Most previous land-surface model calibration studies have defined globalranges for their parameters to search for optimal parameter sets. Little work has been conducted tostudy the impacts of realistic versus global r...Most previous land-surface model calibration studies have defined globalranges for their parameters to search for optimal parameter sets. Little work has been conducted tostudy the impacts of realistic versus global ranges as well as model complexities on the calibrationand uncertainty estimates. The primary purpose of this paper is to investigate these impacts byemploying Bayesian Stochastic Inversion (BSI) to the Chameleon Surface Model (CHASM). The CHASM wasdesigned to explore the general aspects of land-surface energy balance representation within acommon modeling framework that can be run from a simple energy balance formulation to a complexmosaic type structure. The BSI is an uncertainty estimation technique based on Bayes theorem,importance sampling, and very fast simulated annealing. The model forcing data and surface flux datawere collected at seven sites representing a wide range of climate and vegetation conditions. Foreach site, four experiments were performed with simple and complex CHASM formulations as well asrealistic and global parameter ranges. Twenty eight experiments were conducted and 50 000 parametersets were used for each run. The results show that the use of global and realistic ranges givessimilar simulations for both modes for most sites, but the global ranges tend to produce someunreasonable optimal parameter values. Comparison of simple and complex modes shows that the simplemode has more parameters with unreasonable optimal values. Use of parameter ranges and modelcomplexities have significant impacts on frequency distribution of parameters, marginal posteriorprobability density functions, and estimates of uncertainty of simulated sensible and latent heatfluxes. Comparison between model complexity and parameter ranges shows that the former has moresignificant impacts on parameter and uncertainty estimations.展开更多
Severe water erosion is notorious for its harmful effects on land-water resources as well as local societies. The scale effects of water erosion, however, greatly exacerbate the difficulties of accurate erosion evalua...Severe water erosion is notorious for its harmful effects on land-water resources as well as local societies. The scale effects of water erosion, however, greatly exacerbate the difficulties of accurate erosion evaluation and hazard control in the real world. Analyzing the related scale issues is thus urgent for a better understanding of erosion variations as well as reducing such erosion. In this review article, water erosion dynamics across three spatial scales including plot, watershed, and regional scales were selected and discussed. For the study purposes and objectives, the advantages and disadvantages of these scales all demonstrate clear spatial-scale dependence. Plot scale studies are primarily focused on abundant data collection and mechanism discrimination of erosion generation, while watershed scale studies provide valuable information for watershed management and hazard control as well as the development of quantitatively distributed models. Regional studies concentrate more on large-scale erosion assessment, and serve policymakers and stakeholders in achieving the basis for regulatory policy for comprehensive land uses. The results of this study show that the driving forces and mechanisms of water erosion variations among the scales are quite different. As a result, several major aspects contributing to variations in water erosion across the scales are stressed: differences in the methodologies across various scales, different sink-source roles on water erosion processes, and diverse climatic zones and morphological regions. This variability becomes more complex in the context of accelerated global change. The changing climatic factors and earth surface features are considered the fourth key reason responsible for the increased variability of water erosion across spatial scales.展开更多
Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for mor...Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for more than 3y.She was diagnosed with ASs and choroiditis at a local hospital.She has a seven-year history of bilateral high myopia.A fundus examination confirmed the presence of ASs and myopic fundus changes in both eyes.Multimodal imaging revealed an AZOOR complex in the left eye.展开更多
Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol...Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.展开更多
There have been active work to extend the Prolog style Horn Clause logic programming to non-Horn clauses.In this paper,we will analyze the complexities of several such extensions.The purpose is to understand the compu...There have been active work to extend the Prolog style Horn Clause logic programming to non-Horn clauses.In this paper,we will analyze the complexities of several such extensions.The purpose is to understand the computational complexity of these inference systems.The analyses do not prove that any one system is better than the others all the time.But they do suggest that one system may be better than the others for some particular problems.We also discuss the effect of caching.展开更多
Complex trimalleolar ankle fractures are a major orthopaedic challenge,with an incidence of 4.22 per 10000 person-years in the United States and an annual cost of 3.4 billion dollars.This review synthesizes current ev...Complex trimalleolar ankle fractures are a major orthopaedic challenge,with an incidence of 4.22 per 10000 person-years in the United States and an annual cost of 3.4 billion dollars.This review synthesizes current evidence on diagnostic protocols and management strategies,highlighting optimal approaches and emerging trends.Initial care emphasizes soft tissue assessment,often guided by the Tscherne classification,and fracture classification systems.External fixation may be required in open injuries,while early open reduction and internal fixation within six days is linked to improved outcomes.Minimally invasive techniques for the lateral malleolus,including intramedullary nailing and locking plates,are effective,while medial malleolus fractures are commonly managed with screw fixation or tension-band wiring.Posterior malleolus fragments involving more than 25%of the articular surface usually warrant fixation.Alternatives to syndesmotic screws,such as cortical buttons or high-strength sutures,reduce the need for secondary procedures.Arthroscopic-assisted open reduction and internal fixation benefits younger,active patients by enabling concurrent management of intra-articular and ligamentous injuries.Postoperative care prioritizes early weight-bearing and validated functional scores.Despite advances,complications remain common,and further research is needed to refine surgical strategies and improve outcomes.展开更多
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease i...Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the accumulation of misfoldedα-synuclein,forming insoluble Lewy bodies in the substantia nigra pars compacta,which contributes to neurodegeneration.Theseα-synuclein aggregates may act as autoantigens,leading to T-cell-mediated neuroinflammation and contributing to dopaminergic cell death.Our perspective explores the hypothesis that Parkinson's disease may have an autoimmune component,highlighting research that connects peripheral immune responses with neurodegeneration.T cells derived from Parkinson's disease patients appear to have the potential to initiate an autoimmune response againstα-synuclein and its modified peptides,possibly leading to the formation of neo-epitopes.Recent evidence associates Parkinson's disease with abnormal immune responses,as indicated by increased levels of immune cells,such as CD4^(+)and CD8^(+)T cells,observed in both patients and mouse models.The convergence of T cells filtration increasing major histocompatibility complex molecules,and the susceptibility of dopaminergic neurons supports the hypothesis that Parkinson's disease may exhibit autoimmune characteristics.Understanding the immune mechanisms involved in Parkinson's disease will be crucial for developing therapeutic strategies that target the autoimmune aspects of the disease.Novel approaches,including precision medicine based on major histocompatibility complex/human leukocyte antigen typing and early biomarker identification,could pave the way for immune-based treatments aimed at slowing or halting disease progression.This perspective explores the relationship between autoimmunity and Parkinson's disease,suggesting that further research could deepen understanding and offer new therapeutic avenues.In this paper,it is organized to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease.It investigates critical areas such as the autoimmune response observed in Parkinson's disease patients and the role of autoimmune mechanisms targetingα-synuclein in Parkinson's disease.The paper also examines the impact of CD4~+T cells,specifically Th1 and Th17,on neurons through in vitro and ex vivo studies.Additionally,it explores howα-synuclein influences glia-induced neuroinflammation in Parkinson's disease.The discussion extends to the clinical implications and therapeutic landscape,offering insights into potential treatments.Consequently,we aim to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease,incorporating both supportive and opposing views on its classification as an autoimmune disorder and exploring implications for clinical applications.展开更多
By embracing dialogue,cooperation,and a shared vision for peace and prosperity,India and China can navigate the intricacies of the relati on ship to secure a more stable and mutually ben eficial future.
Remotely sensed images have become a powerful source for landuse mapping.So far,no quantitative comparison and evaluation exist on the differences between an image-derived landuse map and a traditional landuse map.The...Remotely sensed images have become a powerful source for landuse mapping.So far,no quantitative comparison and evaluation exist on the differences between an image-derived landuse map and a traditional landuse map.The comparison and evaluation may indicate the possibility for the replacement of a traditional landuse map by an image-derived map.Map complexity is widely used to describe cartographic representations and map effectiveness from intellectual aspect and graphical aspect.This paper quantifies intellectual and graphical map complexities to explore the differences between these two kinds of maps.Intellectual complexity concerns the meaning or significations contained on a map.Graphical complexity concerns spatial characteristics of the graphical content on a map.Results show that the high graphical complexity of the image-derived landuse map is not harmonized with its low intellectual complexity.The intention of this paper is to encourage realistic cognition of the accuracy and problems existing in image-derived landuse maps.展开更多
Faced with complicated external and internal challenges, China's economy continues to see sluggish growth in 2018. Rapid accumulation of household debts, exacerbation in income inequality, tightened real sector li...Faced with complicated external and internal challenges, China's economy continues to see sluggish growth in 2018. Rapid accumulation of household debts, exacerbation in income inequality, tightened real sector liquidity, escalated trade tensions with the US, and weakened external demand pose key problems in China's macroeconomic landscape. The status quo is exacerbated by soaring uncertainty and weakening confidence in the face of persistent resource misallocations and institutional distortions, which cast more shadow on the already dampened consumer sentiment, sluggish private investment growth, and fallen foreign reserves. This summary report highlights the urgency of deeper structural reforms for tackling the various internal and external problems. Based on the IAR-CMM model, with both cyclical and secular factors taken into consideration, our baseline forecast of real GDP growth rate is 6.4%(6.1% using more reliable instead of the official data) in 2019. Alternative scenario analyses and policy simulations are conducted to assess the consequences of possible downside risks and the corresponding policy options needed to ensure the assumed growth targets. These analyses lead us to conclude that comprehensively deepening reform and opening up, which should be both rule-of-law based and market-oriented, with well-designed and well-conceived strategies that properly weigh short-, medium-, and long-term benefits and costs, should continue to be set as the guidance for China's transformation into a phase with sustainable and high-quality growth.展开更多
Several geometric sequences have very low linear complexities when considered as sequences over GF（p）, such as the binary sequences of period q^n - 1 constructed by Chan and Games [1-2] （q is a prime power p^m, p i...Several geometric sequences have very low linear complexities when considered as sequences over GF（p）, such as the binary sequences of period q^n - 1 constructed by Chan and Games [1-2] （q is a prime power p^m, p is an odd prime） with the maximal possible linear complexity q^n-1 when considered as sequences over GF（2）. This indicates that binary sequences with high GF（2） linear complexities LC2 and low GF（p）-linear complexities LCp are not secure for use in stream ciphers. In this article, several lower bounds on the GF（p）-linear complexities of binary sequences is proved and the results are applied to the GF（p）-linear complexities of Blum-Blum-Shub, self-shrinking, and de Bruijn sequences. A lower bound on the number of the binary sequences with LC2 〉 LCD is also presented.展开更多
Aquatic ecosystems are increasingly threatened by multiple human-induced stressors associated with climate and anthropogenic changes,including warming,nutrient pollution,harmful algal blooms,hypoxia,and changes in CO_...Aquatic ecosystems are increasingly threatened by multiple human-induced stressors associated with climate and anthropogenic changes,including warming,nutrient pollution,harmful algal blooms,hypoxia,and changes in CO_(2) and pH.These stressors may affect systems additively and synergistically but may also counteract each other.The resultant ecosystem changes occur rapidly,affecting both biotic and abiotic components and their interactions.Moreover,the complexity of interactions increases as one ascends the food web due to differing sensitivities and exposures among life stages and associated species interactions,such as competition and predation.There is also a need to further understand nontraditional food web interactions,such as mixotrophy,which is the ability to combine photosynthesis and feeding by a single organism.The complexity of these interactions and nontraditional food webs presents challenges to ecosystem modeling and management.Developing ecological models to understand multistressor effects is further challenged by the lack of sufficient data on the effects of interactive stressors across different trophic levels and the substantial variability in climate changes on regional scales.To obtain data on a broad suite of interactions,a nested set of experiments can be employed.Modular,coupled,multitrophic level models will provide the flexibility to explore the additive,amplified,propagated,antagonistic,and/or reduced effects that can emerge from the interactions of multiple stressors.Here,the stressors associated with eutrophication and climate change are reviewed,and then example systems from around the world are used to illustrate their complexity and how model scenarios can be used to examine potential future changes.展开更多
A homomorphism φ of logic programs from P to P＇ is a function mapping Atoms（P） to Atoms（P＇） and it preserves complements and program clauses. For each definite program clause a ← a1,...,an ∈ P it implies that...A homomorphism φ of logic programs from P to P＇ is a function mapping Atoms（P） to Atoms（P＇） and it preserves complements and program clauses. For each definite program clause a ← a1,...,an ∈ P it implies that φ（a） ←- φ（a1）,...,φ（an） is a program clause of P＇. A homomorphism φis an isomorphism if φ is a bijection. In this paper, the complexity of the decision problems on homomorphism and isomorphism for definite logic programs is studied. It is shown that the homomorphism problem （HOM-LP） for definite logic programs is NP-complete, and the isomorphism problem （ISO-LP） is equivalent to the graph isomorphism problem （GI）.展开更多
Chromatin remodeling and transcriptional reprogramming are key mechanisms through which plants respond to environmental challenges.Nucleosomal dynamics associated with the pres-ence/absence(incorporation/eviction)of t...Chromatin remodeling and transcriptional reprogramming are key mechanisms through which plants respond to environmental challenges.Nucleosomal dynamics associated with the pres-ence/absence(incorporation/eviction)of the histone variant H2A.Z is one of the key chromatin remodeling mechanisms associated with environmental response(Coleman-Derr and Zilberman,2012).Very recently,some excellent papers(Shang et al.,2021;Willige et al.,2021;Xue et al.,2021)have addressed the role of a less-explored component of this chromatin remodeling-the INO80 complex.Here,we discuss novel insights revealed in these papers and their potential impacts.展开更多
A new family of GMW sequences over an arbitrary Galois ring was defined by using the trace functions and permutations.This generalizes the concept of GMW sequences over finite fields.Utilizing the Fourier representati...A new family of GMW sequences over an arbitrary Galois ring was defined by using the trace functions and permutations.This generalizes the concept of GMW sequences over finite fields.Utilizing the Fourier representation,we derived an estimate of the linear complexities of this family of GMW sequences.And the result shows that such sequences have large linear complexities.展开更多
The Summer School of Global Development&Country and Region Studies at China Agricultural University brought together scholars,students and practitioners in development from all corners of the globe to critically e...The Summer School of Global Development&Country and Region Studies at China Agricultural University brought together scholars,students and practitioners in development from all corners of the globe to critically examine the complexities of development from an interdisciplinary perspective.The programme comprised a mix of theoretical and practical educational activities that enhanced my understanding of global development,South-South cooperation,and China’s growing involvement in global affairs.展开更多
BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under laparoscopy.Dissecting the third hepatic hilum before parenchymal transection often lead...BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under laparoscopy.Dissecting the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ LLR.AIM To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional methods.METHODS The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively analyzed.In novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the IVC.Then,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a marker.Subsequently,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic vein.The short-term postoperative outcomes and oncological results of the two approaches were evaluated and compared.RESULTS A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel LLR.The novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)compared to conventional LLR.CONCLUSION This novel technique enhances liver resection outcomes by reducing intraoperative complications such as bleeding and tumor compression.It facilitates a safer,in situ removal of complex liver tumors,even in challenging anatomical locations.Compared to conventional methods,this technique offers significant advantages,including reduced operative time,blood loss,and improved overall surgical efficiency.展开更多
BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot program.Chron...BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot program.Chronic diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient outcomes.If proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid patients.AIM To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital care.METHODS The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.RESULTS The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.CONCLUSION This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary approach.The coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient complexity.The superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of care to be replicated.展开更多
Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently...Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms.展开更多
To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bisp...To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bispyridylanthrahydrazone(9,10‑PAH)were designed and synthesized.Utilizing 9‑PAH and 9,10‑PAH as promising anticancer ligands,their respective copper complexes,namely[Cu(L1)Cl_(2)]Cl(1)and{[Cu_(4)(μ_(2)‑Cl)_(3)Cl_(4)(9,10‑PAH)_(2)(DMSO)_(2)]Cl_(2)}_(n)(2),were subsequently synthesized,where the new ligand L1 is formed by coupling two 9‑PAH ligands in the coordination reaction.The chemical and crystal structures of 1 and 2 were elucidated by IR,MS,elemental analysis,and single‑crystal X‑ray diffraction.Complex 1 forms a mononuclear structure.L1 coordinates with Cu through its three N atoms,together with two Cl atoms,to form a five‑coordinated square pyramidal geometry.Complex 2 constitutes a polymeric structure,wherein each structural unit centrosymmetrically encompasses two five‑coordinated binuclear copper complexes(Cu1,Cu2)of 9,10‑PAH,with similar square pyramidal geometry.A chlorine atom(Cl_(2)),located at the symmetry center,bridges Cu1 and Cu1A to connect the two binuclear copper structures.Meanwhile,the two five‑coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom,respectively,thus forming a 1D chain‑like polymeric structure.In vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than cisplatin.Specifically,the IC_(50)values of 2 against HeLa‑229 and SK‑OV‑3 cancer cell lines were determined to be(5.92±0.32)μmol·L^(-1)and(6.48±0.39)μmol·L^(-1),respectively.2 could also block the proliferation of HeLa‑229 cells in S phase and significantly induce cell apoptosis.In addition,fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode,offering insights into its underlying anticancer mechanism.CCDC:2388918,1;2388919,2.展开更多
文摘Most previous land-surface model calibration studies have defined globalranges for their parameters to search for optimal parameter sets. Little work has been conducted tostudy the impacts of realistic versus global ranges as well as model complexities on the calibrationand uncertainty estimates. The primary purpose of this paper is to investigate these impacts byemploying Bayesian Stochastic Inversion (BSI) to the Chameleon Surface Model (CHASM). The CHASM wasdesigned to explore the general aspects of land-surface energy balance representation within acommon modeling framework that can be run from a simple energy balance formulation to a complexmosaic type structure. The BSI is an uncertainty estimation technique based on Bayes theorem,importance sampling, and very fast simulated annealing. The model forcing data and surface flux datawere collected at seven sites representing a wide range of climate and vegetation conditions. Foreach site, four experiments were performed with simple and complex CHASM formulations as well asrealistic and global parameter ranges. Twenty eight experiments were conducted and 50 000 parametersets were used for each run. The results show that the use of global and realistic ranges givessimilar simulations for both modes for most sites, but the global ranges tend to produce someunreasonable optimal parameter values. Comparison of simple and complex modes shows that the simplemode has more parameters with unreasonable optimal values. Use of parameter ranges and modelcomplexities have significant impacts on frequency distribution of parameters, marginal posteriorprobability density functions, and estimates of uncertainty of simulated sensible and latent heatfluxes. Comparison between model complexity and parameter ranges shows that the former has moresignificant impacts on parameter and uncertainty estimations.
基金Under the auspices of National Natural Science Foundation of China (No. 40925003, 40930528, 40801041)
文摘Severe water erosion is notorious for its harmful effects on land-water resources as well as local societies. The scale effects of water erosion, however, greatly exacerbate the difficulties of accurate erosion evaluation and hazard control in the real world. Analyzing the related scale issues is thus urgent for a better understanding of erosion variations as well as reducing such erosion. In this review article, water erosion dynamics across three spatial scales including plot, watershed, and regional scales were selected and discussed. For the study purposes and objectives, the advantages and disadvantages of these scales all demonstrate clear spatial-scale dependence. Plot scale studies are primarily focused on abundant data collection and mechanism discrimination of erosion generation, while watershed scale studies provide valuable information for watershed management and hazard control as well as the development of quantitatively distributed models. Regional studies concentrate more on large-scale erosion assessment, and serve policymakers and stakeholders in achieving the basis for regulatory policy for comprehensive land uses. The results of this study show that the driving forces and mechanisms of water erosion variations among the scales are quite different. As a result, several major aspects contributing to variations in water erosion across the scales are stressed: differences in the methodologies across various scales, different sink-source roles on water erosion processes, and diverse climatic zones and morphological regions. This variability becomes more complex in the context of accelerated global change. The changing climatic factors and earth surface features are considered the fourth key reason responsible for the increased variability of water erosion across spatial scales.
基金Supported by the National Natural Science Foundation of China(No.82171073).
文摘Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for more than 3y.She was diagnosed with ASs and choroiditis at a local hospital.She has a seven-year history of bilateral high myopia.A fundus examination confirmed the presence of ASs and myopic fundus changes in both eyes.Multimodal imaging revealed an AZOOR complex in the left eye.
基金supported by the Shenzhen Medical Research Fund(Grant No.A2303049)Guangdong Basic and Applied Basic Research(Grant No.2023A1515010647)+1 种基金National Natural Science Foundation of China(Grant No.22004135)Shenzhen Science and Technology Program(Grant No.RCBS20210706092409020,GXWD20201231165807008,20200824162253002).
文摘Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.
文摘There have been active work to extend the Prolog style Horn Clause logic programming to non-Horn clauses.In this paper,we will analyze the complexities of several such extensions.The purpose is to understand the computational complexity of these inference systems.The analyses do not prove that any one system is better than the others all the time.But they do suggest that one system may be better than the others for some particular problems.We also discuss the effect of caching.
文摘Complex trimalleolar ankle fractures are a major orthopaedic challenge,with an incidence of 4.22 per 10000 person-years in the United States and an annual cost of 3.4 billion dollars.This review synthesizes current evidence on diagnostic protocols and management strategies,highlighting optimal approaches and emerging trends.Initial care emphasizes soft tissue assessment,often guided by the Tscherne classification,and fracture classification systems.External fixation may be required in open injuries,while early open reduction and internal fixation within six days is linked to improved outcomes.Minimally invasive techniques for the lateral malleolus,including intramedullary nailing and locking plates,are effective,while medial malleolus fractures are commonly managed with screw fixation or tension-band wiring.Posterior malleolus fragments involving more than 25%of the articular surface usually warrant fixation.Alternatives to syndesmotic screws,such as cortical buttons or high-strength sutures,reduce the need for secondary procedures.Arthroscopic-assisted open reduction and internal fixation benefits younger,active patients by enabling concurrent management of intra-articular and ligamentous injuries.Postoperative care prioritizes early weight-bearing and validated functional scores.Despite advances,complications remain common,and further research is needed to refine surgical strategies and improve outcomes.
基金supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。
文摘Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the accumulation of misfoldedα-synuclein,forming insoluble Lewy bodies in the substantia nigra pars compacta,which contributes to neurodegeneration.Theseα-synuclein aggregates may act as autoantigens,leading to T-cell-mediated neuroinflammation and contributing to dopaminergic cell death.Our perspective explores the hypothesis that Parkinson's disease may have an autoimmune component,highlighting research that connects peripheral immune responses with neurodegeneration.T cells derived from Parkinson's disease patients appear to have the potential to initiate an autoimmune response againstα-synuclein and its modified peptides,possibly leading to the formation of neo-epitopes.Recent evidence associates Parkinson's disease with abnormal immune responses,as indicated by increased levels of immune cells,such as CD4^(+)and CD8^(+)T cells,observed in both patients and mouse models.The convergence of T cells filtration increasing major histocompatibility complex molecules,and the susceptibility of dopaminergic neurons supports the hypothesis that Parkinson's disease may exhibit autoimmune characteristics.Understanding the immune mechanisms involved in Parkinson's disease will be crucial for developing therapeutic strategies that target the autoimmune aspects of the disease.Novel approaches,including precision medicine based on major histocompatibility complex/human leukocyte antigen typing and early biomarker identification,could pave the way for immune-based treatments aimed at slowing or halting disease progression.This perspective explores the relationship between autoimmunity and Parkinson's disease,suggesting that further research could deepen understanding and offer new therapeutic avenues.In this paper,it is organized to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease.It investigates critical areas such as the autoimmune response observed in Parkinson's disease patients and the role of autoimmune mechanisms targetingα-synuclein in Parkinson's disease.The paper also examines the impact of CD4~+T cells,specifically Th1 and Th17,on neurons through in vitro and ex vivo studies.Additionally,it explores howα-synuclein influences glia-induced neuroinflammation in Parkinson's disease.The discussion extends to the clinical implications and therapeutic landscape,offering insights into potential treatments.Consequently,we aim to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease,incorporating both supportive and opposing views on its classification as an autoimmune disorder and exploring implications for clinical applications.
文摘By embracing dialogue,cooperation,and a shared vision for peace and prosperity,India and China can navigate the intricacies of the relati on ship to secure a more stable and mutually ben eficial future.
基金supported by the National Key Basic Research and Development Program of China("973"Project)(Grant No.2006CB701306)the Program for New Century Excellent Talents in University(Grant No.NCET-06-0619)the Project of National Natural Science Foundation of China(Grant No.4097119)
文摘Remotely sensed images have become a powerful source for landuse mapping.So far,no quantitative comparison and evaluation exist on the differences between an image-derived landuse map and a traditional landuse map.The comparison and evaluation may indicate the possibility for the replacement of a traditional landuse map by an image-derived map.Map complexity is widely used to describe cartographic representations and map effectiveness from intellectual aspect and graphical aspect.This paper quantifies intellectual and graphical map complexities to explore the differences between these two kinds of maps.Intellectual complexity concerns the meaning or significations contained on a map.Graphical complexity concerns spatial characteristics of the graphical content on a map.Results show that the high graphical complexity of the image-derived landuse map is not harmonized with its low intellectual complexity.The intention of this paper is to encourage realistic cognition of the accuracy and problems existing in image-derived landuse maps.
文摘Faced with complicated external and internal challenges, China's economy continues to see sluggish growth in 2018. Rapid accumulation of household debts, exacerbation in income inequality, tightened real sector liquidity, escalated trade tensions with the US, and weakened external demand pose key problems in China's macroeconomic landscape. The status quo is exacerbated by soaring uncertainty and weakening confidence in the face of persistent resource misallocations and institutional distortions, which cast more shadow on the already dampened consumer sentiment, sluggish private investment growth, and fallen foreign reserves. This summary report highlights the urgency of deeper structural reforms for tackling the various internal and external problems. Based on the IAR-CMM model, with both cyclical and secular factors taken into consideration, our baseline forecast of real GDP growth rate is 6.4%(6.1% using more reliable instead of the official data) in 2019. Alternative scenario analyses and policy simulations are conducted to assess the consequences of possible downside risks and the corresponding policy options needed to ensure the assumed growth targets. These analyses lead us to conclude that comprehensively deepening reform and opening up, which should be both rule-of-law based and market-oriented, with well-designed and well-conceived strategies that properly weigh short-, medium-, and long-term benefits and costs, should continue to be set as the guidance for China's transformation into a phase with sustainable and high-quality growth.
基金supported by the National Natural Science Foundation of China (10871068)
文摘Several geometric sequences have very low linear complexities when considered as sequences over GF（p）, such as the binary sequences of period q^n - 1 constructed by Chan and Games [1-2] （q is a prime power p^m, p is an odd prime） with the maximal possible linear complexity q^n-1 when considered as sequences over GF（2）. This indicates that binary sequences with high GF（2） linear complexities LC2 and low GF（p）-linear complexities LCp are not secure for use in stream ciphers. In this article, several lower bounds on the GF（p）-linear complexities of binary sequences is proved and the results are applied to the GF（p）-linear complexities of Blum-Blum-Shub, self-shrinking, and de Bruijn sequences. A lower bound on the number of the binary sequences with LC2 〉 LCD is also presented.
基金supported in part by the NOAA Awards NA17NOS478180(to ML and PMG),NA19NOS4780183(to PMG and ML),NA15NOS4780184 and NA18NOS4780179(to JMT,WJC and ML),and NA16NOS4780204(to KAR)philanthropy support(to ERH)and by the NSF Award DEB 1911349(to PMG).
文摘Aquatic ecosystems are increasingly threatened by multiple human-induced stressors associated with climate and anthropogenic changes,including warming,nutrient pollution,harmful algal blooms,hypoxia,and changes in CO_(2) and pH.These stressors may affect systems additively and synergistically but may also counteract each other.The resultant ecosystem changes occur rapidly,affecting both biotic and abiotic components and their interactions.Moreover,the complexity of interactions increases as one ascends the food web due to differing sensitivities and exposures among life stages and associated species interactions,such as competition and predation.There is also a need to further understand nontraditional food web interactions,such as mixotrophy,which is the ability to combine photosynthesis and feeding by a single organism.The complexity of these interactions and nontraditional food webs presents challenges to ecosystem modeling and management.Developing ecological models to understand multistressor effects is further challenged by the lack of sufficient data on the effects of interactive stressors across different trophic levels and the substantial variability in climate changes on regional scales.To obtain data on a broad suite of interactions,a nested set of experiments can be employed.Modular,coupled,multitrophic level models will provide the flexibility to explore the additive,amplified,propagated,antagonistic,and/or reduced effects that can emerge from the interactions of multiple stressors.Here,the stressors associated with eutrophication and climate change are reviewed,and then example systems from around the world are used to illustrate their complexity and how model scenarios can be used to examine potential future changes.
基金国家自然科学基金，the Special Foundation for Improving Scientific Research Condition of Guizhou, and the Government Foundation of Guizhou Province，the Government Foundation of Guizhou Province
文摘A homomorphism φ of logic programs from P to P＇ is a function mapping Atoms（P） to Atoms（P＇） and it preserves complements and program clauses. For each definite program clause a ← a1,...,an ∈ P it implies that φ（a） ←- φ（a1）,...,φ（an） is a program clause of P＇. A homomorphism φis an isomorphism if φ is a bijection. In this paper, the complexity of the decision problems on homomorphism and isomorphism for definite logic programs is studied. It is shown that the homomorphism problem （HOM-LP） for definite logic programs is NP-complete, and the isomorphism problem （ISO-LP） is equivalent to the graph isomorphism problem （GI）.
基金Work on epigenetic regulation in our groups is supported by Australian Research Council(ARC)Discovery Project DP190101818(to S.B.)ARC Future Fellowship FT190100403(to S.S.).
文摘Chromatin remodeling and transcriptional reprogramming are key mechanisms through which plants respond to environmental challenges.Nucleosomal dynamics associated with the pres-ence/absence(incorporation/eviction)of the histone variant H2A.Z is one of the key chromatin remodeling mechanisms associated with environmental response(Coleman-Derr and Zilberman,2012).Very recently,some excellent papers(Shang et al.,2021;Willige et al.,2021;Xue et al.,2021)have addressed the role of a less-explored component of this chromatin remodeling-the INO80 complex.Here,we discuss novel insights revealed in these papers and their potential impacts.
文摘A new family of GMW sequences over an arbitrary Galois ring was defined by using the trace functions and permutations.This generalizes the concept of GMW sequences over finite fields.Utilizing the Fourier representation,we derived an estimate of the linear complexities of this family of GMW sequences.And the result shows that such sequences have large linear complexities.
文摘The Summer School of Global Development&Country and Region Studies at China Agricultural University brought together scholars,students and practitioners in development from all corners of the globe to critically examine the complexities of development from an interdisciplinary perspective.The programme comprised a mix of theoretical and practical educational activities that enhanced my understanding of global development,South-South cooperation,and China’s growing involvement in global affairs.
基金Supported by the General Project of the Natural Science Foundation of Chongqing,No.cstc2021jcyj-msxmX0604.
文摘BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under laparoscopy.Dissecting the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ LLR.AIM To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional methods.METHODS The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively analyzed.In novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the IVC.Then,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a marker.Subsequently,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic vein.The short-term postoperative outcomes and oncological results of the two approaches were evaluated and compared.RESULTS A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel LLR.The novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)compared to conventional LLR.CONCLUSION This novel technique enhances liver resection outcomes by reducing intraoperative complications such as bleeding and tumor compression.It facilitates a safer,in situ removal of complex liver tumors,even in challenging anatomical locations.Compared to conventional methods,this technique offers significant advantages,including reduced operative time,blood loss,and improved overall surgical efficiency.
基金Supported by Fundación Progreso y Salud,No.AP-0306-2022-C3-F2.
文摘BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot program.Chronic diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient outcomes.If proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid patients.AIM To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital care.METHODS The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.RESULTS The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.CONCLUSION This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary approach.The coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient complexity.The superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of care to be replicated.
基金National Natural Science Foundation of China(11971211,12171388).
文摘Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms.
文摘To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bispyridylanthrahydrazone(9,10‑PAH)were designed and synthesized.Utilizing 9‑PAH and 9,10‑PAH as promising anticancer ligands,their respective copper complexes,namely[Cu(L1)Cl_(2)]Cl(1)and{[Cu_(4)(μ_(2)‑Cl)_(3)Cl_(4)(9,10‑PAH)_(2)(DMSO)_(2)]Cl_(2)}_(n)(2),were subsequently synthesized,where the new ligand L1 is formed by coupling two 9‑PAH ligands in the coordination reaction.The chemical and crystal structures of 1 and 2 were elucidated by IR,MS,elemental analysis,and single‑crystal X‑ray diffraction.Complex 1 forms a mononuclear structure.L1 coordinates with Cu through its three N atoms,together with two Cl atoms,to form a five‑coordinated square pyramidal geometry.Complex 2 constitutes a polymeric structure,wherein each structural unit centrosymmetrically encompasses two five‑coordinated binuclear copper complexes(Cu1,Cu2)of 9,10‑PAH,with similar square pyramidal geometry.A chlorine atom(Cl_(2)),located at the symmetry center,bridges Cu1 and Cu1A to connect the two binuclear copper structures.Meanwhile,the two five‑coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom,respectively,thus forming a 1D chain‑like polymeric structure.In vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than cisplatin.Specifically,the IC_(50)values of 2 against HeLa‑229 and SK‑OV‑3 cancer cell lines were determined to be(5.92±0.32)μmol·L^(-1)and(6.48±0.39)μmol·L^(-1),respectively.2 could also block the proliferation of HeLa‑229 cells in S phase and significantly induce cell apoptosis.In addition,fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode,offering insights into its underlying anticancer mechanism.CCDC:2388918,1;2388919,2.
