AIM To compare the outcomes of displaced distal radius fractures treated with volar locking plates and with immediate postoperative mobilisation with the outcomes of these fractures treated with modalities that necess...AIM To compare the outcomes of displaced distal radius fractures treated with volar locking plates and with immediate postoperative mobilisation with the outcomes of these fractures treated with modalities that necessitate 6 wk wrist immobilisation.METHODS A prospective,randomised controlled single-centre trial was conducted with 56 patients who had a displaced radius fracture were randomised to treatment either with a volar locking plate(n=29),or another treatment modality(n=27;cast immobilisation with or without wires or external fixator).Outcomes were measured at 12 wk.Functional outcome scores measured were the Patient-Rated Wrist Evaluation(PRWE)Score;Disabilities of the Arm,Shoulder and Hand and activities of daily living(ADLs).Clinical outcomes were wrist range of motion and grip strength.Radiographic parameters were volar inclination and ulnar variance.RESULTS Patients in the volar locking plate group had significantly better PRWE scores,ADL scores,grip strength and range of extension at three months compared with the control group.All radiological parameters were significantly better in the volar locking plate group at 3 mo.CONCLUSION The present study suggests that volar locking plates produced significantly better functional and clinical outcomes at 3 mo compared with other treatment modalities.Anatomical reduction was significantly more likely to be preserved in the plating group.Level of evidence:Ⅱ.展开更多
Background Pancreaticogastrostomy （PG） has been proposed as an alternative to pancreaticojejunostomy （PJ）, assuming that postoperative complications are less frequent. The aim of this research was to compare the s...Background Pancreaticogastrostomy （PG） has been proposed as an alternative to pancreaticojejunostomy （PJ）, assuming that postoperative complications are less frequent. The aim of this research was to compare the safety of PG with PJ reconstruction after pancreaticoduodenectomy.展开更多
China has an endemic history of leprosy for more than two thousand year. Before liberation of China in 1949. leprosy had been endemic mainly in the provinces along the coastal areas and the
Background Stroke-induced transient immune suppression is believed to contribute to post-stroke infections.Theβ-adrenergic receptor antagonist,propranolol,has been shown to prevent stroke-associated pneumonia(SAP)via...Background Stroke-induced transient immune suppression is believed to contribute to post-stroke infections.Theβ-adrenergic receptor antagonist,propranolol,has been shown to prevent stroke-associated pneumonia(SAP)via reversing post-stroke immunosuppression in preclinical studies and in retrospective analysis in stroke patients.However,whether propranolol can reduce the risk of SAP has not been tested in prospective,randomised controlled trials.Aim To describe the rationale and design of a multicentre,prospective,open-label,endpoint-blinded,randomised controlled study to evaluate the safety and efficacy of propranolol hydrochloride injection for the prevention of SAP in patients with intracerebral haemorrhage(ICH)(PROCHASE).Design In this investigator-initiated trial,we compare the safety of the standard medical treatment to standard medical treatment plus intravenous propranolol hydrochloride administration(5 mg daily on days 1–7)in patients with ICH and the efficacy of this intervention to reduce the occurrence of SAP.All patients will be followed up for 90±7 days.Study outcomes The primary efficacy outcome is SAP within 7±1 days diagnosed by the defined algorithm based on a diagnosis of SAP recommendations from the pneumonia in stroke consensus group.The primary safety outcome is defined as severe or moderate bradycardia within 7±1 days.The secondary outcome is a modified Rankin score of 0–3 at 90±7 days after randomisation.Discussion The PROCHASE trial aims to generate clinical evidence regarding the safety and efficacy of propranolol in preventing SAP in patients with ICH.展开更多
文摘AIM To compare the outcomes of displaced distal radius fractures treated with volar locking plates and with immediate postoperative mobilisation with the outcomes of these fractures treated with modalities that necessitate 6 wk wrist immobilisation.METHODS A prospective,randomised controlled single-centre trial was conducted with 56 patients who had a displaced radius fracture were randomised to treatment either with a volar locking plate(n=29),or another treatment modality(n=27;cast immobilisation with or without wires or external fixator).Outcomes were measured at 12 wk.Functional outcome scores measured were the Patient-Rated Wrist Evaluation(PRWE)Score;Disabilities of the Arm,Shoulder and Hand and activities of daily living(ADLs).Clinical outcomes were wrist range of motion and grip strength.Radiographic parameters were volar inclination and ulnar variance.RESULTS Patients in the volar locking plate group had significantly better PRWE scores,ADL scores,grip strength and range of extension at three months compared with the control group.All radiological parameters were significantly better in the volar locking plate group at 3 mo.CONCLUSION The present study suggests that volar locking plates produced significantly better functional and clinical outcomes at 3 mo compared with other treatment modalities.Anatomical reduction was significantly more likely to be preserved in the plating group.Level of evidence:Ⅱ.
文摘Background Pancreaticogastrostomy （PG） has been proposed as an alternative to pancreaticojejunostomy （PJ）, assuming that postoperative complications are less frequent. The aim of this research was to compare the safety of PG with PJ reconstruction after pancreaticoduodenectomy.
文摘China has an endemic history of leprosy for more than two thousand year. Before liberation of China in 1949. leprosy had been endemic mainly in the provinces along the coastal areas and the
文摘Background Stroke-induced transient immune suppression is believed to contribute to post-stroke infections.Theβ-adrenergic receptor antagonist,propranolol,has been shown to prevent stroke-associated pneumonia(SAP)via reversing post-stroke immunosuppression in preclinical studies and in retrospective analysis in stroke patients.However,whether propranolol can reduce the risk of SAP has not been tested in prospective,randomised controlled trials.Aim To describe the rationale and design of a multicentre,prospective,open-label,endpoint-blinded,randomised controlled study to evaluate the safety and efficacy of propranolol hydrochloride injection for the prevention of SAP in patients with intracerebral haemorrhage(ICH)(PROCHASE).Design In this investigator-initiated trial,we compare the safety of the standard medical treatment to standard medical treatment plus intravenous propranolol hydrochloride administration(5 mg daily on days 1–7)in patients with ICH and the efficacy of this intervention to reduce the occurrence of SAP.All patients will be followed up for 90±7 days.Study outcomes The primary efficacy outcome is SAP within 7±1 days diagnosed by the defined algorithm based on a diagnosis of SAP recommendations from the pneumonia in stroke consensus group.The primary safety outcome is defined as severe or moderate bradycardia within 7±1 days.The secondary outcome is a modified Rankin score of 0–3 at 90±7 days after randomisation.Discussion The PROCHASE trial aims to generate clinical evidence regarding the safety and efficacy of propranolol in preventing SAP in patients with ICH.
