To improve the power consumption of parallel applications at the runtime, modern processors provide frequency scaling and power limiting capabilities. In this work, a runtime strategy is proposed to distribute a given...To improve the power consumption of parallel applications at the runtime, modern processors provide frequency scaling and power limiting capabilities. In this work, a runtime strategy is proposed to distribute a given power allocation among the cluster nodes assigned to the application while balancing their performance change. The strategy operates in a timeslice-based manner to estimate the current application performance and power usage per node followed by power redistribution across the nodes. Experiments, performed on four nodes (112 cores) of a modern computing platform interconnected with Infiniband showed that even a significant power budget reduction of 20% may result in a performance degradation of as low as 1% under the proposed strategy compared with the execution in the unlimited power case.展开更多
In order to predict the levels of corona noise from high-voltage alternating current （AC） transmission lines, the mechanism of corona noise and the corresponding theoretical prediction model are investigated. On the...In order to predict the levels of corona noise from high-voltage alternating current （AC） transmission lines, the mechanism of corona noise and the corresponding theoretical prediction model are investigated. On the basis of Drnde model, the motion of positive and negative ions produced by high-voltage corona is analyzed, and the mechanism of corona noise is discovered. The theoretical prediction model is put forward by using Kirchhoff formula, which is verified by the well agreement between our result and others＇ , considering the case of three- phase single lines. Moreover, the calculation results show that for both single and bundled lines, the sound pres- sure level of the typical frequency, i.e. twice the power frequency, attenuates slowly and leads to an obviously in- terferential phenomenon near the transmission lines, but the level of the bundled lines is smaller than that of the single ones under the same transmission voltage. Based on the mechanism of corona noise and the prediction model, it is obvious that bundled lines and/or increased line radius can be adopted to reduce corona noise in the practical engineering applications effectively. This model can also provide a theoretical guidance for the high-volt- age AC transmission line design.展开更多
Recent results in the development of diode-driven high energy, high repetition rate, picosecond lasers, including the demonstration of a cryogenic Yb:YAG active mirror amplifier that produces 1.5 J pulses at 500 Hz re...Recent results in the development of diode-driven high energy, high repetition rate, picosecond lasers, including the demonstration of a cryogenic Yb:YAG active mirror amplifier that produces 1.5 J pulses at 500 Hz repetition rate(0.75 kW average power) are reviewed. These pulses are compressed resulting in the generation of ~5 ps duration,1 J pulses with 0.5 kW average power. A full characterization of this high power cryogenic amplifier, including atwavelength interferometry of the active region under >1 kW average power pump conditions, is presented. An initial demonstration of operation at 1 kW average power(1 J, 1 k Hz) is reported.展开更多
Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors,primarily due to their limited penetration capabilities.Herein,we successfully engineer photodynamic gel...Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors,primarily due to their limited penetration capabilities.Herein,we successfully engineer photodynamic gel-bombs(DCM@OPR)capable of penetrating deeply into tumor tissues utilizing the photodynamic-triggered explosive energy and receptor-mediated transcytosis,significantly enhancing the therapeutic efficacy of breast cancer.The photodynamic gel-bombs were fabricated by loading powerful components of chlorin e6 and MnO_(2) nanoparticles,as wellas Doxorubicin,into a crosslinked Ca^(2+)-gel.Upon exposure to laser irradiation,the obtained photodynamic gel-bombs are capable of generating explosive energy,resulting in their fragmentation into numerous nanofragments.The photodynamic-triggered explosive energy subsequently drives these nanofragments to deeply penetrate into tumor tissues through gap leakage among tumor cells.In addition,the photodynamictriggered explosive energy also promotes the escape of those therapeutic components(including chlorin e6,MnO_(2) nanoparticles,and doxorubicin)and nanofragments from lysosomes.In the subsequent stages,these nanofragments also exhibit excellent transcytosis capacity,facilitating deep penetration into tumor tissues.As expected,the enhanced penetration and accumulation of therapeutic components into tumor tissues can be achieved,significantly enhancing the anti-proliferation capacity against breast cancer.展开更多
文摘To improve the power consumption of parallel applications at the runtime, modern processors provide frequency scaling and power limiting capabilities. In this work, a runtime strategy is proposed to distribute a given power allocation among the cluster nodes assigned to the application while balancing their performance change. The strategy operates in a timeslice-based manner to estimate the current application performance and power usage per node followed by power redistribution across the nodes. Experiments, performed on four nodes (112 cores) of a modern computing platform interconnected with Infiniband showed that even a significant power budget reduction of 20% may result in a performance degradation of as low as 1% under the proposed strategy compared with the execution in the unlimited power case.
文摘In order to predict the levels of corona noise from high-voltage alternating current （AC） transmission lines, the mechanism of corona noise and the corresponding theoretical prediction model are investigated. On the basis of Drnde model, the motion of positive and negative ions produced by high-voltage corona is analyzed, and the mechanism of corona noise is discovered. The theoretical prediction model is put forward by using Kirchhoff formula, which is verified by the well agreement between our result and others＇ , considering the case of three- phase single lines. Moreover, the calculation results show that for both single and bundled lines, the sound pres- sure level of the typical frequency, i.e. twice the power frequency, attenuates slowly and leads to an obviously in- terferential phenomenon near the transmission lines, but the level of the bundled lines is smaller than that of the single ones under the same transmission voltage. Based on the mechanism of corona noise and the prediction model, it is obvious that bundled lines and/or increased line radius can be adopted to reduce corona noise in the practical engineering applications effectively. This model can also provide a theoretical guidance for the high-volt- age AC transmission line design.
基金supported by the U.S. Department of Energy Accelerator Stewardship programme, Office of High Energy Physics, Office of Science under award DE-SC0016136support by the U.S. Department of Energy, Office of Science SBIR programme under award DE-SC0011375
文摘Recent results in the development of diode-driven high energy, high repetition rate, picosecond lasers, including the demonstration of a cryogenic Yb:YAG active mirror amplifier that produces 1.5 J pulses at 500 Hz repetition rate(0.75 kW average power) are reviewed. These pulses are compressed resulting in the generation of ~5 ps duration,1 J pulses with 0.5 kW average power. A full characterization of this high power cryogenic amplifier, including atwavelength interferometry of the active region under >1 kW average power pump conditions, is presented. An initial demonstration of operation at 1 kW average power(1 J, 1 k Hz) is reported.
基金supported by the National Natural Science Foundation of China(82293650,82293651,82293652,22075127,22275080)GuangDong Basic and Applied Basic Research Foundation(2023A1515111182)President Foundation of Zhujiang Hospital,Southern Medical University(yzij2023qn07).
文摘Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors,primarily due to their limited penetration capabilities.Herein,we successfully engineer photodynamic gel-bombs(DCM@OPR)capable of penetrating deeply into tumor tissues utilizing the photodynamic-triggered explosive energy and receptor-mediated transcytosis,significantly enhancing the therapeutic efficacy of breast cancer.The photodynamic gel-bombs were fabricated by loading powerful components of chlorin e6 and MnO_(2) nanoparticles,as wellas Doxorubicin,into a crosslinked Ca^(2+)-gel.Upon exposure to laser irradiation,the obtained photodynamic gel-bombs are capable of generating explosive energy,resulting in their fragmentation into numerous nanofragments.The photodynamic-triggered explosive energy subsequently drives these nanofragments to deeply penetrate into tumor tissues through gap leakage among tumor cells.In addition,the photodynamictriggered explosive energy also promotes the escape of those therapeutic components(including chlorin e6,MnO_(2) nanoparticles,and doxorubicin)and nanofragments from lysosomes.In the subsequent stages,these nanofragments also exhibit excellent transcytosis capacity,facilitating deep penetration into tumor tissues.As expected,the enhanced penetration and accumulation of therapeutic components into tumor tissues can be achieved,significantly enhancing the anti-proliferation capacity against breast cancer.
