Architectural design technology management covers multiple aspects,including the formulation of technical standards,method selection,etc.It plays a key role in design quality,such as establishing a closed-loop managem...Architectural design technology management covers multiple aspects,including the formulation of technical standards,method selection,etc.It plays a key role in design quality,such as establishing a closed-loop management mechanism for the entire process and utilizing BIM collaborative platforms.It also introduces the application of techniques such as parametric design and the construction of quality prediction models.Simultaneously elaborating on the formulation of enterprise standards and other related content,this paper finally proposes an integrated solution while pointing out development bottlenecks and prospects.展开更多
This paper investigates the application of Building Information Modeling(BIM)technology in architectural design and its future developmental trajectories.It begins by elucidating the advantages of BIM technology compa...This paper investigates the application of Building Information Modeling(BIM)technology in architectural design and its future developmental trajectories.It begins by elucidating the advantages of BIM technology compared to conventional design methodologies.Subsequently,it examines the specific implementations of BIM technology in architectural design,highlighting its substantial contributions to improving design precision,operational efficiency,and collaborative processes.Lastly,the paper anticipates the evolutionary trends of BIM technology.Looking ahead,as artificial intelligence,blockchain,and big data technologies continue to advance,BIM technology is poised to experience further innovations and breakthroughs,thereby presenting novel opportunities and challenges for the construction sector.展开更多
In the production and life of ancient Chinese folk artists,through the abstract and geometric arrangement of things,they formed many meaningful patterns.These patterns are widely used in a variety of decorations,refle...In the production and life of ancient Chinese folk artists,through the abstract and geometric arrangement of things,they formed many meaningful patterns.These patterns are widely used in a variety of decorations,reflecting the most simple artistic ideas in the life of the working people,and are also an important embodiment of folk art aesthetics.Many elements of folk patterns have been preserved to this day,and they have an important role in inspiring and guiding today’s art design.This paper mainly analyzes the folk pattern elements and their artistic value,and elaborates on the application of folk pattern elements in architectural design and the specific design methods,to provide certain references for the combination of modern architectural design and traditional folk patterns.展开更多
Against the backdrop of the advancement of the“Double High Plan”and the deepening of the strategy for building a cultural powerhouse,aesthetic education in architectural interior design in higher vocational colleges...Against the backdrop of the advancement of the“Double High Plan”and the deepening of the strategy for building a cultural powerhouse,aesthetic education in architectural interior design in higher vocational colleges faces dual demands for“cultural empowerment”and“skill enhancement.”Currently,prominent issues exist in this field,such as superficial integration of regional culture,disconnection between aesthetic education and professional skill training,and a lack of systematic infiltration paths.This study primarily takes regional culture in Sichuan and Chongqing as research samples,employing literature research,mixed research methods,case analysis,and action research.By analyzing the current status and dilemmas of aesthetic education practices,it constructs a four-dimensional integrated infiltration path for aesthetic education encompassing“resources-implementation-guarantee-evaluation.”This research not only provides an operable practical paradigm for aesthetic education reform in design-related majors in higher vocational colleges but also supports the living transmission of regional culture in Sichuan and Chongqing.展开更多
This study aimed to discuss the mental alogia of national culture in the modernization of architectural landscape design. Taking new Suzhou Museum for an example, the territorial cultural characteristics, the style an...This study aimed to discuss the mental alogia of national culture in the modernization of architectural landscape design. Taking new Suzhou Museum for an example, the territorial cultural characteristics, the style and color of constructions and the application of new materials and technologies in this museum were analyzed, and the demonstration methods of Chinese culture in contemporary architectural design was discussed. The new Suzhou Museum designed by Ieoh Ming Pei properly handled the relationship between tradition and modernity, artistic form and culture, demonstration of cultural connotation and new materials and technologies through the outstanding design conceptions and artistic demonstration skills, which has provided precious and professional experience for the nationalization and modernization of contemporary Chinese architectural design.展开更多
Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle...Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.展开更多
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine...The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.展开更多
Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent materials.While...Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent materials.While macroscale and simple layouts can be realized by conventional top-down manufacturing approaches,many of the sophisticated designs at various length scales remain elusive,due to the lack of adequate manufacturing methods.Recent progress in additive manufacturing(AM)has led to the realization of a myriad of novel metamaterial concepts.AM methods capable of fabricating microscale architectures with high resolution,arbitrary complexity,and high feature fidelity have enabled the rapid development of architected meta materials and drastically reduced the design-computation and experimental-validation cycle.This paper first provides a detailed review of various topologies based on the desired mechanical properties,including stiff,strong,and auxetic(negative Poisson’s ratio)metamaterials,followed by a discussion of the AM technologies capable of fabricating these metamaterials.Finally,we discuss current challenges and recommend future directions for AM and mechanical metamaterials.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
This paper reviews the use of fiber-reinforced polymers （FRPs） in architectural and structural bridge design in the Netherlands. The challenges and opportunities of this relatively new material, both for the archite...This paper reviews the use of fiber-reinforced polymers （FRPs） in architectural and structural bridge design in the Netherlands. The challenges and opportunities of this relatively new material, both for the architect and the engineer, are discussed. An inventory of recent structural solutions in FRP is included, followed by a discussion on architectural FRP applications derived from the architectural practice of the author and of other pioneers.展开更多
Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice mo...Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.展开更多
Through the study of the teaching reform design of the course in Architecture Design using the flipped classroom,this paper discussed the effectiveness of the information-based teaching method for students’ learning....Through the study of the teaching reform design of the course in Architecture Design using the flipped classroom,this paper discussed the effectiveness of the information-based teaching method for students’ learning. It integrated the flipped classroom into all aspects of Architectural Design teaching. By using the flipped classroom,it is expected to effectively solve the problems related to the traditional Architectural Design teaching,enhance the students’ participation in the teaching process,create a learning atmosphere for students,enhance the initiative of self-learning,and promote the improvement in the quality of Architectural Design teaching.展开更多
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced...Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.展开更多
In Wuhan,China,a novel Corona Virus(COVID-19)was detected in December 2019;it has changed the entire world and to date,the number of diagnosed cases is 38,756,2891 and 1,095,2161 people have died.This happened because...In Wuhan,China,a novel Corona Virus(COVID-19)was detected in December 2019;it has changed the entire world and to date,the number of diagnosed cases is 38,756,2891 and 1,095,2161 people have died.This happened because a large number of people got affected and there is a lack of hospitals for COVID-19 patients.One of the precautionary measures for COVID-19 patients is isolation.To support this,there is an urgent need for a platform that makes treatment possible from a distance.Telemedicine systems have been drastically increasing in number and size over recent years.This increasing number intensies the extensive need for telemedicine for the national healthcare system.In this paper,we present Tele-COVID which is a telemedicine application to treat COVID-19 patients from a distance.Tele-COVID is uniquely designed and implemented in Service-Oriented Architecture(SOA)to avoid the problem of interoperability,vendor lock-in,and data interchange.With the help of Tele-COVID,the treatment of patients at a distance is possible without the need for them to visit hospitals;in case of emergency,necessary services can also be provided.展开更多
The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the...The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.展开更多
Before the invention of characters, human beings used images to convey information and express ideas, and such a mode of transmission has still been maintained and even presented in more diversified forms with the pas...Before the invention of characters, human beings used images to convey information and express ideas, and such a mode of transmission has still been maintained and even presented in more diversified forms with the passage of time. Architecture is a significant branch of visual art, it meets functional needs of daily use, and also reflects social culture and its development tendency. This paper analyzed the relationship between architectural design and visual form, explored the expression means of architectural cultures, so as to grasp the development context of history precisely, enrich architectural design and make it a motive of social cultural development.展开更多
Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage dis...Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.展开更多
Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to...Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.展开更多
In the last years, architectural practice has been confronted with a paradigm shift towards the application of digital methods in design activities. In this regard, it is a pedagogic challenge to provide a suitable co...In the last years, architectural practice has been confronted with a paradigm shift towards the application of digital methods in design activities. In this regard, it is a pedagogic challenge to provide a suitable computational background for architectural students, to improve their ability to apply algorithmic-parametric logic, as well as fabrication and prototyping resources to design problem solving. This challenge is even stronger when considering less favored social and technological contexts, such as in Brazil, for example. In this scenario, this article presents and discusses the procedures and the results from a didactic experience carried out in a design computing-oriented discipline, inserted in the curriculum of a Brazilian architecture course. Hence, this paper shares some design computing teaching experiences and presents some results on computational methods and creative approaches, with a view to contribute to a better understanding about the relations between logical thinking, mathematics and architectural design processes.展开更多
Using the software of Ecotect, the simulation of lighting and thermal environment of a real architecture is presented to show the merits and shortcomings by using computer software for simulation of architectural phys...Using the software of Ecotect, the simulation of lighting and thermal environment of a real architecture is presented to show the merits and shortcomings by using computer software for simulation of architectural physical environmental design and estimation. Issues on creating the digital model, parameter setting, process planning and realization are discussed.展开更多
文摘Architectural design technology management covers multiple aspects,including the formulation of technical standards,method selection,etc.It plays a key role in design quality,such as establishing a closed-loop management mechanism for the entire process and utilizing BIM collaborative platforms.It also introduces the application of techniques such as parametric design and the construction of quality prediction models.Simultaneously elaborating on the formulation of enterprise standards and other related content,this paper finally proposes an integrated solution while pointing out development bottlenecks and prospects.
基金Scientific and Technological Research Program of Chongqing Municipal Education Commission(Project No.:KJQN202301907)。
文摘This paper investigates the application of Building Information Modeling(BIM)technology in architectural design and its future developmental trajectories.It begins by elucidating the advantages of BIM technology compared to conventional design methodologies.Subsequently,it examines the specific implementations of BIM technology in architectural design,highlighting its substantial contributions to improving design precision,operational efficiency,and collaborative processes.Lastly,the paper anticipates the evolutionary trends of BIM technology.Looking ahead,as artificial intelligence,blockchain,and big data technologies continue to advance,BIM technology is poised to experience further innovations and breakthroughs,thereby presenting novel opportunities and challenges for the construction sector.
文摘In the production and life of ancient Chinese folk artists,through the abstract and geometric arrangement of things,they formed many meaningful patterns.These patterns are widely used in a variety of decorations,reflecting the most simple artistic ideas in the life of the working people,and are also an important embodiment of folk art aesthetics.Many elements of folk patterns have been preserved to this day,and they have an important role in inspiring and guiding today’s art design.This paper mainly analyzes the folk pattern elements and their artistic value,and elaborates on the application of folk pattern elements in architectural design and the specific design methods,to provide certain references for the combination of modern architectural design and traditional folk patterns.
基金a phased research result of the 2024 Chongqing Vocational Education Teaching Reform Research Project,“Exploration and Practice of the‘Dual-Subject Three-Stage Three-Integration’Model for Aesthetic Education Infiltration in Architectural Interior Design”(Z2241471).
文摘Against the backdrop of the advancement of the“Double High Plan”and the deepening of the strategy for building a cultural powerhouse,aesthetic education in architectural interior design in higher vocational colleges faces dual demands for“cultural empowerment”and“skill enhancement.”Currently,prominent issues exist in this field,such as superficial integration of regional culture,disconnection between aesthetic education and professional skill training,and a lack of systematic infiltration paths.This study primarily takes regional culture in Sichuan and Chongqing as research samples,employing literature research,mixed research methods,case analysis,and action research.By analyzing the current status and dilemmas of aesthetic education practices,it constructs a four-dimensional integrated infiltration path for aesthetic education encompassing“resources-implementation-guarantee-evaluation.”This research not only provides an operable practical paradigm for aesthetic education reform in design-related majors in higher vocational colleges but also supports the living transmission of regional culture in Sichuan and Chongqing.
文摘This study aimed to discuss the mental alogia of national culture in the modernization of architectural landscape design. Taking new Suzhou Museum for an example, the territorial cultural characteristics, the style and color of constructions and the application of new materials and technologies in this museum were analyzed, and the demonstration methods of Chinese culture in contemporary architectural design was discussed. The new Suzhou Museum designed by Ieoh Ming Pei properly handled the relationship between tradition and modernity, artistic form and culture, demonstration of cultural connotation and new materials and technologies through the outstanding design conceptions and artistic demonstration skills, which has provided precious and professional experience for the nationalization and modernization of contemporary Chinese architectural design.
基金The National Natural Science Foundation of China(No.71271053)the Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXLX13_082)
文摘Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.
文摘The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(2021B0301030001)project supported by the Space Utilization System of China Manned Space Engineering(KJZ-YY-WCL03)+6 种基金National Key Laboratory Foundation of Science and Technology on Materials under Shock and Impact(6142902210109)National Key Research and Development Program of China(2018YFB0905600 and 2017YFB0310400)National Natural Science Foundation of China(51472188 and 51521001)Natural Research Funds of Hubei Province(2016CFB583)Natural Research Funds of Shenzhen,Fundamental Research Funds for the Central Universities China,State Key Laboratory of Advanced Electromagnetic Engineering and Technology(Huazhong University of Science and Technology)the Science and Technology Project of the Global Energy Interconnection Research Institute Co.,Ltd.(SGGR0000WLJS1801080)the 111 Project(B13035)。
文摘Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent materials.While macroscale and simple layouts can be realized by conventional top-down manufacturing approaches,many of the sophisticated designs at various length scales remain elusive,due to the lack of adequate manufacturing methods.Recent progress in additive manufacturing(AM)has led to the realization of a myriad of novel metamaterial concepts.AM methods capable of fabricating microscale architectures with high resolution,arbitrary complexity,and high feature fidelity have enabled the rapid development of architected meta materials and drastically reduced the design-computation and experimental-validation cycle.This paper first provides a detailed review of various topologies based on the desired mechanical properties,including stiff,strong,and auxetic(negative Poisson’s ratio)metamaterials,followed by a discussion of the AM technologies capable of fabricating these metamaterials.Finally,we discuss current challenges and recommend future directions for AM and mechanical metamaterials.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘This paper reviews the use of fiber-reinforced polymers （FRPs） in architectural and structural bridge design in the Netherlands. The challenges and opportunities of this relatively new material, both for the architect and the engineer, are discussed. An inventory of recent structural solutions in FRP is included, followed by a discussion on architectural FRP applications derived from the architectural practice of the author and of other pioneers.
文摘Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.
文摘Through the study of the teaching reform design of the course in Architecture Design using the flipped classroom,this paper discussed the effectiveness of the information-based teaching method for students’ learning. It integrated the flipped classroom into all aspects of Architectural Design teaching. By using the flipped classroom,it is expected to effectively solve the problems related to the traditional Architectural Design teaching,enhance the students’ participation in the teaching process,create a learning atmosphere for students,enhance the initiative of self-learning,and promote the improvement in the quality of Architectural Design teaching.
基金The study was financially supported by the key project of Science and Technology Commission of Shanghai Local Gov-ernment (No. 015211010), the National Natural Science Foundation of China (No. 50171038) and the China-Belgium bi-lateral project (No. 2001-242).
文摘Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.
文摘In Wuhan,China,a novel Corona Virus(COVID-19)was detected in December 2019;it has changed the entire world and to date,the number of diagnosed cases is 38,756,2891 and 1,095,2161 people have died.This happened because a large number of people got affected and there is a lack of hospitals for COVID-19 patients.One of the precautionary measures for COVID-19 patients is isolation.To support this,there is an urgent need for a platform that makes treatment possible from a distance.Telemedicine systems have been drastically increasing in number and size over recent years.This increasing number intensies the extensive need for telemedicine for the national healthcare system.In this paper,we present Tele-COVID which is a telemedicine application to treat COVID-19 patients from a distance.Tele-COVID is uniquely designed and implemented in Service-Oriented Architecture(SOA)to avoid the problem of interoperability,vendor lock-in,and data interchange.With the help of Tele-COVID,the treatment of patients at a distance is possible without the need for them to visit hospitals;in case of emergency,necessary services can also be provided.
文摘The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.
文摘Before the invention of characters, human beings used images to convey information and express ideas, and such a mode of transmission has still been maintained and even presented in more diversified forms with the passage of time. Architecture is a significant branch of visual art, it meets functional needs of daily use, and also reflects social culture and its development tendency. This paper analyzed the relationship between architectural design and visual form, explored the expression means of architectural cultures, so as to grasp the development context of history precisely, enrich architectural design and make it a motive of social cultural development.
基金This work was supported by grants from the National Sciences Fund(31370938 and 81272528)The Fund(81272528)offered experiment material and collected the data for analysisThe Fund(31370938)helped design the study and was helpful in preparing the manuscript.
文摘Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.
文摘Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.
文摘In the last years, architectural practice has been confronted with a paradigm shift towards the application of digital methods in design activities. In this regard, it is a pedagogic challenge to provide a suitable computational background for architectural students, to improve their ability to apply algorithmic-parametric logic, as well as fabrication and prototyping resources to design problem solving. This challenge is even stronger when considering less favored social and technological contexts, such as in Brazil, for example. In this scenario, this article presents and discusses the procedures and the results from a didactic experience carried out in a design computing-oriented discipline, inserted in the curriculum of a Brazilian architecture course. Hence, this paper shares some design computing teaching experiences and presents some results on computational methods and creative approaches, with a view to contribute to a better understanding about the relations between logical thinking, mathematics and architectural design processes.
文摘Using the software of Ecotect, the simulation of lighting and thermal environment of a real architecture is presented to show the merits and shortcomings by using computer software for simulation of architectural physical environmental design and estimation. Issues on creating the digital model, parameter setting, process planning and realization are discussed.
