Background Malnutrition is prevalent in patients with coronary disease. However, it’s unknown whether malnutrition would affect the risk of CA-AKI in patients undergoing coronary angiography(CAG). Methods We included...Background Malnutrition is prevalent in patients with coronary disease. However, it’s unknown whether malnutrition would affect the risk of CA-AKI in patients undergoing coronary angiography(CAG). Methods We included patients with documented data for calculating controlling nutritional status(CONUT) score from a prospective multicenter cohort study(REICIN study) recruiting 4271 consecutive patients undergoing CAG(with or without percutaneous coronary intervention) from January 2013 to February 2016(NCT01402232). Patients were stratified as normal group(CONUT score 0-1), mild malnutrition group(CONUT score 2-4) and severe malnutrition group(CONUT score>4). CA-AKI was defined as an increase of serum creatinine level of >0.3 mg/d L or >50% within the first 48 hours since the procedure. The association of malnutrition and the risk of CA-AKI was examined by multivariable logistics regression analysis. 3862 patients undergoing CAG(median age: 63.1 ±10.7 years, 76.7% were male) were finally included in this study. Results Overall, 1769(45.8%) patients were complicated with mild malnutrition, 386(10.0%) were with severe malnutrition and 127(3.3%) patients eventually developed CA-AKI. The patients in severe malnutrition status were older, with worse cardiorenal function and had higher CA-AKI incidence than those without malnutrition. Adjusted multivariate logistic regression analysis demonstrated that mild malnutrition was 1.76-fold(95% CI 1.07-2.95) and the severe malnutrition was 2.77-fold(95%CI 1.41-5.37) higher risk of CA-AKI(all P<0.05, respectively) compared with patients in normal nutrition status.In addition, malnutrition level was also associated with an elevated risk of follow-up all-cause mortality(Log-Rank P<0.001). Conclusion Malnutrition is prevalent and associated with increased risk of CA-AKI among patients undergoing CAG.展开更多
Background:Biological age is a reliable indicator reflecting the real physiological state and aging status of individu-als.This study was aimed at exploring the association between biological age and contrast-associat...Background:Biological age is a reliable indicator reflecting the real physiological state and aging status of individu-als.This study was aimed at exploring the association between biological age and contrast-associated acute kidney injury(CA-AKI).Methods:This retrospective study was conducted on 4078 patients with coronary artery disease(CAD)undergoing coronary angiography(CAG).Biological age was calculated according to chronological age and blood biomarkers,and the“age gap,”reflecting retardation or acceleration of biological aging,was further determined.Logistic regres-sion analysis was used to examine the association of the biological age and age gap with CA-AKI.Receiver operating characteristic(ROC)analysis and subgroup analysis were also conducted.Results:Among the 4078 patients(68.00[61.00,74.00]years,2680(65.7%)men),725 CA-AKI cases were identi-fied.Older biological age(≥79.3 vs.<79.3 years,OR[95%CI]=3.319[2.714 to 4.059])and greater age gap(≥1.12 vs.<1.12,OR[95%CI]=2.700[2.240 to 3.256])were independent risk factors for CA-AKI(both P<0.001).ROC analysis indicated that biological age(AUC=0.672)and age gap(AUC=0.672)had better predictive ability for CA-AKI than chronological age(AUC=0.583).Subgroup analysis also indicated similar findings(all P<0.001).Conclusion:Biological age was found to be an independent risk factor for CA-AKI after CAG,with better predictive value than chronological age.展开更多
基金supported by Guangdong Provincial science and technology project (2020B1111170011)Guangdong Provincial science and technology project (KJ022021049)The National Science Foundation for Young Scientists of China(grant no.82070360)
文摘Background Malnutrition is prevalent in patients with coronary disease. However, it’s unknown whether malnutrition would affect the risk of CA-AKI in patients undergoing coronary angiography(CAG). Methods We included patients with documented data for calculating controlling nutritional status(CONUT) score from a prospective multicenter cohort study(REICIN study) recruiting 4271 consecutive patients undergoing CAG(with or without percutaneous coronary intervention) from January 2013 to February 2016(NCT01402232). Patients were stratified as normal group(CONUT score 0-1), mild malnutrition group(CONUT score 2-4) and severe malnutrition group(CONUT score>4). CA-AKI was defined as an increase of serum creatinine level of >0.3 mg/d L or >50% within the first 48 hours since the procedure. The association of malnutrition and the risk of CA-AKI was examined by multivariable logistics regression analysis. 3862 patients undergoing CAG(median age: 63.1 ±10.7 years, 76.7% were male) were finally included in this study. Results Overall, 1769(45.8%) patients were complicated with mild malnutrition, 386(10.0%) were with severe malnutrition and 127(3.3%) patients eventually developed CA-AKI. The patients in severe malnutrition status were older, with worse cardiorenal function and had higher CA-AKI incidence than those without malnutrition. Adjusted multivariate logistic regression analysis demonstrated that mild malnutrition was 1.76-fold(95% CI 1.07-2.95) and the severe malnutrition was 2.77-fold(95%CI 1.41-5.37) higher risk of CA-AKI(all P<0.05, respectively) compared with patients in normal nutrition status.In addition, malnutrition level was also associated with an elevated risk of follow-up all-cause mortality(Log-Rank P<0.001). Conclusion Malnutrition is prevalent and associated with increased risk of CA-AKI among patients undergoing CAG.
基金supported by grants from the Zhejiang Provincial Health Department(2018KY460)Traditional Chinese Medicine Science and Technology Project of Zhejiang Province(2021ZB172).
文摘Background:Biological age is a reliable indicator reflecting the real physiological state and aging status of individu-als.This study was aimed at exploring the association between biological age and contrast-associated acute kidney injury(CA-AKI).Methods:This retrospective study was conducted on 4078 patients with coronary artery disease(CAD)undergoing coronary angiography(CAG).Biological age was calculated according to chronological age and blood biomarkers,and the“age gap,”reflecting retardation or acceleration of biological aging,was further determined.Logistic regres-sion analysis was used to examine the association of the biological age and age gap with CA-AKI.Receiver operating characteristic(ROC)analysis and subgroup analysis were also conducted.Results:Among the 4078 patients(68.00[61.00,74.00]years,2680(65.7%)men),725 CA-AKI cases were identi-fied.Older biological age(≥79.3 vs.<79.3 years,OR[95%CI]=3.319[2.714 to 4.059])and greater age gap(≥1.12 vs.<1.12,OR[95%CI]=2.700[2.240 to 3.256])were independent risk factors for CA-AKI(both P<0.001).ROC analysis indicated that biological age(AUC=0.672)and age gap(AUC=0.672)had better predictive ability for CA-AKI than chronological age(AUC=0.583).Subgroup analysis also indicated similar findings(all P<0.001).Conclusion:Biological age was found to be an independent risk factor for CA-AKI after CAG,with better predictive value than chronological age.
