Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for...Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.展开更多
Earth is the place of human existence and life. Without the earth,there is no human,no nature either. To study human existence,the earth of human living is firstly studied. By the study of many natural phenomena on th...Earth is the place of human existence and life. Without the earth,there is no human,no nature either. To study human existence,the earth of human living is firstly studied. By the study of many natural phenomena on the earth,we firstly put forward the theory of earth ecosystem,expound its definition,structure,aim,function,content and significance,and illustrate the characteristics of earth ecosystem. So we found the theory of earth ecosystem,and unveil the variable processes and the operation mechanisms of earth ecosystem. We put forward the earth ecosystem and its theoretic system,which are different from the previous ＂ earth system science＂ and ＂ Gaia hypothesis＂. We consider that among each part of the environment,between environment and organism,there are organic,close and coalescent relationships,so that the earth ecosystem is able to have a sustainable development. Even if there is no life,the earth ecosystem also can control and regulate the earth changes,and possesses the stable state. Therefore,the foundation of the earth ecosystem theory is conducive to the studies of the global problems： the change processes and trends of resources,ecologies,environments,disasters,and so on.展开更多
基金supported by the National Natural Science Foundation of China(No.82203343)the National Postdoctoral Program for Innovative Talents of China(No.BX20220273)+3 种基金China Postdoctoral Science Foundation(No.2022M712874)Henan Province Key Research and Development Promotion Special Project(Science and Technology)in 2023(No.232102311007)Henan Province Key Scientific Research Project of Colleges and Universities in 2023(No.23A310007)the Outstanding Youth Project of Henan Provincial Natural Science Foundation(No.252300421123)。
文摘Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.
文摘Earth is the place of human existence and life. Without the earth,there is no human,no nature either. To study human existence,the earth of human living is firstly studied. By the study of many natural phenomena on the earth,we firstly put forward the theory of earth ecosystem,expound its definition,structure,aim,function,content and significance,and illustrate the characteristics of earth ecosystem. So we found the theory of earth ecosystem,and unveil the variable processes and the operation mechanisms of earth ecosystem. We put forward the earth ecosystem and its theoretic system,which are different from the previous ＂ earth system science＂ and ＂ Gaia hypothesis＂. We consider that among each part of the environment,between environment and organism,there are organic,close and coalescent relationships,so that the earth ecosystem is able to have a sustainable development. Even if there is no life,the earth ecosystem also can control and regulate the earth changes,and possesses the stable state. Therefore,the foundation of the earth ecosystem theory is conducive to the studies of the global problems： the change processes and trends of resources,ecologies,environments,disasters,and so on.
