Aging is considered the main risk factor for the development of several diseases,including the leading neurodegenerative disorders.While the cellular features of aging are complex and multifaceted,neuronal senescence ...Aging is considered the main risk factor for the development of several diseases,including the leading neurodegenerative disorders.While the cellular features of aging are complex and multifaceted,neuronal senescence has emerged as a major contributor and driver of this process in the mammalian cell.Cellular senescence is a programmed response to stress and irreparable damage,which drives the cell into an apoptosis-resistant,non-proliferative state.Senescent cells can also deleteriously affect neighboring,non-senescent cells.Senescence is a complex and multifaceted process associated with a wide range of cellular events,including the secretion of pro-inflammatory molecules and the arrest of the cell cycle.展开更多
Obese individuals who subsequently sustain a traumatic brain injury(TBI)exhibit worsened outcomes including longer periods of rehabilitation(Eagle et al.,2023).In obese individuals,prolonged symptomology is associated...Obese individuals who subsequently sustain a traumatic brain injury(TBI)exhibit worsened outcomes including longer periods of rehabilitation(Eagle et al.,2023).In obese individuals,prolonged symptomology is associated with increased levels of circulato ry pro-inflammatory marke rs up to 1 year postTBI(Eagle et al.,2023).展开更多
汞是一种具有挥发性、持久性和生物累积性的有毒物质,而燃煤电厂是向大气排放汞的主要人为来源。利用催化法脱除烟气中的汞,是一种有效的脱汞方法。为了深入了解烟气催化脱汞领域的最新研究进展及研究热点趋势,采用Web of Science核心...汞是一种具有挥发性、持久性和生物累积性的有毒物质,而燃煤电厂是向大气排放汞的主要人为来源。利用催化法脱除烟气中的汞,是一种有效的脱汞方法。为了深入了解烟气催化脱汞领域的最新研究进展及研究热点趋势,采用Web of Science核心数据库,数据可视化分析软件CiteSpace、HistCite Pro和VOSviewer,对1995—2023年该库收集的相关文献进行计量分析和可视化分析,并从发文量前10的国家、机构、作者、期刊以及关键词等方面对1995—2023年烟气催化脱汞领域的研究现状进行分析,对了解烟气催化脱汞领域的研究方向、研究热点和发展趋势具有一定的指导意义。展开更多
文摘Aging is considered the main risk factor for the development of several diseases,including the leading neurodegenerative disorders.While the cellular features of aging are complex and multifaceted,neuronal senescence has emerged as a major contributor and driver of this process in the mammalian cell.Cellular senescence is a programmed response to stress and irreparable damage,which drives the cell into an apoptosis-resistant,non-proliferative state.Senescent cells can also deleteriously affect neighboring,non-senescent cells.Senescence is a complex and multifaceted process associated with a wide range of cellular events,including the secretion of pro-inflammatory molecules and the arrest of the cell cycle.
文摘Obese individuals who subsequently sustain a traumatic brain injury(TBI)exhibit worsened outcomes including longer periods of rehabilitation(Eagle et al.,2023).In obese individuals,prolonged symptomology is associated with increased levels of circulato ry pro-inflammatory marke rs up to 1 year postTBI(Eagle et al.,2023).
文摘汞是一种具有挥发性、持久性和生物累积性的有毒物质,而燃煤电厂是向大气排放汞的主要人为来源。利用催化法脱除烟气中的汞,是一种有效的脱汞方法。为了深入了解烟气催化脱汞领域的最新研究进展及研究热点趋势,采用Web of Science核心数据库,数据可视化分析软件CiteSpace、HistCite Pro和VOSviewer,对1995—2023年该库收集的相关文献进行计量分析和可视化分析,并从发文量前10的国家、机构、作者、期刊以及关键词等方面对1995—2023年烟气催化脱汞领域的研究现状进行分析,对了解烟气催化脱汞领域的研究方向、研究热点和发展趋势具有一定的指导意义。
文摘目的研究以涤痰汤为基础,随证加减化裁方治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺部感染的临床疗效及对血清白介素-6(interleukin-6,IL-6)、干扰素γ(interferon gamma,IFN-γ)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平的影响。方法纳入2022年1月—2023年6月医院收治的124例慢性阻塞性肺疾病合并肺部感染患者,采用随机数字表法分为研究组(62例)和对照组(62例)。对照组采用西医常规治疗,研究组在常规治疗的基础上联合涤痰汤化裁方治疗。对比两组治疗后的临床疗效、中医证候积分、血气指标血氧分压(partial pressure of oxygen,PaO_(2))、血氧饱和度(oxygen saturation of blood,SaO_(2))、动脉血二氧化碳分压(partial pressure of arterial blood carbon dioxide,PaCO_(2))水平、肺功能第一秒用力呼气量(forced expiratory volume in the first second,FEV_(1))、最大自主通气量(maximalvoluntaryventilation,MVV)、用力肺活量(forced vital capacity,FVC)、第一秒用力呼气量与用力肺活量的比值(FEV_(1)/FVC)水平、促炎因子IL-6、IFN-γ及TNF-α水平。结果两组患者治疗前各项肺功能检测指标、血气指标、中医证候积分、血清IL-6、IFN-γ及TNF-α差异均无统计学意义(P>0.05)。治疗后,研究组患者的总有效率为96.77%高于对照组的87.10%(P<0.05);研究组患者治疗后的中医证候积分值小于对照组(P<0.05);两组患者治疗后的血气指标如PaO_(2)、SaO_(2)均升高、PaCO_(2)均降低,且研究组改善更明显(P<0.05);两组患者治疗后的肺功能指标如FEV_(1)、MVV、FVC、FEV_(1)/FVC均升高,且研究组改善更明显(P<0.05);两组患者治疗后血清IL-6、IFN-γ及TNF-α水平均降低,且研究组改善更明显,差异具有统计学意义(P<0.05)。结论涤痰汤化裁方治疗慢性阻塞性肺疾病合并肺部感染有较高的疗效,其能改善患者肺功能、缓解临床症状及降低血清IL-6、IFN-γ及TNF-α水平。
