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Quantum Secure Multiparty Computation:Bridging Privacy,Security,and Scalability in the Post-Quantum Era
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作者 Sghaier Guizani Tehseen Mazhar Habib Hamam 《Computers, Materials & Continua》 2026年第4期1-25,共25页
The advent of quantum computing poses a significant challenge to traditional cryptographic protocols,particularly those used in SecureMultiparty Computation(MPC),a fundamental cryptographic primitive for privacypreser... The advent of quantum computing poses a significant challenge to traditional cryptographic protocols,particularly those used in SecureMultiparty Computation(MPC),a fundamental cryptographic primitive for privacypreserving computation.Classical MPC relies on cryptographic techniques such as homomorphic encryption,secret sharing,and oblivious transfer,which may become vulnerable in the post-quantum era due to the computational power of quantum adversaries.This study presents a review of 140 peer-reviewed articles published between 2000 and 2025 that used different databases like MDPI,IEEE Explore,Springer,and Elsevier,examining the applications,types,and security issues with the solution of Quantum computing in different fields.This review explores the impact of quantum computing on MPC security,assesses emerging quantum-resistant MPC protocols,and examines hybrid classicalquantum approaches aimed at mitigating quantum threats.We analyze the role of Quantum Key Distribution(QKD),post-quantum cryptography(PQC),and quantum homomorphic encryption in securing multiparty computations.Additionally,we discuss the challenges of scalability,computational efficiency,and practical deployment of quantumsecure MPC frameworks in real-world applications such as privacy-preserving AI,secure blockchain transactions,and confidential data analysis.This review provides insights into the future research directions and open challenges in ensuring secure,scalable,and quantum-resistant multiparty computation. 展开更多
关键词 quantum computing secure multiparty computation(MPC) post-quantum cryptography(PQC) quantum key distribution(QKD) privacy-preserving computation quantum homomorphic encryption quantum network security federated learning blockchain security quantum cryptography
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Virtual QPU:A Novel Implementation of Quantum Computing
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作者 Danyang Zheng Jinchen Xv +1 位作者 Xin Zhou Zheng Shan 《Computers, Materials & Continua》 2026年第4期1008-1029,共22页
The increasing popularity of quantum computing has resulted in a considerable rise in demand for cloud quantum computing usage in recent years.Nevertheless,the rapid surge in demand for cloud-based quantum computing r... The increasing popularity of quantum computing has resulted in a considerable rise in demand for cloud quantum computing usage in recent years.Nevertheless,the rapid surge in demand for cloud-based quantum computing resources has led to a scarcity.In order to meet the needs of an increasing number of researchers,it is imperative to facilitate efficient and flexible access to computing resources in a cloud environment.In this paper,we propose a novel quantum computing paradigm,Virtual QPU(VQPU),which addresses this issue and enhances quantum cloud throughput with guaranteed circuit fidelity.The proposal introduces three innovative concepts:(1)The integration of virtualization technology into the field of quantum computing to enhance quantum cloud throughput.(2)The introduction of an asynchronous execution of circuits methodology to improve quantum computing flexibility.(3)The development of a virtual QPU allocation scheme for quantum tasks in a cloud environment to improve circuit fidelity.The concepts have been validated through the utilization of a self-built simulated quantum cloud platform. 展开更多
关键词 quantum computing scheduling parallel computing computational paradigm
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Random State Approach to Quantum Computation of Electronic-Structure Properties
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作者 Yiran Bai Feng Xiong Xueheng Kuang 《Chinese Physics Letters》 2026年第1期89-104,共16页
Classical computation of electronic properties in large-scale materials remains challenging.Quantum computation has the potential to offer advantages in memory footprint and computational scaling.However,general and v... Classical computation of electronic properties in large-scale materials remains challenging.Quantum computation has the potential to offer advantages in memory footprint and computational scaling.However,general and viable quantum algorithms for simulating large-scale materials are still limited.We propose and implement random-state quantum algorithms to calculate electronic-structure properties of real materials.Using a random state circuit on a small number of qubits,we employ real-time evolution with first-order Trotter decomposition and Hadamard test to obtain electronic density of states,and we develop a modified quantum phase estimation algorithm to calculate real-space local density of states via direct quantum measurements.Furthermore,we validate these algorithms by numerically computing the density of states and spatial distributions of electronic states in graphene,twisted bilayer graphene quasicrystals,and fractal lattices,covering system sizes from hundreds to thousands of atoms.Our results manifest that the random-state quantum algorithms provide a general and qubit-efficient route to scalable simulations of electronic properties in large-scale periodic and aperiodic materials. 展开更多
关键词 periodic materials random state circuit random state quantum algorithms electronic structure properties density states aperiodic materials quantum algorithms quantum computation
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Mask-coding-assisted continuous-variable quantum direct communication with orbital angular momentum multiplexing
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作者 Zhengwen Cao Yujie Wang +2 位作者 Geng Chai Xinlei Chen Yuan Lu 《Chinese Physics B》 2025年第2期64-72,共9页
Quantum secure direct communication(QSDC) is a communication method based on quantum mechanics and it is used to transmit secret messages. Unlike quantum key distribution, secret messages can be transmitted directly o... Quantum secure direct communication(QSDC) is a communication method based on quantum mechanics and it is used to transmit secret messages. Unlike quantum key distribution, secret messages can be transmitted directly on a quantum channel with QSDC. Higher channel capacity and noise suppression capabilities are key to achieving longdistance quantum communication. Here, we report a continuous-variable QSDC scheme based on mask-coding and orbital angular momentum, in which the mask-coding is employed to protect the security of the transmitting messages and to suppress the influence of excess noise. The combination of orbital angular momentum and information block transmission effectively improves the secrecy capacity. In the 800 information blocks ×1310 bits length 10-km experiment, the results show a statistical average bit error rate of 0.38%, a system excess noise value of 0.0184 SNU, and a final secrecy capacity of 6.319×10~6 bps. Therefore, this scheme reduces error bits while increasing secrecy capacity, providing a solution for long-distance large-scale quantum communication, which is capable of transmitting text, images and other information of reasonable size. 展开更多
关键词 continuous-variable quantum direct communication orbital angular momentum mask coding
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Quantum-accelerated active distribution network planning based on coherent photonic quantum computers
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作者 Yu Xin Haipeng Xie Wei Fu 《iEnergy》 2025年第2期107-120,共14页
Active distribution network(ADN)planning is crucial for achieving a cost-effective transition to modern power systems,yet it poses significant challenges as the system scale increases.The advent of quantum computing o... Active distribution network(ADN)planning is crucial for achieving a cost-effective transition to modern power systems,yet it poses significant challenges as the system scale increases.The advent of quantum computing offers a transformative approach to solve ADN planning.To fully leverage the potential of quantum computing,this paper proposes a photonic quantum acceleration algorithm.First,a quantum-accelerated framework for ADN planning is proposed on the basis of coherent photonic quantum computers.The ADN planning model is then formulated and decomposed into discrete master problems and continuous subproblems to facilitate the quantum optimization process.The photonic quantum-embedded adaptive alternating direction method of multipliers(PQA-ADMM)algorithm is subsequently proposed to equivalently map the discrete master problem onto a quantum-interpretable model,enabling its deployment on a photonic quantum computer.Finally,a comparative analysis with various solvers,including Gurobi,demonstrates that the proposed PQA-ADMM algorithm achieves significant speedup on the modified IEEE 33-node and IEEE 123-node systems,highlighting its effectiveness. 展开更多
关键词 Active distribution network planning coherent photonic quantum computer photonic quantum-embedded adaptive ADMM algorithm quantum computing
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Duality Computing in Quantum Computers 被引量:10
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作者 LONG Gui-Lu LIU Yang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第12期1303-1306,共4页
In this letter,we propose a duality computing mode,which resembles particle-wave duality property whena quantum system such as a quantum computer passes through a double-slit.In this mode,computing operations arenot n... In this letter,we propose a duality computing mode,which resembles particle-wave duality property whena quantum system such as a quantum computer passes through a double-slit.In this mode,computing operations arenot necessarily unitary.The duality mode provides a natural link between classical computing and quantum computing.In addition,the duality mode provides a new tool for quantum algorithm design. 展开更多
关键词 duality computer duality quantum computer duality computing mode
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Scaled Up Chip Pushes Quantum Computing a Bit Closer to Reality 被引量:1
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作者 Chris Palmer 《Engineering》 2025年第7期6-8,共3页
In the 9 December 2024 issue of Nature[1],a team of Google engineers reported breakthrough results using“Willow”,their lat-est quantum computing chip(Fig.1).By meeting a milestone“below threshold”reduction in the ... In the 9 December 2024 issue of Nature[1],a team of Google engineers reported breakthrough results using“Willow”,their lat-est quantum computing chip(Fig.1).By meeting a milestone“below threshold”reduction in the rate of errors that plague super-conducting circuit-based quantum computing systems(Fig.2),the work moves the field another step towards its promised super-charged applications,albeit likely still many years away.Areas expected to benefit from quantum computing include,among others,drug discovery,materials science,finance,cybersecurity,and machine learning. 展开更多
关键词 materials science BREAKTHROUGH drug discovery willow chip quantum computing superconducting circuits error reduction applications
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Practical security of continuous-variable quantum key distribution under finite-dimensional effect of multi-dimensional reconciliation 被引量:2
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作者 Yingming Zhou Xue-Qin Jiang +3 位作者 Weiqi Liu Tao Wang Peng Huang Guihua Zeng 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第5期101-107,共7页
The well-known multi-dimensional reconciliation is an effective method used in the continuous-variable quantum key distribution in the long-distance and the low signal-to-noise-ratio scenarios.The virtual channel empl... The well-known multi-dimensional reconciliation is an effective method used in the continuous-variable quantum key distribution in the long-distance and the low signal-to-noise-ratio scenarios.The virtual channel employed to exchange data is generally established by using a finite-dimensional rotation in the reconciliation procedure.In this paper,we found that the finite dimension of the multi-dimensional reconciliation inevitably leads to the mismatch of the signal-to-noise-ratio between the quantum channel and the virtual channel,which may be called the finite-dimension effect.Such an effect results in an overestimation on the secret key rate,and subsequently induces vital practical security loopholes. 展开更多
关键词 multi-dimensional reconciliation finite-dimensional effect continuous-variable quantum key distribution
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Finite-size analysis of continuous-variable quantum key distribution with entanglement in the middle 被引量:1
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作者 Ying Guo Yu Su +2 位作者 Jian Zhou Ling Zhang Duan Huang 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第1期232-239,共8页
Continuous-variable quantum key distribution(CVQKD) protocols with entanglement in the middle(EM) enable long maximal transmission distances for quantum communications. For the security analysis of the protocols, it i... Continuous-variable quantum key distribution(CVQKD) protocols with entanglement in the middle(EM) enable long maximal transmission distances for quantum communications. For the security analysis of the protocols, it is usually assumed that Eve performs collective Gaussian attacks and there is a lack of finite-size analysis of the protocols. However,in this paper we consider the finite-size regime of the EM-based CVQKD protocols by exposing the protocol to collective attacks and coherent attacks. We differentiate between the collective attacks and the coherent attacks while comparing asymptotic key rate and the key rate in the finite-size scenarios. Moreover, both symmetric and asymmetric configurations are collated in a contrastive analysis. As expected, the derived results in the finite-size scenarios are less useful than those acquired in the asymptotic regime. Nevertheless, we find that CVQKD with entanglement in the middle is capable of providing fully secure secret keys taking the finite-size effects into account with transmission distances of more than 30 km. 展开更多
关键词 continuous-variable quantum key distribution ENTANGLEMENT in the middle FINITE-SIZE coherent attack
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Improving Continuous-Variable Measurement-Device-Independent Multipartite Quantum Communication with Optical Amplifiers 被引量:1
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作者 郭迎 赵微 +3 位作者 李飞 黄端 廖骎 谢才浪 《Communications in Theoretical Physics》 SCIE CAS CSCD 2017年第8期191-200,共10页
The developing tendency of continuous-variable (CV) measurement-device-independent (MDI) quantum cryptography is to cope with the practical issue of implementing sealable quantum networks. Up to now, most theoreti... The developing tendency of continuous-variable (CV) measurement-device-independent (MDI) quantum cryptography is to cope with the practical issue of implementing sealable quantum networks. Up to now, most theoretical and experimental researches on CV-MDI QKD are focused on two-party protocols. However, we suggest a CV-MDI multipartite quantum secret sharing (QSS) protocol use the EPR states coupled with optical amplifiers. More remarkable, QSS is the real application in multipartite CV-MDI QKD, in other words, is the concrete implementation method of multipartite CV-MDI QKD. It can implement a practical quantum network scheme, under which the legal participants create the secret correlations by using EPR states connecting to an untrusted relay via insecure links and applying the multi-entangled Greenberger-Horne-Zeilinger (GHZ) state analysis at relay station. Even if there is a possibility that the relay may be completely tampered, the legal participants are still able to extract a secret key from network communication. The numerical simulation indicates that the quantum network communication can be achieved in an asymmetric scenario, fulfilling the demands of a practical quantum network. Additionally, we illustrate that the use of optical amplifiers can compensate the partial inherent imperfections of detectors and increase the transmission distance of the CV-MDI quantum system. 展开更多
关键词 continuous-variable quantum network Greenberger Horne Zeilinger state optical amplifier
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Rise of quantum correlations in non-Markovian environments in continuous-variable systems 被引量:1
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作者 刘辛 吴薇 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第7期263-268,共6页
We investigate the time evolution of quantum correlations, which are measured by Gaussian quantum discord in a continuous-variable bipartite system subject to common and independent non-Markovian environments. Conside... We investigate the time evolution of quantum correlations, which are measured by Gaussian quantum discord in a continuous-variable bipartite system subject to common and independent non-Markovian environments. Considering an initial two-mode Gaussian symmetric squeezed thermal state, we show that quantum correlations can be created during the non-Markovian evolution, which is different from the Markovian process. Furthermore, we find that the temperature is a key factor during the evolution in non-Markovian environments. For common reservoirs, a maximum creation of quantum correlations may occur under an appropriate temperature. For independent reservoirs, the non-Markovianity of the total system corresponds to the subsystem whose temperature is higher. In both common and independent environments, the Gaussian quantum discord is influenced by the temperature and the photon number of each mode. 展开更多
关键词 quantum correlation non-Markovian environment continuous-variable systems
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Spherical reconciliation for a continuous-variable quantum key distribution 被引量:1
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作者 卢钊 史建红 李风光 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第4期109-114,共6页
Information reconciliation is a significant step for a continuous-variable quantum key distribution(CV-QKD) system.We propose a reconciliation method that allows two authorized parties to extract a consistent and se... Information reconciliation is a significant step for a continuous-variable quantum key distribution(CV-QKD) system.We propose a reconciliation method that allows two authorized parties to extract a consistent and secure binary key in a CV-QKD protocol,which is based on Gaussian-modulated coherent states and homodyne detection.This method named spherical reconciliation is based on spherical quantization and non-binary low-density parity-check(LDPC) codes.With the suitable signal-to-noise ratio(SNR) and code rate of non-binary LDPC codes,spherical reconciliation algorithm has a high efficiency and can extend the transmission distance of CV-QKD. 展开更多
关键词 continuous-variable quantum key distribution QUANTIZATION spherical reconciliation
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Continuous-variable quantum key distribution based on continuous random basis choice 被引量:1
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作者 Weiqi Liu Jinye Peng +3 位作者 Peng Huang Shiyu Wang Tao Wang Guihua Zeng 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第7期214-219,共6页
Gaussian-modulated coherent state quantum key distribution is gradually moving towards practical application. Generally, the involved scheme is based on the binary random basis choice. To improve the performance and s... Gaussian-modulated coherent state quantum key distribution is gradually moving towards practical application. Generally, the involved scheme is based on the binary random basis choice. To improve the performance and security, we present a scheme based on a continuous random basis choice. The results show that our scheme obviously improves the performance, such as the secure communication distance. Our scheme avoids comparing the measurement basis and discarding the key bits, and it can be easily implemented with current technology. Moreover, the imperfection of the basis choice can be well removed by the known phase compensation algorithm. 展开更多
关键词 continuous-variable quantum key distribution basis choice
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Security Simulation of Continuous-Variable Quantum Key Distribution over Air-to-Water Channel Using Monte Carlo Method 被引量:1
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作者 Cai-Lang Xie Ying Guo +2 位作者 Yi-Jun Wang Duan Huang Ling Zhang 《Chinese Physics Letters》 SCIE CAS CSCD 2018年第9期10-13,共4页
Considering the ocean water's optical attenuation and the roughness of the sea surface, we analyze the security of continuous-variable (CV) quantum key distribution (QKD) based Mr-to-water channel. The effects of... Considering the ocean water's optical attenuation and the roughness of the sea surface, we analyze the security of continuous-variable (CV) quantum key distribution (QKD) based Mr-to-water channel. The effects of the absorp- tion and scattering on the transmittance of underwater quantum channel and the maximum secure transmission distance are studied. Considering the roughness of the sea surface, we simulate the performance bounds of CV QKD with different wind speeds using the Monte Carlo method. The results show that even if the secret key rate gradually reduces as the wind speed increases, the maximum transmission distance will not be affected obviously. Compared to the works regarding short-distance underwater optical communication, our research represents a significant step towards establishing secure communication between air platform and submarine vehicle. 展开更多
关键词 QKD Security Simulation of continuous-variable quantum Key Distribution over Air-to-Water Channel Using Monte Carlo Method CV
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Practical Security of the Continuous-Variable Quantum Key Distribution with Locally-Generated Local Oscillators 被引量:1
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作者 Biao Huang Yongjun Zhu +2 位作者 Pu Tang Yongmei Huang Zhenming Peng 《Journal of Applied Mathematics and Physics》 2019年第11期2751-2759,共9页
Continuous-variable quantum key distribution (CVQKD) with the local local oscillator (LLO) is confronted with new security problems due to the reference pulses transmitted together with quantum signals over the insecu... Continuous-variable quantum key distribution (CVQKD) with the local local oscillator (LLO) is confronted with new security problems due to the reference pulses transmitted together with quantum signals over the insecure quantum channel. In this paper, we propose a method of phase attack on reference pulses of the LLO-CVQKD with time-multiplexing. Under this phase attack, the phase drifts of reference pulses are manipulated by eavesdroppers, and then the phase compensation error is increased. Consequently, the secret key rate is reduced due to the imperfect phase compensation for quantum signals. Based on the noise model of imperfect phase compensation, the practical security of LLO-CVQKD under phase attack is analyzed. The simulation results show that the practical security is reduced due to the phase attack, yet it is still tight when system parameters are estimated by training signals. 展开更多
关键词 continuous-variable quantum Key Distribution Local Oscillator Reference Pulse PRACTICAL SECURITY Phase Attack
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Privacy-preserving computation meets quantum computing:A scoping review
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作者 Aitor Gómez-Goiri Iñaki Seco-Aguirre +1 位作者 Oscar Lage Alejandra Ruiz 《Digital Communications and Networks》 2025年第6期1707-1721,共15页
Privacy-Preserving Computation(PPC)comprises the techniques,schemes and protocols which ensure privacy and confidentiality in the context of secure computation and data analysis.Most of the current PPC techniques rely... Privacy-Preserving Computation(PPC)comprises the techniques,schemes and protocols which ensure privacy and confidentiality in the context of secure computation and data analysis.Most of the current PPC techniques rely on the complexity of cryptographic operations,which are expected to be efficiently solved by quantum computers soon.This review explores how PPC can be built on top of quantum computing itself to alleviate these future threats.We analyze quantum proposals for Secure Multi-party Computation,Oblivious Transfer and Homomorphic Encryption from the last decade focusing on their maturity and the challenges they currently face.Our findings show a strong focus on purely theoretical works,but a rise on the experimental consideration of these techniques in the last 5 years.The applicability of these techniques to actual use cases is an underexplored aspect which could lead to the practical assessment of these techniques. 展开更多
关键词 quantum computing Privacy-preserving computation Oblivious transfer Secure multi-party computation Homomorphic encryption Scoping review
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Quantum Inspired Adaptive Resource Management Algorithm for Scalable and Energy Efficient Fog Computing in Internet of Things(IoT)
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作者 Sonia Khan Naqash Younas +3 位作者 Musaed Alhussein Wahib Jamal Khan Muhammad Shahid Anwar Khursheed Aurangzeb 《Computer Modeling in Engineering & Sciences》 2025年第3期2641-2660,共20页
Effective resource management in the Internet of Things and fog computing is essential for efficient and scalable networks.However,existing methods often fail in dynamic and high-demand environments,leading to resourc... Effective resource management in the Internet of Things and fog computing is essential for efficient and scalable networks.However,existing methods often fail in dynamic and high-demand environments,leading to resource bottlenecks and increased energy consumption.This study aims to address these limitations by proposing the Quantum Inspired Adaptive Resource Management(QIARM)model,which introduces novel algorithms inspired by quantum principles for enhanced resource allocation.QIARM employs a quantum superposition-inspired technique for multi-state resource representation and an adaptive learning component to adjust resources in real time dynamically.In addition,an energy-aware scheduling module minimizes power consumption by selecting optimal configurations based on energy metrics.The simulation was carried out in a 360-minute environment with eight distinct scenarios.This study introduces a novel quantum-inspired resource management framework that achieves up to 98%task offload success and reduces energy consumption by 20%,addressing critical challenges of scalability and efficiency in dynamic fog computing environments. 展开更多
关键词 quantum computing resource management energy efficiency fog computing Internet of Things
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Decarbonization of Building Operations with Adaptive Quantum Computing-Based Model Predictive Control
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作者 Akshay Ajagekar Fengqi You 《Engineering》 2025年第10期90-103,共14页
This work proposes an adaptive quantum approximate optimization-based model predictive control(MPC)strategy for energy management in buildings equipped with battery energy storage and renewable energy generation syste... This work proposes an adaptive quantum approximate optimization-based model predictive control(MPC)strategy for energy management in buildings equipped with battery energy storage and renewable energy generation systems.The learning-based parameter transfer scheme to realize adaptive quantum optimization leverages Bayesian optimization to predict initial quantum circuit parameters.When applied to the MPC problems formulated as quadratic unconstrained binary optimization problems,this approach computes optimal controls to minimize the net energy consumption levels in buildings and promotes decarbonization while reducing the computational efforts required for the quantum approximate optimization algorithm as the building energy system trajectory progresses.The energy efficiency and the decarbonization benefits of the proposed quantum optimization-based MPC strategy are demonstrated on buildings at the Cornell University campus.The proposed quantum computing-based technique to address MPC problems in buildings demonstrates energy-efficient and low-carbon building operation with a 6.8% improvement over deterministic MPC and presents opportunities for scaling to larger control problems with a significant reduction in utilized quantum computing resources.A reduction of 41.2% in carbon emissions is also achieved with the proposed control strategy facilitated by efficiently managing battery energy storage and renewable generation sources to promote a push toward carbonneutral building operations. 展开更多
关键词 quantum computing Carbon neutrality Building energy control quantum approximate optimization
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Quantum Computing Gamble Bets on Stealthy Majorana Qubits
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作者 Chris Palmer 《Engineering》 2025年第12期8-10,共3页
With a paper published in the 19 February 2025 issue of Nature[1],Microsoft(Redmond,WA,USA)fanned the flames of its unique vision for quantum computing:a stable,error-resistant qubit based on the Majorana fermion,one ... With a paper published in the 19 February 2025 issue of Nature[1],Microsoft(Redmond,WA,USA)fanned the flames of its unique vision for quantum computing:a stable,error-resistant qubit based on the Majorana fermion,one of the strangest and most elusive particles in physics.The Microsoft Azure Quantum research team’s descriptions of a means to detect the as-yet theoretical particles[1]—called“an entirely new state of matter”by Microsoft’s chief executive officer[2]—and a design for a chip powered by them(Fig.1)[3]have refocused attention on the company’s ambition to build a topological quantum computer.The approach—if it works—could potentially leapfrog every other in the field. 展开更多
关键词 stealthy qubits topological quantum computer majorana fermions stable qubits majorana fermionone error resistant qubits quantum computing microsoft azure
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Developing a Predictive Platform for Salmonella Antimicrobial Resistance Based on a Large Language Model and Quantum Computing
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作者 Yujie You Kan Tan +1 位作者 Zekun Jiang Le Zhang 《Engineering》 2025年第5期174-184,共11页
As a common foodborne pathogen,Salmonella poses risks to public health safety,common given the emergence of antimicrobial-resistant strains.However,there is currently a lack of systematic platforms based on large lang... As a common foodborne pathogen,Salmonella poses risks to public health safety,common given the emergence of antimicrobial-resistant strains.However,there is currently a lack of systematic platforms based on large language models(LLMs)for Salmonella resistance prediction,data presentation,and data sharing.To overcome this issue,we firstly propose a two-step feature-selection process based on the chi-square test and conditional mutual information maximization to find the key Salmonella resistance genes in a pan-genomics analysis and develop an LLM-based Salmonella antimicrobial-resistance predictive(SARPLLM)algorithm to achieve accurate antimicrobial-resistance prediction,based on Qwen2 LLM and low-rank adaptation.Secondly,we optimize the time complexity to compute the sample distance from the linear to logarithmic level by constructing a quantum data augmentation algorithm denoted as QSMOTEN.Thirdly,we build up a user-friendly Salmonella antimicrobial-resistance predictive online platform based on knowledge graphs,which not only facilitates online resistance prediction for users but also visualizes the pan-genomics analysis results of the Salmonella datasets. 展开更多
关键词 Salmonella resistance prediction Pan-genomics Large language model quantum computing BIOINFORMATICS
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