Objective:To analyze the effects of continuous self-management education on the selfcare ability and health behavior of patients with tumor through peripherally inserted central venous catheters(PICC).Methods:The peri...Objective:To analyze the effects of continuous self-management education on the selfcare ability and health behavior of patients with tumor through peripherally inserted central venous catheters(PICC).Methods:The period from August 2018 to August 2020 was used as the research time range,and the random number table method was used as the basis for grouping.80 patients with malignant tumors who regularly performed fixed catheter maintenance care in the PICC clinic of our hospital were admitted in the experimental group(given PICC specialist nursing,and implemented continuous self-management education),and 80 patients with PICC tube malignant tumors discharged from the superior hospital during this time range served as the control group(return to the original catheterization hospital from time to time or perform catheter maintenance care in the nursing clinic of our hospital).The self-care ability scores,health behavior scores,and complications during intubation between both groups were analyzed.Results:(1)There was no significant difference in self-care ability score and healthy behavior score between groups before the intervention,P>0.05;the self-care ability score and health behavior score of the research group were better than the control group after intervention,P<0.05;(2)After investigation,the incidence of complications in the research group(2.50%)was lower than that of the control group(10.00%),but there was no difference between the groups,P>0.05.Conclusion:Continuous self-management education has good effects on improving the self-care ability of tumor patients with PICC intubation.It can urge patients to maintain good health behaviors and reduce complications.It is worthy of promotion.展开更多
Objective:To investigate the effects of health education based on the Transtheoretical Model(TTM)on self-management and vascular crisis in patients undergoing finger replantation surgery.Methods:A total of 106 patient...Objective:To investigate the effects of health education based on the Transtheoretical Model(TTM)on self-management and vascular crisis in patients undergoing finger replantation surgery.Methods:A total of 106 patients who underwent finger replantation surgery between January 2025 and December 2025 were randomly divided into control and intervention groups using a random number table method(control group,n=52;intervention group,n=54).The control group received standard perioperative nursing care,while the intervention group received TTM-based health education in addition to standard care.Self-management levels and incidence of vascular crisis were compared between the two groups.Results:After intervention,the Adult Health Self-Management Skills Rating Scale(AHSMSRS)scores in both groups increased significantly compared with baseline(control:91.26±5.49 to 116.97±8.15;intervention:90.39±6.72 to 136.38±9.36,p<0.001).The intervention group showed significantly higher AHSMSRS scores than the control group(136.38±9.36 vs.116.97±8.15,p<0.001).Similarly,general self-efficacy scores increased significantly in both groups,with the intervention group demonstrating superior improvement(36.73±4.78 vs.28.49±4.11,p<0.001).The incidence of vascular crisis was significantly lower in the intervention group(5.5%)compared with the control group(19.23%,χ2=3.421,p<0.05).Conclusion:Health education based on the Transtheoretical Model effectively enhances self-management abilities and self-efficacy in patients undergoing finger replantation surgery,and significantly reduces the incidence of postoperative vascular crisis.展开更多
BACKGROUND Despite societal guidelines recommending targeted screening for Barrett’s esophagus(BE)and esophageal adenocarcinoma(EAC)in individuals with gastroesophageal reflux symptoms(GERS),screening adherence is su...BACKGROUND Despite societal guidelines recommending targeted screening for Barrett’s esophagus(BE)and esophageal adenocarcinoma(EAC)in individuals with gastroesophageal reflux symptoms(GERS),screening adherence is suboptimal.Current screening approaches fail to identify individuals not seeking medical consultation for GERS or whose GERS are managed with‘over-the-counter’(OTC)acid suppressant therapies.AIM To assess patients’self-management and help-seeking behavior for GERS.METHODS This cross-sectional study collected data from the Dutch general population aged 18-75 years between January and April 2023 using a web-based survey.The survey included questions regarding self-management(e.g.,use of acid suppressant therapy with or without prescription)and help-seeking behavior(e.g.,consulting a primary care provider)for GERS.Simple random sampling was performed to select individuals within the target age group.In total,18156 randomly selected individuals were invited to participate.The study protocol was registered in ClinicalTrials.gov(identifier:NCT05689918).RESULTS Of the 18156 invited individuals,3214 participants(17.7%)completed the survey,of which 1572 participants(48.9%)reported GERS.Of these,904 participants(57.5%)had never consulted a primary care provider for these symptoms,of which 331 participants(36.6%)reported taking OTC acid suppressant therapy in the past six months and 100 participants(11.1%)fulfilled the screening criteria for BE and EAC according to the European Society of Gastrointestinal Endoscopy Guideline.CONCLUSION The population fulfilling the screening criteria for BE and EAC is incompletely identified,suggesting potential underutilization of medical consultation.Raising public awareness of GERS as a risk factor for EAC is needed.展开更多
Fluctuating chronic conditions(FCC)in young adults aged 18-30 years,such as type 1 diabetes(T1D),sickle cell disease(SCD),and inflammatory bowel disease(IBD),present unique self-management challenges due to unpredicta...Fluctuating chronic conditions(FCC)in young adults aged 18-30 years,such as type 1 diabetes(T1D),sickle cell disease(SCD),and inflammatory bowel disease(IBD),present unique self-management challenges due to unpredictable symptom patterns that disrupt daily life.Tailored self-management interventions are essential for improving quality of life and health outcomes in this population.This scoping review synthesizes the literature on self-management interventions for young adults with T1D,SCD,and IBD,focusing on key concepts,intervention components,barriers,facilitators,and underlying theoretical frameworks.A systematic search was conducted across seven databases(PubMed,Embase,Cochrane Library,PsycINFO,Medline,CINAHL,and Web of Science)for studies in English published between January 2003 and January 2025.Studies were included if they examined self-management interventions for T1D,SCD,or IBD in young adults aged 18-30 years.Thirty-three studies met the inclusion criteria.Key interventions identified included structured educational programs,digital health tools,and peer support networks.Across different conditions,common themes emerged emphasizing patient education,empowerment,self-regulation,and psychosocial support.Interventions that integrated technology with peer support demonstrated improved engagement and health outcomes.Despite the diversity of approaches,there remains a need for more developmentally appropriate,inclusive interventions that address both condition-specific and shared challenges faced by young adults with FCC.This review highlights gaps in the current evidence base and underscores the importance of personalized,technology-enabled strategies to optimize self-management and health outcomes for this population.展开更多
Objective To help China’s pharmaceutical enterprises better understand continuous manufacturing,and to promote the development of new technologies and innovation in the pharmaceutical industry.Methods The advantages ...Objective To help China’s pharmaceutical enterprises better understand continuous manufacturing,and to promote the development of new technologies and innovation in the pharmaceutical industry.Methods The advantages and challenges of continuous manufacturing were summarized through literature research.Then,a comprehensive comparative analysis was conducted on the application of continuous manufacturing of approved and listed varieties by querying the evaluation documents of Europe,the USA,Japan,and China.Results and Conclusion The issues that Chinese pharmaceutical enterprises should pay attention to when applying continuous manufacturing technique were discussed from four aspects:feasibility analysis,variety selection,process research,and communication with regulatory authorities.Continuous manufacturing is an innovative technique that can change the production of the pharmaceutical industry.However,the uncertainty of new technique and the various changes brought about by continuous manufacturing models pose many challenges to its application.Implementing continuous manufacturing requires enterprises to have technological knowledge in quality management,research and development,and regulatory aspects.Enterprises should take advantage of the opportunity period before and after the emergence of new technique to seize the breakthrough of innovation so that continuous manufacturing can be better implemented in China.展开更多
Background:Continuous care for children with enterostomy and their families has been gaining popularity in China.Objective:To evaluate the feasibility of continuous care for children with enterostomy and their familie...Background:Continuous care for children with enterostomy and their families has been gaining popularity in China.Objective:To evaluate the feasibility of continuous care for children with enterostomy and their families in China.Methods:The PubMed,Web of Science,Embase,Cochrane Library,EBSCO,CNKI,CBM,VIP,and WanFang were searched for clinical trials until December 30,2025.Two reviewers independently searched articles,evaluated quality and extracted data.This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA).Results:33 studies involving 2774 participants were included.The meta-analysis showed that continuous care strategy can significantly reduce the incidence of complications in children with enterostomy(OR=0.20,95%CI=0.16-0.26,p<0.001,I2=0%),effectively improve the family caregiver ability for enterostomy(MD=-10.34,95%CI=-13.82 to-6.85,p<0.001,I2=99%),shorten the time for family members to replace stoma bags(MD=-13.57,95%CI=-19.66 to-7.49,p<0.001,I2=100%),and alleviate negative emotions such as anxiety(SMD=-1.80,95%CI=-2.36 to-1.23,p<0.001,I2=92%)and depression(SMD=-1.54,95%CI=-2.04 to-1.04,p<0.001,I2=89%)in the families of the affected children.Conclusions:Continuous care can reduce complications of enterostomy in children,improve the family caregiver ability for enterostomy and alleviate negative emotions of family members such as anxiety and depression.展开更多
Local resonant acoustic metamaterials have broad applications in sound insulation,yet their single-configuration designs often exhibit limited and discontinuous bandgap widths,hindering full-frequency noise attenuatio...Local resonant acoustic metamaterials have broad applications in sound insulation,yet their single-configuration designs often exhibit limited and discontinuous bandgap widths,hindering full-frequency noise attenuation across the human auditory range.This study presents a double-phase fidget-spinner-shaped acoustic metamaterial(DFAM),specifically designed to achieve an ultra-broad,low-frequency continuous bandgap by means of synergistic structural optimization,enabling effective and robust control of audible noise.Based on Bloch's theorem and the finite element method,the dispersion relation of the DFAM structure is calculated and verified by the transmission loss curves.The propagation characteristics of sound waves within the structure are further analyzed for noise frequencies that fall within the passband.The influence of the geometric and physical parameters on the bandgap is investigated,and the corresponding transmission loss in the propagation direction is further calculated.A hybrid collaborative design strategy,leveraging multi-parameter optimization and bandgap complementarity,is developed to construct a metastructure with continuous bandgap coverage from 20 Hz to 1000 Hz.The resulting metastructure demonstrates exceptional broadband noise attenuation,achieving a total bandgap width of 876.3 Hz(87.63% of the target range)with the transmission loss up to-762.78 d B in a three-periodic arrangement.The simulation and experimental results for the transmission loss of the DFAM metastructure show strong agreement in the low-frequency range.This work provides a novel framework for designing ultra-wide low-frequency continuous bandgap metastructures,offering significant potential for noise mitigation in complex environments.展开更多
We report an immobilized enzyme-catalyzed batch and continuous-flow synthesis of optically pure ethyl(R)-pantothenate((R)-PaOEt),the direct precursor of d-pantothenic acid.Firstly,a ketoreductase mutant designated as ...We report an immobilized enzyme-catalyzed batch and continuous-flow synthesis of optically pure ethyl(R)-pantothenate((R)-PaOEt),the direct precursor of d-pantothenic acid.Firstly,a ketoreductase mutant designated as M2,carrying two-point mutations of F97L and M242F relative to the wild-type SSCR,was constructed by site-directed mutagenesis,exhibited simultaneously improved activity toward ethyl 2′-ketopantothenate(K-PaOEt)and isopropanol,and could effectively catalyze the stereoselective reduction of K-PaOEt to(R)-PaOEt by using isopropanol as the sacrificial co-substrate to regenerate NADPH.After screening six commercially available carriers,an amino resin LXTE-700 was identified as the best solid support for the immobilization of M2 via the glutaraldehyde activation method.Upon optimization of the immobilization process and reaction conditions,the fabricated immobilized enzyme M2@amino resin demonstrated excellent recyclability and reusability,with the complete conversion of K-PaOEt to(R)-PaOEt being still realized after 12 cycles of reuse.Finally,M2@amino resin-catalyzed synthesis of(R)-PaOEt was successfully implemented in continuous-flow,accomplishing a 6.3 times higher space-time yield than that with the batch synthesis(529.2 versus 84 g L^(-1) d^(-1)).Our developed flow biocatalysis system also features an outstanding operational stability,as evidenced by the 100%conversion rate achieved after 15 consecutive days of operation.展开更多
The rapid decay of the surface wettability of plasma-treated polymers remains a critical limitation for their practical application in advanced materials.This study introduces a continuous atmospheric pressure plasma(...The rapid decay of the surface wettability of plasma-treated polymers remains a critical limitation for their practical application in advanced materials.This study introduces a continuous atmospheric pressure plasma(APP)technique for fabricating polyethylene(PE)separators with durable wettability,and elucidates the underlying mechanism.A systematic comparison of APP treatments with non-deposition and deposition gases,including Ar,Ar/O_(2),Ar/tetramethylcyclotetrasiloxane(TMCTS),and Ar/O_(2)/TMCTS,revealed the key impact factors in achieving durable wettability.Owing to the synergistic interactions of SiO_(x)C_(y)H_(z)nanoparticulate deposition,physical etching,and oxidative functionalization,the PE separator treated by Ar/O_(2)/TMCTS exhibited a 17.5-fold electrolyte wetting area compared to the original one.The improved surface energy and roughness of the SiO_(x)C_(y)H_(z)nanoparticle coating enhanced its electrochemical performance.The ionic conductivity increased by 1.9 times,while the charge transfer resistance decreased by 73.7%.Remarkably,owing to further oxidation of the SiO_(x)C_(y)H_(z)nanoparticle coating and the increase in its silica-like structure,the wetting area of the Ar/O_(2)/TMCTS-treated separator was still over 14-fold larger than that of the original separator after aging for 90 days.This study demonstrates an eco-friendly and scalable approach for fabricating high-performance battery separators and provides mechanistic insights into durable wettability by APP.展开更多
Autonomous truck platooning,as a novel transportationmode,has attracted significant attention due to its potential to improve transportation efficiency,reduce energy consumption,and lower operational costs.However,thi...Autonomous truck platooning,as a novel transportationmode,has attracted significant attention due to its potential to improve transportation efficiency,reduce energy consumption,and lower operational costs.However,this emerging mode poses new challenges to the dynamic performance of long-span bridges.This study aims to investigate the impact of autonomous truck platoons on the dynamic performance of continuous beam bridges.Using finite element software to construct accurate vehicle-bridge interaction models,we simulated the dynamic response between vehicle platoons and bridge structures.The study systematically evaluated the effects of four key factors—vehicle speed,number of formations,vehicle spacing,and vehicle weight—on mid-span deformation and the dynamic amplification factor of bridges.Taking a long-span continuous beam bridge as the research object and employing orthogonal experimental designmethods,we efficiently explored themulti-factor interactive effects on bridge dynamic response.Research results indicate that vehicle speed is the dominant factor affecting the bridge dynamic coefficient,showing a significant positive correlation.The interaction between vehicle spacing and the number of formations has a substantial impact on the dynamic coefficient,particularly under conditions of high-speed operation,large-scale formations,tight vehicle spacing,and heavy-load multi-factor coupling.These conditions can significantly increase mid-span bridge deformation and the dynamic coefficient,potentially exceeding design live-load standard value in specific scenarios.Based on the experimental results,this study recommends that truck formations strictly control vehicle speed during operation,maintain appropriate vehicle spacing,limit the number of formations,and regulate loading conditions to ensure normal bridge operation and long-termdurability.The research findings provide scientific guidance for optimizing truck formation strategies and ensuring bridge safety.展开更多
Maintaining constant mold level variations during the continuous casting process is essential to guarantee the effectiveness and quality of steel production. An unsupervised deep learning-based mold level anomaly dete...Maintaining constant mold level variations during the continuous casting process is essential to guarantee the effectiveness and quality of steel production. An unsupervised deep learning-based mold level anomaly detection (MLAD) model for real-time monitoring of mold level fluctuations under varying operating conditions was proposed. The MLAD framework employs a two-stage encoder-decoder structure with adversarial training to accurately reconstruct time-series mold level data. In the first stage, the model learns long-term trends by reconstructing input windows, while in the second stage, it employs reconstruction errors as focus scores to capture short-term anomaly patterns. A transformer-based architecture, incorporating multi-head attention mechanisms and positional encoding, enables MLAD to capture both local and global temporal dependencies. In addition, a novel multi-threshold strategy, based on extreme value theory, is implemented to enhance the model’s ability and to adapt to varying operating conditions, including startup, steady-state, and shutdown phases. The model was validated with over 240-h real data from a steel factory. The results demonstrate its superior performance in anomaly detection compared to popular methods, with a precision of 0.9937, recall of 0.9932, and a low false alarm rate of 0.0038. MLAD represents a significant advancement in the detection of nonlinear and nonstationary anomalies in industrial processes, offering an efficient solution for smart manufacturing systems. Therefore, the established model could be used for online anomaly detection of mold level with real-time data.展开更多
1.Introduction.Pancreaticoduodenectomy is an essential surgical procedure for the treatment of malignant tumors in the pancreatic head,distal common bile duct,and duodenal papilla,and is widely used in clinical practi...1.Introduction.Pancreaticoduodenectomy is an essential surgical procedure for the treatment of malignant tumors in the pancreatic head,distal common bile duct,and duodenal papilla,and is widely used in clinical practice.One of the primary determinants of surgical success is the durability of the pancreaticojejunal anastomosis.展开更多
The transient phenomena of re-oxidation and slag entrapment occurring in the tundish during the ladle change-over process have been proven detrimental to clean steel production.Therefore,an unsteady three-phase turbul...The transient phenomena of re-oxidation and slag entrapment occurring in the tundish during the ladle change-over process have been proven detrimental to clean steel production.Therefore,an unsteady three-phase turbulence model,coupling velocity,temperature,and phase field was established to study the effect of the ladle shroud immersion depth on the slag eye formation,slag entrainment,slag dragging,air dragging,and flow characteristics during the ladle change-over process of a two-strand tundish.The results showed that reducing the immersion depth decreases the high-velocity region area under the slag layer in the quasi-steady process.During the emptying stage,as the molten bath level gradually decreases,the outlet temperature exhibits a trend of initially decreasing and subsequently increasing across all three shroud immersion depths.However,under a 210 mm shroud immersion depth,molten slag and air are dragged into the shroud,forming slag droplets and causing significant fluctuations,with a maximum scalar velocity of 0.0764 m/s at the monitoring point.In the filling stage,air and molten slag are dragged into the molten bath,forming bubbles and slag droplets at an immersion depth of 210 mm.Bubbles are observed within the molten slag layer,which can readily cause an emulsification phenomenon,making it easier to be dragged as slag droplets.Additionally,the slag eye area measured under 210 mm immersion depth at 45 s is 0.303 m^(2),while the maximum scalar velocity of 2.4259 m/s is detected at 12 s.At an immersion depth of 360 mm,the average area of the slag eye is minimized to 0.06268 m2,with corresponding variances of 0.006753,representing the optimal immersion depth.展开更多
A full-sectional microstructure characterization method was developed to investigate the formation of coarse slag rims during the continuous casting of hypo-peritectic steel.The cross-sectional microstructural analysi...A full-sectional microstructure characterization method was developed to investigate the formation of coarse slag rims during the continuous casting of hypo-peritectic steel.The cross-sectional microstructural analysis of typical slag rims for two highly crystalline powders revealed that their formation was primarily driven by the solidification of the liquid slag.Distinct differences were observed in the microstructures of slag rims from the two powders.Powder A(characterized by a higher breaking temperature and viscosity)displayed alternating lamellar microstructures of coarse and fine phases,with the coarse phases composed of akermanite-gehlenite transition phases.In contrast,powder B(with a lower breaking temperature and viscosity)predominantly comprised regular akermanite-gehlenite crystals interspersed with a certain amount of glassy phases.Numerical simulations of a three-phase fluid flow coupled with heat transfer indicate that slag rim formation correlates with mold oscillation.Solidification of the liquid slag at the slag rim front predominantly occurs during the negative stroke of the mold oscillation.The average heating rate during the ascending stage of the mold reaches approximately 100 K·s^(−1),whereas the average cooling rate during the descending stage attains 400 K·s^(−1).This temperature variation leads to the formation of lamellar microstructures,whereas the ascending stage promotes the formation of coarse structures and thicker slag rims.Based on the powder properties,two distinct formation pathways exist for highly crystalline mold powders.For the powders with a higher breaking temperature,higher viscosity,and narrower solidification range(powder A),coarse microstructures and thicker slag rims were preferentially formed.For powders with lower breaking temperature and viscosity and wider solidification ranges(powder B),the liquid slag resisted rapid solidification,and the extended mushy zone allowed the partial liquid slag to persist at the slag rim front,promoting the formation of a thin slag rim.This study enhances the understanding of slag rim formation in highly crystalline mold powders and provides critical insights into the control of longitudinal surface cracks in hypo-peritectic steel.展开更多
Objective:To investigate the effects of switching to either Prandilin 25R monotherapy or Prandilin 25R combined with ganagliflozin proline tablets after short-term intensive continuous subcutaneous insulin infusion du...Objective:To investigate the effects of switching to either Prandilin 25R monotherapy or Prandilin 25R combined with ganagliflozin proline tablets after short-term intensive continuous subcutaneous insulin infusion during hospitalization in elderly patients with type 2 diabetes mellitus on glycemic control,glycometabolic indicators,and cardiovascular risk factors,and to evaluate the safety of the two regimens.Methods:A total of 78 elderly patients with type 2 diabetes mellitus admitted to our hospital from January 2025 to September 2025 were selected and randomly divided into a control group and an observation group,with 39 cases in each group.The control group received monotherapy with insulin lispro protamine recombinant injection(Prandilin 25R)after intensive continuous subcutaneous insulin infusion,while the observation group received Prandilin 25R combined with ganagliflozin proline tablets.Continuous glucose monitoring(CGM)was performed for 14 days during the intensive continuous subcutaneous insulin infusion therapy phase in the hospital,followed by routine fingertip blood glucose monitoring after 14 days.Glycemic control indicators,glycometabolic indicators,and the incidence of adverse reactions were compared between the two groups.Results:After treatment,the mean amplitude of glycemic excursions and the 24-hour blood glucose standard deviation were significantly lower in the observation group than in the control group,while the time spent within the target blood glucose range was significantly higher(p<0.05).The levels of glycated hemoglobin,fasting blood glucose,and 2-hour postprandial blood glucose were better in the observation group than in the control group;moreover,the body mass index,systolic blood pressure,and blood lipid levels improved more significantly in the observation group than in the control group(p<0.05).There was no statistically significant difference in the incidence of hypoglycemia between the two groups.Conclusion:Combination therapy with ganagliflozin proline tablets after short-term intensive continuous subcutaneous insulin infusion therapy can effectively improve glycemic variability in elderly patients with type 2 diabetes mellitus,with good safety.This suggests that ganagliflozin proline tablets have a hypoglycemic advantage in the combination regimen and possess high clinical promotional value.展开更多
The flow behavior of molten steel in the thin slab mold under high casting speed conditions was investigated,with a focus on the multi-mode continuous casting and rolling mold.A steel-slag two-phase flow model was est...The flow behavior of molten steel in the thin slab mold under high casting speed conditions was investigated,with a focus on the multi-mode continuous casting and rolling mold.A steel-slag two-phase flow model was established using large eddy simulation,the volume of fluid,and magnetohydrodynamics methods through numerical simulation.The maximum flow velocity and wave height at the steel-slag interface within the mold are critical evaluation criteria for analyzing asymmetric flow under varying casting speeds and electromagnetic braking.The results indicate that the asymmetric flows within the mold do not occur synchronously.The severity of the asymmetric flow correlates with the velocity difference across the steel-slag interface.A greater biased flow prolongs the time required to revert to a steady state.When the magnetic field intensity is set to 0.24 T and the magnetic pole position is at 390 mm from the steel-slag interface,this configuration can reduce the velocity of the steel-slag interface,thereby mitigating the asymmetric flow.Additionally,it can diminish the velocity,impact depth,and impact intensity on the narrow face of the jet,thus improving the distribution of velocity and turbulent kinetic energy within the mold.This configuration prolongs the time required for the steel-slag interface to transition from a stable state to its maximum velocity and shortens the time for the interface to return to stability from an unstable state.Moreover,it ensures the positional stability of the steel-slag interface,confining its position within−3 mm.展开更多
Continuous variable cross-section recycled extrusion(CVCE)is an advanced technique of severe plastic deformation.Ti–6Al–4V alloy was deformed with different processing parameters by CVCE,and then the microstructure ...Continuous variable cross-section recycled extrusion(CVCE)is an advanced technique of severe plastic deformation.Ti–6Al–4V alloy was deformed with different processing parameters by CVCE,and then the microstructure characterization,refinement mechanism and deformation mechanism were investigated simultaneously.The results demonstrate that the average size of grain is refined from 14 to 2.78μm as Ti–6Al–4V alloy is deformed at 800℃ with a speed of 2 mm/s over 6 passes,and the microstructure is equiaxed and distributed homogeneously along the radial direction.Furthermore,in the process of CVCE,basal slip(0001)<110>is transformed to prismatic slip(100)<110>system and pyramidal slip(112)<113>system,with a reduction in low angle grain boundaries from 69.6%to 61.2%.Moreover,the grain refinement mechanism of CVCE is dislocation multiplication and cross-slip migration within the grain at the initial stage of deformation,which results in the formation of substructures and micro-shear bands as well as grain refinement.In addition,the nucleation and growth of dynamic recrystallization grains are beneficial to eliminating the dislocations,subgrain boundaries and other defects in the matrix,which finally results in the grains refinement.展开更多
Under the background of achieving energy efficiency and carbon reduction,the use of Continuous Casting-Direct Hot Charging Rolling(CC-DHCR)technology was explored at the Hot Rolling Plant of Baosteel,China.As temperat...Under the background of achieving energy efficiency and carbon reduction,the use of Continuous Casting-Direct Hot Charging Rolling(CC-DHCR)technology was explored at the Hot Rolling Plant of Baosteel,China.As temperature variation and temperature uniformity directly affect the rolling quality of the billet,numerical simulations of the billet temperature profile changes in the CC-DHCR were conducted at the start of the industrial trial,and the billet temperature distribution and cross-section temperature difference during its transportation and throughout the heating process were analyzed.According to numerical simulation calculations,the average temperature of billet discharged from the heating furnace was 1150℃,which after subsequent controlled cooling met the final rolling temperature requirements of(880±30)℃for this kind of steel.The maximum temperature difference of the billet discharged from the furnace was within 35 K,which meets the billet heating uniformity requirements of the rolling process.The simulation results were compared with experimental results,and the rationality of the simulation was validated.In addition,the industrial trial billet was rolled,and the rolling quality was good during tracking.In this CC-DHCR industrial trial,the fuel consumption was 28.6 kgce/t(kilogram coal equivalent per ton),a reduction of 33.7%compared with the current traditional process,and CO 2 emissions were reduced by 38.09 kg/t.展开更多
Dear Editor,This letter proposes a reinforcement learning-based predictive learning algorithm for unknown continuous-time nonlinear systems with observation loss.Firstly,we construct a temporal nonzero-sum game over p...Dear Editor,This letter proposes a reinforcement learning-based predictive learning algorithm for unknown continuous-time nonlinear systems with observation loss.Firstly,we construct a temporal nonzero-sum game over predictive control input sequences,deriving multiple optimal predictive control input sequences from its solution.展开更多
China has achieved a major engineering milestone in the construction of the Beishan Underground Research Laboratory(URL)for geological disposal of high-level radioactive waste(HLW).On December 26,2025,the project team...China has achieved a major engineering milestone in the construction of the Beishan Underground Research Laboratory(URL)for geological disposal of high-level radioactive waste(HLW).On December 26,2025,the project team successfully completed the excavation of the world's first deep,continuous small-radius,steep spiral ramp by a tunnel boring machine(TBM)named Beishan No.1,which marked the completion of the underground main structure of Beishan URL.展开更多
文摘Objective:To analyze the effects of continuous self-management education on the selfcare ability and health behavior of patients with tumor through peripherally inserted central venous catheters(PICC).Methods:The period from August 2018 to August 2020 was used as the research time range,and the random number table method was used as the basis for grouping.80 patients with malignant tumors who regularly performed fixed catheter maintenance care in the PICC clinic of our hospital were admitted in the experimental group(given PICC specialist nursing,and implemented continuous self-management education),and 80 patients with PICC tube malignant tumors discharged from the superior hospital during this time range served as the control group(return to the original catheterization hospital from time to time or perform catheter maintenance care in the nursing clinic of our hospital).The self-care ability scores,health behavior scores,and complications during intubation between both groups were analyzed.Results:(1)There was no significant difference in self-care ability score and healthy behavior score between groups before the intervention,P>0.05;the self-care ability score and health behavior score of the research group were better than the control group after intervention,P<0.05;(2)After investigation,the incidence of complications in the research group(2.50%)was lower than that of the control group(10.00%),but there was no difference between the groups,P>0.05.Conclusion:Continuous self-management education has good effects on improving the self-care ability of tumor patients with PICC intubation.It can urge patients to maintain good health behaviors and reduce complications.It is worthy of promotion.
文摘Objective:To investigate the effects of health education based on the Transtheoretical Model(TTM)on self-management and vascular crisis in patients undergoing finger replantation surgery.Methods:A total of 106 patients who underwent finger replantation surgery between January 2025 and December 2025 were randomly divided into control and intervention groups using a random number table method(control group,n=52;intervention group,n=54).The control group received standard perioperative nursing care,while the intervention group received TTM-based health education in addition to standard care.Self-management levels and incidence of vascular crisis were compared between the two groups.Results:After intervention,the Adult Health Self-Management Skills Rating Scale(AHSMSRS)scores in both groups increased significantly compared with baseline(control:91.26±5.49 to 116.97±8.15;intervention:90.39±6.72 to 136.38±9.36,p<0.001).The intervention group showed significantly higher AHSMSRS scores than the control group(136.38±9.36 vs.116.97±8.15,p<0.001).Similarly,general self-efficacy scores increased significantly in both groups,with the intervention group demonstrating superior improvement(36.73±4.78 vs.28.49±4.11,p<0.001).The incidence of vascular crisis was significantly lower in the intervention group(5.5%)compared with the control group(19.23%,χ2=3.421,p<0.05).Conclusion:Health education based on the Transtheoretical Model effectively enhances self-management abilities and self-efficacy in patients undergoing finger replantation surgery,and significantly reduces the incidence of postoperative vascular crisis.
文摘BACKGROUND Despite societal guidelines recommending targeted screening for Barrett’s esophagus(BE)and esophageal adenocarcinoma(EAC)in individuals with gastroesophageal reflux symptoms(GERS),screening adherence is suboptimal.Current screening approaches fail to identify individuals not seeking medical consultation for GERS or whose GERS are managed with‘over-the-counter’(OTC)acid suppressant therapies.AIM To assess patients’self-management and help-seeking behavior for GERS.METHODS This cross-sectional study collected data from the Dutch general population aged 18-75 years between January and April 2023 using a web-based survey.The survey included questions regarding self-management(e.g.,use of acid suppressant therapy with or without prescription)and help-seeking behavior(e.g.,consulting a primary care provider)for GERS.Simple random sampling was performed to select individuals within the target age group.In total,18156 randomly selected individuals were invited to participate.The study protocol was registered in ClinicalTrials.gov(identifier:NCT05689918).RESULTS Of the 18156 invited individuals,3214 participants(17.7%)completed the survey,of which 1572 participants(48.9%)reported GERS.Of these,904 participants(57.5%)had never consulted a primary care provider for these symptoms,of which 331 participants(36.6%)reported taking OTC acid suppressant therapy in the past six months and 100 participants(11.1%)fulfilled the screening criteria for BE and EAC according to the European Society of Gastrointestinal Endoscopy Guideline.CONCLUSION The population fulfilling the screening criteria for BE and EAC is incompletely identified,suggesting potential underutilization of medical consultation.Raising public awareness of GERS as a risk factor for EAC is needed.
文摘Fluctuating chronic conditions(FCC)in young adults aged 18-30 years,such as type 1 diabetes(T1D),sickle cell disease(SCD),and inflammatory bowel disease(IBD),present unique self-management challenges due to unpredictable symptom patterns that disrupt daily life.Tailored self-management interventions are essential for improving quality of life and health outcomes in this population.This scoping review synthesizes the literature on self-management interventions for young adults with T1D,SCD,and IBD,focusing on key concepts,intervention components,barriers,facilitators,and underlying theoretical frameworks.A systematic search was conducted across seven databases(PubMed,Embase,Cochrane Library,PsycINFO,Medline,CINAHL,and Web of Science)for studies in English published between January 2003 and January 2025.Studies were included if they examined self-management interventions for T1D,SCD,or IBD in young adults aged 18-30 years.Thirty-three studies met the inclusion criteria.Key interventions identified included structured educational programs,digital health tools,and peer support networks.Across different conditions,common themes emerged emphasizing patient education,empowerment,self-regulation,and psychosocial support.Interventions that integrated technology with peer support demonstrated improved engagement and health outcomes.Despite the diversity of approaches,there remains a need for more developmentally appropriate,inclusive interventions that address both condition-specific and shared challenges faced by young adults with FCC.This review highlights gaps in the current evidence base and underscores the importance of personalized,technology-enabled strategies to optimize self-management and health outcomes for this population.
文摘Objective To help China’s pharmaceutical enterprises better understand continuous manufacturing,and to promote the development of new technologies and innovation in the pharmaceutical industry.Methods The advantages and challenges of continuous manufacturing were summarized through literature research.Then,a comprehensive comparative analysis was conducted on the application of continuous manufacturing of approved and listed varieties by querying the evaluation documents of Europe,the USA,Japan,and China.Results and Conclusion The issues that Chinese pharmaceutical enterprises should pay attention to when applying continuous manufacturing technique were discussed from four aspects:feasibility analysis,variety selection,process research,and communication with regulatory authorities.Continuous manufacturing is an innovative technique that can change the production of the pharmaceutical industry.However,the uncertainty of new technique and the various changes brought about by continuous manufacturing models pose many challenges to its application.Implementing continuous manufacturing requires enterprises to have technological knowledge in quality management,research and development,and regulatory aspects.Enterprises should take advantage of the opportunity period before and after the emergence of new technique to seize the breakthrough of innovation so that continuous manufacturing can be better implemented in China.
文摘Background:Continuous care for children with enterostomy and their families has been gaining popularity in China.Objective:To evaluate the feasibility of continuous care for children with enterostomy and their families in China.Methods:The PubMed,Web of Science,Embase,Cochrane Library,EBSCO,CNKI,CBM,VIP,and WanFang were searched for clinical trials until December 30,2025.Two reviewers independently searched articles,evaluated quality and extracted data.This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA).Results:33 studies involving 2774 participants were included.The meta-analysis showed that continuous care strategy can significantly reduce the incidence of complications in children with enterostomy(OR=0.20,95%CI=0.16-0.26,p<0.001,I2=0%),effectively improve the family caregiver ability for enterostomy(MD=-10.34,95%CI=-13.82 to-6.85,p<0.001,I2=99%),shorten the time for family members to replace stoma bags(MD=-13.57,95%CI=-19.66 to-7.49,p<0.001,I2=100%),and alleviate negative emotions such as anxiety(SMD=-1.80,95%CI=-2.36 to-1.23,p<0.001,I2=92%)and depression(SMD=-1.54,95%CI=-2.04 to-1.04,p<0.001,I2=89%)in the families of the affected children.Conclusions:Continuous care can reduce complications of enterostomy in children,improve the family caregiver ability for enterostomy and alleviate negative emotions of family members such as anxiety and depression.
基金Project supported by the National Natural Science Foundation of China(No.12572020)the Key Project of Natural Science Foundation of Hebei Province of China(No.A2023210064)。
文摘Local resonant acoustic metamaterials have broad applications in sound insulation,yet their single-configuration designs often exhibit limited and discontinuous bandgap widths,hindering full-frequency noise attenuation across the human auditory range.This study presents a double-phase fidget-spinner-shaped acoustic metamaterial(DFAM),specifically designed to achieve an ultra-broad,low-frequency continuous bandgap by means of synergistic structural optimization,enabling effective and robust control of audible noise.Based on Bloch's theorem and the finite element method,the dispersion relation of the DFAM structure is calculated and verified by the transmission loss curves.The propagation characteristics of sound waves within the structure are further analyzed for noise frequencies that fall within the passband.The influence of the geometric and physical parameters on the bandgap is investigated,and the corresponding transmission loss in the propagation direction is further calculated.A hybrid collaborative design strategy,leveraging multi-parameter optimization and bandgap complementarity,is developed to construct a metastructure with continuous bandgap coverage from 20 Hz to 1000 Hz.The resulting metastructure demonstrates exceptional broadband noise attenuation,achieving a total bandgap width of 876.3 Hz(87.63% of the target range)with the transmission loss up to-762.78 d B in a three-periodic arrangement.The simulation and experimental results for the transmission loss of the DFAM metastructure show strong agreement in the low-frequency range.This work provides a novel framework for designing ultra-wide low-frequency continuous bandgap metastructures,offering significant potential for noise mitigation in complex environments.
基金the Science and Technology R&D Major Project of Jiangxi Province(No.20244AFI92001)the National Natural Science Foundation of China(Nos.22071033 and 21801047)for the financial supports.
文摘We report an immobilized enzyme-catalyzed batch and continuous-flow synthesis of optically pure ethyl(R)-pantothenate((R)-PaOEt),the direct precursor of d-pantothenic acid.Firstly,a ketoreductase mutant designated as M2,carrying two-point mutations of F97L and M242F relative to the wild-type SSCR,was constructed by site-directed mutagenesis,exhibited simultaneously improved activity toward ethyl 2′-ketopantothenate(K-PaOEt)and isopropanol,and could effectively catalyze the stereoselective reduction of K-PaOEt to(R)-PaOEt by using isopropanol as the sacrificial co-substrate to regenerate NADPH.After screening six commercially available carriers,an amino resin LXTE-700 was identified as the best solid support for the immobilization of M2 via the glutaraldehyde activation method.Upon optimization of the immobilization process and reaction conditions,the fabricated immobilized enzyme M2@amino resin demonstrated excellent recyclability and reusability,with the complete conversion of K-PaOEt to(R)-PaOEt being still realized after 12 cycles of reuse.Finally,M2@amino resin-catalyzed synthesis of(R)-PaOEt was successfully implemented in continuous-flow,accomplishing a 6.3 times higher space-time yield than that with the batch synthesis(529.2 versus 84 g L^(-1) d^(-1)).Our developed flow biocatalysis system also features an outstanding operational stability,as evidenced by the 100%conversion rate achieved after 15 consecutive days of operation.
基金supported by the National Natural Science Foundation of China(No.12075054)the Fundamental Research Funds for the Central Universities(No.CUSF-DH-T-2024069)。
文摘The rapid decay of the surface wettability of plasma-treated polymers remains a critical limitation for their practical application in advanced materials.This study introduces a continuous atmospheric pressure plasma(APP)technique for fabricating polyethylene(PE)separators with durable wettability,and elucidates the underlying mechanism.A systematic comparison of APP treatments with non-deposition and deposition gases,including Ar,Ar/O_(2),Ar/tetramethylcyclotetrasiloxane(TMCTS),and Ar/O_(2)/TMCTS,revealed the key impact factors in achieving durable wettability.Owing to the synergistic interactions of SiO_(x)C_(y)H_(z)nanoparticulate deposition,physical etching,and oxidative functionalization,the PE separator treated by Ar/O_(2)/TMCTS exhibited a 17.5-fold electrolyte wetting area compared to the original one.The improved surface energy and roughness of the SiO_(x)C_(y)H_(z)nanoparticle coating enhanced its electrochemical performance.The ionic conductivity increased by 1.9 times,while the charge transfer resistance decreased by 73.7%.Remarkably,owing to further oxidation of the SiO_(x)C_(y)H_(z)nanoparticle coating and the increase in its silica-like structure,the wetting area of the Ar/O_(2)/TMCTS-treated separator was still over 14-fold larger than that of the original separator after aging for 90 days.This study demonstrates an eco-friendly and scalable approach for fabricating high-performance battery separators and provides mechanistic insights into durable wettability by APP.
基金The authors would like to thank the support by“111”Project“Centre on Safety and Intelligent Operation of Sea Bridge(D21013)”.
文摘Autonomous truck platooning,as a novel transportationmode,has attracted significant attention due to its potential to improve transportation efficiency,reduce energy consumption,and lower operational costs.However,this emerging mode poses new challenges to the dynamic performance of long-span bridges.This study aims to investigate the impact of autonomous truck platoons on the dynamic performance of continuous beam bridges.Using finite element software to construct accurate vehicle-bridge interaction models,we simulated the dynamic response between vehicle platoons and bridge structures.The study systematically evaluated the effects of four key factors—vehicle speed,number of formations,vehicle spacing,and vehicle weight—on mid-span deformation and the dynamic amplification factor of bridges.Taking a long-span continuous beam bridge as the research object and employing orthogonal experimental designmethods,we efficiently explored themulti-factor interactive effects on bridge dynamic response.Research results indicate that vehicle speed is the dominant factor affecting the bridge dynamic coefficient,showing a significant positive correlation.The interaction between vehicle spacing and the number of formations has a substantial impact on the dynamic coefficient,particularly under conditions of high-speed operation,large-scale formations,tight vehicle spacing,and heavy-load multi-factor coupling.These conditions can significantly increase mid-span bridge deformation and the dynamic coefficient,potentially exceeding design live-load standard value in specific scenarios.Based on the experimental results,this study recommends that truck formations strictly control vehicle speed during operation,maintain appropriate vehicle spacing,limit the number of formations,and regulate loading conditions to ensure normal bridge operation and long-termdurability.The research findings provide scientific guidance for optimizing truck formation strategies and ensuring bridge safety.
基金supported by the Key Science and Technology Project of HBIS Materials Institute(No.HG2022328)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.311021013).
文摘Maintaining constant mold level variations during the continuous casting process is essential to guarantee the effectiveness and quality of steel production. An unsupervised deep learning-based mold level anomaly detection (MLAD) model for real-time monitoring of mold level fluctuations under varying operating conditions was proposed. The MLAD framework employs a two-stage encoder-decoder structure with adversarial training to accurately reconstruct time-series mold level data. In the first stage, the model learns long-term trends by reconstructing input windows, while in the second stage, it employs reconstruction errors as focus scores to capture short-term anomaly patterns. A transformer-based architecture, incorporating multi-head attention mechanisms and positional encoding, enables MLAD to capture both local and global temporal dependencies. In addition, a novel multi-threshold strategy, based on extreme value theory, is implemented to enhance the model’s ability and to adapt to varying operating conditions, including startup, steady-state, and shutdown phases. The model was validated with over 240-h real data from a steel factory. The results demonstrate its superior performance in anomaly detection compared to popular methods, with a precision of 0.9937, recall of 0.9932, and a low false alarm rate of 0.0038. MLAD represents a significant advancement in the detection of nonlinear and nonstationary anomalies in industrial processes, offering an efficient solution for smart manufacturing systems. Therefore, the established model could be used for online anomaly detection of mold level with real-time data.
文摘1.Introduction.Pancreaticoduodenectomy is an essential surgical procedure for the treatment of malignant tumors in the pancreatic head,distal common bile duct,and duodenal papilla,and is widely used in clinical practice.One of the primary determinants of surgical success is the durability of the pancreaticojejunal anastomosis.
基金supported by the National Natural Science Foundation of China(Nos.52422408 and 52171031)the Liaoning Xingliao Talents-Top-notch Young Talents Project(No.XLYC2203064)+1 种基金the Excellent Youth Fund of Liaoning Natural Science Foundation(No.2023JH3/10200001)the Fundamental Research Funds for the Central Universities(No.N2425004).
文摘The transient phenomena of re-oxidation and slag entrapment occurring in the tundish during the ladle change-over process have been proven detrimental to clean steel production.Therefore,an unsteady three-phase turbulence model,coupling velocity,temperature,and phase field was established to study the effect of the ladle shroud immersion depth on the slag eye formation,slag entrainment,slag dragging,air dragging,and flow characteristics during the ladle change-over process of a two-strand tundish.The results showed that reducing the immersion depth decreases the high-velocity region area under the slag layer in the quasi-steady process.During the emptying stage,as the molten bath level gradually decreases,the outlet temperature exhibits a trend of initially decreasing and subsequently increasing across all three shroud immersion depths.However,under a 210 mm shroud immersion depth,molten slag and air are dragged into the shroud,forming slag droplets and causing significant fluctuations,with a maximum scalar velocity of 0.0764 m/s at the monitoring point.In the filling stage,air and molten slag are dragged into the molten bath,forming bubbles and slag droplets at an immersion depth of 210 mm.Bubbles are observed within the molten slag layer,which can readily cause an emulsification phenomenon,making it easier to be dragged as slag droplets.Additionally,the slag eye area measured under 210 mm immersion depth at 45 s is 0.303 m^(2),while the maximum scalar velocity of 2.4259 m/s is detected at 12 s.At an immersion depth of 360 mm,the average area of the slag eye is minimized to 0.06268 m2,with corresponding variances of 0.006753,representing the optimal immersion depth.
基金supported by the National Natural Science Foundation of China(No.52274318).
文摘A full-sectional microstructure characterization method was developed to investigate the formation of coarse slag rims during the continuous casting of hypo-peritectic steel.The cross-sectional microstructural analysis of typical slag rims for two highly crystalline powders revealed that their formation was primarily driven by the solidification of the liquid slag.Distinct differences were observed in the microstructures of slag rims from the two powders.Powder A(characterized by a higher breaking temperature and viscosity)displayed alternating lamellar microstructures of coarse and fine phases,with the coarse phases composed of akermanite-gehlenite transition phases.In contrast,powder B(with a lower breaking temperature and viscosity)predominantly comprised regular akermanite-gehlenite crystals interspersed with a certain amount of glassy phases.Numerical simulations of a three-phase fluid flow coupled with heat transfer indicate that slag rim formation correlates with mold oscillation.Solidification of the liquid slag at the slag rim front predominantly occurs during the negative stroke of the mold oscillation.The average heating rate during the ascending stage of the mold reaches approximately 100 K·s^(−1),whereas the average cooling rate during the descending stage attains 400 K·s^(−1).This temperature variation leads to the formation of lamellar microstructures,whereas the ascending stage promotes the formation of coarse structures and thicker slag rims.Based on the powder properties,two distinct formation pathways exist for highly crystalline mold powders.For the powders with a higher breaking temperature,higher viscosity,and narrower solidification range(powder A),coarse microstructures and thicker slag rims were preferentially formed.For powders with lower breaking temperature and viscosity and wider solidification ranges(powder B),the liquid slag resisted rapid solidification,and the extended mushy zone allowed the partial liquid slag to persist at the slag rim front,promoting the formation of a thin slag rim.This study enhances the understanding of slag rim formation in highly crystalline mold powders and provides critical insights into the control of longitudinal surface cracks in hypo-peritectic steel.
文摘Objective:To investigate the effects of switching to either Prandilin 25R monotherapy or Prandilin 25R combined with ganagliflozin proline tablets after short-term intensive continuous subcutaneous insulin infusion during hospitalization in elderly patients with type 2 diabetes mellitus on glycemic control,glycometabolic indicators,and cardiovascular risk factors,and to evaluate the safety of the two regimens.Methods:A total of 78 elderly patients with type 2 diabetes mellitus admitted to our hospital from January 2025 to September 2025 were selected and randomly divided into a control group and an observation group,with 39 cases in each group.The control group received monotherapy with insulin lispro protamine recombinant injection(Prandilin 25R)after intensive continuous subcutaneous insulin infusion,while the observation group received Prandilin 25R combined with ganagliflozin proline tablets.Continuous glucose monitoring(CGM)was performed for 14 days during the intensive continuous subcutaneous insulin infusion therapy phase in the hospital,followed by routine fingertip blood glucose monitoring after 14 days.Glycemic control indicators,glycometabolic indicators,and the incidence of adverse reactions were compared between the two groups.Results:After treatment,the mean amplitude of glycemic excursions and the 24-hour blood glucose standard deviation were significantly lower in the observation group than in the control group,while the time spent within the target blood glucose range was significantly higher(p<0.05).The levels of glycated hemoglobin,fasting blood glucose,and 2-hour postprandial blood glucose were better in the observation group than in the control group;moreover,the body mass index,systolic blood pressure,and blood lipid levels improved more significantly in the observation group than in the control group(p<0.05).There was no statistically significant difference in the incidence of hypoglycemia between the two groups.Conclusion:Combination therapy with ganagliflozin proline tablets after short-term intensive continuous subcutaneous insulin infusion therapy can effectively improve glycemic variability in elderly patients with type 2 diabetes mellitus,with good safety.This suggests that ganagliflozin proline tablets have a hypoglycemic advantage in the combination regimen and possess high clinical promotional value.
基金support from the National Natural Science Foundation of China(Grant Nos.52174313 and 52304350)thank all members of the Hebei High Quality Steel Continuous Casting Engineering Technology Research Center at North China University of Science and Technology,Tangshan,China.
文摘The flow behavior of molten steel in the thin slab mold under high casting speed conditions was investigated,with a focus on the multi-mode continuous casting and rolling mold.A steel-slag two-phase flow model was established using large eddy simulation,the volume of fluid,and magnetohydrodynamics methods through numerical simulation.The maximum flow velocity and wave height at the steel-slag interface within the mold are critical evaluation criteria for analyzing asymmetric flow under varying casting speeds and electromagnetic braking.The results indicate that the asymmetric flows within the mold do not occur synchronously.The severity of the asymmetric flow correlates with the velocity difference across the steel-slag interface.A greater biased flow prolongs the time required to revert to a steady state.When the magnetic field intensity is set to 0.24 T and the magnetic pole position is at 390 mm from the steel-slag interface,this configuration can reduce the velocity of the steel-slag interface,thereby mitigating the asymmetric flow.Additionally,it can diminish the velocity,impact depth,and impact intensity on the narrow face of the jet,thus improving the distribution of velocity and turbulent kinetic energy within the mold.This configuration prolongs the time required for the steel-slag interface to transition from a stable state to its maximum velocity and shortens the time for the interface to return to stability from an unstable state.Moreover,it ensures the positional stability of the steel-slag interface,confining its position within−3 mm.
基金supported by the fund of National Natural Science Foundation of China(No.U25A20205)Xi'an Science and Technology Plan Program(No.24LLRHZDZX0008)+1 种基金Key R&D Project in Shaanxi Province(No.2024GX-YBXM-211)Xianyang Science and Technology Plan Program(No.L2025-ZDYF-GDZB-014).
文摘Continuous variable cross-section recycled extrusion(CVCE)is an advanced technique of severe plastic deformation.Ti–6Al–4V alloy was deformed with different processing parameters by CVCE,and then the microstructure characterization,refinement mechanism and deformation mechanism were investigated simultaneously.The results demonstrate that the average size of grain is refined from 14 to 2.78μm as Ti–6Al–4V alloy is deformed at 800℃ with a speed of 2 mm/s over 6 passes,and the microstructure is equiaxed and distributed homogeneously along the radial direction.Furthermore,in the process of CVCE,basal slip(0001)<110>is transformed to prismatic slip(100)<110>system and pyramidal slip(112)<113>system,with a reduction in low angle grain boundaries from 69.6%to 61.2%.Moreover,the grain refinement mechanism of CVCE is dislocation multiplication and cross-slip migration within the grain at the initial stage of deformation,which results in the formation of substructures and micro-shear bands as well as grain refinement.In addition,the nucleation and growth of dynamic recrystallization grains are beneficial to eliminating the dislocations,subgrain boundaries and other defects in the matrix,which finally results in the grains refinement.
文摘Under the background of achieving energy efficiency and carbon reduction,the use of Continuous Casting-Direct Hot Charging Rolling(CC-DHCR)technology was explored at the Hot Rolling Plant of Baosteel,China.As temperature variation and temperature uniformity directly affect the rolling quality of the billet,numerical simulations of the billet temperature profile changes in the CC-DHCR were conducted at the start of the industrial trial,and the billet temperature distribution and cross-section temperature difference during its transportation and throughout the heating process were analyzed.According to numerical simulation calculations,the average temperature of billet discharged from the heating furnace was 1150℃,which after subsequent controlled cooling met the final rolling temperature requirements of(880±30)℃for this kind of steel.The maximum temperature difference of the billet discharged from the furnace was within 35 K,which meets the billet heating uniformity requirements of the rolling process.The simulation results were compared with experimental results,and the rationality of the simulation was validated.In addition,the industrial trial billet was rolled,and the rolling quality was good during tracking.In this CC-DHCR industrial trial,the fuel consumption was 28.6 kgce/t(kilogram coal equivalent per ton),a reduction of 33.7%compared with the current traditional process,and CO 2 emissions were reduced by 38.09 kg/t.
基金supported by the National Natural Science Foundation of China(62433014,62373287,62573324,62333005,62273255)in part by the International Exchange Program for Graduate Students of Tongji University(4360143306)+3 种基金in part by the Fundamental Research Funds for Central Universities(22120230311)supported by DeutscheForschungsgemeinschaft(DFG,German Research Foundation)under Germany’s Excellence Strategy(EXC 2075390740016,468094890)support by the Stuttgart Center for Simulation Science(SimTech)the International Max Planck Research School for Intelligent Systems(IMPRS-IS)for supporting Y.Xie。
文摘Dear Editor,This letter proposes a reinforcement learning-based predictive learning algorithm for unknown continuous-time nonlinear systems with observation loss.Firstly,we construct a temporal nonzero-sum game over predictive control input sequences,deriving multiple optimal predictive control input sequences from its solution.
文摘China has achieved a major engineering milestone in the construction of the Beishan Underground Research Laboratory(URL)for geological disposal of high-level radioactive waste(HLW).On December 26,2025,the project team successfully completed the excavation of the world's first deep,continuous small-radius,steep spiral ramp by a tunnel boring machine(TBM)named Beishan No.1,which marked the completion of the underground main structure of Beishan URL.
