Purpose To propose a method for simultaneous fluorescence and Compton scattering computed tomography by using linearly polarized X-rays.Methods Monte Carlo simulations were adopted to demonstrate the feasibility of th...Purpose To propose a method for simultaneous fluorescence and Compton scattering computed tomography by using linearly polarized X-rays.Methods Monte Carlo simulations were adopted to demonstrate the feasibility of the proposed method.In the simulations,the phantom is a polytetrafluoroethylene cylinder inside which are cylindrical columns containing aluminum,water,and gold(Au)-loaded water solutions with Au concentrations ranging between 0.5 and 4.0 wt%,and a parallel-hole collimator imaging geometry was adopted.The light source was modeled based on a Thomson scattering X-ray source.The phantom images for both imaging modalities were reconstructed using a maximumlikelihood expectation maximization algorithm.Results Both the X-ray fluorescence computed tomography(XFCT)and Compton scattering computed tomography(CSCT)images of the phantom were accurately reconstructed.A similar attenuation contrast problem for the different cylindrical columns in the phantom can be resolved in the XFCT and CSCT images.The interplay between XFCT and CSCT was analyzed,and the contrast-to-noise ratio(CNR)of the reconstruction was improved by correcting for the mutual influence between the two imaging modalities.Compared with K-edge subtraction imaging,XFCT exhibits a CNR advantage for the phantom.Conclusion Simultaneous XFCT and CSCT can be realized by using linearly polarized X-rays.The synergy between the two imaging modalities would have an important application in cancer radiation therapy.展开更多
The purpose of this research is to investigate the feasibility of using low contrast agent concentration with X-ray computed tomography in visualizing and diagnosing the human vascular system while minimizing the risk...The purpose of this research is to investigate the feasibility of using low contrast agent concentration with X-ray computed tomography in visualizing and diagnosing the human vascular system while minimizing the risk of toxicity to the patient. This research investigated the effect of several iodine contrast agent concentrations on the ability to extract and visualize human vessels using simulated computed tomography scans. Monte Carlo simulation was used to perform these computed tomography acquisitions. The simulated patient was based on actual computed tomography angiography data, where a technique was developed to simulate brain vessels with contrast agents ranging from 0 mg to 20 mg of iodine. The simulation used segmented patient data along with basic image processing techniques to model the various levels of iodine concentrations. Cone beam computed tomography projections of a patient injected with and without iodine were acquired in the simulations. Subtraction of the corresponding projections was performed to generate images caused by the contrast agent. Then, histogram analysis of these differences was used to assess the validity of extracting and visualizing the human vessels. The smallest amount of iodine, 0.5 mg, helped better visualize the brain vessels and 2 mg of iodine was high enough to show almost 90% of the vessels. Additionally, the vessels were clearly visible in all the subtracted images. This research showed very promising outcomes in using low concentrations of iodine. Thus, this study proposes for the pharmaceutical companies and others interested to clinically investigate and evaluate the efficacy of using low concentrations of iodine and the associated side effects.展开更多
Due to seasonal climate alterations,the microstructure and permeability of granite residual soil are easily affected by multiple dry-wet cycles.The X-ray micro computed tomography(micro-CT)acted as a nondestructive to...Due to seasonal climate alterations,the microstructure and permeability of granite residual soil are easily affected by multiple dry-wet cycles.The X-ray micro computed tomography(micro-CT)acted as a nondestructive tool for characterizing the microstructure of soil samples exposed to a range of damage levels induced by dry-wet cycles.Subsequently,the variations of pore distribution and permeability due to drywet cycling effects were revealed based on three-dimensional(3D)pore distribution analysis and seepage simulations.According to the results,granite residual soils could be separated into four different components,namely,pores,clay,quartz,and hematite,from micro-CT images.The reconstructed 3D pore models dynamically demonstrated the expanding and connecting patterns of pore structures during drywet cycles.The values of porosity and connectivity are positively correlated with the number of dry-wet cycles,which were expressed by exponential and linear functions,respectively.The pore volume probability distribution curves of granite residual soil coincide with the χ^(2)distribution curve,which verifies the effectiveness of the assumption of χ^(2)distribution probability.The pore volume distribution curves suggest that the pores in soils were divided into four types based on their volumes,i.e.micropores,mesopores,macropores,and cracks.From a quantitative and visual perspective,considerable small pores are gradually transformed into cracks with a large volume and a high connectivity.Under the action of dry-wet cycles,the number of seepage flow streamlines which contribute to water permeation in seepage simulation increases distinctly,as well as the permeability and hydraulic conductivity.The calculated hydraulic conductivity is comparable with measured ones with an acceptable error margin in general,verifying the accuracy of seepage simulations based on micro-CT results.展开更多
A scattering correction method for a panel detector based cone beam computed tomography system is presented. First, the x-ray spectrum of the system is acquired by using the Monte Carlo simulation method. Secondly, sc...A scattering correction method for a panel detector based cone beam computed tomography system is presented. First, the x-ray spectrum of the system is acquired by using the Monte Carlo simulation method. Secondly, scattered photon distribution is calculated and stored as correction matrixes by using the Monte Carlo simulation method according to scanned objects and computed tomography system specialties. Thirdly, scattered photons are removed from projection data by correction matrixes. A comparison of reconstruction image between before and after scattering correction demonstrates that the scattering correction method is effective for the panel detector based cone beam computed tomography system.展开更多
Objective： To evaluate the pelvic lymph node coverage of conventional pelvic fields based on bony landmarks in Chinese patients with cervical cancer by using computed tomography （CT） simulation images to contour pe...Objective： To evaluate the pelvic lymph node coverage of conventional pelvic fields based on bony landmarks in Chinese patients with cervical cancer by using computed tomography （CT） simulation images to contour pelvic vessels as substitutes for lymph nodes location. Methods： A retrospective review of CT simulation images and conventional pelvic radiation planning data sets was performed in 100 patients with cervical cancer at the International Federation of Gynecology and Obstetrics （FIGO） Stage liB to IIIB in our hospital. Pelvic arteries were contoured on CT simulation images, and the outlines of conventional pelvic fields were drawn as defined by the gynecologic oncology group （GOG） after hiding the contours. The distances between the following vessel contours and field borders were measured： D1, the superior border of the anterior/posterior （AP） field and the bifurcation of abdominal aorta; D2, the ipsilateral border of the AP field and the distal end of external iliac artery; and D3, the anterior border of the lateral （LAT） field and the distal end of the external iliac artery. The distances were recorded as positive values if the measuring point was within the conventional pelvic fields, or they were recorded as negative values. Lymph nodes coverage was considered adequate when D1≥0 mm, D2〉17 mm or D3≥7 mm. Results： All patients had at least 1 inadequate margin, 97 patients （97.0%） had 2, and 22 patients （22.0%） had all the 3. On the AP field, 95 patients （95%） had the measuring point, the bifurcation of the abdominal aorta, out of the field （D1〈0 mm）, and all the patients had a distance less than 17.0 mm between the distal end of the external iliac artery and ipsilateral border （D2〈1 7.0 mm）. On the LAT field, 24 patients （24%） had a distance less than 7.0 mm between the distal end of the external iliac artery and anterior border （D3〈7.0 mm）. Conclusion： We observed that conventional pelvic fields based on bony landmarks provided inadequate coverage of pelvic lymph nodes in our patients with cervical cancer. CT simulation may be a feasible technique for planning pelvic fields optimally and individually.展开更多
The geometry of joints has a significant influence on the mechanical properties of rocks.To simplify the curved joint shapes in rocks,the joint shape is usually treated as straight lines or planes in most laboratory e...The geometry of joints has a significant influence on the mechanical properties of rocks.To simplify the curved joint shapes in rocks,the joint shape is usually treated as straight lines or planes in most laboratory experiments and numerical simulations.In this study,the computerized tomography (CT) scanning and photogrammetry were employed to obtain the internal and surface joint structures of a limestone sample,respectively.To describe the joint geometry,the edge detection algorithms and a three-dimensional (3D) matrix mapping method were applied to reconstruct CT-based and photogrammetry-based jointed rock models.For comparison tests,the numerical uniaxial compression tests were conducted on an intact rock sample and a sample with a joint simplified to a plane using the parallel computing method.The results indicate that the mechanical characteristics and failure process of jointed rocks are significantly affected by the geometry of joints.The presence of joints reduces the uniaxial compressive strength (UCS),elastic modulus,and released acoustic emission (AE) energy of rocks by 37%–67%,21%–24%,and 52%–90%,respectively.Compared to the simplified joint sample,the proposed photogrammetry-based numerical model makes the most of the limited geometry information of joints.The UCS,accumulative released AE energy,and elastic modulus of the photogrammetry-based sample were found to be very close to those of the CT-based sample.The UCS value of the simplified joint sample (i.e.38.5 MPa) is much lower than that of the CT-based sample (i.e.72.3 MPa).Additionally,the accumulative released AE energy observed in the simplified joint sample is 3.899 times lower than that observed in the CT-based sample.CT scanning provides a reliable means to visualize the joints in rocks,which can be used to verify the reliability of photogrammetry techniques.The application of the photogrammetry-based sample enables detailed analysis for estimating the mechanical properties of jointed rocks.展开更多
Although emission spectral tomography （EST） combines emission spectral measurement with optical computed tomography （OCT）, it is difficult to gain transient emission data from a large number of views, therefore, h...Although emission spectral tomography （EST） combines emission spectral measurement with optical computed tomography （OCT）, it is difficult to gain transient emission data from a large number of views, therefore, high precision OCT algorithms with few views ought to be studied for EST application. To improve the reconstruction precision in the case of few views, a new computed tomography reconstruction algorithm based on multipurpose optimal criterion and simulated annealing theory （multi-criterion simulated annealing reconstruction technique, MCSART） is proposed. This algorithm can suffice criterion of least squares, criterion of most uniformity, and criterion of most smoothness synchronously. We can get global optimal solution by MCSART algorithm with simulated annealing theory. The simulating experiment result shows that this algorithm is superior to the traditional algorithms under various noises.展开更多
Photoacoustic imaging(PAI)has been developed,and photoacoustic computed tomography(PACT)is widely used for in vivo tissue and mouse imaging.Simulated annealing(SA)algorithm solves optimization problems,and compressed ...Photoacoustic imaging(PAI)has been developed,and photoacoustic computed tomography(PACT)is widely used for in vivo tissue and mouse imaging.Simulated annealing(SA)algorithm solves optimization problems,and compressed sensing(CS)recovers sparse signals from undersampled measurements.We aim to develop an advanced sparse imaging framework for PACT,which invloves the use of SA to¯nd an optimal sparse array element distribution and CS to perform sparse imaging.PACT reconstructions were performed using a dummy and porcine liver phantoms.Compared to traditional sparse reconstruction algorithms,the proposed method recovers signals using few ultrasonic transducer elements,enabling high-speed,low-cost PACT for practical application.展开更多
基金supported by the National Natural Science Foundation of China(Nos.12375157,12027902,and 11905011)。
文摘Purpose To propose a method for simultaneous fluorescence and Compton scattering computed tomography by using linearly polarized X-rays.Methods Monte Carlo simulations were adopted to demonstrate the feasibility of the proposed method.In the simulations,the phantom is a polytetrafluoroethylene cylinder inside which are cylindrical columns containing aluminum,water,and gold(Au)-loaded water solutions with Au concentrations ranging between 0.5 and 4.0 wt%,and a parallel-hole collimator imaging geometry was adopted.The light source was modeled based on a Thomson scattering X-ray source.The phantom images for both imaging modalities were reconstructed using a maximumlikelihood expectation maximization algorithm.Results Both the X-ray fluorescence computed tomography(XFCT)and Compton scattering computed tomography(CSCT)images of the phantom were accurately reconstructed.A similar attenuation contrast problem for the different cylindrical columns in the phantom can be resolved in the XFCT and CSCT images.The interplay between XFCT and CSCT was analyzed,and the contrast-to-noise ratio(CNR)of the reconstruction was improved by correcting for the mutual influence between the two imaging modalities.Compared with K-edge subtraction imaging,XFCT exhibits a CNR advantage for the phantom.Conclusion Simultaneous XFCT and CSCT can be realized by using linearly polarized X-rays.The synergy between the two imaging modalities would have an important application in cancer radiation therapy.
文摘The purpose of this research is to investigate the feasibility of using low contrast agent concentration with X-ray computed tomography in visualizing and diagnosing the human vascular system while minimizing the risk of toxicity to the patient. This research investigated the effect of several iodine contrast agent concentrations on the ability to extract and visualize human vessels using simulated computed tomography scans. Monte Carlo simulation was used to perform these computed tomography acquisitions. The simulated patient was based on actual computed tomography angiography data, where a technique was developed to simulate brain vessels with contrast agents ranging from 0 mg to 20 mg of iodine. The simulation used segmented patient data along with basic image processing techniques to model the various levels of iodine concentrations. Cone beam computed tomography projections of a patient injected with and without iodine were acquired in the simulations. Subtraction of the corresponding projections was performed to generate images caused by the contrast agent. Then, histogram analysis of these differences was used to assess the validity of extracting and visualizing the human vessels. The smallest amount of iodine, 0.5 mg, helped better visualize the brain vessels and 2 mg of iodine was high enough to show almost 90% of the vessels. Additionally, the vessels were clearly visible in all the subtracted images. This research showed very promising outcomes in using low concentrations of iodine. Thus, this study proposes for the pharmaceutical companies and others interested to clinically investigate and evaluate the efficacy of using low concentrations of iodine and the associated side effects.
基金supported by the National Natural Science Foundation of China (Grant Nos. 12102312 and 41372314)State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Open Foundation, Chengdu University of Technology, China (Grant No. SKLGP2021K011)
文摘Due to seasonal climate alterations,the microstructure and permeability of granite residual soil are easily affected by multiple dry-wet cycles.The X-ray micro computed tomography(micro-CT)acted as a nondestructive tool for characterizing the microstructure of soil samples exposed to a range of damage levels induced by dry-wet cycles.Subsequently,the variations of pore distribution and permeability due to drywet cycling effects were revealed based on three-dimensional(3D)pore distribution analysis and seepage simulations.According to the results,granite residual soils could be separated into four different components,namely,pores,clay,quartz,and hematite,from micro-CT images.The reconstructed 3D pore models dynamically demonstrated the expanding and connecting patterns of pore structures during drywet cycles.The values of porosity and connectivity are positively correlated with the number of dry-wet cycles,which were expressed by exponential and linear functions,respectively.The pore volume probability distribution curves of granite residual soil coincide with the χ^(2)distribution curve,which verifies the effectiveness of the assumption of χ^(2)distribution probability.The pore volume distribution curves suggest that the pores in soils were divided into four types based on their volumes,i.e.micropores,mesopores,macropores,and cracks.From a quantitative and visual perspective,considerable small pores are gradually transformed into cracks with a large volume and a high connectivity.Under the action of dry-wet cycles,the number of seepage flow streamlines which contribute to water permeation in seepage simulation increases distinctly,as well as the permeability and hydraulic conductivity.The calculated hydraulic conductivity is comparable with measured ones with an acceptable error margin in general,verifying the accuracy of seepage simulations based on micro-CT results.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.60672104 and 10527003)the National Basic Research Program of China(Grant No.2006CB705705)the Joint Research Foundation of Beijing Education Committee, China(Grant No.JD100010607)
文摘A scattering correction method for a panel detector based cone beam computed tomography system is presented. First, the x-ray spectrum of the system is acquired by using the Monte Carlo simulation method. Secondly, scattered photon distribution is calculated and stored as correction matrixes by using the Monte Carlo simulation method according to scanned objects and computed tomography system specialties. Thirdly, scattered photons are removed from projection data by correction matrixes. A comparison of reconstruction image between before and after scattering correction demonstrates that the scattering correction method is effective for the panel detector based cone beam computed tomography system.
文摘Objective： To evaluate the pelvic lymph node coverage of conventional pelvic fields based on bony landmarks in Chinese patients with cervical cancer by using computed tomography （CT） simulation images to contour pelvic vessels as substitutes for lymph nodes location. Methods： A retrospective review of CT simulation images and conventional pelvic radiation planning data sets was performed in 100 patients with cervical cancer at the International Federation of Gynecology and Obstetrics （FIGO） Stage liB to IIIB in our hospital. Pelvic arteries were contoured on CT simulation images, and the outlines of conventional pelvic fields were drawn as defined by the gynecologic oncology group （GOG） after hiding the contours. The distances between the following vessel contours and field borders were measured： D1, the superior border of the anterior/posterior （AP） field and the bifurcation of abdominal aorta; D2, the ipsilateral border of the AP field and the distal end of external iliac artery; and D3, the anterior border of the lateral （LAT） field and the distal end of the external iliac artery. The distances were recorded as positive values if the measuring point was within the conventional pelvic fields, or they were recorded as negative values. Lymph nodes coverage was considered adequate when D1≥0 mm, D2〉17 mm or D3≥7 mm. Results： All patients had at least 1 inadequate margin, 97 patients （97.0%） had 2, and 22 patients （22.0%） had all the 3. On the AP field, 95 patients （95%） had the measuring point, the bifurcation of the abdominal aorta, out of the field （D1〈0 mm）, and all the patients had a distance less than 17.0 mm between the distal end of the external iliac artery and ipsilateral border （D2〈1 7.0 mm）. On the LAT field, 24 patients （24%） had a distance less than 7.0 mm between the distal end of the external iliac artery and anterior border （D3〈7.0 mm）. Conclusion： We observed that conventional pelvic fields based on bony landmarks provided inadequate coverage of pelvic lymph nodes in our patients with cervical cancer. CT simulation may be a feasible technique for planning pelvic fields optimally and individually.
基金supported by the National Natural Science Foundation of China(Grant Nos.42277150,41977219)Henan Provincial Science and Technology Research Project(Grant No.222102320271).
文摘The geometry of joints has a significant influence on the mechanical properties of rocks.To simplify the curved joint shapes in rocks,the joint shape is usually treated as straight lines or planes in most laboratory experiments and numerical simulations.In this study,the computerized tomography (CT) scanning and photogrammetry were employed to obtain the internal and surface joint structures of a limestone sample,respectively.To describe the joint geometry,the edge detection algorithms and a three-dimensional (3D) matrix mapping method were applied to reconstruct CT-based and photogrammetry-based jointed rock models.For comparison tests,the numerical uniaxial compression tests were conducted on an intact rock sample and a sample with a joint simplified to a plane using the parallel computing method.The results indicate that the mechanical characteristics and failure process of jointed rocks are significantly affected by the geometry of joints.The presence of joints reduces the uniaxial compressive strength (UCS),elastic modulus,and released acoustic emission (AE) energy of rocks by 37%–67%,21%–24%,and 52%–90%,respectively.Compared to the simplified joint sample,the proposed photogrammetry-based numerical model makes the most of the limited geometry information of joints.The UCS,accumulative released AE energy,and elastic modulus of the photogrammetry-based sample were found to be very close to those of the CT-based sample.The UCS value of the simplified joint sample (i.e.38.5 MPa) is much lower than that of the CT-based sample (i.e.72.3 MPa).Additionally,the accumulative released AE energy observed in the simplified joint sample is 3.899 times lower than that observed in the CT-based sample.CT scanning provides a reliable means to visualize the joints in rocks,which can be used to verify the reliability of photogrammetry techniques.The application of the photogrammetry-based sample enables detailed analysis for estimating the mechanical properties of jointed rocks.
基金This work was supported by the Chinese Natural Science Foundation of China(No.60577016)the Foundation(No. 0512034)of Jiangxi Natural Science+1 种基金the Science and Technology Program(No. 2006-164)of Jiangxi Provincial Department of Educationthe Program(No.2005-314)of Key Laboratory of Nondestructive Testing Technology,Ministry of Education.
文摘Although emission spectral tomography （EST） combines emission spectral measurement with optical computed tomography （OCT）, it is difficult to gain transient emission data from a large number of views, therefore, high precision OCT algorithms with few views ought to be studied for EST application. To improve the reconstruction precision in the case of few views, a new computed tomography reconstruction algorithm based on multipurpose optimal criterion and simulated annealing theory （multi-criterion simulated annealing reconstruction technique, MCSART） is proposed. This algorithm can suffice criterion of least squares, criterion of most uniformity, and criterion of most smoothness synchronously. We can get global optimal solution by MCSART algorithm with simulated annealing theory. The simulating experiment result shows that this algorithm is superior to the traditional algorithms under various noises.
基金funded by the National Key Research and Development Program of China(2019YFC0117400)Jilin Province and Chinese Academy of Sciences Science and Technology Cooperation High-tech Industrialization Special Fund Project(2020SYHZ0027).
文摘Photoacoustic imaging(PAI)has been developed,and photoacoustic computed tomography(PACT)is widely used for in vivo tissue and mouse imaging.Simulated annealing(SA)algorithm solves optimization problems,and compressed sensing(CS)recovers sparse signals from undersampled measurements.We aim to develop an advanced sparse imaging framework for PACT,which invloves the use of SA to¯nd an optimal sparse array element distribution and CS to perform sparse imaging.PACT reconstructions were performed using a dummy and porcine liver phantoms.Compared to traditional sparse reconstruction algorithms,the proposed method recovers signals using few ultrasonic transducer elements,enabling high-speed,low-cost PACT for practical application.
