To investigate neural features of the colonlc wall in pa-AIMtents with slow transit constipation(STC).METHODS Fourteen patients(1 man and 13 women;mean age,44 years;range,26-68 years)with STC underwent a partial or to...To investigate neural features of the colonlc wall in pa-AIMtents with slow transit constipation(STC).METHODS Fourteen patients(1 man and 13 women;mean age,44 years;range,26-68 years)with STC underwent a partial or total colectomy.By using a semlquantltative immunohistochemustry,resected sigmold colon speclmens lrom 14 patients with STC and 11 non-obstructed rectal adenocarcinoma as controls were investigated with rabbit anti-vasoactive intestinal peptide ant-substance P and anti-a-100 protein antibody.RESULTS Hematoxylln and eosn stalning showed atrophic smooth muscle in 3 patients with STC.In patients with STC,the mean content ol vasoactive intestlnal peptide(VIP)in the myen-teric plexus was lower than that in the controls(P<0.05).Substance P(SP)in the myenteric plexus ol STC was decreased sig-nilicantly when compared with the controls(P<0.001).S-100protein was increased in the colonic was ot STC(P<0.005).CONCLUSION Patients with STC have alteratlons of VIP and SP in the colonic myenteric plexus.展开更多
文摘To investigate neural features of the colonlc wall in pa-AIMtents with slow transit constipation(STC).METHODS Fourteen patients(1 man and 13 women;mean age,44 years;range,26-68 years)with STC underwent a partial or total colectomy.By using a semlquantltative immunohistochemustry,resected sigmold colon speclmens lrom 14 patients with STC and 11 non-obstructed rectal adenocarcinoma as controls were investigated with rabbit anti-vasoactive intestinal peptide ant-substance P and anti-a-100 protein antibody.RESULTS Hematoxylln and eosn stalning showed atrophic smooth muscle in 3 patients with STC.In patients with STC,the mean content ol vasoactive intestlnal peptide(VIP)in the myen-teric plexus was lower than that in the controls(P<0.05).Substance P(SP)in the myenteric plexus ol STC was decreased sig-nilicantly when compared with the controls(P<0.001).S-100protein was increased in the colonic was ot STC(P<0.005).CONCLUSION Patients with STC have alteratlons of VIP and SP in the colonic myenteric plexus.
