Configuring computational fluid dynamics(CFD)simulations typically demands extensive domain expertise,limiting broader access.Although large language models(LLMs)have advanced scientific computing,their use in automat...Configuring computational fluid dynamics(CFD)simulations typically demands extensive domain expertise,limiting broader access.Although large language models(LLMs)have advanced scientific computing,their use in automating CFD workflows is underdeveloped.We introduce a novel approach centered on domain-specific LLM adaptation.By fine-tuning Qwen2.5-7B-Instruct on NL2FOAM,our custom dataset of 28,716 natural language-to-OpenFOAM configuration pairs with chain-of-thought(CoT)annotations enables direct translation from natural language descriptions to executable CFD setups.A multi-agent system orchestrates the process,autonomously verifying inputs,generating configurations,running simulations,and correcting errors.Evaluation on a benchmark of 21 diverse flow cases demonstrates state-of-the-art performance,achieving 88.7%solution accuracy and 82.6%first-attempt success rate.This significantly outperforms larger general-purpose models such as Qwen2.5-72B-Instruct,DeepSeek-R1,and Llama3.3-70B-Instruct,while also requiring fewer correction iterations and maintaining high computational efficiency.The results highlight the critical role of domain-specific adaptation in deploying LLM assistants for complex engineering workflows.Our code and fine-tuned model have been deposited at https://github.com/YYgroup/AutoCFD.展开更多
Conventional oncology faces challenges such as suboptimal drug delivery,tumor heterogeneity,and therapeutic resistance,indicating a need formore personalized,andmechanistically grounded and predictive treatment strate...Conventional oncology faces challenges such as suboptimal drug delivery,tumor heterogeneity,and therapeutic resistance,indicating a need formore personalized,andmechanistically grounded and predictive treatment strategies.This review explores the convergence of Computational Fluid Dynamics(CFD)and Machine Learning(ML)as an integrated framework to address these issues in modern cancer therapy.The paper discusses recent advancements where CFD models simulate complex tumor microenvironmental conditions,like interstitial fluid pressure(IFP)and drug perfusion,and ML enhances simulation workflows,automates image-based segmentation,and enhances predictive accuracy.The synergy between CFD and ML improves scalability and enables patientspecific treatment planning.Methodologically,it coversmulti-scalemodeling approaches,nanotherapeutic simulations,imaging integration,and emerging AI-driven frameworks.The paper identifies gaps in current applications,including the need for robust clinical validation,real-time model adaptability,and ethical data integration.Future directions suggest that CFD–ML hybrids could serve as digital twins for tumor evolution,offering insights for adaptive therapies.The review advocates for a computationally augmented oncology ecosystem that combines biological complexity with engineering precision for next-generation cancer care.展开更多
Many fishes use undulatory fin to propel themselves in the underwater environment. These locomotor mechanisms have a popular interest to many researchers. In the present study, we perform a three-dimensional unsteady ...Many fishes use undulatory fin to propel themselves in the underwater environment. These locomotor mechanisms have a popular interest to many researchers. In the present study, we perform a three-dimensional unsteady computation of an undulatory mechanical fin that is driven by Shape Memory Alloy （SMA）. The objective of the computation is to investigate the fluid dynamics of force production associated with the undulatory mechanical fin. An unstructured, grid-based, unsteady Navier-Stokes solver with automatic adaptive remeshing is used to compute the unsteady flow around the fin through five complete cycles. The pressure distribution on fin surface is computed and integrated to provide fin forces which are decomposed into lift and thrust. The velocity field is also computed throughout the swimming cycle. Finally, a comparison is conducted to reveal the dynamics of force generation according to the kinematic parameters of the undulatory fin （amplitude, frequency and wavelength）.展开更多
Computational fluid dynamics（CFD） simulations are adopted to investigate rectangular microchannel flows with various periodic micro-structured wall by introducing velocity slip boundary condition at low Reynolds num...Computational fluid dynamics（CFD） simulations are adopted to investigate rectangular microchannel flows with various periodic micro-structured wall by introducing velocity slip boundary condition at low Reynolds number. The purpose of the current study is to numerically find out the effects of periodic micro-structured wall on the flow resistance in rectangular microchannel with the different spacings between microridges ranging from 15 to 60 pm. The simulative results indicate that pressure drop with different spacing between microridges increases linearly with flow velocity and decreases monotonically with slip velocity; Pressure drop reduction also increases with the spacing between microridges at the same condition of slip velocity and flow velocity. The results of numerical simulation are compared with theoretical predictions and experimental results in the literatures. It is found that there is qualitative agreement between them.展开更多
To find out and improve the flow characteristics inside the intake system of cylinder head,the application of computational fluid dynamics(CFD)in the evaluation and optimization of the reconstructed intake system base...To find out and improve the flow characteristics inside the intake system of cylinder head,the application of computational fluid dynamics(CFD)in the evaluation and optimization of the reconstructed intake system based on slicing reverse method was proposed.The flow characteristics were found out through CFD,and the velocity vector field,pressure field and turbulent kinetic energy field for different valve lifts were discussed,which were in good agreement with experimental data,and the quality of reconstruction was evaluated.In order to improve its flow characteristic,an optimization plan was proposed.The results show that the flow characteristics after optimization are obviously improved.The results can provide a reference for the design and optimization of the intake system of cylinder head.展开更多
River bank erosion models are an important prerequisite for understanding the development of river meanders and for estimating likely land-loss and potential danger to floodplain infrastructure. Although bank erosion ...River bank erosion models are an important prerequisite for understanding the development of river meanders and for estimating likely land-loss and potential danger to floodplain infrastructure. Although bank erosion models have been developed that consider large-scale mass failure, the contribution of fluvial erosion (the process of particle-by-particle erosion due to the shearing action of the river flow) to bank retreat has not received as much consideration. In principle, such fluvial bank erosion rates can be quantified using excess shear stress formulations, but in practice, it has proven difficult to estimate the parameters involved. In this study, a series of three-dimensional Computational Fluid Dynamics (CFD) simulations for a meander loop on the River Asker (200 m long) at Bridport in southern England were undertaken to elucidate the overall flow structures and in particular to provide estimates of the applied fluid shear stress exerted on the riverbanks. The CFD models, which simulated relatively low and relatively high flow conditions, were established using Fluent 6.2 software. The modelling outcomes show that the key qualitative features of the flow endure even as flow discharge varies. At bank full, the degrees of velocity and simulated shear stresses within the inner bank separation zones are shown to be higher than those observed under low flow conditions, and that these elevated shear stresses may be sufficient to result in the removal of accumulated sediments into the main downstream flow.展开更多
Journal bearings are important parts to keep the high dynamic performance of rotor machinery. Some methods have already been proposed to analysis the flow field of journal bearings, and in most of these methods simpli...Journal bearings are important parts to keep the high dynamic performance of rotor machinery. Some methods have already been proposed to analysis the flow field of journal bearings, and in most of these methods simplified physical model and classic Reynolds equation are always applied. While the application of the general computational fluid dynamics （CFD）-fluid structure interaction （FSI） techniques is more beneficial for analysis of the fluid field in a journal bearing when more detailed solutions are needed. This paper deals with the quasi-coupling calculation of transient fluid dynamics of oil film in journal bearings and rotor dynamics with CFD-FSI techniques. The fluid dynamics of oil film is calculated by applying the so-called ＂dynamic mesh＂ technique. A new mesh movement approacb is presented while the dynamic mesh models provided by FLUENT are not suitable for the transient oil flow in journal bearings. The proposed mesh movement approach is based on the structured mesh. When the joumal moves, the movement distance of every grid in the flow field of bearing can be calculated, and then the update of the volume mesh can be handled automatically by user defined function （UDF）. The journal displacement at each time step is obtained by solving the moving equations of the rotor-bearing system under the known oil film force condition. A case study is carried out to calculate the locus of the journal center and pressure distribution of the journal in order to prove the feasibility of this method. The calculating results indicate that the proposed method can predict the transient flow field of a journal bearing in a rotor-bearing system where more realistic models are involved. The presented calculation method provides a basis for studying the nonlinear dynamic behavior of a general rotor-bearing system.展开更多
The effect of mixing on the precipitation of barium sulfate in a continuous stirred tank is simulated numerically with different feeding location, feed concentration, impeller speed and residence time through solving ...The effect of mixing on the precipitation of barium sulfate in a continuous stirred tank is simulated numerically with different feeding location, feed concentration, impeller speed and residence time through solving the standard momentum and mass transport equations in combination with the moment equations for crystal population balance. The numerical method was validated with the literature data. The simulation results including the distribution of the local supersaturation ratio distribution in the precipitator, mean crystal size and coefficient of variation under different operating conditions compared well with experimental data in the literature. The effect of the presence of a draft tube on precipitation were also investigated, and it is suggested that the installation of a draft tube increased the mean crystal size, in general agreement with experimental work in the literature.展开更多
Turbulence in the wake generated by wind flow over buildings or obstacles may produce complex flow patterns in downstream areas.Examples include the recirculating flow and wind deficit areas behind an airport terminal...Turbulence in the wake generated by wind flow over buildings or obstacles may produce complex flow patterns in downstream areas.Examples include the recirculating flow and wind deficit areas behind an airport terminal building and their potential impacts on the aircraft landing on nearby runways.A computational fluid dynamics(CFD) simulation of the wind flow over an airport terminal building was performed in this study of the effect of the building wake on landing aircraft.Under normal meteorological conditions,the studied airport terminal building causes limited effects on landing aircraft because most of the aircraft have already landed before entering the turbulent wake region.By simulating the approach of a tropical cyclone,additional CFD sensitivity tests were performed to study the impacts of building wake under extreme meteorological conditions.It was found that,in a narrow range of prevalent wind directions with wind speeds larger than a certain threshold value,a substantial drop in wind speed(>3.6 m/s) along the glide path of aircraft was observed in the building wake.Our CFD results also showed that under the most critical situation,a drop in wind speed as large as 6.4 m/s occurred right at the touchdown point of landing aircraft on the runway,an effect which may have a significant impact on aircraft operations.This study indicated that a comprehensive analysis of the potential impacts of building wake on aircraft operations should be carried out for airport terminals and associated buildings in airfields to ensure safe aviation operation under all meteorological conditions and to facilitate implementation of precautionary measures.展开更多
Computational fluid dynamics （CFD） codes are being increasingly used in the simulation of submarine oil spills. This study focuses on the process of oil spills, from damaged submarine pipes, to the sea surface, usin...Computational fluid dynamics （CFD） codes are being increasingly used in the simulation of submarine oil spills. This study focuses on the process of oil spills, from damaged submarine pipes, to the sea surface, using numerical models. The underwater oil spill model is developed, and a description of the governing equations is proposed, along with modifications required for the particalization of the control volume. Available experimental data were introduced to evaluate the validity of the CFD predictions, the results of which proved to be in good agreement with the experimental data. The effects of oil leak rate, leak diameter, current velocity, and oil density are investigated, by the validated CFD model, to estimate the undersea leakage time, the lateral migration distance, and surface diffusion range when the oil reaches the sea surface. Results indicate that the leakage time and lateral migration distance increase with decreasing leak rates and leak diameter, and increase with increasing current velocity and oil density. On the other hand, a large leak diameter, high density, high leak rate, or fast currents result in a greater surface diffusion range. The findings and analysis presented here will provide practical predictions of oil spills, and guidance for emergency rescues.展开更多
An electronic-nose is developed based on eight quartz-crystal-microbalance (QCM) gas sensors in a sensor box, and is used to detect Chinese liquors at room temperature. Each sensor is a highly-accurate and highly-sens...An electronic-nose is developed based on eight quartz-crystal-microbalance (QCM) gas sensors in a sensor box, and is used to detect Chinese liquors at room temperature. Each sensor is a highly-accurate and highly-sensitive oscillator that has experienced airflow disturbances under the condition of varying room temperatures due to unstable flow-induced forces on the sensors surfaces. The three-dimensional (3D) nature of the airflow inside the sensor box and the interactions of the airflow on the sensors surfaces at different temperatures are studied by computational fluid dynamics (CFD) tools. Higher simulation accuracy is achieved by optimizing meshes, meshing the computational domain using a fine unstructural tetrahedron mesh. An optimum temperature, 30 ℃, is obtained by analyzing the distributions of velocity streamlines and the static pressure, as well as the flow-induced forces over time, all of which may be used to improve the identification accuracy of the electronic-nose for achieving stable and repeatable signals by removing the influence of temperature.展开更多
The pressure loss of cross-flow perforated of physical modeling, simulation and data processing. muffler has been computed with the procedure Three-dimensional computational fluid dynamics （CFD） has been used to inv...The pressure loss of cross-flow perforated of physical modeling, simulation and data processing. muffler has been computed with the procedure Three-dimensional computational fluid dynamics （CFD） has been used to investigate the relations of porosities, flow velocity and diameter of the holes with the pressure loss. Accordingly, some preliminary results have been obtained that pressure loss increases with porosity descent as nearly a hyperbolic trend, rising flow velocity of the input makes the pressure loss increasing with parabola trend, diameter of holes affects little about pressure loss of the muffler. Otherwise, the holes on the perforated pipes make the air flow gently and meanly, which decreases the air impact to the wall and pipes in the muffler. A practical perforated muffler is used to illustrate the available of this method for pressure loss computation, and the comparison shows that the computation results with the method of CFD has reference value for muffler design.展开更多
Patients with extracorporeal membrane oxygenation still suffer from high rates of complication that linked to the flow field within the blood pump.So it is essential to optimise the geometry of the pump.The specificat...Patients with extracorporeal membrane oxygenation still suffer from high rates of complication that linked to the flow field within the blood pump.So it is essential to optimise the geometry of the pump.The specification of shroud design is arguably the necessary design parameter in the centrifugal pump.However,the hemodynamic performances of the different shroud designs have not been studied extensively.In this study,ten different shroud designs were made and divided into two groups as the different covering locations(A:Covering the blade leading edge,B:Covering the blade trailing edge).In every group,six shroud designs with the covering proportions of 0,1/5,2/5,3/5,4/5,1 were made.Detailed computational fluid dynamics(CFD)analyses were performed to investigate their effects on hemodynamics and hydraulic performance at the constant flow condition(4000 rpm,5 L/min).The percentage volumes of the scalar shear stress in specific threshold(τ<1 Pa:Thrombosis,τ>9 Pa:the destruction of von Willebrand factor,τ>50 Pa:Platelet activation,τ>150 Pa:Break of red blood)were used to compare the blood damage of the different shroud designs.Also,the modified index of hemolysis(MIH)were calculated based on a Eulerian approach for different pumps.CFD simulations predicted an increase in the pump head,hydraulic efficiency,a fraction of fluid volume with scalar shear stress values above a threshold(9 Pa,50 Pa,150 Pa)and MIH with increasing shroud covering proportions from 0 to 1 in the same covering location.Also,these above results were higher in group B than group A.This means that the risks of the hemolysis,thrombosis and bleeding increased as the rise of the covering proportion and they were higher in the pump whose shroud covers the blade trailing edge.展开更多
According to the recently developed single-trough floating machine with the world's largest volume(inflatable mechanical agitation flotation machine with volume of 320 m3) in China, the gas-fluid two-phase flow in...According to the recently developed single-trough floating machine with the world's largest volume(inflatable mechanical agitation flotation machine with volume of 320 m3) in China, the gas-fluid two-phase flow in flotation cell was simulated using computational fluid dynamics method. It is shown that hexahedral mesh scheme is more suitable for the complex structure of the flotation cell than tetrahedral mesh scheme, and a mesh quality ranging from 0.7 to 1.0 is obtained. Comparative studies of the standard k-ε, k-ω and realizable k-ε turbulence models were carried out. It is indicated that the standard k-ε turbulence model could give a result relatively close to the practice and the liquid phase flow field is well characterized. In addition, two obvious recirculation zones are formed in the mixing zones, and the pressure on the rotor and stator is well characterized. Furthermore, the simulation results using improved standard k-ε turbulence model show that surface tension coefficient of 0.072, drag model of Grace and coefficient of 4, and lift coefficient of 0.001 can be achieved. The research results suggest that gas-fluid two-phase flow in large flotation cell can be well simulated using computational fluid dynamics method.展开更多
Computational fluid dynamics （CFD） plays a major role in predicting the flow behavior of a ship. With the development of fast computers and robust CFD software, CFD has become an important tool for designers and eng...Computational fluid dynamics （CFD） plays a major role in predicting the flow behavior of a ship. With the development of fast computers and robust CFD software, CFD has become an important tool for designers and engineers in the ship industry. In this paper, the hull form of a ship was optimized for total resistance using CFD as a calculation tool and a genetic algorithm as an optimization tool. CFD based optimization consists of major steps involving automatic generation of geometry based on design parameters, automatic generation of mesh, automatic analysis of fluid flow to calculate the required objective/cost function, and finally an optimization tool to evaluate the cost for optimization. In this paper, integration of a genetic algorithm program, written in MATLAB, was carried out with the geometry and meshing software GAMBIT and CFD analysis software FLUENT. Different geometries of additive bulbous bow were incorporated in the original hull based on design parameters. These design variables were optimized to achieve a minimum cost function of ＂total resistance＂. Integration of a genetic algorithm with CFD tools proves to be effective for hull form ootimization.展开更多
Enhancing damping characteristic is one of the effective methods to solve the instability problem of the rotor system.The three-dimensional numerical analysis model of scallop damper seal was established,and the effec...Enhancing damping characteristic is one of the effective methods to solve the instability problem of the rotor system.The three-dimensional numerical analysis model of scallop damper seal was established,and the effects of inlet pressures,preswirl ratios,rotational speeds,interlaced angles and seal cavity depths on the rotordynamic characteristics of scallop damper seal were studied based on dynamic mesh method and multi-frequencies elliptic whirling model.Results show that the direct stiffness of the scallop damper seal increases with decreasing inlet pressure and increasing rotational speed and cavity depth.When the seal cavity is interlaced by a certain angle,which shows positive direct stiffness.The effective damping of the scallop damper seal increases with the increasing inlet pressure,the decreasing preswirl ratio and the rotational speed and cavity depth.There exists an optimal interlaced angle to maximize the effective damping and the system stability.The leakage of the scallop damper seal is significantly reduced with decreasing inlet pressure.The preswirl will reduce the leakage flowrate,and the rotational speed has a slight effect on the leakage performance.The leakage of the scallop damper seal decreases with increasing seal cavity depth.展开更多
Poppet valves are basic components of many manufacturing operations and industrial processes. The valve plug will withstand unbalanced pressure during the switching process due to the complex fluid-structure interacti...Poppet valves are basic components of many manufacturing operations and industrial processes. The valve plug will withstand unbalanced pressure during the switching process due to the complex fluid-structure interaction(FSI) in the local flow condition, especially with the occurrence of cavitation, which results in a convoluted generation and propagation of mechanical and fluid-dynamic vibrations. In the present work, computational fluid dynamics(CFD) approaches are proposed to model the flow-driven movement of the disc, in consideration of the valve stem rigidity, for a cryogenic poppet valve with liquid nitrogen as the working fluid. Cavitation effects are included in the CFD simulations. The relationship between the displacement of the disc and the resistance of the stem is obtained in advance using the finite element method(FEM), and implemented in CFD calculations based on the user-defined functions(UDFs). The disc vibration is realized using the dynamic mesh technology according to the resultant flow field force and resistance of the stem determined in the UDF. The vibration characteristics of the valve disc, including velocity and vibration frequency, are presented. The temporal evolutions of cavitation behavior due to the vibration are also captured. Comparisons of results between cavitation and non-cavitation conditions are made, and spectral analysis of the transient pressure fluctuations reveals that the presence of cavitation induces transient unbalanced loads on the valve disc and generates instantaneous tremendous pressure fluctuations in the flow field. Various pressure differences between the inlet and outlet as well as valve openings are modeled to probe the influences of FSI on valve disc vibration mechanisms.The consequent analysis gives deeper insights and improves understanding of the mechanism of the complicated interaction between the cavitating flow and the vibration of the valve disc.展开更多
Owing to the special working characteristics and operation requirements,lots of working ships have notches in different sizes and shapes in their hulls.In order to study the resistance performance of the vessel with n...Owing to the special working characteristics and operation requirements,lots of working ships have notches in different sizes and shapes in their hulls.In order to study the resistance performance of the vessel with notches,a series of model resistance tests were performed in respect to the 4 500 m 3 /h cutter suction dredger,and the tests were simulated based on the computational fluid dynamics software FLUENT.Based on analysis to the experimental data and the computational fluid dynamics(CFD) calculation results,the change of the flow field and the resistance performance caused by the notches were studied,and the reliability of the software in simulation of viscous flow around the hull was proved.It provides the basis for the future study and the design optimization of this kind of working ships.展开更多
An optimization study using a comprehensive 3D, multi-phase, non-isothermal model of a PEM （proton exchange membrane） fuel cell that incorporates significant physical processes and key parameters affecting fuel cell...An optimization study using a comprehensive 3D, multi-phase, non-isothermal model of a PEM （proton exchange membrane） fuel cell that incorporates significant physical processes and key parameters affecting fuel cell performance is presented and discussed in detail. The model accounts for both gas and liquid phase in the same computational domain, and thus allows for the implementation of phase change inside the gas diffusion layers. The model includes the transport of gaseous species, liquid water, protons, energy, and water dissolved in the ion-conducting polymer. Water is assumed to be exchanged among three phases： liquid, vapottr, and dissolved, with equilibrium among these phases being assumed. This model also takes into account convection and diffusion of different species in the channels as well as in the porous gas diffusion layer, heat transfer in the solids as well as in the gases, and electrochemical reactions. The results showed that the present multi-phase model is capable of identifying important parameters for the wetting behaviour of the gas diffusion layers and can be used to identify conditions that might lead to the onset of pore plugging, which has a detrimental effect on the fuel cell performance. This model is used to study the effects of several operating, design, and material parameters on fuel cell performance. Detailed analyses of the fuel cell performance under various operating conditions have been conducted and examined.展开更多
The effect of wind environment is becoming increasingly important in analyzing and selecting sites for better naturalventilation of residential buildings, external comfort, and pollution dispersion. The mainpurpose of...The effect of wind environment is becoming increasingly important in analyzing and selecting sites for better naturalventilation of residential buildings, external comfort, and pollution dispersion. The mainpurpose of this study was to develop a setof methods for wind environment assessment in coastal concave terrains. This set of methods can be used to provide quantifiableindicators of preferable wind conditions and help site analysis. Firstly, a total of 20 types of coastal bays with concave terrains inEast Asia were characterized to find ideal locations. The selected areas were divided into five categories according to the mainterrain features. Then a sample database for the concave terrains was compiled for modelling comparisons. Secondly, a number ofkey wind variables were identified. Computational fluid dynamics （CFD） models of the typical coastal concave terrains identifiedas a result of the study were created, and the local wind environments were simulated with input from geographic informationsystem （GIS） and statistic package for social science （SPSS） analysis. A measure of wind suitability was proposed that takes windvelocity and wind direction into account using GIS. Finally, SPSS was used to find the relationship between wind suitability andkey terrain factors. The results showed that wind suitability was significantly associated with terrain factors, especially altitude.The results suggest that residential building sites should be selected such that their bay openings face the direction of the prevailingwind and that the opposite direction should be avoided.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.52306126,22350710788,12432010,11988102,92270203)the Xplore Prize.
文摘Configuring computational fluid dynamics(CFD)simulations typically demands extensive domain expertise,limiting broader access.Although large language models(LLMs)have advanced scientific computing,their use in automating CFD workflows is underdeveloped.We introduce a novel approach centered on domain-specific LLM adaptation.By fine-tuning Qwen2.5-7B-Instruct on NL2FOAM,our custom dataset of 28,716 natural language-to-OpenFOAM configuration pairs with chain-of-thought(CoT)annotations enables direct translation from natural language descriptions to executable CFD setups.A multi-agent system orchestrates the process,autonomously verifying inputs,generating configurations,running simulations,and correcting errors.Evaluation on a benchmark of 21 diverse flow cases demonstrates state-of-the-art performance,achieving 88.7%solution accuracy and 82.6%first-attempt success rate.This significantly outperforms larger general-purpose models such as Qwen2.5-72B-Instruct,DeepSeek-R1,and Llama3.3-70B-Instruct,while also requiring fewer correction iterations and maintaining high computational efficiency.The results highlight the critical role of domain-specific adaptation in deploying LLM assistants for complex engineering workflows.Our code and fine-tuned model have been deposited at https://github.com/YYgroup/AutoCFD.
基金supported by the Ministry of Higher Education Malaysia for the Fundamental Research Grant Scheme[FRGS/1/2023/TK04/USM/03/1].
文摘Conventional oncology faces challenges such as suboptimal drug delivery,tumor heterogeneity,and therapeutic resistance,indicating a need formore personalized,andmechanistically grounded and predictive treatment strategies.This review explores the convergence of Computational Fluid Dynamics(CFD)and Machine Learning(ML)as an integrated framework to address these issues in modern cancer therapy.The paper discusses recent advancements where CFD models simulate complex tumor microenvironmental conditions,like interstitial fluid pressure(IFP)and drug perfusion,and ML enhances simulation workflows,automates image-based segmentation,and enhances predictive accuracy.The synergy between CFD and ML improves scalability and enables patientspecific treatment planning.Methodologically,it coversmulti-scalemodeling approaches,nanotherapeutic simulations,imaging integration,and emerging AI-driven frameworks.The paper identifies gaps in current applications,including the need for robust clinical validation,real-time model adaptability,and ethical data integration.Future directions suggest that CFD–ML hybrids could serve as digital twins for tumor evolution,offering insights for adaptive therapies.The review advocates for a computationally augmented oncology ecosystem that combines biological complexity with engineering precision for next-generation cancer care.
文摘Many fishes use undulatory fin to propel themselves in the underwater environment. These locomotor mechanisms have a popular interest to many researchers. In the present study, we perform a three-dimensional unsteady computation of an undulatory mechanical fin that is driven by Shape Memory Alloy （SMA）. The objective of the computation is to investigate the fluid dynamics of force production associated with the undulatory mechanical fin. An unstructured, grid-based, unsteady Navier-Stokes solver with automatic adaptive remeshing is used to compute the unsteady flow around the fin through five complete cycles. The pressure distribution on fin surface is computed and integrated to provide fin forces which are decomposed into lift and thrust. The velocity field is also computed throughout the swimming cycle. Finally, a comparison is conducted to reveal the dynamics of force generation according to the kinematic parameters of the undulatory fin （amplitude, frequency and wavelength）.
基金National Natural Science Foundation of China (No.50435030)
文摘Computational fluid dynamics（CFD） simulations are adopted to investigate rectangular microchannel flows with various periodic micro-structured wall by introducing velocity slip boundary condition at low Reynolds number. The purpose of the current study is to numerically find out the effects of periodic micro-structured wall on the flow resistance in rectangular microchannel with the different spacings between microridges ranging from 15 to 60 pm. The simulative results indicate that pressure drop with different spacing between microridges increases linearly with flow velocity and decreases monotonically with slip velocity; Pressure drop reduction also increases with the spacing between microridges at the same condition of slip velocity and flow velocity. The results of numerical simulation are compared with theoretical predictions and experimental results in the literatures. It is found that there is qualitative agreement between them.
基金“Strategic Cooperation of Science and Technology between Nanchong City and Southwest Petroleum University 2018” Special Fund Project,China(Nos.18SXHZ0030,18SXHZ0054)
文摘To find out and improve the flow characteristics inside the intake system of cylinder head,the application of computational fluid dynamics(CFD)in the evaluation and optimization of the reconstructed intake system based on slicing reverse method was proposed.The flow characteristics were found out through CFD,and the velocity vector field,pressure field and turbulent kinetic energy field for different valve lifts were discussed,which were in good agreement with experimental data,and the quality of reconstruction was evaluated.In order to improve its flow characteristic,an optimization plan was proposed.The results show that the flow characteristics after optimization are obviously improved.The results can provide a reference for the design and optimization of the intake system of cylinder head.
文摘River bank erosion models are an important prerequisite for understanding the development of river meanders and for estimating likely land-loss and potential danger to floodplain infrastructure. Although bank erosion models have been developed that consider large-scale mass failure, the contribution of fluvial erosion (the process of particle-by-particle erosion due to the shearing action of the river flow) to bank retreat has not received as much consideration. In principle, such fluvial bank erosion rates can be quantified using excess shear stress formulations, but in practice, it has proven difficult to estimate the parameters involved. In this study, a series of three-dimensional Computational Fluid Dynamics (CFD) simulations for a meander loop on the River Asker (200 m long) at Bridport in southern England were undertaken to elucidate the overall flow structures and in particular to provide estimates of the applied fluid shear stress exerted on the riverbanks. The CFD models, which simulated relatively low and relatively high flow conditions, were established using Fluent 6.2 software. The modelling outcomes show that the key qualitative features of the flow endure even as flow discharge varies. At bank full, the degrees of velocity and simulated shear stresses within the inner bank separation zones are shown to be higher than those observed under low flow conditions, and that these elevated shear stresses may be sufficient to result in the removal of accumulated sediments into the main downstream flow.
基金supported by National Hi-tech Research and Development Program of China (863 Program, Grant No. 2009AA04Z413)Zhejiang Provincial Natural Science Foundation of China (Grant No. Y1110109)
文摘Journal bearings are important parts to keep the high dynamic performance of rotor machinery. Some methods have already been proposed to analysis the flow field of journal bearings, and in most of these methods simplified physical model and classic Reynolds equation are always applied. While the application of the general computational fluid dynamics （CFD）-fluid structure interaction （FSI） techniques is more beneficial for analysis of the fluid field in a journal bearing when more detailed solutions are needed. This paper deals with the quasi-coupling calculation of transient fluid dynamics of oil film in journal bearings and rotor dynamics with CFD-FSI techniques. The fluid dynamics of oil film is calculated by applying the so-called ＂dynamic mesh＂ technique. A new mesh movement approacb is presented while the dynamic mesh models provided by FLUENT are not suitable for the transient oil flow in journal bearings. The proposed mesh movement approach is based on the structured mesh. When the joumal moves, the movement distance of every grid in the flow field of bearing can be calculated, and then the update of the volume mesh can be handled automatically by user defined function （UDF）. The journal displacement at each time step is obtained by solving the moving equations of the rotor-bearing system under the known oil film force condition. A case study is carried out to calculate the locus of the journal center and pressure distribution of the journal in order to prove the feasibility of this method. The calculating results indicate that the proposed method can predict the transient flow field of a journal bearing in a rotor-bearing system where more realistic models are involved. The presented calculation method provides a basis for studying the nonlinear dynamic behavior of a general rotor-bearing system.
基金Supported by the National Natural Science Foundation of China (Nos.20236050, 50134020) and the Special Funds for Major State Basic Research Program of China (973 Program, 2004CB217604).
文摘The effect of mixing on the precipitation of barium sulfate in a continuous stirred tank is simulated numerically with different feeding location, feed concentration, impeller speed and residence time through solving the standard momentum and mass transport equations in combination with the moment equations for crystal population balance. The numerical method was validated with the literature data. The simulation results including the distribution of the local supersaturation ratio distribution in the precipitator, mean crystal size and coefficient of variation under different operating conditions compared well with experimental data in the literature. The effect of the presence of a draft tube on precipitation were also investigated, and it is suggested that the installation of a draft tube increased the mean crystal size, in general agreement with experimental work in the literature.
基金supported by the Committee for Research and Conference Grants (CRCG) of The University of Hong Kong,China
文摘Turbulence in the wake generated by wind flow over buildings or obstacles may produce complex flow patterns in downstream areas.Examples include the recirculating flow and wind deficit areas behind an airport terminal building and their potential impacts on the aircraft landing on nearby runways.A computational fluid dynamics(CFD) simulation of the wind flow over an airport terminal building was performed in this study of the effect of the building wake on landing aircraft.Under normal meteorological conditions,the studied airport terminal building causes limited effects on landing aircraft because most of the aircraft have already landed before entering the turbulent wake region.By simulating the approach of a tropical cyclone,additional CFD sensitivity tests were performed to study the impacts of building wake under extreme meteorological conditions.It was found that,in a narrow range of prevalent wind directions with wind speeds larger than a certain threshold value,a substantial drop in wind speed(>3.6 m/s) along the glide path of aircraft was observed in the building wake.Our CFD results also showed that under the most critical situation,a drop in wind speed as large as 6.4 m/s occurred right at the touchdown point of landing aircraft on the runway,an effect which may have a significant impact on aircraft operations.This study indicated that a comprehensive analysis of the potential impacts of building wake on aircraft operations should be carried out for airport terminals and associated buildings in airfields to ensure safe aviation operation under all meteorological conditions and to facilitate implementation of precautionary measures.
基金The National Basic Research Program(973 Program)under contract No.2014CB046803the National Natural Science Foundation of China under contract No.51239008the National Science and Technology Major Project under contract No.2016ZX05028005-004
文摘Computational fluid dynamics （CFD） codes are being increasingly used in the simulation of submarine oil spills. This study focuses on the process of oil spills, from damaged submarine pipes, to the sea surface, using numerical models. The underwater oil spill model is developed, and a description of the governing equations is proposed, along with modifications required for the particalization of the control volume. Available experimental data were introduced to evaluate the validity of the CFD predictions, the results of which proved to be in good agreement with the experimental data. The effects of oil leak rate, leak diameter, current velocity, and oil density are investigated, by the validated CFD model, to estimate the undersea leakage time, the lateral migration distance, and surface diffusion range when the oil reaches the sea surface. Results indicate that the leakage time and lateral migration distance increase with decreasing leak rates and leak diameter, and increase with increasing current velocity and oil density. On the other hand, a large leak diameter, high density, high leak rate, or fast currents result in a greater surface diffusion range. The findings and analysis presented here will provide practical predictions of oil spills, and guidance for emergency rescues.
基金Project supported by the National Natural Science Foundation of China(Nos.61876059 and U1501251)
文摘An electronic-nose is developed based on eight quartz-crystal-microbalance (QCM) gas sensors in a sensor box, and is used to detect Chinese liquors at room temperature. Each sensor is a highly-accurate and highly-sensitive oscillator that has experienced airflow disturbances under the condition of varying room temperatures due to unstable flow-induced forces on the sensors surfaces. The three-dimensional (3D) nature of the airflow inside the sensor box and the interactions of the airflow on the sensors surfaces at different temperatures are studied by computational fluid dynamics (CFD) tools. Higher simulation accuracy is achieved by optimizing meshes, meshing the computational domain using a fine unstructural tetrahedron mesh. An optimum temperature, 30 ℃, is obtained by analyzing the distributions of velocity streamlines and the static pressure, as well as the flow-induced forces over time, all of which may be used to improve the identification accuracy of the electronic-nose for achieving stable and repeatable signals by removing the influence of temperature.
文摘The pressure loss of cross-flow perforated of physical modeling, simulation and data processing. muffler has been computed with the procedure Three-dimensional computational fluid dynamics （CFD） has been used to investigate the relations of porosities, flow velocity and diameter of the holes with the pressure loss. Accordingly, some preliminary results have been obtained that pressure loss increases with porosity descent as nearly a hyperbolic trend, rising flow velocity of the input makes the pressure loss increasing with parabola trend, diameter of holes affects little about pressure loss of the muffler. Otherwise, the holes on the perforated pipes make the air flow gently and meanly, which decreases the air impact to the wall and pipes in the muffler. A practical perforated muffler is used to illustrate the available of this method for pressure loss computation, and the comparison shows that the computation results with the method of CFD has reference value for muffler design.
基金This work partly sponsored by the National Natural Science Foundation of China(Grant No.11602007,91430215,11572014)BJUT Foundation Fund(Grant No.015000514316007)+1 种基金Key research and development program(2016YFC0103201,2017YFC0111104)New Talent(015000514118002).
文摘Patients with extracorporeal membrane oxygenation still suffer from high rates of complication that linked to the flow field within the blood pump.So it is essential to optimise the geometry of the pump.The specification of shroud design is arguably the necessary design parameter in the centrifugal pump.However,the hemodynamic performances of the different shroud designs have not been studied extensively.In this study,ten different shroud designs were made and divided into two groups as the different covering locations(A:Covering the blade leading edge,B:Covering the blade trailing edge).In every group,six shroud designs with the covering proportions of 0,1/5,2/5,3/5,4/5,1 were made.Detailed computational fluid dynamics(CFD)analyses were performed to investigate their effects on hemodynamics and hydraulic performance at the constant flow condition(4000 rpm,5 L/min).The percentage volumes of the scalar shear stress in specific threshold(τ<1 Pa:Thrombosis,τ>9 Pa:the destruction of von Willebrand factor,τ>50 Pa:Platelet activation,τ>150 Pa:Break of red blood)were used to compare the blood damage of the different shroud designs.Also,the modified index of hemolysis(MIH)were calculated based on a Eulerian approach for different pumps.CFD simulations predicted an increase in the pump head,hydraulic efficiency,a fraction of fluid volume with scalar shear stress values above a threshold(9 Pa,50 Pa,150 Pa)and MIH with increasing shroud covering proportions from 0 to 1 in the same covering location.Also,these above results were higher in group B than group A.This means that the risks of the hemolysis,thrombosis and bleeding increased as the rise of the covering proportion and they were higher in the pump whose shroud covers the blade trailing edge.
基金Project(51074027)supported by the National Natural Science Foundation of China
文摘According to the recently developed single-trough floating machine with the world's largest volume(inflatable mechanical agitation flotation machine with volume of 320 m3) in China, the gas-fluid two-phase flow in flotation cell was simulated using computational fluid dynamics method. It is shown that hexahedral mesh scheme is more suitable for the complex structure of the flotation cell than tetrahedral mesh scheme, and a mesh quality ranging from 0.7 to 1.0 is obtained. Comparative studies of the standard k-ε, k-ω and realizable k-ε turbulence models were carried out. It is indicated that the standard k-ε turbulence model could give a result relatively close to the practice and the liquid phase flow field is well characterized. In addition, two obvious recirculation zones are formed in the mixing zones, and the pressure on the rotor and stator is well characterized. Furthermore, the simulation results using improved standard k-ε turbulence model show that surface tension coefficient of 0.072, drag model of Grace and coefficient of 4, and lift coefficient of 0.001 can be achieved. The research results suggest that gas-fluid two-phase flow in large flotation cell can be well simulated using computational fluid dynamics method.
文摘Computational fluid dynamics （CFD） plays a major role in predicting the flow behavior of a ship. With the development of fast computers and robust CFD software, CFD has become an important tool for designers and engineers in the ship industry. In this paper, the hull form of a ship was optimized for total resistance using CFD as a calculation tool and a genetic algorithm as an optimization tool. CFD based optimization consists of major steps involving automatic generation of geometry based on design parameters, automatic generation of mesh, automatic analysis of fluid flow to calculate the required objective/cost function, and finally an optimization tool to evaluate the cost for optimization. In this paper, integration of a genetic algorithm program, written in MATLAB, was carried out with the geometry and meshing software GAMBIT and CFD analysis software FLUENT. Different geometries of additive bulbous bow were incorporated in the original hull based on design parameters. These design variables were optimized to achieve a minimum cost function of ＂total resistance＂. Integration of a genetic algorithm with CFD tools proves to be effective for hull form ootimization.
基金co-supported by the National Natural Science Foundation of China(No.51875361)the Natural Science Foundation of Shanghai,China(No.20ZR1439200)。
文摘Enhancing damping characteristic is one of the effective methods to solve the instability problem of the rotor system.The three-dimensional numerical analysis model of scallop damper seal was established,and the effects of inlet pressures,preswirl ratios,rotational speeds,interlaced angles and seal cavity depths on the rotordynamic characteristics of scallop damper seal were studied based on dynamic mesh method and multi-frequencies elliptic whirling model.Results show that the direct stiffness of the scallop damper seal increases with decreasing inlet pressure and increasing rotational speed and cavity depth.When the seal cavity is interlaced by a certain angle,which shows positive direct stiffness.The effective damping of the scallop damper seal increases with the increasing inlet pressure,the decreasing preswirl ratio and the rotational speed and cavity depth.There exists an optimal interlaced angle to maximize the effective damping and the system stability.The leakage of the scallop damper seal is significantly reduced with decreasing inlet pressure.The preswirl will reduce the leakage flowrate,and the rotational speed has a slight effect on the leakage performance.The leakage of the scallop damper seal decreases with increasing seal cavity depth.
基金supported by the National Natural Science Foundation of China(Nos.51636007 and 51976177)the Key Research and Development Plan of Zhejiang Province(No.2020C01029),China。
文摘Poppet valves are basic components of many manufacturing operations and industrial processes. The valve plug will withstand unbalanced pressure during the switching process due to the complex fluid-structure interaction(FSI) in the local flow condition, especially with the occurrence of cavitation, which results in a convoluted generation and propagation of mechanical and fluid-dynamic vibrations. In the present work, computational fluid dynamics(CFD) approaches are proposed to model the flow-driven movement of the disc, in consideration of the valve stem rigidity, for a cryogenic poppet valve with liquid nitrogen as the working fluid. Cavitation effects are included in the CFD simulations. The relationship between the displacement of the disc and the resistance of the stem is obtained in advance using the finite element method(FEM), and implemented in CFD calculations based on the user-defined functions(UDFs). The disc vibration is realized using the dynamic mesh technology according to the resultant flow field force and resistance of the stem determined in the UDF. The vibration characteristics of the valve disc, including velocity and vibration frequency, are presented. The temporal evolutions of cavitation behavior due to the vibration are also captured. Comparisons of results between cavitation and non-cavitation conditions are made, and spectral analysis of the transient pressure fluctuations reveals that the presence of cavitation induces transient unbalanced loads on the valve disc and generates instantaneous tremendous pressure fluctuations in the flow field. Various pressure differences between the inlet and outlet as well as valve openings are modeled to probe the influences of FSI on valve disc vibration mechanisms.The consequent analysis gives deeper insights and improves understanding of the mechanism of the complicated interaction between the cavitating flow and the vibration of the valve disc.
文摘Owing to the special working characteristics and operation requirements,lots of working ships have notches in different sizes and shapes in their hulls.In order to study the resistance performance of the vessel with notches,a series of model resistance tests were performed in respect to the 4 500 m 3 /h cutter suction dredger,and the tests were simulated based on the computational fluid dynamics software FLUENT.Based on analysis to the experimental data and the computational fluid dynamics(CFD) calculation results,the change of the flow field and the resistance performance caused by the notches were studied,and the reliability of the software in simulation of viscous flow around the hull was proved.It provides the basis for the future study and the design optimization of this kind of working ships.
基金Project supported by the Postgraduate Programs of the International Technological University (ITU), London, UK
文摘An optimization study using a comprehensive 3D, multi-phase, non-isothermal model of a PEM （proton exchange membrane） fuel cell that incorporates significant physical processes and key parameters affecting fuel cell performance is presented and discussed in detail. The model accounts for both gas and liquid phase in the same computational domain, and thus allows for the implementation of phase change inside the gas diffusion layers. The model includes the transport of gaseous species, liquid water, protons, energy, and water dissolved in the ion-conducting polymer. Water is assumed to be exchanged among three phases： liquid, vapottr, and dissolved, with equilibrium among these phases being assumed. This model also takes into account convection and diffusion of different species in the channels as well as in the porous gas diffusion layer, heat transfer in the solids as well as in the gases, and electrochemical reactions. The results showed that the present multi-phase model is capable of identifying important parameters for the wetting behaviour of the gas diffusion layers and can be used to identify conditions that might lead to the onset of pore plugging, which has a detrimental effect on the fuel cell performance. This model is used to study the effects of several operating, design, and material parameters on fuel cell performance. Detailed analyses of the fuel cell performance under various operating conditions have been conducted and examined.
基金supported by the National Natural Science Foundation of China(Nos.51208466 and 51238011)the Science and Technology Research Program of Chinese Ministry of Housing and Urban-Rural Development(No.2014R2-036)+2 种基金the Humanities and Social Sciences Research Foundation of the Ministry of Education(No.17YJAZH136)the Natural Science Foundation of Zhejiang Province(No.LY16E0 80011)the Social Sciences Planning Project of Zhejiang Province(No.12JCSH02YB),China
文摘The effect of wind environment is becoming increasingly important in analyzing and selecting sites for better naturalventilation of residential buildings, external comfort, and pollution dispersion. The mainpurpose of this study was to develop a setof methods for wind environment assessment in coastal concave terrains. This set of methods can be used to provide quantifiableindicators of preferable wind conditions and help site analysis. Firstly, a total of 20 types of coastal bays with concave terrains inEast Asia were characterized to find ideal locations. The selected areas were divided into five categories according to the mainterrain features. Then a sample database for the concave terrains was compiled for modelling comparisons. Secondly, a number ofkey wind variables were identified. Computational fluid dynamics （CFD） models of the typical coastal concave terrains identifiedas a result of the study were created, and the local wind environments were simulated with input from geographic informationsystem （GIS） and statistic package for social science （SPSS） analysis. A measure of wind suitability was proposed that takes windvelocity and wind direction into account using GIS. Finally, SPSS was used to find the relationship between wind suitability andkey terrain factors. The results showed that wind suitability was significantly associated with terrain factors, especially altitude.The results suggest that residential building sites should be selected such that their bay openings face the direction of the prevailingwind and that the opposite direction should be avoided.
