Diabetes is highly prevalent among the elderly worldwide,with the highest number of diabetes cases in China.Yet,the management of diabetes remains unsatisfactory.Recent advances in digital health technologies have fac...Diabetes is highly prevalent among the elderly worldwide,with the highest number of diabetes cases in China.Yet,the management of diabetes remains unsatisfactory.Recent advances in digital health technologies have facilitated the establishment of smart wards for diabetes patients.There is a lack of smart wards tailored specifically for older diabetes patients who encounter unique challenges in glycemic control and diabetes management,including an increased vulnerability to hypoglycemia,the presence of multiple chronic diseases,and cognitive decline.In this review,studies on digital health technologies for diabetes in China and beyond were summarized to elucidate how the adoption of digital health technologies,such as real-time continuous glucose monitoring,sensor-augmented pump technology,and their integration with 5th generation networks,big data cloud storage,and hospital information systems,can address issues specifically related to elderly diabetes patients in hospital wards.Furthermore,the challenges and future directions for establishing and implementing smart wards for elderly diabetes patients are discussed,and these challenges may also be applicable to other countries worldwide,not just in China.Taken together,the smart wards may enhance clinical outcomes,address specific issues,and eventually improve patient-centered hospital care for elderly patients with diabetes.展开更多
Ensuring the consistent mechanical performance of three-dimensional(3D)-printed continuous fiber-reinforced composites is a significant challenge in additive manufacturing.The current reliance on manual monitoring exa...Ensuring the consistent mechanical performance of three-dimensional(3D)-printed continuous fiber-reinforced composites is a significant challenge in additive manufacturing.The current reliance on manual monitoring exacerbates this challenge by rendering the process vulnerable to environmental changes and unexpected factors,resulting in defects and inconsistent product quality,particularly in unmanned long-term operations or printing in extreme environments.To address these issues,we developed a process monitoring and closed-loop feedback control strategy for the 3D printing process.Real-time printing image data were captured and analyzed using a well-trained neural network model,and a real-time control module-enabled closed-loop feedback control of the flow rate was developed.The neural network model,which was based on image processing and artificial intelligence,enabled the recognition of flow rate values with an accuracy of 94.70%.The experimental results showed significant improvements in both the surface performance and mechanical properties of printed composites,with three to six times improvement in tensile strength and elastic modulus,demonstrating the effectiveness of the strategy.This study provides a generalized process monitoring and feedback control method for the 3D printing of continuous fiber-reinforced composites,and offers a potential solution for remote online monitoring and closed-loop adjustment in unmanned or extreme space environments.展开更多
The application of liquid core reduction(LCR)technology in thin slab continuous casting can refine the internal microstruc-tures of slabs and improve their production efficiency.To avoid crack risks caused by large de...The application of liquid core reduction(LCR)technology in thin slab continuous casting can refine the internal microstruc-tures of slabs and improve their production efficiency.To avoid crack risks caused by large deformation during the LCR process and to minimize the thickness of the slab in bending segments,the maximum theoretical reduction amount and the corresponding reduction scheme for the LCR process must be determined.With SPA-H weathering steel as a specific research steel grade,the distributions of tem-perature and deformation fields of a slab with the LCR process were analyzed using a three-dimensional thermal-mechanical finite ele-ment model.High-temperature tensile tests were designed to determine the critical strain of corner crack propagation and intermediate crack initiation with various strain rates and temperatures,and a prediction model of the critical strain for two typical cracks,combining the effects of strain rate and temperature,was proposed by incorporating the Zener-Hollomon parameter.The crack risks with different LCR schemes were calculated using the crack risk prediction model,and the maximum theoretical reduction amount for the SPA-H slab with a transverse section of 145 mm×1600 mm was 41.8 mm,with corresponding reduction amounts for Segment 0 to Segment 4 of 15.8,7.3,6.5,6.4,and 5.8 mm,respectively.展开更多
In this work,fow behavior and dynamic recrystallization(DRX)mechanism of a low carbon martensitic stainless bearing steel,CSS-42L,were investigated using a thermomechanical simulator under the temperature and strain r...In this work,fow behavior and dynamic recrystallization(DRX)mechanism of a low carbon martensitic stainless bearing steel,CSS-42L,were investigated using a thermomechanical simulator under the temperature and strain rate ranges of 900 to 1100℃ and 0.1 to 20 s^(−1),respectively.The Arrhenius-type constitutive equation was established based on the fow stress curves.Moreover,the peak stress decreased with the increase in deformation temperature and the decrease in strain rate.There were two DRX mechanisms during hot deformation of the current studied steel,the main one being discontinuous dynamic recrystallization mechanism,acting through grain boundary bulging and migration,and the auxiliary one being continuous dynamic recrystallization mechanism,working through the rotation of sub-grains.On the basis of microstructural characterizations,power dissipation maps and fow instability maps,the optimized hot deformation parameters for CSS-42L bearing steel were determined as 1050℃/0.1 s^(−1) and 1100℃/1 s^(−1).展开更多
Fiber-reinforced composites are an ideal material for the lightweight design of aerospace structures. Especially in recent years, with the rapid development of composite additive manufacturing technology, the design o...Fiber-reinforced composites are an ideal material for the lightweight design of aerospace structures. Especially in recent years, with the rapid development of composite additive manufacturing technology, the design optimization of variable stiffness of fiber-reinforced composite laminates has attracted widespread attention from scholars and industry. In these aerospace composite structures, numerous cutout panels and shells serve as access points for maintaining electrical, fuel, and hydraulic systems. The traditional fiber-reinforced composite laminate subtractive drilling manufacturing inevitably faces the problems of interlayer delamination, fiber fracture, and burr of the laminate. Continuous fiber additive manufacturing technology offers the potential for integrated design optimization and manufacturing with high structural performance. Considering the integration of design and manufacturability in continuous fiber additive manufacturing, the paper proposes linear and nonlinear filtering strategies based on the Normal Distribution Fiber Optimization (NDFO) material interpolation scheme to overcome the challenge of discrete fiber optimization results, which are difficult to apply directly to continuous fiber additive manufacturing. With minimizing structural compliance as the objective function, the proposed approach provides a strategy to achieve continuity of discrete fiber paths in the variable stiffness design optimization of composite laminates with regular and irregular holes. In the variable stiffness design optimization model, the number of candidate fiber laying angles in the NDFO material interpolation scheme is considered as design variable. The sensitivity information of structural compliance with respect to the number of candidate fiber laying angles is obtained using the analytical sensitivity analysis method. Based on the proposed variable stiffness design optimization method for complex perforated composite laminates, the numerical examples consider the variable stiffness design optimization of typical non-perforated and perforated composite laminates with circular, square, and irregular holes, and systematically discuss the number of candidate discrete fiber laying angles, discrete fiber continuous filtering strategies, and filter radius on structural compliance, continuity, and manufacturability. The optimized discrete fiber angles of variable stiffness laminates are converted into continuous fiber laying paths using a streamlined process for continuous fiber additive manufacturing. Meanwhile, the optimized non-perforated and perforated MBB beams after discrete fiber continuous treatment, are manufactured using continuous fiber co-extrusion additive manufacturing technology to verify the effectiveness of the variable stiffness fiber optimization framework proposed in this paper.展开更多
Enamel demineralization often occurs in the early stage of dental caries.Studying the microscopic mechanism of enamel demineralization is essential to prevent and treat dental caries.Terahertz(THz)technolo⁃gy,especial...Enamel demineralization often occurs in the early stage of dental caries.Studying the microscopic mechanism of enamel demineralization is essential to prevent and treat dental caries.Terahertz(THz)technolo⁃gy,especially continuous wave(CW)THz near-field scanning microscopy(THz-SNOM)with its nanoscale reso⁃lution,can be promising in biomedical imaging.In addition,compared with traditional THz time-domain spec⁃troscopy(TDS),portable solid-state source as the emission has higher power and SNR,lower cost,and can ob⁃tain more precise imaging.In this study,we employ CW THz-SNOM to further break the resolution limitations of conventional THz imaging techniques and successfully achieve the near-field imaging of demineralized enamel at the nanoscale.We keenly observe that the near-field signal of the enamel significantly lowers as demineralization deepens,mainly due to the decrease in permittivity.This new approach offers valuable insights into the micro⁃scopic processes of enamel demineralization,laying the foundation for further research and treatment.展开更多
Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This r...Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This review mainly summarized the research reports on short process forming techniques for brazing and soldering materials.Firstly,the traditional process and its shortcomings were presented.Secondly,the latest research of short process forming technologies,such as continuous casting technique,atomization powder technique,solder ball forming technique,and rapid solidification technique,was summarized,and the traditional forming performance of several brazing and soldering materials was introduced.Finally,the current restrictions and research trends of short process forming technique for brazing and solder materials were put forward,providing theoretical guidance and reference for related research and technique development in brazing and soldering field.展开更多
Plant diseases are a major threat that can severely impact the production of agriculture and forestry.This can lead to the disruption of ecosystem functions and health.With its ability to capture continuous narrow-ban...Plant diseases are a major threat that can severely impact the production of agriculture and forestry.This can lead to the disruption of ecosystem functions and health.With its ability to capture continuous narrow-band spectra,hyperspectral technology has become a crucial tool to monitor crop diseases using remote sensing.However,existing continuous wavelet analysis(CWA)methods suffer from feature redundancy issues,while the continuous wavelet projection algorithm(CWPA),an optimization approach for feature selection,has not been fully validated to monitor plant diseases.This study utilized rice bacterial leaf blight(BLB)as an example by evaluating the performance of four wavelet basis functions-Gaussian2,Mexican hat,Meyer,andMorlet-within theCWAandCWPAframeworks.Additionally,the classification models were constructed using the k-nearest neighbors(KNN),randomforest(RF),and Naïve Bayes(NB)algorithms.The results showed the following:(1)Compared to traditional CWA,CWPA significantly reduced the number of required features.Under the CWPA framework,almost all the model combinations achieved maximum classification accuracy with only one feature.In contrast,the CWA framework required three to seven features.(2)Thechoice of wavelet basis functions markedly affected the performance of themodel.Of the four functions tested,the Meyer wavelet demonstrated the best overall performance in both the CWPA and CWA frameworks.(3)Under theCWPAframework,theMeyer-KNNandMeyer-NBcombinations achieved the highest overall accuracy of 93.75%using just one feature.In contrast,under the CWA framework,the CWA-RF combination achieved comparable accuracy(93.75%)but required six features.This study verified the technical advantages of CWPA for monitoring crop diseases,identified an optimal wavelet basis function selection scheme,and provided reliable technical support to precisely monitor BLB in rice(Oryza sativa).Moreover,the proposed methodological framework offers a scalable approach for the early diagnosis and assessment of plant stress,which can contribute to improved accuracy and timeliness when plant stress is monitored.展开更多
Pediatric type 1 diabetes(T1D)is a lifelong condition requiring meticulous glucose management to prevent acute and chronic complications.Conventional management of diabetic patients does not allow for continuous monit...Pediatric type 1 diabetes(T1D)is a lifelong condition requiring meticulous glucose management to prevent acute and chronic complications.Conventional management of diabetic patients does not allow for continuous monitoring of glucose trends,and can place patients at risk for hypo-and hyperglycemia.Continuous glucose monitors(CGMs)have emerged as a mainstay for pediatric diabetic care and are continuing to advance treatment by providing real-time blood glucose(BG)data,with trend analysis aided by machine learning(ML)algorithms.These predictive analytics serve to prevent against dangerous BG variations in the perioperative environment for fasted children undergoing surgical stress.Integration of CGM data into electronic health records(EHR)is essential,as it establishes a foundation for future technologic interfaces with artificial intelligence(AI).Challenges in perioperative CGM implementation include equitable device access,protection of patient privacy and data accuracy,ensuring institution of standardized protocols,and financing the cumbersome healthcare costs associated with staff training and technology platforms.This paper advocates for implementation of CGM data into the EHR utilizing multiple facets of AI/ML algorithms.展开更多
BACKGROUND Continuous glucose monitoring(CGM)metrics,such as time in range(TIR)and glycemic risk index(GRI),have been linked to various diabetes-related complications,including diabetic foot(DF).AIM To investigate the...BACKGROUND Continuous glucose monitoring(CGM)metrics,such as time in range(TIR)and glycemic risk index(GRI),have been linked to various diabetes-related complications,including diabetic foot(DF).AIM To investigate the association between CGM-derived indicators and the risk of DF in individuals with type 2 diabetes mellitus(T2DM).METHODS A total of 591 individuals with T2DM(297 with DF and 294 without DF)were enrolled.Relevant clinical data,complications,comorbidities,hematological parameters,and 72-hour CGM data were collected.Logistic regression analysis was employed to examine the relationship between these measurements and the risk of DF.RESULTS Individuals with DF exhibited higher mean blood glucose(MBG)levels and increased proportions of time above range(TAR),TAR level 1,and TAR level 2,but lower TIR(all P<0.001).Patients with DF had significantly lower rates of achieving target ranges for TIR,TAR,and TAR level 2 than those without DF(all P<0.05).Logistic regression analysis revealed that GRI,MBG,and TAR level 1 were positively associated with DF risk,while TIR was inversely correlated(all P<0.05).Achieving TIR and TAR was inversely correlated with white blood cell count and glycated hemoglobin A1c levels(P<0.05).Additionally,achieving TAR was influenced by fasting plasma glucose,body mass index,diabetes duration,and antidiabetic medication use.CONCLUSION CGM metrics,particularly TIR and GRI,are significantly associated with the risk of DF in T2DM,emphasizing the importance of improved glucose control.展开更多
The insensitive munitions compound nitroguanidine(NQ)is used by the U.S.Army to avoid unintended explosions.However,NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aq...The insensitive munitions compound nitroguanidine(NQ)is used by the U.S.Army to avoid unintended explosions.However,NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aquatic organisms,indicating the need for effective remediation strategies.Thus,we investigated the feasibility of treating water contaminated with NQ in continuous-flow columns packed with zero-valent iron(ZVI)or iron sulfide(FeS).Initially,the impact of pH on NQ transformation by ZVI or FeS was evaluated in batch experiments.The pseudo first-order rate constant for NQ transformation(k_(1,NQ))by ZVI was 8-10 times higher at pH 3.0 compared to pH 5.5 and 7.0,whereas similar k_(1,NQ)values were obtained for FeS at pH 5.5-10.0.Based on these findings,the influent p H fed to the ZVIand Fe S-packed columns was adjusted to 3.0 and 5.5,respectively.Both reactors transformed NQ into nitrosoguanidine(Nso Q).Further transformation of Nso Q by ZVI produced aminoguanidine,guanidine,and cyanamide,whereas Nso Q transformation by Fe S produced guanidine,ammonium,and traces of urea.ZVI outperformed Fe S as a reactive material to remove NQ.The ZVI-packed column effectively removed NQ below detection even after 45 d of operation(490 pore volumes,PV).In contrast,NQ breakthrough(removal efficiency<85%)was observed after 18 d(180 PV)in the Fe S-packed column.The high NQ removal efficiency and long service life of the ZVI-packed column(>490 PV)suggest that the technology is a promising approach for NQ treatment in packed-bed reactors and in situ remediation.展开更多
Radio frequency(RF)cavities for advanced storage rings,also known as diffraction-limited storage rings,are under development.To this end,a competitive and promising approach involves normal-conducting continuous wave ...Radio frequency(RF)cavities for advanced storage rings,also known as diffraction-limited storage rings,are under development.To this end,a competitive and promising approach involves normal-conducting continuous wave technology.The design and preliminary test of a 499.654 MHz RF cavity for the Wuhan Advanced Light Source(WALS)based on specific beam parameters were conducted at the SSRF.Multi-objective evolutionary algorithms have been utilized to optimize RF properties,such as the power loss and power density,resulting in better performance in the continuous wave mode.Further improvements were made to suppress multipacting effects in the working area.To operate stably with the beam,higher-order mode dampers were applied to better address the coupling bunch instability than in previous designs,along with thermal analysis to achieve the desired RF performance.Comprehensive simulation studies demonstrated the stable operation of the RF cavity at the defined beam parameters in the WALS design.A prototype RF cavity was then developed,and the RF performance results in a low-power test showed good agreement with the design and simulation,exhibiting readiness for high-power experiments and operation.展开更多
Background:Mammalian cells possess molecular clocks,the adequate functioning of which is decisive for metabolic health.Exercise is known to modulate these clocks,potentially having distinct effects on metabolism depen...Background:Mammalian cells possess molecular clocks,the adequate functioning of which is decisive for metabolic health.Exercise is known to modulate these clocks,potentially having distinct effects on metabolism depending on the time of day.This study aimed to investigate the impact of morning vs.evening moderate-intensity aerobic exercise on glucose regulation and energy metabolism in healthy men and women.It also aimed to elucidate molecular mechanisms within skeletal muscle.Methods:Using a randomized crossover design,healthy men(n=18)and women(n=17)performed a 60-min bout of moderate-intensity aerobic exercise in the morning and evening.Glucose regulation was continuously monitored starting 24 h prior to the exercise day and continuing until 48 h post-exercise for each experimental condition.Energy expenditure and substrate oxidation were measured by indirect calorimetry during exercise and at rest before and after exercise for 30 min.Skeletal muscle biopsies were collected immediately before and after exercise to assess mitochondrial function,transcriptome,and mitochondrial proteome.Results:Results indicated similar systemic glucose,energy expenditure,and substrate oxidation during and after exercise in both sexes.Notably,transcriptional analysis,mitochondrial function,and mitochondrial proteomics revealed marked sexual dimorphism and time of day variations.Conclusion:The sexual dimorphism and time of day variations observed in the skeletal muscle in response to exercise may translate into observable systemic effects with higher exercise-intensity or chronic exercise interventions.This study provides a foundational molecular framework for precise exercise prescription in the clinical setting.展开更多
Hardenability significantly impacts the distortion of gear during heat treatment,correlated to the uniformity of solute distribution in steel matrix.The experimental analysis was conducted on the macrostructure,solute...Hardenability significantly impacts the distortion of gear during heat treatment,correlated to the uniformity of solute distribution in steel matrix.The experimental analysis was conducted on the macrostructure,solute distribution,dendrite structure,and rod hardenability of 20CrMnTiH gear steel in continuously cast blooms and hot roller rods.The evaluation approach by the standards for the hardenability of gear steel rods and the corresponding blooms was analyzed,and the inheritance mechanism from solidification segregation to hardenability fluctuation of gear steel was revealed.The results indicate that semi-macroscopic spot segregation located in the equiaxed zone exhibits larger size,higher solute enrichment,and worse solute homogeneity,leading to significant solute fluctuations in the blooms and hardenability fluctuation in the rods.By increasing the liquid steel superheat from 35 to 40℃,reducing the mold electromagnetic stirring from 300 to 100 A,and implementing the soft reduction(SR)of 7 mm at the solidification end,the equiaxed ratio of the strand decreased from 26.42%to 6.69%.Consequently,the solute fluctuation range and standard deviation decrease significantly in the transverse section,while the maximum segregation ratio,average fluctuation range,and average standard deviation of solutes C,Cr,and Mn in the spot segregation decrease at the same time.At the meanwhile,the equiaxed ratio of the rod decreased from 24.89%to 4.09%,and the structure of the hardenability detection zone was transformed from equiaxed crystals to columnar crystals.Furthermore,the solute fluctuation range and standard deviation in the transverse section decreased,while the homogeneity in spot segregation was also improved.The hardness difference of A and B surfaces at J9 and J15 positions was smaller than 2 HRC,meeting the qualification standard for hardenability.展开更多
Mediterranean forest communities are particularly diverse but at risk due to their sensitivity to global warming.Understanding the long-term vulnerability of Mediterranean vegetation to climate change is crucial for c...Mediterranean forest communities are particularly diverse but at risk due to their sensitivity to global warming.Understanding the long-term vulnerability of Mediterranean vegetation to climate change is crucial for conservation and management purposes.Studies on past changes of forest communities in response to climate change at ecologically meaningful resolutions(i.e.,decadal time scales) are therefore essential,but still very rare.The Holocene thermal maximum(HTM;ca.10,000-5,000 cal years before the present(BP)) may be used to study species and community responses to warmer conditions than during recent decades.We performed highresolution multiproxy palaeoecological analyses on sediments from crater Lake Mezzano in central Italy to reconstruct vegetation,diversity,and fire dynamics between 8,450 and 7,050 cal years BP.Ordination,crosscorrelation,and species-response analyses were used to investigate the response of Mediterranean forest communities to HTM climate warming,human impact,and fire.Vegetational changes prior to 7,450 cal years BP were driven by climate.Fagus sylvatica spread into mixed deciduous oak forests during the Early Holocene in response to declining seasonality(cooler summers and warmer winters).Subsequently,Fagus sylvatica declined and evergreen Quercus ilex expanded after 8,200 cal years BP when the climate became warmer.Although reduced,Fagus sylvatica remained important together with deciduous oaks.The co-existence of Fagus sylvatica and evergreen Quercus forests is extremely rare today.Human impact significantly affected forest vegetation after7,450 cal years BP,when Neolithic agricultural activities became important,ultimately extirpating these special communities but fostering the overall biodiversity.However,their past occurrence in several central Italian calderas during the HTM suggests that these environments provided habitats that permitted the thriving of cooltemperate forests of Fagus sylvatica under mesomediterranean conditions,with summers ca.1-2℃ warmer than today.Cool and moist calderas may thus become increasingly important for maintaining Mediterranean mesophilous forest species under global warming conditions.展开更多
Wattwil,Switzerland,April l,2025-The art of re-orientation runs through Heberlein's l90-year companyhistory.Georg Philipp Heberlein and his descendants ranan exemplary family business with roots in yarn dyeing.Itd...Wattwil,Switzerland,April l,2025-The art of re-orientation runs through Heberlein's l90-year companyhistory.Georg Philipp Heberlein and his descendants ranan exemplary family business with roots in yarn dyeing.Itdeveloped into a corporate group and ultimately became ahighly spectalised company that is regarded as the world'sleading provider of air interlacing and air texturing jets forsynthetic continuous filament yarns.展开更多
Benefiting from the widespread potential applications in the era of the Internet of Thing and metaverse,triboelectric and piezoelectric nanogenerators(TENG&PENG)have attracted considerably increasing attention.The...Benefiting from the widespread potential applications in the era of the Internet of Thing and metaverse,triboelectric and piezoelectric nanogenerators(TENG&PENG)have attracted considerably increasing attention.Their outstanding characteristics,such as self-powered ability,high output performance,integration compatibility,cost-effectiveness,simple configurations,and versatile operation modes,could effectively expand the lifetime of vastly distributed wearable,implantable,and environmental devices,eventually achieving self-sustainable,maintenance-free,and reliable systems.However,current triboelectric/piezoelectric based active(i.e.self-powered)sensors still encounter serious bottlenecks in continuous monitoring and multimodal applications due to their intrinsic limitations of monomodal kinetic response and discontinuous transient output.This work systematically summarizes and evaluates the recent research endeavors to address the above challenges,with detailed discussions on the challenge origins,designing strategies,device performance,and corresponding diverse applications.Finally,conclusions and outlook regarding the research gap in self-powered continuous multimodal monitoring systems are provided,proposing the necessity of future research development in this field.展开更多
Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuo...Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuous light exposure.This study aimed to investigate the morphological and functional alterations in BAT under continuous light conditions and to identify traditional Chinese medicine compounds capable of reversing these changes.Methods:A metabolic disorder model was established by subjecting mice to continuous light exposure for 5 weeks.During this period,body weight,food intake,and body fat percentage were monitored.Serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were measured to assess lipid metabolism.Histological changes in BAT were examined using H&E staining.The expression of the thermogenic marker uncoupling protein 1(UCP1)in BAT was determined by RT-qPCR and Western blot to evaluate thermogenic function.RNA sequencing(RNA-seq)was employed to identify differentially expressed genes(DEGs)involved in BAT whitening induced by prolonged continuous light exposure.DEGs were analyzed using the connectivity map(CMap)database to identify potential preventive and therapeutic compounds.The therapeutic efficacy of the selected compounds was subsequently evaluated using the above indicators,and key pathways were validated through western blot analysis.Results:After 5 weeks of continuous light exposure,mice exhibited increased body fat percentage and serum levels of TG,impaired mitochondrial function,reduced thermogenic capacity,and whitening of BAT.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analyses indicated that BAT whitening was primarily associated with the adenosine 5'-monophosphate-activated protein kinase(AMPK)signaling pathway,fatty acid metabolism,and circadian rhythm.Ten hub genes identified using Cytoscape were mainly related to AMPK signaling and heat shock proteins.In vivo experiments showed that cordycepin significantly attenuated the increase in body fat percentage caused by prolonged light exposure.This effect was mediated by activation of the AMPK/PGC-1α/UCP1 signaling pathway,which restored the multilocular morphology and thermogenic function of BAT.Conclusion:Cordycepin mitigates continuous light-induced BAT whitening and metabolic disturbances by activating the AMPK signaling pathway.展开更多
The purpose of this paper is to show that by using a certain type of discrete-continuous limit, a series of integral entities can be defined(Mittag-Leffler multi-index functions, associated coherent states and their p...The purpose of this paper is to show that by using a certain type of discrete-continuous limit, a series of integral entities can be defined(Mittag-Leffler multi-index functions, associated coherent states and their properties), which are counterparts of the corresponding discrete entities. We built and examine the properties of a new aspect of generalized integral multi-index Mittag-Leffler functions and we constructed and examined the properties of coherent states associated with this new function. This approach is motivated through the fact that these functions can be connected with the coherent states of the continuous spectrum, as well as with so-called nu-function.展开更多
Precipitation of carbides, nitrides, and carbonitrides is an important factor influencing the formation of surface transverse cracks in the continuous casting of microalloyed steel, affecting the quality and yield of ...Precipitation of carbides, nitrides, and carbonitrides is an important factor influencing the formation of surface transverse cracks in the continuous casting of microalloyed steel, affecting the quality and yield of the final product. Based on previous investigation, the precipitation sequence and temperature, position and mode, as well as the size, morphology, and number of different types of precipitates were reviewed. The effects of C, N, Nb, Ti, and V on the precipitation behavior and surface transverse cracks in continuous casting slabs were summarized, with a particular emphasis on the new achievements concerning Ti addition. The critical amounts of different elements to avoid serious surface cracks during continuous casting were proposed. The control mechanisms and industrial effects of composition optimization, cooling design, and chamfered mold configuration to improve surface transverse cracks in continuous casting slabs were also illustrated, and the recent application of surface microstructure control technology was emphasized. The characteristics, advantages, and shortcomings of existing theoretical and experimental methods in investigating continuous casting surface cracks regarding precipitation are finally discussed, and a new setup with advanced functions is introduced.展开更多
基金Supported by Post-Subsidy Funds from the National Clinical Research Center,Ministry of Science and Technology of China,No.303-01-001-0272-08Beijing Municipal Administration of Hospitals Incubating Program,No.PX2022032Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(PWD&RPP-MRI),No.JYY2023-13.
文摘Diabetes is highly prevalent among the elderly worldwide,with the highest number of diabetes cases in China.Yet,the management of diabetes remains unsatisfactory.Recent advances in digital health technologies have facilitated the establishment of smart wards for diabetes patients.There is a lack of smart wards tailored specifically for older diabetes patients who encounter unique challenges in glycemic control and diabetes management,including an increased vulnerability to hypoglycemia,the presence of multiple chronic diseases,and cognitive decline.In this review,studies on digital health technologies for diabetes in China and beyond were summarized to elucidate how the adoption of digital health technologies,such as real-time continuous glucose monitoring,sensor-augmented pump technology,and their integration with 5th generation networks,big data cloud storage,and hospital information systems,can address issues specifically related to elderly diabetes patients in hospital wards.Furthermore,the challenges and future directions for establishing and implementing smart wards for elderly diabetes patients are discussed,and these challenges may also be applicable to other countries worldwide,not just in China.Taken together,the smart wards may enhance clinical outcomes,address specific issues,and eventually improve patient-centered hospital care for elderly patients with diabetes.
基金supported by National Key Research and Development Program of China(Grant No.2023YFB4604100)National Key Research and Development Program of China(Grant No.2022YFB3806104)+4 种基金Key Research and Development Program in Shaanxi Province(Grant No.2021LLRH-08-17)Young Elite Scientists Sponsorship Program by CAST(No.2023QNRC001)K C Wong Education Foundation of ChinaYouth Innovation Team of Shaanxi Universities of ChinaKey Research and Development Program of Shaanxi Province(Grant 2021LLRH-08-3.1).
文摘Ensuring the consistent mechanical performance of three-dimensional(3D)-printed continuous fiber-reinforced composites is a significant challenge in additive manufacturing.The current reliance on manual monitoring exacerbates this challenge by rendering the process vulnerable to environmental changes and unexpected factors,resulting in defects and inconsistent product quality,particularly in unmanned long-term operations or printing in extreme environments.To address these issues,we developed a process monitoring and closed-loop feedback control strategy for the 3D printing process.Real-time printing image data were captured and analyzed using a well-trained neural network model,and a real-time control module-enabled closed-loop feedback control of the flow rate was developed.The neural network model,which was based on image processing and artificial intelligence,enabled the recognition of flow rate values with an accuracy of 94.70%.The experimental results showed significant improvements in both the surface performance and mechanical properties of printed composites,with three to six times improvement in tensile strength and elastic modulus,demonstrating the effectiveness of the strategy.This study provides a generalized process monitoring and feedback control method for the 3D printing of continuous fiber-reinforced composites,and offers a potential solution for remote online monitoring and closed-loop adjustment in unmanned or extreme space environments.
基金supported by the National Natural Science Foundation of China(No.52474355)the Liaoning Province Science and Technology Plan Joint Program(Key Research and Development Program Project),China(Nos.2022JH25/10200003 and 2023JH2/101800058).
文摘The application of liquid core reduction(LCR)technology in thin slab continuous casting can refine the internal microstruc-tures of slabs and improve their production efficiency.To avoid crack risks caused by large deformation during the LCR process and to minimize the thickness of the slab in bending segments,the maximum theoretical reduction amount and the corresponding reduction scheme for the LCR process must be determined.With SPA-H weathering steel as a specific research steel grade,the distributions of tem-perature and deformation fields of a slab with the LCR process were analyzed using a three-dimensional thermal-mechanical finite ele-ment model.High-temperature tensile tests were designed to determine the critical strain of corner crack propagation and intermediate crack initiation with various strain rates and temperatures,and a prediction model of the critical strain for two typical cracks,combining the effects of strain rate and temperature,was proposed by incorporating the Zener-Hollomon parameter.The crack risks with different LCR schemes were calculated using the crack risk prediction model,and the maximum theoretical reduction amount for the SPA-H slab with a transverse section of 145 mm×1600 mm was 41.8 mm,with corresponding reduction amounts for Segment 0 to Segment 4 of 15.8,7.3,6.5,6.4,and 5.8 mm,respectively.
基金fnancially supported by the Scientifc Research Project of the Department of Education in Hunan Prov ince,China(Grant No.23B0533).
文摘In this work,fow behavior and dynamic recrystallization(DRX)mechanism of a low carbon martensitic stainless bearing steel,CSS-42L,were investigated using a thermomechanical simulator under the temperature and strain rate ranges of 900 to 1100℃ and 0.1 to 20 s^(−1),respectively.The Arrhenius-type constitutive equation was established based on the fow stress curves.Moreover,the peak stress decreased with the increase in deformation temperature and the decrease in strain rate.There were two DRX mechanisms during hot deformation of the current studied steel,the main one being discontinuous dynamic recrystallization mechanism,acting through grain boundary bulging and migration,and the auxiliary one being continuous dynamic recrystallization mechanism,working through the rotation of sub-grains.On the basis of microstructural characterizations,power dissipation maps and fow instability maps,the optimized hot deformation parameters for CSS-42L bearing steel were determined as 1050℃/0.1 s^(−1) and 1100℃/1 s^(−1).
基金supports for this research were provided by the National Natural Science Foundation of China(No.12272301,12002278,U1906233)the Guangdong Basic and Applied Basic Research Foundation,China(Nos.2023A1515011970,2024A1515010256)+1 种基金the Dalian City Supports Innovation and Entrepreneurship Projects for High-Level Talents,China(2021RD16)the Key R&D Project of CSCEC,China(No.CSCEC-2020-Z-4).
文摘Fiber-reinforced composites are an ideal material for the lightweight design of aerospace structures. Especially in recent years, with the rapid development of composite additive manufacturing technology, the design optimization of variable stiffness of fiber-reinforced composite laminates has attracted widespread attention from scholars and industry. In these aerospace composite structures, numerous cutout panels and shells serve as access points for maintaining electrical, fuel, and hydraulic systems. The traditional fiber-reinforced composite laminate subtractive drilling manufacturing inevitably faces the problems of interlayer delamination, fiber fracture, and burr of the laminate. Continuous fiber additive manufacturing technology offers the potential for integrated design optimization and manufacturing with high structural performance. Considering the integration of design and manufacturability in continuous fiber additive manufacturing, the paper proposes linear and nonlinear filtering strategies based on the Normal Distribution Fiber Optimization (NDFO) material interpolation scheme to overcome the challenge of discrete fiber optimization results, which are difficult to apply directly to continuous fiber additive manufacturing. With minimizing structural compliance as the objective function, the proposed approach provides a strategy to achieve continuity of discrete fiber paths in the variable stiffness design optimization of composite laminates with regular and irregular holes. In the variable stiffness design optimization model, the number of candidate fiber laying angles in the NDFO material interpolation scheme is considered as design variable. The sensitivity information of structural compliance with respect to the number of candidate fiber laying angles is obtained using the analytical sensitivity analysis method. Based on the proposed variable stiffness design optimization method for complex perforated composite laminates, the numerical examples consider the variable stiffness design optimization of typical non-perforated and perforated composite laminates with circular, square, and irregular holes, and systematically discuss the number of candidate discrete fiber laying angles, discrete fiber continuous filtering strategies, and filter radius on structural compliance, continuity, and manufacturability. The optimized discrete fiber angles of variable stiffness laminates are converted into continuous fiber laying paths using a streamlined process for continuous fiber additive manufacturing. Meanwhile, the optimized non-perforated and perforated MBB beams after discrete fiber continuous treatment, are manufactured using continuous fiber co-extrusion additive manufacturing technology to verify the effectiveness of the variable stiffness fiber optimization framework proposed in this paper.
基金Supported by the National Natural Science Foundation of China(61988102,62401113,92463308)。
文摘Enamel demineralization often occurs in the early stage of dental caries.Studying the microscopic mechanism of enamel demineralization is essential to prevent and treat dental caries.Terahertz(THz)technolo⁃gy,especially continuous wave(CW)THz near-field scanning microscopy(THz-SNOM)with its nanoscale reso⁃lution,can be promising in biomedical imaging.In addition,compared with traditional THz time-domain spec⁃troscopy(TDS),portable solid-state source as the emission has higher power and SNR,lower cost,and can ob⁃tain more precise imaging.In this study,we employ CW THz-SNOM to further break the resolution limitations of conventional THz imaging techniques and successfully achieve the near-field imaging of demineralized enamel at the nanoscale.We keenly observe that the near-field signal of the enamel significantly lowers as demineralization deepens,mainly due to the decrease in permittivity.This new approach offers valuable insights into the micro⁃scopic processes of enamel demineralization,laying the foundation for further research and treatment.
基金National Key Research and Development Program(2021YFB3401101)。
文摘Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This review mainly summarized the research reports on short process forming techniques for brazing and soldering materials.Firstly,the traditional process and its shortcomings were presented.Secondly,the latest research of short process forming technologies,such as continuous casting technique,atomization powder technique,solder ball forming technique,and rapid solidification technique,was summarized,and the traditional forming performance of several brazing and soldering materials was introduced.Finally,the current restrictions and research trends of short process forming technique for brazing and solder materials were put forward,providing theoretical guidance and reference for related research and technique development in brazing and soldering field.
基金supported by the‘Pioneer’and‘Leading Goose’R&D Program of Zhejiang(Grant No.2023C02018)Zhejiang Provincial Natural Science Foundation of China(Grant No.LTGN23D010002)+2 种基金National Natural Science Foundation of China(Grant No.42371385)Funds of the Natural Science Foundation of Hangzhou(Grant No.2024SZRYBD010001)Nanxun Scholars Program of ZJWEU(Grant No.RC2022010755).
文摘Plant diseases are a major threat that can severely impact the production of agriculture and forestry.This can lead to the disruption of ecosystem functions and health.With its ability to capture continuous narrow-band spectra,hyperspectral technology has become a crucial tool to monitor crop diseases using remote sensing.However,existing continuous wavelet analysis(CWA)methods suffer from feature redundancy issues,while the continuous wavelet projection algorithm(CWPA),an optimization approach for feature selection,has not been fully validated to monitor plant diseases.This study utilized rice bacterial leaf blight(BLB)as an example by evaluating the performance of four wavelet basis functions-Gaussian2,Mexican hat,Meyer,andMorlet-within theCWAandCWPAframeworks.Additionally,the classification models were constructed using the k-nearest neighbors(KNN),randomforest(RF),and Naïve Bayes(NB)algorithms.The results showed the following:(1)Compared to traditional CWA,CWPA significantly reduced the number of required features.Under the CWPA framework,almost all the model combinations achieved maximum classification accuracy with only one feature.In contrast,the CWA framework required three to seven features.(2)Thechoice of wavelet basis functions markedly affected the performance of themodel.Of the four functions tested,the Meyer wavelet demonstrated the best overall performance in both the CWPA and CWA frameworks.(3)Under theCWPAframework,theMeyer-KNNandMeyer-NBcombinations achieved the highest overall accuracy of 93.75%using just one feature.In contrast,under the CWA framework,the CWA-RF combination achieved comparable accuracy(93.75%)but required six features.This study verified the technical advantages of CWPA for monitoring crop diseases,identified an optimal wavelet basis function selection scheme,and provided reliable technical support to precisely monitor BLB in rice(Oryza sativa).Moreover,the proposed methodological framework offers a scalable approach for the early diagnosis and assessment of plant stress,which can contribute to improved accuracy and timeliness when plant stress is monitored.
文摘Pediatric type 1 diabetes(T1D)is a lifelong condition requiring meticulous glucose management to prevent acute and chronic complications.Conventional management of diabetic patients does not allow for continuous monitoring of glucose trends,and can place patients at risk for hypo-and hyperglycemia.Continuous glucose monitors(CGMs)have emerged as a mainstay for pediatric diabetic care and are continuing to advance treatment by providing real-time blood glucose(BG)data,with trend analysis aided by machine learning(ML)algorithms.These predictive analytics serve to prevent against dangerous BG variations in the perioperative environment for fasted children undergoing surgical stress.Integration of CGM data into electronic health records(EHR)is essential,as it establishes a foundation for future technologic interfaces with artificial intelligence(AI).Challenges in perioperative CGM implementation include equitable device access,protection of patient privacy and data accuracy,ensuring institution of standardized protocols,and financing the cumbersome healthcare costs associated with staff training and technology platforms.This paper advocates for implementation of CGM data into the EHR utilizing multiple facets of AI/ML algorithms.
基金Supported by Yunnan Province Academician(Expert)Workstation Project,No.202305AF150097the Basic Research Program of Yunnan Province(Kunming Medical University Joint Special Project),No.202101AY070001-276+3 种基金the National Natural Science Foundation of China,No.82160159the Key Project Program of Yunnan Province(Kunming Medical University Joint Special Project),No.202301AY070001-013the Major Science and Technology Project of Yunnan Province,No.202202AA100004the Double First-class University Construction Project of Yunnan University,No.CY22624106.
文摘BACKGROUND Continuous glucose monitoring(CGM)metrics,such as time in range(TIR)and glycemic risk index(GRI),have been linked to various diabetes-related complications,including diabetic foot(DF).AIM To investigate the association between CGM-derived indicators and the risk of DF in individuals with type 2 diabetes mellitus(T2DM).METHODS A total of 591 individuals with T2DM(297 with DF and 294 without DF)were enrolled.Relevant clinical data,complications,comorbidities,hematological parameters,and 72-hour CGM data were collected.Logistic regression analysis was employed to examine the relationship between these measurements and the risk of DF.RESULTS Individuals with DF exhibited higher mean blood glucose(MBG)levels and increased proportions of time above range(TAR),TAR level 1,and TAR level 2,but lower TIR(all P<0.001).Patients with DF had significantly lower rates of achieving target ranges for TIR,TAR,and TAR level 2 than those without DF(all P<0.05).Logistic regression analysis revealed that GRI,MBG,and TAR level 1 were positively associated with DF risk,while TIR was inversely correlated(all P<0.05).Achieving TIR and TAR was inversely correlated with white blood cell count and glycated hemoglobin A1c levels(P<0.05).Additionally,achieving TAR was influenced by fasting plasma glucose,body mass index,diabetes duration,and antidiabetic medication use.CONCLUSION CGM metrics,particularly TIR and GRI,are significantly associated with the risk of DF in T2DM,emphasizing the importance of improved glucose control.
基金financially supported by the Strategic Environmental Research and Development Program(Grant No.ER19-1075)。
文摘The insensitive munitions compound nitroguanidine(NQ)is used by the U.S.Army to avoid unintended explosions.However,NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aquatic organisms,indicating the need for effective remediation strategies.Thus,we investigated the feasibility of treating water contaminated with NQ in continuous-flow columns packed with zero-valent iron(ZVI)or iron sulfide(FeS).Initially,the impact of pH on NQ transformation by ZVI or FeS was evaluated in batch experiments.The pseudo first-order rate constant for NQ transformation(k_(1,NQ))by ZVI was 8-10 times higher at pH 3.0 compared to pH 5.5 and 7.0,whereas similar k_(1,NQ)values were obtained for FeS at pH 5.5-10.0.Based on these findings,the influent p H fed to the ZVIand Fe S-packed columns was adjusted to 3.0 and 5.5,respectively.Both reactors transformed NQ into nitrosoguanidine(Nso Q).Further transformation of Nso Q by ZVI produced aminoguanidine,guanidine,and cyanamide,whereas Nso Q transformation by Fe S produced guanidine,ammonium,and traces of urea.ZVI outperformed Fe S as a reactive material to remove NQ.The ZVI-packed column effectively removed NQ below detection even after 45 d of operation(490 pore volumes,PV).In contrast,NQ breakthrough(removal efficiency<85%)was observed after 18 d(180 PV)in the Fe S-packed column.The high NQ removal efficiency and long service life of the ZVI-packed column(>490 PV)suggest that the technology is a promising approach for NQ treatment in packed-bed reactors and in situ remediation.
基金supported by National Natural Science Foundation of China(Nos.12222513,12105345,12175292,and No.12405178)。
文摘Radio frequency(RF)cavities for advanced storage rings,also known as diffraction-limited storage rings,are under development.To this end,a competitive and promising approach involves normal-conducting continuous wave technology.The design and preliminary test of a 499.654 MHz RF cavity for the Wuhan Advanced Light Source(WALS)based on specific beam parameters were conducted at the SSRF.Multi-objective evolutionary algorithms have been utilized to optimize RF properties,such as the power loss and power density,resulting in better performance in the continuous wave mode.Further improvements were made to suppress multipacting effects in the working area.To operate stably with the beam,higher-order mode dampers were applied to better address the coupling bunch instability than in previous designs,along with thermal analysis to achieve the desired RF performance.Comprehensive simulation studies demonstrated the stable operation of the RF cavity at the defined beam parameters in the WALS design.A prototype RF cavity was then developed,and the RF performance results in a low-power test showed good agreement with the design and simulation,exhibiting readiness for high-power experiments and operation.
基金funded by the Spanish Ministry of Culture and Sport,Consejo Superior de Deportes,Plan de Recuperación,Transformación y Resiliencia,Unión Europea,Next Generation EUAyudas Europeas a Proyectos de Investigaci on Aplicada a la Actividad Física Beneficiosa para la Salud y la Medicina Deportiva(EXP_77437)+9 种基金by the Spanish Ministry of Science and Innovation(PID2022-141506OB-I00)the European Regional Development Funds(ERDF)by the University of Granada Plan Propio de Investigación-Excellence actions:Unit of Excellence on Exercise Nutrition and Health(UCEENS)supported by the Spanish Ministry of Education,Culture and Sport(FPU19/03745 and FPU20/05530,respectively)supported by the Juan de la Cierva Formación Grant FJC2020-044453-I funded by Ministerio de Ciencia e Innovaci on/Agencia Estatal de Investigaci on MCIN/AEI/10.13039/501100011033European Union Next Generation,Plan de Recuperación,Transformación y Resilencia(EU/PRTR)“Ramón y Cajal fellowship 2013-2017”funded by MCIN/AEI/10.13039/501100011033 and“El Fondo Social Europeo invierte en tu futuro”partially supported by the Grant PID2020-114054RA-I001001100482funded by MCIN/AEI/10.13039/501100011033supported by a grant from the MCIN/AEI/10.13039/501100011033,Spain,and the ERDF(PID2021-126788OB-I00).
文摘Background:Mammalian cells possess molecular clocks,the adequate functioning of which is decisive for metabolic health.Exercise is known to modulate these clocks,potentially having distinct effects on metabolism depending on the time of day.This study aimed to investigate the impact of morning vs.evening moderate-intensity aerobic exercise on glucose regulation and energy metabolism in healthy men and women.It also aimed to elucidate molecular mechanisms within skeletal muscle.Methods:Using a randomized crossover design,healthy men(n=18)and women(n=17)performed a 60-min bout of moderate-intensity aerobic exercise in the morning and evening.Glucose regulation was continuously monitored starting 24 h prior to the exercise day and continuing until 48 h post-exercise for each experimental condition.Energy expenditure and substrate oxidation were measured by indirect calorimetry during exercise and at rest before and after exercise for 30 min.Skeletal muscle biopsies were collected immediately before and after exercise to assess mitochondrial function,transcriptome,and mitochondrial proteome.Results:Results indicated similar systemic glucose,energy expenditure,and substrate oxidation during and after exercise in both sexes.Notably,transcriptional analysis,mitochondrial function,and mitochondrial proteomics revealed marked sexual dimorphism and time of day variations.Conclusion:The sexual dimorphism and time of day variations observed in the skeletal muscle in response to exercise may translate into observable systemic effects with higher exercise-intensity or chronic exercise interventions.This study provides a foundational molecular framework for precise exercise prescription in the clinical setting.
基金supported by the Weifang Science and Technology Development Plan Project in China(No.2023ZJ1166).
文摘Hardenability significantly impacts the distortion of gear during heat treatment,correlated to the uniformity of solute distribution in steel matrix.The experimental analysis was conducted on the macrostructure,solute distribution,dendrite structure,and rod hardenability of 20CrMnTiH gear steel in continuously cast blooms and hot roller rods.The evaluation approach by the standards for the hardenability of gear steel rods and the corresponding blooms was analyzed,and the inheritance mechanism from solidification segregation to hardenability fluctuation of gear steel was revealed.The results indicate that semi-macroscopic spot segregation located in the equiaxed zone exhibits larger size,higher solute enrichment,and worse solute homogeneity,leading to significant solute fluctuations in the blooms and hardenability fluctuation in the rods.By increasing the liquid steel superheat from 35 to 40℃,reducing the mold electromagnetic stirring from 300 to 100 A,and implementing the soft reduction(SR)of 7 mm at the solidification end,the equiaxed ratio of the strand decreased from 26.42%to 6.69%.Consequently,the solute fluctuation range and standard deviation decrease significantly in the transverse section,while the maximum segregation ratio,average fluctuation range,and average standard deviation of solutes C,Cr,and Mn in the spot segregation decrease at the same time.At the meanwhile,the equiaxed ratio of the rod decreased from 24.89%to 4.09%,and the structure of the hardenability detection zone was transformed from equiaxed crystals to columnar crystals.Furthermore,the solute fluctuation range and standard deviation in the transverse section decreased,while the homogeneity in spot segregation was also improved.The hardness difference of A and B surfaces at J9 and J15 positions was smaller than 2 HRC,meeting the qualification standard for hardenability.
基金funded by the Swiss National Science Foundation(SNF 200020_182084).
文摘Mediterranean forest communities are particularly diverse but at risk due to their sensitivity to global warming.Understanding the long-term vulnerability of Mediterranean vegetation to climate change is crucial for conservation and management purposes.Studies on past changes of forest communities in response to climate change at ecologically meaningful resolutions(i.e.,decadal time scales) are therefore essential,but still very rare.The Holocene thermal maximum(HTM;ca.10,000-5,000 cal years before the present(BP)) may be used to study species and community responses to warmer conditions than during recent decades.We performed highresolution multiproxy palaeoecological analyses on sediments from crater Lake Mezzano in central Italy to reconstruct vegetation,diversity,and fire dynamics between 8,450 and 7,050 cal years BP.Ordination,crosscorrelation,and species-response analyses were used to investigate the response of Mediterranean forest communities to HTM climate warming,human impact,and fire.Vegetational changes prior to 7,450 cal years BP were driven by climate.Fagus sylvatica spread into mixed deciduous oak forests during the Early Holocene in response to declining seasonality(cooler summers and warmer winters).Subsequently,Fagus sylvatica declined and evergreen Quercus ilex expanded after 8,200 cal years BP when the climate became warmer.Although reduced,Fagus sylvatica remained important together with deciduous oaks.The co-existence of Fagus sylvatica and evergreen Quercus forests is extremely rare today.Human impact significantly affected forest vegetation after7,450 cal years BP,when Neolithic agricultural activities became important,ultimately extirpating these special communities but fostering the overall biodiversity.However,their past occurrence in several central Italian calderas during the HTM suggests that these environments provided habitats that permitted the thriving of cooltemperate forests of Fagus sylvatica under mesomediterranean conditions,with summers ca.1-2℃ warmer than today.Cool and moist calderas may thus become increasingly important for maintaining Mediterranean mesophilous forest species under global warming conditions.
文摘Wattwil,Switzerland,April l,2025-The art of re-orientation runs through Heberlein's l90-year companyhistory.Georg Philipp Heberlein and his descendants ranan exemplary family business with roots in yarn dyeing.Itdeveloped into a corporate group and ultimately became ahighly spectalised company that is regarded as the world'sleading provider of air interlacing and air texturing jets forsynthetic continuous filament yarns.
基金supported by the National Key R&D Program of China(Grant Nos.2022YFB3603403,2021YFB3600502)the National Natural Science Foundation of China(Grant Nos.62075040,62301150)+3 种基金the Southeast University Interdisciplinary Research Program for Young Scholars(2024FGC1007)the Start-up Research Fund of Southeast University(RF1028623164)the Nanjing Science and Technology Innovation Project for Returned Overseas Talent(4206002302)the Fundamental Research Funds for the Central Universities(2242024K40015).
文摘Benefiting from the widespread potential applications in the era of the Internet of Thing and metaverse,triboelectric and piezoelectric nanogenerators(TENG&PENG)have attracted considerably increasing attention.Their outstanding characteristics,such as self-powered ability,high output performance,integration compatibility,cost-effectiveness,simple configurations,and versatile operation modes,could effectively expand the lifetime of vastly distributed wearable,implantable,and environmental devices,eventually achieving self-sustainable,maintenance-free,and reliable systems.However,current triboelectric/piezoelectric based active(i.e.self-powered)sensors still encounter serious bottlenecks in continuous monitoring and multimodal applications due to their intrinsic limitations of monomodal kinetic response and discontinuous transient output.This work systematically summarizes and evaluates the recent research endeavors to address the above challenges,with detailed discussions on the challenge origins,designing strategies,device performance,and corresponding diverse applications.Finally,conclusions and outlook regarding the research gap in self-powered continuous multimodal monitoring systems are provided,proposing the necessity of future research development in this field.
文摘Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuous light exposure.This study aimed to investigate the morphological and functional alterations in BAT under continuous light conditions and to identify traditional Chinese medicine compounds capable of reversing these changes.Methods:A metabolic disorder model was established by subjecting mice to continuous light exposure for 5 weeks.During this period,body weight,food intake,and body fat percentage were monitored.Serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were measured to assess lipid metabolism.Histological changes in BAT were examined using H&E staining.The expression of the thermogenic marker uncoupling protein 1(UCP1)in BAT was determined by RT-qPCR and Western blot to evaluate thermogenic function.RNA sequencing(RNA-seq)was employed to identify differentially expressed genes(DEGs)involved in BAT whitening induced by prolonged continuous light exposure.DEGs were analyzed using the connectivity map(CMap)database to identify potential preventive and therapeutic compounds.The therapeutic efficacy of the selected compounds was subsequently evaluated using the above indicators,and key pathways were validated through western blot analysis.Results:After 5 weeks of continuous light exposure,mice exhibited increased body fat percentage and serum levels of TG,impaired mitochondrial function,reduced thermogenic capacity,and whitening of BAT.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analyses indicated that BAT whitening was primarily associated with the adenosine 5'-monophosphate-activated protein kinase(AMPK)signaling pathway,fatty acid metabolism,and circadian rhythm.Ten hub genes identified using Cytoscape were mainly related to AMPK signaling and heat shock proteins.In vivo experiments showed that cordycepin significantly attenuated the increase in body fat percentage caused by prolonged light exposure.This effect was mediated by activation of the AMPK/PGC-1α/UCP1 signaling pathway,which restored the multilocular morphology and thermogenic function of BAT.Conclusion:Cordycepin mitigates continuous light-induced BAT whitening and metabolic disturbances by activating the AMPK signaling pathway.
文摘The purpose of this paper is to show that by using a certain type of discrete-continuous limit, a series of integral entities can be defined(Mittag-Leffler multi-index functions, associated coherent states and their properties), which are counterparts of the corresponding discrete entities. We built and examine the properties of a new aspect of generalized integral multi-index Mittag-Leffler functions and we constructed and examined the properties of coherent states associated with this new function. This approach is motivated through the fact that these functions can be connected with the coherent states of the continuous spectrum, as well as with so-called nu-function.
基金supported by the Fundamental Research Funds for the Central Universities(No.FRF-TP-19-017A3)National Natural Science Foundation of China(No.51874026).
文摘Precipitation of carbides, nitrides, and carbonitrides is an important factor influencing the formation of surface transverse cracks in the continuous casting of microalloyed steel, affecting the quality and yield of the final product. Based on previous investigation, the precipitation sequence and temperature, position and mode, as well as the size, morphology, and number of different types of precipitates were reviewed. The effects of C, N, Nb, Ti, and V on the precipitation behavior and surface transverse cracks in continuous casting slabs were summarized, with a particular emphasis on the new achievements concerning Ti addition. The critical amounts of different elements to avoid serious surface cracks during continuous casting were proposed. The control mechanisms and industrial effects of composition optimization, cooling design, and chamfered mold configuration to improve surface transverse cracks in continuous casting slabs were also illustrated, and the recent application of surface microstructure control technology was emphasized. The characteristics, advantages, and shortcomings of existing theoretical and experimental methods in investigating continuous casting surface cracks regarding precipitation are finally discussed, and a new setup with advanced functions is introduced.
