Computerized cognitive training (CCT) can improve cognition in older adults. However, specific programs for this target group have rarely been developed, and predictors of training success are largely unclear. In a ra...Computerized cognitive training (CCT) can improve cognition in older adults. However, specific programs for this target group have rarely been developed, and predictors of training success are largely unclear. In a randomized controlled pilot trial, we examined effects of a six-week CCT, tailored to the cognitive profile of healthy older adults (EG, n = 21) as compared to a nonspecific CCT (CG, n = 18) matched in frequency and intensity. No interaction effects between Group and Time were found. However, within-group analysis showed significant gains in verbal and non-verbal memory, executive and visuospatial functions and subjective cognitive concerns (SCC) in the EG, while the CG only benefitted in non-verbal memory and set-shifting. Low cognitive performance and lower SCC at baseline were the most consistent predictors of cognitive gains in the EG. Thus, CCTs specifically tailored to older adults seem advantageous compared to non-specific CCT. Further, we conclude that SCC may be related to reduced cognitive plasticity.展开更多
Background Schizophrenia is characterised by pervasive cognitive deficits that significantly impair daily functioning and quality of life.Pharmacological treatments have limited efficacy in addressing these deficits,h...Background Schizophrenia is characterised by pervasive cognitive deficits that significantly impair daily functioning and quality of life.Pharmacological treatments have limited efficacy in addressing these deficits,highlighting the need for adjunctive interventions like computerised cognitive training(CCT).Aims This study aimed to evaluate the effects of a 30-session CCT programme on mental well-being and cognitive performance in individuals with schizophrenia.Additionally,it assessed the usability and acceptability of CCT in this population.Methods A double-blind,randomised clinical trial was conducted with 54 participants assigned to intervention and control groups.Cognitive and mental health outcomes were assessed using validated tools such as the Depression Anxiety Stress Scale 21,the Warwick-Edinburgh Mental Wellbeing Scale and the Cambridge Neuropsychological Test Automated Battery.Usability was measured with the System Usability Scale(SUS).Assessments were conducted at baseline,post-intervention and 3 months post-follow-up.Results The CCT intervention significantly improved mental well-being,reduced stress and enhanced working memory(paired associate learning,spatial working memory and spatial span)compared with controls.However,no significant effects were observed for anxiety,depression or executive function.Usability scores were high(SUS=83.51),and compliance rates were strong(92.7%),indicating favourable participant engagement.Conclusion CCT demonstrated potential as an adjunctive treatment for schizophrenia,with significant improvements in targeted cognitive and mental health domains.The high usability and compliance rates support its feasibility for broader implementation.Further research is needed to optimise protocols and explore long-term benefits.CCT offers a promising approach to addressing mental health and cognitive challenges in schizophrenia,particularly for stress and working memory.Its usability and acceptability suggest it could be seamlessly integrated into clinical practice.展开更多
Computerized cognitive training(CCT)has been found to improve a range of skills such as attention,working memory,inhibition control,and decision making.However,the relationship between the initial performance,amount o...Computerized cognitive training(CCT)has been found to improve a range of skills such as attention,working memory,inhibition control,and decision making.However,the relationship between the initial performance,amount of improvement,time constant,and asymptotic performance level in CCT is still unclear.In the current study,we performed selective attention training on college students and addressed this issue by mathematically modeling the learning curve with an exponential function.Twenty-nine students completed approximately 10 days of CCT.Presentation time served as the dependent variable and was measured by three-down/one-up adaptive algorithms.We fitted an exponential function to the estimated block thresholds during CCT and obtained three learning parameters(amount of improvement,time constant,and asymptotic performance level)for all subjects.The initial performance was defined by the sum of the amount of improvement and the asymp-totic performance level.Pearson correlation analyses were conducted between the initial performance and the three leaning parameters.The ini-tial performance was positively correlated with the amount of improvement and asymptotic performance level,but was negatively correlated with the time constant.The time constant was negatively correlated with the amount of improvement and asymptotic performance level.Poorer initial performance was linked to a larger amount of improvement,shorter time constant,and higher asymptotic threshold,which supported the compensation account.Our results may help improve the present understanding of the nature of the CCT process and demonstrate the advan-tages of using a customized training protocol to enhance the efficiency of cognitive training in practical applications.展开更多
基金supported by the Federal Ministry of Education and Research under Grant 16SV5917.
文摘Computerized cognitive training (CCT) can improve cognition in older adults. However, specific programs for this target group have rarely been developed, and predictors of training success are largely unclear. In a randomized controlled pilot trial, we examined effects of a six-week CCT, tailored to the cognitive profile of healthy older adults (EG, n = 21) as compared to a nonspecific CCT (CG, n = 18) matched in frequency and intensity. No interaction effects between Group and Time were found. However, within-group analysis showed significant gains in verbal and non-verbal memory, executive and visuospatial functions and subjective cognitive concerns (SCC) in the EG, while the CG only benefitted in non-verbal memory and set-shifting. Low cognitive performance and lower SCC at baseline were the most consistent predictors of cognitive gains in the EG. Thus, CCTs specifically tailored to older adults seem advantageous compared to non-specific CCT. Further, we conclude that SCC may be related to reduced cognitive plasticity.
基金supported by a grant from University of Social Welfare and Rehabilitation Sciences for the research expenses.
文摘Background Schizophrenia is characterised by pervasive cognitive deficits that significantly impair daily functioning and quality of life.Pharmacological treatments have limited efficacy in addressing these deficits,highlighting the need for adjunctive interventions like computerised cognitive training(CCT).Aims This study aimed to evaluate the effects of a 30-session CCT programme on mental well-being and cognitive performance in individuals with schizophrenia.Additionally,it assessed the usability and acceptability of CCT in this population.Methods A double-blind,randomised clinical trial was conducted with 54 participants assigned to intervention and control groups.Cognitive and mental health outcomes were assessed using validated tools such as the Depression Anxiety Stress Scale 21,the Warwick-Edinburgh Mental Wellbeing Scale and the Cambridge Neuropsychological Test Automated Battery.Usability was measured with the System Usability Scale(SUS).Assessments were conducted at baseline,post-intervention and 3 months post-follow-up.Results The CCT intervention significantly improved mental well-being,reduced stress and enhanced working memory(paired associate learning,spatial working memory and spatial span)compared with controls.However,no significant effects were observed for anxiety,depression or executive function.Usability scores were high(SUS=83.51),and compliance rates were strong(92.7%),indicating favourable participant engagement.Conclusion CCT demonstrated potential as an adjunctive treatment for schizophrenia,with significant improvements in targeted cognitive and mental health domains.The high usability and compliance rates support its feasibility for broader implementation.Further research is needed to optimise protocols and explore long-term benefits.CCT offers a promising approach to addressing mental health and cognitive challenges in schizophrenia,particularly for stress and working memory.Its usability and acceptability suggest it could be seamlessly integrated into clinical practice.
基金supported by Natural Science Founda-tion of Hunan Province(2020JJ7070)to CL.
文摘Computerized cognitive training(CCT)has been found to improve a range of skills such as attention,working memory,inhibition control,and decision making.However,the relationship between the initial performance,amount of improvement,time constant,and asymptotic performance level in CCT is still unclear.In the current study,we performed selective attention training on college students and addressed this issue by mathematically modeling the learning curve with an exponential function.Twenty-nine students completed approximately 10 days of CCT.Presentation time served as the dependent variable and was measured by three-down/one-up adaptive algorithms.We fitted an exponential function to the estimated block thresholds during CCT and obtained three learning parameters(amount of improvement,time constant,and asymptotic performance level)for all subjects.The initial performance was defined by the sum of the amount of improvement and the asymp-totic performance level.Pearson correlation analyses were conducted between the initial performance and the three leaning parameters.The ini-tial performance was positively correlated with the amount of improvement and asymptotic performance level,but was negatively correlated with the time constant.The time constant was negatively correlated with the amount of improvement and asymptotic performance level.Poorer initial performance was linked to a larger amount of improvement,shorter time constant,and higher asymptotic threshold,which supported the compensation account.Our results may help improve the present understanding of the nature of the CCT process and demonstrate the advan-tages of using a customized training protocol to enhance the efficiency of cognitive training in practical applications.
