and phase reconstruction is performed with quick phase retrieval by omega oscillation filtering(qPROOF).Furthermore,we show that the IAP generation favors certain carrier envelope phases(CEPs)in the narrow gate,i.e.,IAP is only efficiently produced for certain CEPs,which eliminates the requirement of CEP stabilization.The demonstrated scheme for IAP generation in principle has much higher conversion efficiency than the long-wave driver scheme according to the wavelength scaling law of HHG.Our work suggests an alternative way to generate ultrashort IAPs by applying GDOG on few-cycle free-CEP NIR driving pulses,and is thereby of great importance to facilitate the development of attosecond science and technology.
