Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle...Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.展开更多
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine...The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice mo...Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.展开更多
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced...Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.展开更多
After a thorough review of some controllable parameters,which included field investigations,cavern dimensions,explosive,rock strength etc.,cut,contour,lifters and stoping holes were introduced for blasting cavern of n...After a thorough review of some controllable parameters,which included field investigations,cavern dimensions,explosive,rock strength etc.,cut,contour,lifters and stoping holes were introduced for blasting cavern of nucleus submarine.These design were conducted using a U.Langefors and B.Kihlstrom theory.展开更多
The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the...The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.展开更多
Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage dis...Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.展开更多
The desired economics of hard rock surface mining is mainly determined by the parameters of process design which minimize the overall cost per tonne of the rock mined in drilling, blasting, handling and primary crushi...The desired economics of hard rock surface mining is mainly determined by the parameters of process design which minimize the overall cost per tonne of the rock mined in drilling, blasting, handling and primary crushing in given rockmass conditions. The most effective parameters of process design could be established based on the regression models of the cumulative influence of rockmass and mine design parameters on the overall cost per tonne of the rock drilled, blasted, handled and crushed. These models could be developed from the huge data accumulated worldwide on the costs per tonne of hard rock surface mining in drilling, blasting, handling and primary crushing vs the parameters of rockmass and mine design. This paper only dwelt on the development of regression models for oversize generation, blasthole productivity and blasting cost for iron ore surface mines, whose data is available. The SPSS standard statistical correlation – regression analysis software was used in the analysis. Interpretation of the models generated shows that the individual effects of the determinant rockmass and blast design parameters on oversize generation, blasthole productivity and blasting cost are all in compliance with the findings of other researchers and the theory of explosive rock fragmentation and could be used for the estimation of oversize generation, blasthole productivity and blasting cost in rockmass and blast design conditions similar to those of the iron ore surface mines examined in this study. However, the regression models obtained here could not be used alone for the optimization of blast design because most of the determinant parameters also have conflicting effect on the other processes of drilling, handling and primary crushing the blasted rock. Also, the quality and content of the regression models could be enhanced further by increasing the content of rockmass and blast design parameters and the volume of data considered in the regression analysis.展开更多
Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to...Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.展开更多
Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual sk...Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual skill. Here we propose a computer-aided method for fabricating finger pros-theses to save time and allow fabrications that do not require considerable manual skill. In this method, the dimensions of a patient’s healthy finger on the contralateral hand are first measured using a caliper. Using these dimensions, a three-dimensional model is constructed for fabricating a prosthesis for the patient’s impaired finger. Using the 3D model, a mold is designed using 3D modeling tools and a computer-aided design system. The resulting mold is then fabricated using a 3D printer. A finger prosthesis is fabricated by pouring silicone resin into the mold. A finger prosthesis for a volunteer was experimentally fabricated according to the proposed method. To evaluate the size and shape of the finger prosthesis, the difference between the finger prosthesis and the original finger of the volunteer was analyzed. Because the average difference between them was 0.25 mm, it was concluded that the proposed method could be used to fabricate a finger prosthesis of adequate size and shape.展开更多
The article is to study the development of computer-aided design of X-ray microtomography—the device for investigating the structure and construction of three-dimensional images of organic and inorganic objects on th...The article is to study the development of computer-aided design of X-ray microtomography—the device for investigating the structure and construction of three-dimensional images of organic and inorganic objects on the basis of shadow projections. This article provides basic information regarding CAD of X-ray microtomography and a scheme consisting of three levels. The article also shows basic relations of X-ray computed tomography, the generalized scheme of an X-ray microtomographic scanner. The methods of X-ray imaging of the spatial microstructure and morphometry of materials are described. The main characteristics of an X-ray microtomographic scanner, the X-ray source, X-ray optical elements and mechanical components of the positioning system are shown. The block scheme and software functional scheme for intelligent neural network system of analysis of the internal microstructure of objects are presented. The method of choice of design parameters of CAD of X-ray microtomography aims at improving the quality of design and reducing costs of it. It is supposed to reduce the design time and eliminate the growing number of engineers involved in development and construction of X-ray microtomographic scanners.展开更多
One of the most important factors influencing on a tunnel blast efficiency is the proper design of blasting pattern. Among blasting parameters, blasthole diameter and tunnel face area are more significant so that any ...One of the most important factors influencing on a tunnel blast efficiency is the proper design of blasting pattern. Among blasting parameters, blasthole diameter and tunnel face area are more significant so that any change in these parameters could finally affect on specific charge and specific drilling. There are mainly two groups of methods for tunnel blast design categorized based on the parallel cuts and angular cuts. In this research, a software for tunnel blast design was developed to analyze the effect and sensitiveness of blasthole diameter and the tunnel face area on blasting results in different blast design models. Using the software, it is quickly possible to determine specific charge, specific drilling and number of blastholes for each blast design model. The relations between both of blasthole diameters and the tunnel face area with the above parameters in different blast design models were then investigated to yield a set of equations with the highest correlations to compare the methods. The results showed that angular method requires more blasthole numbers than parallel method in similar condition(blasthole diameter and tunnel face area). Moreover, the specific charge values yielded by the two methods are approximately the same and very close together.展开更多
To solve the uneven burden of same-type holes reducing the blasting efficiency due to the limitation of drilling equipment,we need a double-face program-controlled planning method for hole position parameters used on ...To solve the uneven burden of same-type holes reducing the blasting efficiency due to the limitation of drilling equipment,we need a double-face program-controlled planning method for hole position parameters used on a computer-controlled drilling jumbo.The cross-section splits into even and uneven areas.It also considers the uneven burden at the hole’s entrance and bottom.In the uneven area,various qualifying factors are made to optimize the hole spacing and maximize the burden uniformity,combined with the features of the area edges and gridbased segmentation methods.The hole position coordinates and angles in the even area are derived using recursion and iteration algorithms.As a case,this method presents all holes in a 4.8 m wide and 3.6 m high cross-section.Compared with the design produced by the drawing method,our planning in the uneven area improved the standard deviation of the hole burden by 40%.The improved hole layout facilitates the evolution of precise,efficient,and intelligent blasting in underground mines.展开更多
Blast furnace scheme design is very important, since it directly affects the performance, cost and configuration of the blast furnace. An evaluation approach to furnace scheme design was brought forward based on artif...Blast furnace scheme design is very important, since it directly affects the performance, cost and configuration of the blast furnace. An evaluation approach to furnace scheme design was brought forward based on artificial neural network. Ten independent parameters which determined a scheme design were proposed. The improved threelayer BP network algorithm was used to build the evaluation model in which the 10 independent parameters were taken as input evaluation indexes and the degree to which the scheme design satisfies the requirements of the blast furnace as output. It was trained by the existing samples of the scheme design and the experts＇ experience, and then tested by the other samples so as to develop the evaluation model. As an example, it is found that a good scheme design of blast furnace can be chosen by using the evaluation model proposed.展开更多
Interlaid rock is an important component in the construction of neighborhood tunnels that supports and reinforces the area between two tunnels.However,the blasting load during excavation can sometimes damage the inter...Interlaid rock is an important component in the construction of neighborhood tunnels that supports and reinforces the area between two tunnels.However,the blasting load during excavation can sometimes damage the interlaid rock and threaten the stability of a tunnel’s structure.This paper presents a case study of the small clearance section of the Liantang highway tunnel project in Shenzhen,China,where the minimum distance between the two tunnels involved is only 0.5 m.To reduce the damage to the interlaid rock caused by blasting loads,we proposed a four-part excavation method with a vibrationcushioning rock layer in the following tunnel of neighborhood tunnels.Numerical simulation was used to model the damage prevention mechanism of the vibration-cushioning rock layer and to better understand the propagation of cracks in the interlaid rock.Furthermore,based on the simulation results,combined microseismic controlled-blasting technology was implemented,using innovative blasting patterns combined with different charge structures and blasting equipment designed according to the varying thickness of the interlaid rock.Finally,this implementation succeeded in protecting interlaid rock during blasting operations.展开更多
The increasing threat of explosions on the battle field and the terrorist action requires the development of more effective blast resistance materials and structures.Curved structure can support the external loads eff...The increasing threat of explosions on the battle field and the terrorist action requires the development of more effective blast resistance materials and structures.Curved structure can support the external loads effectively by virtue of their spatial curvature.In review of the excellent energy absorption property of auxetic structure,employing auxetic structure as core material in curved sandwich shows the potential to improve the protection performance.In this study,a novel cylindrical sandwich panel with double arrow auxetic(DAA) core was designed and the numerical model was built by ABAQUS.Due to the complexity of the structure,systematic parameter study and optimal design are conducted.Two cases of optimal design were considered,case1 focuses on reducing the deflection and mass of the structure,while case2 focuses on reducing the deflection and increasing the energy absorption per unit mass.Parameter study and optimal design were conducted based on Latin Hypercube Sampling(LHD)method,artificial neural networks(ANN) metamodel and the nondominated sorting genetic algorithm(NSGA-Ⅱ).The Pareto front was obtained and the cylindrical DAA structure performed much better than its equal solid panel in both blast resistance and energy absorption capacity.Optimization results can be used as a reference for different applications.展开更多
Reducing the blasting vibration is important for blasting excavation in subway tunnel construction.Taking the 3rd bid section of Line 3 of Qingdao subway project as an example,the distance between tunnel vault and gro...Reducing the blasting vibration is important for blasting excavation in subway tunnel construction.Taking the 3rd bid section of Line 3 of Qingdao subway project as an example,the distance between tunnel vault and ground is 5 ~ 8 m.In order to insure the safety of the upper buildings,technologies of parallel cut with large diameter empty hole,one-time initiation and delay by parts,and multiple shallow holes were adopted in the project.The results showed that the maximum value of vertical vibration was limited in the criterion allowance,and the upper buildings were not damaged.Besides,problems were solved that the number of nonel detonator was difficult to meet the requirements of excavating a large cross-section tunnel by blasting,multiple cross-section could’t be initiated simultaneously,and construction efficiency was low,which ensure the construction safety and schedule.展开更多
In the past, blast-resistant designs for structures were often constructed with massive type structural systems, which relied more on brute strength than on finesse to achieve the required blast resistance. However, s...In the past, blast-resistant designs for structures were often constructed with massive type structural systems, which relied more on brute strength than on finesse to achieve the required blast resistance. However, structures composed of COLD-FORMED steel components, such as sheet metal and metal studs, have shown great promise in providing blast resistance with the added benefits of low cost and ease of construction. Some examples of using such structures to provide containment for package handling facilities (PHF) are described in the paper for situations where blast containment is needed, such as a potential package bomb being discovered during the package vetting process. Results from tests and analytic data are used to illustrate aspects of design peculiar to such types of applications. Designs for specific capacities of PHF are described.展开更多
For figuring out the stress interference of multiphase fracture combinations and its effect on the fracture initiation pressure of subsequent hydraulic fracturing,a calculation model for the coupled stress field with ...For figuring out the stress interference of multiphase fracture combinations and its effect on the fracture initiation pressure of subsequent hydraulic fracturing,a calculation model for the coupled stress field with multiple induced fractures preexisted was established based on the calculation model for the stress field with single induced fracture preexisted,and the change laws of circumferential stress field around the wellbore under the effect of induced stress were analyzed.Then,the fracture initiation pressure of subsequent hydraulic fracturing was calculated according to the fracturing mechanics criterion.Finally,the effects of the length,phase,horizontal principal stress difference co-efficient and quantity of preexisting fractures on its initiation pressure were analyzed.And the following research results were obtained.First,the circumferential stress difference in the area near the fractures behind the preexisting fractures increase greatly and even the horizontal principal stress is reversed.Second,as the length of new preexisting fractures increases,the initiation pressure of initial preexisting fractures rises first and then drops.And when the length of new preexisting fractures is equal to that of the initial preexisting fractures,the initiation pressure of initial preexisting fractures drops quickly first and then slowly.Third,the initiation pressure of high phase fractures is lower than that of low phase fractures.Fourth,with the increase of fracture quantity,the initiation pressure of new preexisting fractures drops gradually,but the decline trend of initiation pressure difference is not obvious.Fifth,the stress interference of multiphase fractures influences the fracture initiation pressure,and high-phase long fractures and low-phase short fractures are both favorable for the simultaneous initiation of multiphase fractures.Sixth,syn-chronous propagation of multiple fractures can generate more complicated stress interference and excite the evolution of hydraulic fracture network,so as to realize uniform fracturing stimulation.In conclusion,the research results can provide a theoretical guidance for the design of fracturing operation,e.g.perforation phase of blasting induced fracturing,scale of induced fractures,and pump pressure of subsequent hydraulic fracturing.展开更多
基金The National Natural Science Foundation of China(No.71271053)the Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXLX13_082)
文摘Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.
文摘The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.
基金The study was financially supported by the key project of Science and Technology Commission of Shanghai Local Gov-ernment (No. 015211010), the National Natural Science Foundation of China (No. 50171038) and the China-Belgium bi-lateral project (No. 2001-242).
文摘Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.
文摘After a thorough review of some controllable parameters,which included field investigations,cavern dimensions,explosive,rock strength etc.,cut,contour,lifters and stoping holes were introduced for blasting cavern of nucleus submarine.These design were conducted using a U.Langefors and B.Kihlstrom theory.
文摘The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.
基金This work was supported by grants from the National Sciences Fund(31370938 and 81272528)The Fund(81272528)offered experiment material and collected the data for analysisThe Fund(31370938)helped design the study and was helpful in preparing the manuscript.
文摘Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.
文摘The desired economics of hard rock surface mining is mainly determined by the parameters of process design which minimize the overall cost per tonne of the rock mined in drilling, blasting, handling and primary crushing in given rockmass conditions. The most effective parameters of process design could be established based on the regression models of the cumulative influence of rockmass and mine design parameters on the overall cost per tonne of the rock drilled, blasted, handled and crushed. These models could be developed from the huge data accumulated worldwide on the costs per tonne of hard rock surface mining in drilling, blasting, handling and primary crushing vs the parameters of rockmass and mine design. This paper only dwelt on the development of regression models for oversize generation, blasthole productivity and blasting cost for iron ore surface mines, whose data is available. The SPSS standard statistical correlation – regression analysis software was used in the analysis. Interpretation of the models generated shows that the individual effects of the determinant rockmass and blast design parameters on oversize generation, blasthole productivity and blasting cost are all in compliance with the findings of other researchers and the theory of explosive rock fragmentation and could be used for the estimation of oversize generation, blasthole productivity and blasting cost in rockmass and blast design conditions similar to those of the iron ore surface mines examined in this study. However, the regression models obtained here could not be used alone for the optimization of blast design because most of the determinant parameters also have conflicting effect on the other processes of drilling, handling and primary crushing the blasted rock. Also, the quality and content of the regression models could be enhanced further by increasing the content of rockmass and blast design parameters and the volume of data considered in the regression analysis.
文摘Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.
文摘Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual skill. Here we propose a computer-aided method for fabricating finger pros-theses to save time and allow fabrications that do not require considerable manual skill. In this method, the dimensions of a patient’s healthy finger on the contralateral hand are first measured using a caliper. Using these dimensions, a three-dimensional model is constructed for fabricating a prosthesis for the patient’s impaired finger. Using the 3D model, a mold is designed using 3D modeling tools and a computer-aided design system. The resulting mold is then fabricated using a 3D printer. A finger prosthesis is fabricated by pouring silicone resin into the mold. A finger prosthesis for a volunteer was experimentally fabricated according to the proposed method. To evaluate the size and shape of the finger prosthesis, the difference between the finger prosthesis and the original finger of the volunteer was analyzed. Because the average difference between them was 0.25 mm, it was concluded that the proposed method could be used to fabricate a finger prosthesis of adequate size and shape.
文摘The article is to study the development of computer-aided design of X-ray microtomography—the device for investigating the structure and construction of three-dimensional images of organic and inorganic objects on the basis of shadow projections. This article provides basic information regarding CAD of X-ray microtomography and a scheme consisting of three levels. The article also shows basic relations of X-ray computed tomography, the generalized scheme of an X-ray microtomographic scanner. The methods of X-ray imaging of the spatial microstructure and morphometry of materials are described. The main characteristics of an X-ray microtomographic scanner, the X-ray source, X-ray optical elements and mechanical components of the positioning system are shown. The block scheme and software functional scheme for intelligent neural network system of analysis of the internal microstructure of objects are presented. The method of choice of design parameters of CAD of X-ray microtomography aims at improving the quality of design and reducing costs of it. It is supposed to reduce the design time and eliminate the growing number of engineers involved in development and construction of X-ray microtomographic scanners.
文摘One of the most important factors influencing on a tunnel blast efficiency is the proper design of blasting pattern. Among blasting parameters, blasthole diameter and tunnel face area are more significant so that any change in these parameters could finally affect on specific charge and specific drilling. There are mainly two groups of methods for tunnel blast design categorized based on the parallel cuts and angular cuts. In this research, a software for tunnel blast design was developed to analyze the effect and sensitiveness of blasthole diameter and the tunnel face area on blasting results in different blast design models. Using the software, it is quickly possible to determine specific charge, specific drilling and number of blastholes for each blast design model. The relations between both of blasthole diameters and the tunnel face area with the above parameters in different blast design models were then investigated to yield a set of equations with the highest correlations to compare the methods. The results showed that angular method requires more blasthole numbers than parallel method in similar condition(blasthole diameter and tunnel face area). Moreover, the specific charge values yielded by the two methods are approximately the same and very close together.
基金financially supported by the Fundamental Research Funds for the Central Universities(No.FRF-AT-19-005)the National Natural Science Foundation of China(No.51934001).
文摘To solve the uneven burden of same-type holes reducing the blasting efficiency due to the limitation of drilling equipment,we need a double-face program-controlled planning method for hole position parameters used on a computer-controlled drilling jumbo.The cross-section splits into even and uneven areas.It also considers the uneven burden at the hole’s entrance and bottom.In the uneven area,various qualifying factors are made to optimize the hole spacing and maximize the burden uniformity,combined with the features of the area edges and gridbased segmentation methods.The hole position coordinates and angles in the even area are derived using recursion and iteration algorithms.As a case,this method presents all holes in a 4.8 m wide and 3.6 m high cross-section.Compared with the design produced by the drawing method,our planning in the uneven area improved the standard deviation of the hole burden by 40%.The improved hole layout facilitates the evolution of precise,efficient,and intelligent blasting in underground mines.
基金Provincial Natural Science Foundation of Sichuan Province of China (04JY029-003-2)
文摘Blast furnace scheme design is very important, since it directly affects the performance, cost and configuration of the blast furnace. An evaluation approach to furnace scheme design was brought forward based on artificial neural network. Ten independent parameters which determined a scheme design were proposed. The improved threelayer BP network algorithm was used to build the evaluation model in which the 10 independent parameters were taken as input evaluation indexes and the degree to which the scheme design satisfies the requirements of the blast furnace as output. It was trained by the existing samples of the scheme design and the experts＇ experience, and then tested by the other samples so as to develop the evaluation model. As an example, it is found that a good scheme design of blast furnace can be chosen by using the evaluation model proposed.
基金the National Natural Science Foundation of China(No.51934001).
文摘Interlaid rock is an important component in the construction of neighborhood tunnels that supports and reinforces the area between two tunnels.However,the blasting load during excavation can sometimes damage the interlaid rock and threaten the stability of a tunnel’s structure.This paper presents a case study of the small clearance section of the Liantang highway tunnel project in Shenzhen,China,where the minimum distance between the two tunnels involved is only 0.5 m.To reduce the damage to the interlaid rock caused by blasting loads,we proposed a four-part excavation method with a vibrationcushioning rock layer in the following tunnel of neighborhood tunnels.Numerical simulation was used to model the damage prevention mechanism of the vibration-cushioning rock layer and to better understand the propagation of cracks in the interlaid rock.Furthermore,based on the simulation results,combined microseismic controlled-blasting technology was implemented,using innovative blasting patterns combined with different charge structures and blasting equipment designed according to the varying thickness of the interlaid rock.Finally,this implementation succeeded in protecting interlaid rock during blasting operations.
文摘The increasing threat of explosions on the battle field and the terrorist action requires the development of more effective blast resistance materials and structures.Curved structure can support the external loads effectively by virtue of their spatial curvature.In review of the excellent energy absorption property of auxetic structure,employing auxetic structure as core material in curved sandwich shows the potential to improve the protection performance.In this study,a novel cylindrical sandwich panel with double arrow auxetic(DAA) core was designed and the numerical model was built by ABAQUS.Due to the complexity of the structure,systematic parameter study and optimal design are conducted.Two cases of optimal design were considered,case1 focuses on reducing the deflection and mass of the structure,while case2 focuses on reducing the deflection and increasing the energy absorption per unit mass.Parameter study and optimal design were conducted based on Latin Hypercube Sampling(LHD)method,artificial neural networks(ANN) metamodel and the nondominated sorting genetic algorithm(NSGA-Ⅱ).The Pareto front was obtained and the cylindrical DAA structure performed much better than its equal solid panel in both blast resistance and energy absorption capacity.Optimization results can be used as a reference for different applications.
文摘Reducing the blasting vibration is important for blasting excavation in subway tunnel construction.Taking the 3rd bid section of Line 3 of Qingdao subway project as an example,the distance between tunnel vault and ground is 5 ~ 8 m.In order to insure the safety of the upper buildings,technologies of parallel cut with large diameter empty hole,one-time initiation and delay by parts,and multiple shallow holes were adopted in the project.The results showed that the maximum value of vertical vibration was limited in the criterion allowance,and the upper buildings were not damaged.Besides,problems were solved that the number of nonel detonator was difficult to meet the requirements of excavating a large cross-section tunnel by blasting,multiple cross-section could’t be initiated simultaneously,and construction efficiency was low,which ensure the construction safety and schedule.
文摘In the past, blast-resistant designs for structures were often constructed with massive type structural systems, which relied more on brute strength than on finesse to achieve the required blast resistance. However, structures composed of COLD-FORMED steel components, such as sheet metal and metal studs, have shown great promise in providing blast resistance with the added benefits of low cost and ease of construction. Some examples of using such structures to provide containment for package handling facilities (PHF) are described in the paper for situations where blast containment is needed, such as a potential package bomb being discovered during the package vetting process. Results from tests and analytic data are used to illustrate aspects of design peculiar to such types of applications. Designs for specific capacities of PHF are described.
基金Project supported by the National Natural Science Foundation of China,“Microscopic Damage Mechanism of Saturated Brittle Rock during Blasting Induced Fracturing and Its Control Law on Macroscopic Damage”(No.51874339)the Natural Science Foundation of Shandong Province,“Study on the Coupled Response Mechanism of Crack Propagation and Rock Damage in the fracturing condition of multistage strong pulse”(No.ZR2016EEQ04)the Fundamental Research Funds for the Central Universities,China,“Study on the Mechanical Mechanism of Multistage Blasting Induced SRV in Deep-Seated Tight Reservoirs with High Horizontal Stress Difference”(No.17CX05004).
文摘For figuring out the stress interference of multiphase fracture combinations and its effect on the fracture initiation pressure of subsequent hydraulic fracturing,a calculation model for the coupled stress field with multiple induced fractures preexisted was established based on the calculation model for the stress field with single induced fracture preexisted,and the change laws of circumferential stress field around the wellbore under the effect of induced stress were analyzed.Then,the fracture initiation pressure of subsequent hydraulic fracturing was calculated according to the fracturing mechanics criterion.Finally,the effects of the length,phase,horizontal principal stress difference co-efficient and quantity of preexisting fractures on its initiation pressure were analyzed.And the following research results were obtained.First,the circumferential stress difference in the area near the fractures behind the preexisting fractures increase greatly and even the horizontal principal stress is reversed.Second,as the length of new preexisting fractures increases,the initiation pressure of initial preexisting fractures rises first and then drops.And when the length of new preexisting fractures is equal to that of the initial preexisting fractures,the initiation pressure of initial preexisting fractures drops quickly first and then slowly.Third,the initiation pressure of high phase fractures is lower than that of low phase fractures.Fourth,with the increase of fracture quantity,the initiation pressure of new preexisting fractures drops gradually,but the decline trend of initiation pressure difference is not obvious.Fifth,the stress interference of multiphase fractures influences the fracture initiation pressure,and high-phase long fractures and low-phase short fractures are both favorable for the simultaneous initiation of multiphase fractures.Sixth,syn-chronous propagation of multiple fractures can generate more complicated stress interference and excite the evolution of hydraulic fracture network,so as to realize uniform fracturing stimulation.In conclusion,the research results can provide a theoretical guidance for the design of fracturing operation,e.g.perforation phase of blasting induced fracturing,scale of induced fractures,and pump pressure of subsequent hydraulic fracturing.
