The dialogue between the mammalian conceptus(embryo/fetus and associated membranes) involves signaling for pregnancy recognition and maintenance of pregnancy during the critical peri-implantation period of pregnancy w...The dialogue between the mammalian conceptus(embryo/fetus and associated membranes) involves signaling for pregnancy recognition and maintenance of pregnancy during the critical peri-implantation period of pregnancy when the stage is set for implantation and placentation that precedes fetal development. Uterine epithelial cells secrete and/or transport a wide range of molecules, including nutrients,collectively referred to as histotroph that are transported into the fetal-placental vascular system to support growth and development of the conceptus. The availability of uterine-derived histotroph has long-term consequences for the health and well-being of the fetus and the prevention of adult onset of metabolic diseases. Histotroph includes numerous amino acids, but arginine plays a particularly important role as a source of nitric oxide and polyamines required for fetal-placental development in rodents, swine and humans through mechanisms that remain to be fully elucidated. Mechanisms whereby arginine regulates expression of genes via the mechanistic target of rapamycin cell signaling pathways critical to conceptus development, implantation and placentation are discussed in detail in this review.展开更多
This study explores the role of artificial intelligence(AI)in the conceptual design phase of interior design education,focusing on AI’s potential to help students visualise and refine creative ideas.Conducted within ...This study explores the role of artificial intelligence(AI)in the conceptual design phase of interior design education,focusing on AI’s potential to help students visualise and refine creative ideas.Conducted within a design studio course,the research integrates textto-image generators,particularly Midjourney to support students’design processes.Implemented in the fourth week of a 14-week course,a structured workshop introduced students to Midjourney,with surveys conducted both at this stage and during the final submission to capture changes in student perspectives.Using a two-phase case study involving a workshop,surveys,and interviews among senior undergraduate students in the bachelor’s program of the Interior Architecture and Environmental Design Department,the study assesses the impact of AI prompts,from simple keywords to detailed narratives,on concept development and project outcomes.Findings indicate that AI broadens design possibilities,facilitates iterative ideation,and improves conceptual precision through high-fidelity visualizations.While students view AI as a valuable addition to their creative process,they also express concerns about ethics and the need to balance AI’s benefits with preserving design authenticity.This research contributes to the broader discussion on AI’s role in design,advocating for a balanced integration that respects both technological potential and human creativity.展开更多
基金supported by National Research Initiative Competitive Grants from the Animal Reproduction Program (2008-35203-19120, 2009-35206-05211, 201167015-20067, and 2011-67015-20028)Animal Growth & Nutrient Utilization Program (2008-35206-18764) of the USDA National Institute of Food and AgricultureTexas A&M Agri Life Research (H-8200)
文摘The dialogue between the mammalian conceptus(embryo/fetus and associated membranes) involves signaling for pregnancy recognition and maintenance of pregnancy during the critical peri-implantation period of pregnancy when the stage is set for implantation and placentation that precedes fetal development. Uterine epithelial cells secrete and/or transport a wide range of molecules, including nutrients,collectively referred to as histotroph that are transported into the fetal-placental vascular system to support growth and development of the conceptus. The availability of uterine-derived histotroph has long-term consequences for the health and well-being of the fetus and the prevention of adult onset of metabolic diseases. Histotroph includes numerous amino acids, but arginine plays a particularly important role as a source of nitric oxide and polyamines required for fetal-placental development in rodents, swine and humans through mechanisms that remain to be fully elucidated. Mechanisms whereby arginine regulates expression of genes via the mechanistic target of rapamycin cell signaling pathways critical to conceptus development, implantation and placentation are discussed in detail in this review.
文摘This study explores the role of artificial intelligence(AI)in the conceptual design phase of interior design education,focusing on AI’s potential to help students visualise and refine creative ideas.Conducted within a design studio course,the research integrates textto-image generators,particularly Midjourney to support students’design processes.Implemented in the fourth week of a 14-week course,a structured workshop introduced students to Midjourney,with surveys conducted both at this stage and during the final submission to capture changes in student perspectives.Using a two-phase case study involving a workshop,surveys,and interviews among senior undergraduate students in the bachelor’s program of the Interior Architecture and Environmental Design Department,the study assesses the impact of AI prompts,from simple keywords to detailed narratives,on concept development and project outcomes.Findings indicate that AI broadens design possibilities,facilitates iterative ideation,and improves conceptual precision through high-fidelity visualizations.While students view AI as a valuable addition to their creative process,they also express concerns about ethics and the need to balance AI’s benefits with preserving design authenticity.This research contributes to the broader discussion on AI’s role in design,advocating for a balanced integration that respects both technological potential and human creativity.
