Developing chemically complex intermetallic alloys(CCIMAs)is considered an effective strategy for overcoming the serious brittleness of conventional intermetallic alloys,especially under a high stress level.However,mo...Developing chemically complex intermetallic alloys(CCIMAs)is considered an effective strategy for overcoming the serious brittleness of conventional intermetallic alloys,especially under a high stress level.However,most CCIMAs still struggle to achieve yield strengths exceeding gigapascals,limiting their use as reliable structural materials in many engineering fields.展开更多
Multiple sclerosis (MS) is characterized by chronic,slowly expanding lesions with the accumulation of myeloid cells,which lead to brain atrophy and progressive disability.The role of mitochondria,especially mitochondr...Multiple sclerosis (MS) is characterized by chronic,slowly expanding lesions with the accumulation of myeloid cells,which lead to brain atrophy and progressive disability.The role of mitochondria,especially mitochondrial respiratory complexes and metabolites,in controlling myeloid immune responses,is well-documented but not fully understood in diseases of the central nervous system (CNS).The groundbreaking study by Prof.Peruzzotti-Jametti et al.[1],entitled"Mitochondrial complexⅠactivity in microglia sustains neuroinflammation"published in Nature,delves into the intricate dynamics between mitochondrial function within microglia and the perpetuation of chronic neuroinflammation,specifically in MS.The core point of their investigation is the hypothesis that mitochondrial complexⅠ(CI) activity,through a mechanism known as reverse electron transport (RET),generates reactive oxygen species (ROS) in microglia,thereby sustaining inflammatory response in the CNS.This increases ROS production from the mitochondria,which is thought to be a crucial factor in the maintenance of a pro-inflammatory state in the microglia,contributing to the pathology of MS and similar neuroinflammatory diseases.展开更多
Binuclear complexes have attracted extensive attention in fields such as catalysis because of their likely bimetallic synergistic effect;however,the mechanism and factors influencing this synergism remain unclear.In t...Binuclear complexes have attracted extensive attention in fields such as catalysis because of their likely bimetallic synergistic effect;however,the mechanism and factors influencing this synergism remain unclear.In this work,six bis-β-ketoimine binuclear titanium complexes4a-4f containing different alkylthio sidearms and configurations were synthesized and characterized by nuclear magnetic resonance hydrogen spectrum(~1H-NMR),nuclear magnetic resonance carbon spectrum(^(13)C-NMR),Fourier transform infrared spectrum(FTIR),and elemental analysis.The intermetallic distances of isomeric complexes 4a,4d,4e and 4f determined through density functional theory(DFT)optimization were in the order 4a<4d<4e<4f and were found to significantly influence the catalytic performance for ethylene(co)polymerization.These complexes could efficiently catalyze ethylene polymerization and ethylene/1-hexene or ethylene/1-octene copolymerization with high activity to produce highmolecular-weight ethylene homo-and co-polymers.Among the three binuclear titanium complexes 4a-4c with similar structures but different lengths of alkylthio sidearms,complex 4a,which contained the shortest methylthio sidearm,exhibited the highest activity for ethylene polymerization and copolymerization with 1-hexene or 1-octene.Additionally,for ethylene/1-hexene or ethylene/1-octene copolymerization,it showed the highest comonomer incorporation compared with propylthio(4b)and octylthio(4c)derivatives because of the smaller steric hindrance of the methyl group in 4a and the more open coordination space for vinyl monomers.Furthermore,among the isomeric complexes 4a,4d,4e and4f,complex 4a with the shortest bimetallic distance also exhibited the highest activity towards ethylene(co)polymerization,and the highest 1-hexene or 1-octene incorporation in comparison with its regioisomeric counterparts 4d,4e and p-phenyl-bridged analog 4f,owing to a more appropriate bimetallic distance that is conducive to a synergistic effect.展开更多
The complex topography of natural bedrock shorelines on islands necessitates detailed model testing to thoroughly inves-tigate wave overtopping mechanisms and their variation patterns.This understanding is vital for o...The complex topography of natural bedrock shorelines on islands necessitates detailed model testing to thoroughly inves-tigate wave overtopping mechanisms and their variation patterns.This understanding is vital for optimizing the elevation of coastal structures to meet the design requirements for wave overtopping and to ensure safety and efficacy.This paper investigates a nuclear power plant project on an island in Zhejiang Province,China.This study employs small-scale overall model tests and large-scale lo-cal model tests to examine the complex dynamics of wave interaction with the island’s shoreline.It analyzes the influences of wave parameters,shoreline geometry,and underwater topography on wave overtopping behavior.Comparisons between physical model re-sults and empirical formulae reveal substantial discrepancies in overtopping rates across different model scales.The results stress the remarkable effect of accurate underwater topography representation on wave overtopping predictions and emphasize the need for pre-cise topographic modeling.The results also show that overtopping discharges for complex terrains deviate considerably from values determined using traditional empirical formulas for breakwater overtopping.This outcome indicates that conventional methods may insufficiently address the complexities of natural coastal features.To guarantee reliable predictions of overtopping volumes at specif-ic elevations along complex coastlines,this study advocates employing physical modeling across numerous scales while accounting for detailed terrain and hydrodynamic characteristics.展开更多
Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic a...Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic and whole-rock geochemical data,we report the first discovery of a latest Cambrian–Early Ordovician forearc-arc rock sequence in the Eastern Alps.This sequence includes granitic gneisses,amphibolites,and amphibole plagiogneisses from the ophiolitic Speik Complex and Gleinalpe Complex.These rocks exhibit geochemical affinities with typical oceanic plagiogranites,forearc basalts(FABs),and island arc basalts,respectively.The latest Cambrian plagiogranitic protoliths(491±2 Ma)are shearing-type plagiogranites that were formed in the tectonic setting of forearc spreading.The latest Cambrian FABs(496–489 Ma)have similar geochemical compositions and positiveεHf(t)values(+2.5 to+14.9)to the depleted mid-ocean ridge basalts.However,they show depletion in high field strength elements(HFSEs;e.g.,Nb,Ta,and Zr)and have relatively low Ti/V ratios.These features suggest that they were derived from a depleted mantle source modified by subducting slab-released components in a forearc environment.The Early Ordovician basaltic protoliths(476–472 Ma)of amphibole plagiogneisses show enrichment in large ion lithophile elements and depletion in HFSEs(e.g.Nb,Ta,Zr,and Hf),implying a mature island arc environment.These metaigneous rocks,along with the coeval boninite-like high-Mg amphibolites near the study area,form a typical rock sequence resembling that of the Izu–Bonin–Mariana(IBM)arc system.The Speik and Gleinalpe complexes document a complete magmatic evolution from subduction initiation to mature arc development within the West Proto-Tethys Ocean.Integrating our new data with published work,we reconstruct the late Ediacaran–early Paleozoic tectonic evolution of the northern Gondwana.During the late Ediacaran–early Cambrian,the rollback of the West Proto-Tethys oceanic plate triggered the separation of the Wechsel-Silvretta-Gleinalpe continental arc from the northern Gondwana.This process led to the formation of the Speik back-arc oceanic basin,a southwestern branch of the West Proto-Tethys Ocean.In the latest Cambrian–Early Ordovician,subduction initiation occurred in the Speik Ocean,which subsequently developed into an intra-oceanic arc system.During the Early Devonian,the Speik Ocean closed and the Wechsel-Silvretta-Gleinalpe continental arc reattached to the Gondwana,as evidenced by the metamorphic event at ca.400 Ma.展开更多
Passive optical motion capture technology is an effective mean to conduct high-precision pose estimation of small scenes of mobile robots;nevertheless,in the case of complex background and stray light interference in ...Passive optical motion capture technology is an effective mean to conduct high-precision pose estimation of small scenes of mobile robots;nevertheless,in the case of complex background and stray light interference in the scene,due to the infuence of target adhesion and environmental reflection,this technology cannot estimate the pose accurately.A passive binocular optical motion capture technology under complex illumination based on binocular camera and fixed retroreflective marker balls has been proposed.By fixing multiple hemispherical retrorefective marker balls on a rigid base,it uses binocular camera for depth estimation to obtain the fixed position relationship between the feature points.After performing unsupervised state estimation without manual operation,it overcomes the infuence of refection spots in the background.Meanwhile,contour extraction and ellipse least square fitting are used to extract the marker balls with incomplete shape as the feature points,so as to solve the problem of target adhesion in the scene.A FANUC m10i-a robot moving with 6-DOF is used for verification using the above methods in a complex lighting environment of a welding laboratory.The result shows that the average of absolute position errors is 5.793mm,the average of absolute rotation errors is 1.997°the average of relative position errors is 0.972 mm,and the average of relative rotation errors is 0.002°.Therefore,this technology meets the requirements of high-precision measurement in a complex lighting environment when estimating the 6-DOF-motion mobile robot and has very significant application prospects in complex scenes.展开更多
Lishiite,(Ca_(2)□)Sr_(3)(CO_(3))_(5),is a new mineral species from Shaxiongdong,Hubei Province,China.It mainly occours as conchoidal crystals and with combination of hexagonal prism and pyramid and is associated with...Lishiite,(Ca_(2)□)Sr_(3)(CO_(3))_(5),is a new mineral species from Shaxiongdong,Hubei Province,China.It mainly occours as conchoidal crystals and with combination of hexagonal prism and pyramid and is associated with calcite,K-feldspar,albite,aegirine,apatite,and ancylite-(Ce)(?)and strontianite etc.Lishiite is brittle with conchiform fracture and has a Mohs hardness of approximately 4 and none cleavages were observed.The Vickers microhardness(VHN10)is 197.42 kg/mm^(2)(range:166.88 kg/mm^(2) to 214.58 kg/mm^(2)),and the calculated density of lishiite is 3.696 g/cm3.Hand specimen of lishiite are yellow-brown.The empirical chemical formula of the lishiite is ^(A)(Ca_(1.18)Sr_(0.25)Na_(0.19□1.38))_(Σ3.00)^( B)[Sr_(2.17)(Ce_(0.42)La_(0.24)Nd_(0.09)Eu_(0.01))_(Σ0.76) Ba_(0.07)]_(Σ3.00)(C_(5.05)O_(15)).As a member of the burbankite group,the general formula of lishiite follows the general formula A_(3)B_(3)(CO_(3))_(5),where A=Na,Ca,or and B=Sr,Ba,REE,or Ca.Its crystal structure is hexagonal(space group P6_(3)mc)with unit cell parameters a=10.4898(5)Å,c=6.4167(5)Å,and V=611.47(6)Å^(3),characterized by layers of AO_(8) and BO_(10) polyhedra connected to[CO_(3)]^(3−)groups.The discovery of lishiite provides new insights into the evolutionary history of rare earth element(REE)carbonate deposit formation.展开更多
The kinetics of isothermal reduction of the carbon bearing pellets, which were mainly composed of Bayanobo complex iron ore and pulverized coal, was investigated by thermogravimetry at the temperature of 1 273-1 673 K...The kinetics of isothermal reduction of the carbon bearing pellets, which were mainly composed of Bayanobo complex iron ore and pulverized coal, was investigated by thermogravimetry at the temperature of 1 273-1 673 K. The effects of xC/xO and the atmospheres on the extent of reduction also were investigated. The results indicate that the fractional reaction increased proportionally with temperature increasing and heating temperature is the significant influence factor to the reaction of carbon bearing pellets. The optimum xC/xO is 1.2 and the effect of atmosphere on the reduction of iron oxides is almost negligible. The results can be interpreted that the reaction was initially controlled by a mixed controlled mechanism of carbon gasification and interface chemical reaction, and in the later stage, interface chemical reaction became the rate-controlling step. Apparent activation energy values of reduction at different levels of fractional reaction were calculated. Before F （fraction of reaction）=0.5, the apparent activation energy ranges from 66.39 to 75.64 kJ/mol, while after F=0.5, the apparent activation energy is 80.98 to 85.37 kJ/mol.展开更多
BACKGROUND Schizophrenia afflicts 1%of the world population.Clinical studies suggest that schizophrenia patients may have an imbalance of mitochondrial energy metabolism via inhibition of mitochondrial complex I activ...BACKGROUND Schizophrenia afflicts 1%of the world population.Clinical studies suggest that schizophrenia patients may have an imbalance of mitochondrial energy metabolism via inhibition of mitochondrial complex I activity.Moreover,recent studies have shown that ERVWE1 is also a risk factor for schizophrenia.Nevertheless,there is no available literature concerning the relationship between complex I deficits and ERVWE1 in schizophrenia.Identifying risk factors and blood-based biomarkers for schizophrenia may provide new guidelines for early interventions and prevention programs.AIM To address novel potential risk factors and the underlying mechanisms of mitochondrial complex I deficiency caused by ERVWE1 in schizophrenia.METHODS Quantitative polymerase chain reaction(qPCR)and enzyme-linked immunosorbent assay were used to detect differentially expressed risk factors in blood samples.Clinical statistical analyses were performed by median analyses and Mann-Whitney U analyses.Spearman’s rank correlation was applied to examine the correlation between different risk factors in blood samples.qPCR,western blot analysis,and luciferase assay were performed to confirm the relationship among ERVWE1,cytoplasmic polyadenylation element-binding protein 1(CPEB1),NADH dehydrogenase ubiquinone flavoprotein 2(NDUFV2),and NDUFV2 pseudogene(NDUFV2P1).The complex I enzyme activity microplate assay was carried out to evaluate the complex I activity induced by ERVWE1.RESULTS Herein,we reported decreasing levels of CPEB1 and NDUFV2 in schizophrenia patients.Further studies showed that ERVWE1 was negatively correlated with CPEB1 and NDUFV2 in schizophrenia.Moreover,NDUFV2P1 was increased and demonstrated a significant positive correlation with ERVWE1 and a negative correlation with NDUFV2 in schizophrenia.In vitro experiments disclosed that ERVWE1 suppressed NDUFV2 expression and promoter activity by increasing NDUFV2P1 level.The luciferase assay revealed that ERVWE1 could enhance the promoter activity of NDUFV2P1.Additionally,ERVWE1 downregulated the expression of CPEB1 by suppressing the promoter activity,and the 400 base pair sequence at the 3′terminus of the promoter was the minimum sequence required.Advanced studies showed that CPEB1 participated in regulating the NDUFV2P1/NDUFV2 axis mediated by ERVWE1.Finally,we found that ERVWE1 inhibited complex I activity in SH-SY5Y cells via the CPEB1/NDUFV2P1/NDUFV2 signaling pathway.CONCLUSION In conclusion,CPEB1 and NDUFV2 might be novel potential blood-based biomarkers and pathogenic factors in schizophrenia.Our findings also reveal a novel mechanism of ERVWE1 in the etiology of schizophrenia.展开更多
This article chronicles a failed research project.We designed and carried out a psychological intervention aimed at increasing esogastric and lung cancer patients’emotional competencies after treatments.We present th...This article chronicles a failed research project.We designed and carried out a psychological intervention aimed at increasing esogastric and lung cancer patients’emotional competencies after treatments.We present the final protocol of the study,a randomized controlled trial in a public hospital,and describe the difficulties encountered and our subsequent reflections,to provide researchers and clinicians with advice for the implementation of such interventions.Firstly,the role of psychology,emotions,and emotional competencies,is still underacknowledged in cancer care.Pedagogical efforts must be made to convince both physicians and patients of the importance of those elements.Secondly and consequently,even distressed patients sure to benefit from such an intervention,do not take it up.In particular,male patients often declined the intervention due to gender stereotypes,and as such creativity is needed to present such interventions in a motivating way for patients.Finally,and most importantly,even if there is a good rationale for a psychological intervention and all favorable conditions are present,it is essential to first conduct a feasibility/pilot study.Indeed,even the most thorough preparation is no guarantee of anticipating all issues due to important gaps between theory and practice.展开更多
In our previous study,a novel organic selenium compound Eb was synthesized and found to have significant antitumor activity with much less toxicity compared with the leading compound Ebselen.Unfortunately,Eb was pract...In our previous study,a novel organic selenium compound Eb was synthesized and found to have significant antitumor activity with much less toxicity compared with the leading compound Ebselen.Unfortunately,Eb was practically insoluble in water （2.57 μg/mL） and had very low oral bioavailability,thus its clinical application was greatly limited.In the present study,the inclusion complex of Eb with 2-hydroxypropyl-β-cyclodextrin （HP-βCD） was prepared and pharmacokinetics of Eb and the inclusion complex were investigated.The water solubility of Eb was dramatically enhanced by inclusion with HP-βCD,which reached 8.4 mg/mL.The pharmacokinetic study showed that the elimination half-life （t 1/2β） of Eb was between 22 h and 30 h and the distribution half-life （t 1/2α） of Eb was 1 h.The results indicated that Eb was rapidly distributed to tissues but slowly eliminated in rats.The absolute bioavailability of Eb/HP-βCD inclusion complex solution through the oral route was 28.3%,and it was 1552% that of Eb in its pure form.In summary,the absorption of Eb in the Eb/HP-βCD inclusion complex was better and faster than that of Eb in its pure form.展开更多
Objective:Qualitative research on therapeutic components is necessary to evaluate the efficacy of complex interventions in healthcare.As few qualitative syntheses have been conducted,this study aimed to derive a new c...Objective:Qualitative research on therapeutic components is necessary to evaluate the efficacy of complex interventions in healthcare.As few qualitative syntheses have been conducted,this study aimed to derive a new conceptual framework for understanding the components of complex interventions and provide evidence for the implementation and evaluation of complex healthcare interventions.Methods:A systematic search of seven databases was conducted to identify qualitative studies that explored components of complex healthcare interventions.Meta-ethnography was used to analyze the data and thematic analysis was used to build the conceptual framework.Results:Of the 35 included studies,most complex interventions were non-pharmacological,with cancer accounting for 22%,mental health for 14%,and stroke for 8%.Half of the studies were conducted in the United Kingdom.Three main categories emerged:what should healthcare workers do?what qualifications should they have?and what should patients do?Five main themes were identified:psychological,biological,cognitive and behavioral,environmental,and social support.Conclusion:This analysis provides a reference for designing components of complex interventions in further studies.展开更多
BACKGROUND Lisfranc injuries have not received much attention by orthopedic doctors in the past,and there is little related research on the diagnosis and treatment of these injuries.In recent years with the rise in fo...BACKGROUND Lisfranc injuries have not received much attention by orthopedic doctors in the past,and there is little related research on the diagnosis and treatment of these injuries.In recent years with the rise in foot and ankle surgery,doctors are now paying more attention to this type of injury.However,there is still a high rate of missed diagnosis due to insufficient attention causing treatment delays or inadequate treatments,which eventually result in greater sequelae;including long-term pain,arthritis,foot deformity etc.In particular,for cases with a mild Lisfranc joint complex injury,the incidence of sequelae is higher.AIM To select an active surgical treatment for an atypical Lisfranc joint complex injury and to evaluate the clinical efficacy of the surgical treatment.METHODS The clinical data of 18 patients,including 10 males and 8 females aged 20-64 years with Lisfranc injuries treated in our department from January 2017 to September 2019 were retrospectively analyzed.All patients were treated with an open reduction and internal fixation method using locking titanium mini-plates and hollow screws or Kirschner wires.X-ray images were taken and follow-up was performed monthly after the operation;the internal fixation was then removed 4-5 mo after the operation;and the American Orthopedic Foot and Ankle Society(AOFAS)score was used for evaluation on the last follow-up.RESULTS All patients were followed up for 6-12 mo.A good/excellent AOFAS score was observed in 88.9%of patients.CONCLUSION For atypical Lisfranc joint complex injuries,active open reduction and internal fixation can be performed to enable patients to obtain a good prognosis and satisfactory functional recovery.展开更多
This paper puts forward a complex inner product averaging method for calculating normal form of ODE. Compared with conventional averaging method, the theoretic analytical process has such simple forms as to realize co...This paper puts forward a complex inner product averaging method for calculating normal form of ODE. Compared with conventional averaging method, the theoretic analytical process has such simple forms as to realize computer program easily. Results can be applied in both autonomous and non-autonomous systems. At last, an example is resolved to verify the method.展开更多
Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in a...Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in association with rotations or radial/ulnar deviations.In order to treat professional athletes,a detailed specific knowledge of the pathology is needed.Moreover,the clinician should fully understand the specific and unique environment and needs of the athletes,their priorities and goals,the type of sport,the time of the season,and the position played.An early diagnosis and appropriate management with the quickest possible recovery time are the uppermost goals for both the athlete and the surgeon.A compromise between conservative vs surgical indications,athletes’needs and expectations,and financial implications should be achieved.Arthroscopic procedures should be timely planned when indicated as they could allow early diagnosis and treatment at the same time.Conservative measures are often used as first line treatment when possible.Peripheral lesions are treated by arthroscopic repair,whilst central lesions are treated by arthroscopic debridement.Further procedures(such as the Wafer procedure,ulnar osteotomies,etc.)have specific indications and great implications with regard to rehabilitation.展开更多
Metabolic reprogramming,a newly recognized trait of tumor biology,is an intensively studied prospect for oncology medicines.For numerous tumors and cancer cell subpopulations,oxidative phosphorylation(OXPHOS)is essent...Metabolic reprogramming,a newly recognized trait of tumor biology,is an intensively studied prospect for oncology medicines.For numerous tumors and cancer cell subpopulations,oxidative phosphorylation(OXPHOS)is essential for their biosynthetic and bioenergetic functions.Cancer cells with mutations in isocitrate dehydrogenase 1(IDH1)exhibit differentiation arrest,epigenetic and transcriptional reprogramming,and sensitivity to mitochondrial OXPHOS inhibitors.In this study,we report that berberine,which is widely used in China to treat intestinal infections,acted solely at the mitochondrial electron transport chain(ETC)complex I,and that its association with IDH1 mutant inhibitor(IDH1^(m)i)AG-120 decreased mitochondrial activity and enhanced antileukemic effect in vitro and in vivo.Our study gives a scientific rationale for the therapy of IDH1 mutant acute myeloid leukemia(AML)patients using combinatory mitochondrial targeted medicines,particularly those who are resistant to or relapsing from IDH1m i.展开更多
Since Manufacturing Execution System (MES) is a bridge which links the upper planning system of the enterprise and the control system of the shop floor, various kinds of the information with different characteristics ...Since Manufacturing Execution System (MES) is a bridge which links the upper planning system of the enterprise and the control system of the shop floor, various kinds of the information with different characteristics flow through the system. The information environment of MES and its effect on MES scheduling are analyzed. A methodological proposal is given to address the problem of agile scheduling in a complex information environment, based on which a microeconomic market and game theoretic model-based scheduling approach is presented. The future development of this method is also discussed.展开更多
The Proterozoic Miaowan Ophiolite Complex is a highly dismembered ophiolitic complex cropping out near the northern margin of the Yangtze Craton(Peng et al.,2012).The rocks of this complex consist of,from bottom
The FT-IR spectra for K_2NbF_7-FLINAK-O^(2-) solution were measured and compared with the spectra of crystalline K_2NbF_7 and K_2NbOF_6.The results show that the niobium fluoro-complex and/or oxyfluoro-complex ions ar...The FT-IR spectra for K_2NbF_7-FLINAK-O^(2-) solution were measured and compared with the spectra of crystalline K_2NbF_7 and K_2NbOF_6.The results show that the niobium fluoro-complex and/or oxyfluoro-complex ions are presented in these solutions.NbF_7^(2-) complex ion is the predominant species in Nb(V)-FLINAK solution(not considering oxide impurity).The influence of O^(2-) on the oxyfluoro-complex ions shows that NbOF_6^(3-) as a stable monooxyfluoro-complex anion presented in FLINAK-O^(2-) systems and the number of NbOF_6^(3-) species are increased with increasing of O^(2-) when molar ratio of O^(2-)/Nb(V) is less than 1.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.52222112,52101151 and 52101135)Hong Kong Research Grant Council(RGC)(No.C1020-21G)+1 种基金Shenzhen Science and Technology Program(No.RCBS20210609103202012)APT research was conducted at the Inter-University 3D APT Unit of City University of Hong Kong(CityU),which is supported by the CityU grant 9360161
文摘Developing chemically complex intermetallic alloys(CCIMAs)is considered an effective strategy for overcoming the serious brittleness of conventional intermetallic alloys,especially under a high stress level.However,most CCIMAs still struggle to achieve yield strengths exceeding gigapascals,limiting their use as reliable structural materials in many engineering fields.
基金supported by the Taishan Scholars Program of Shandong Province(tsqn202312344).
文摘Multiple sclerosis (MS) is characterized by chronic,slowly expanding lesions with the accumulation of myeloid cells,which lead to brain atrophy and progressive disability.The role of mitochondria,especially mitochondrial respiratory complexes and metabolites,in controlling myeloid immune responses,is well-documented but not fully understood in diseases of the central nervous system (CNS).The groundbreaking study by Prof.Peruzzotti-Jametti et al.[1],entitled"Mitochondrial complexⅠactivity in microglia sustains neuroinflammation"published in Nature,delves into the intricate dynamics between mitochondrial function within microglia and the perpetuation of chronic neuroinflammation,specifically in MS.The core point of their investigation is the hypothesis that mitochondrial complexⅠ(CI) activity,through a mechanism known as reverse electron transport (RET),generates reactive oxygen species (ROS) in microglia,thereby sustaining inflammatory response in the CNS.This increases ROS production from the mitochondria,which is thought to be a crucial factor in the maintenance of a pro-inflammatory state in the microglia,contributing to the pathology of MS and similar neuroinflammatory diseases.
基金financially supported by the National Natural Science Foundation of China(No.21172269)the Fundamental Research Funds for the Central Universities,SouthCentral Minzu University(No.CZH24005)。
文摘Binuclear complexes have attracted extensive attention in fields such as catalysis because of their likely bimetallic synergistic effect;however,the mechanism and factors influencing this synergism remain unclear.In this work,six bis-β-ketoimine binuclear titanium complexes4a-4f containing different alkylthio sidearms and configurations were synthesized and characterized by nuclear magnetic resonance hydrogen spectrum(~1H-NMR),nuclear magnetic resonance carbon spectrum(^(13)C-NMR),Fourier transform infrared spectrum(FTIR),and elemental analysis.The intermetallic distances of isomeric complexes 4a,4d,4e and 4f determined through density functional theory(DFT)optimization were in the order 4a<4d<4e<4f and were found to significantly influence the catalytic performance for ethylene(co)polymerization.These complexes could efficiently catalyze ethylene polymerization and ethylene/1-hexene or ethylene/1-octene copolymerization with high activity to produce highmolecular-weight ethylene homo-and co-polymers.Among the three binuclear titanium complexes 4a-4c with similar structures but different lengths of alkylthio sidearms,complex 4a,which contained the shortest methylthio sidearm,exhibited the highest activity for ethylene polymerization and copolymerization with 1-hexene or 1-octene.Additionally,for ethylene/1-hexene or ethylene/1-octene copolymerization,it showed the highest comonomer incorporation compared with propylthio(4b)and octylthio(4c)derivatives because of the smaller steric hindrance of the methyl group in 4a and the more open coordination space for vinyl monomers.Furthermore,among the isomeric complexes 4a,4d,4e and4f,complex 4a with the shortest bimetallic distance also exhibited the highest activity towards ethylene(co)polymerization,and the highest 1-hexene or 1-octene incorporation in comparison with its regioisomeric counterparts 4d,4e and p-phenyl-bridged analog 4f,owing to a more appropriate bimetallic distance that is conducive to a synergistic effect.
基金funded by the National Natural Science Foundation of China(Nos.52039005,52371258,52071031)the Tianjin Science and Technology Plan Project(No.22PTZWHZ00060)the Subtopic of National Key Research and Development Program Projects(No.2022YFB2602301).
文摘The complex topography of natural bedrock shorelines on islands necessitates detailed model testing to thoroughly inves-tigate wave overtopping mechanisms and their variation patterns.This understanding is vital for optimizing the elevation of coastal structures to meet the design requirements for wave overtopping and to ensure safety and efficacy.This paper investigates a nuclear power plant project on an island in Zhejiang Province,China.This study employs small-scale overall model tests and large-scale lo-cal model tests to examine the complex dynamics of wave interaction with the island’s shoreline.It analyzes the influences of wave parameters,shoreline geometry,and underwater topography on wave overtopping behavior.Comparisons between physical model re-sults and empirical formulae reveal substantial discrepancies in overtopping rates across different model scales.The results stress the remarkable effect of accurate underwater topography representation on wave overtopping predictions and emphasize the need for pre-cise topographic modeling.The results also show that overtopping discharges for complex terrains deviate considerably from values determined using traditional empirical formulas for breakwater overtopping.This outcome indicates that conventional methods may insufficiently address the complexities of natural coastal features.To guarantee reliable predictions of overtopping volumes at specif-ic elevations along complex coastlines,this study advocates employing physical modeling across numerous scales while accounting for detailed terrain and hydrodynamic characteristics.
基金supported by the National Natural Science Foundation of China(Grant Nos.42272244 and 91755212)Taishan Scholars(Grant No.ts20190918).
文摘Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic and whole-rock geochemical data,we report the first discovery of a latest Cambrian–Early Ordovician forearc-arc rock sequence in the Eastern Alps.This sequence includes granitic gneisses,amphibolites,and amphibole plagiogneisses from the ophiolitic Speik Complex and Gleinalpe Complex.These rocks exhibit geochemical affinities with typical oceanic plagiogranites,forearc basalts(FABs),and island arc basalts,respectively.The latest Cambrian plagiogranitic protoliths(491±2 Ma)are shearing-type plagiogranites that were formed in the tectonic setting of forearc spreading.The latest Cambrian FABs(496–489 Ma)have similar geochemical compositions and positiveεHf(t)values(+2.5 to+14.9)to the depleted mid-ocean ridge basalts.However,they show depletion in high field strength elements(HFSEs;e.g.,Nb,Ta,and Zr)and have relatively low Ti/V ratios.These features suggest that they were derived from a depleted mantle source modified by subducting slab-released components in a forearc environment.The Early Ordovician basaltic protoliths(476–472 Ma)of amphibole plagiogneisses show enrichment in large ion lithophile elements and depletion in HFSEs(e.g.Nb,Ta,Zr,and Hf),implying a mature island arc environment.These metaigneous rocks,along with the coeval boninite-like high-Mg amphibolites near the study area,form a typical rock sequence resembling that of the Izu–Bonin–Mariana(IBM)arc system.The Speik and Gleinalpe complexes document a complete magmatic evolution from subduction initiation to mature arc development within the West Proto-Tethys Ocean.Integrating our new data with published work,we reconstruct the late Ediacaran–early Paleozoic tectonic evolution of the northern Gondwana.During the late Ediacaran–early Cambrian,the rollback of the West Proto-Tethys oceanic plate triggered the separation of the Wechsel-Silvretta-Gleinalpe continental arc from the northern Gondwana.This process led to the formation of the Speik back-arc oceanic basin,a southwestern branch of the West Proto-Tethys Ocean.In the latest Cambrian–Early Ordovician,subduction initiation occurred in the Speik Ocean,which subsequently developed into an intra-oceanic arc system.During the Early Devonian,the Speik Ocean closed and the Wechsel-Silvretta-Gleinalpe continental arc reattached to the Gondwana,as evidenced by the metamorphic event at ca.400 Ma.
基金the National Key Research and Development Program of China(No.2018YFB1305005)。
文摘Passive optical motion capture technology is an effective mean to conduct high-precision pose estimation of small scenes of mobile robots;nevertheless,in the case of complex background and stray light interference in the scene,due to the infuence of target adhesion and environmental reflection,this technology cannot estimate the pose accurately.A passive binocular optical motion capture technology under complex illumination based on binocular camera and fixed retroreflective marker balls has been proposed.By fixing multiple hemispherical retrorefective marker balls on a rigid base,it uses binocular camera for depth estimation to obtain the fixed position relationship between the feature points.After performing unsupervised state estimation without manual operation,it overcomes the infuence of refection spots in the background.Meanwhile,contour extraction and ellipse least square fitting are used to extract the marker balls with incomplete shape as the feature points,so as to solve the problem of target adhesion in the scene.A FANUC m10i-a robot moving with 6-DOF is used for verification using the above methods in a complex lighting environment of a welding laboratory.The result shows that the average of absolute position errors is 5.793mm,the average of absolute rotation errors is 1.997°the average of relative position errors is 0.972 mm,and the average of relative rotation errors is 0.002°.Therefore,this technology meets the requirements of high-precision measurement in a complex lighting environment when estimating the 6-DOF-motion mobile robot and has very significant application prospects in complex scenes.
基金supported by the project China Geological Survey(DD202501026090)the National Key Research and Development Program of China(2024YFC2910102).
文摘Lishiite,(Ca_(2)□)Sr_(3)(CO_(3))_(5),is a new mineral species from Shaxiongdong,Hubei Province,China.It mainly occours as conchoidal crystals and with combination of hexagonal prism and pyramid and is associated with calcite,K-feldspar,albite,aegirine,apatite,and ancylite-(Ce)(?)and strontianite etc.Lishiite is brittle with conchiform fracture and has a Mohs hardness of approximately 4 and none cleavages were observed.The Vickers microhardness(VHN10)is 197.42 kg/mm^(2)(range:166.88 kg/mm^(2) to 214.58 kg/mm^(2)),and the calculated density of lishiite is 3.696 g/cm3.Hand specimen of lishiite are yellow-brown.The empirical chemical formula of the lishiite is ^(A)(Ca_(1.18)Sr_(0.25)Na_(0.19□1.38))_(Σ3.00)^( B)[Sr_(2.17)(Ce_(0.42)La_(0.24)Nd_(0.09)Eu_(0.01))_(Σ0.76) Ba_(0.07)]_(Σ3.00)(C_(5.05)O_(15)).As a member of the burbankite group,the general formula of lishiite follows the general formula A_(3)B_(3)(CO_(3))_(5),where A=Na,Ca,or and B=Sr,Ba,REE,or Ca.Its crystal structure is hexagonal(space group P6_(3)mc)with unit cell parameters a=10.4898(5)Å,c=6.4167(5)Å,and V=611.47(6)Å^(3),characterized by layers of AO_(8) and BO_(10) polyhedra connected to[CO_(3)]^(3−)groups.The discovery of lishiite provides new insights into the evolutionary history of rare earth element(REE)carbonate deposit formation.
基金Sponsored by National Key Technology Research and Development Program of China(2008BAB32B05)Postdoctoral Science Foundation of China(2012m510320)
文摘The kinetics of isothermal reduction of the carbon bearing pellets, which were mainly composed of Bayanobo complex iron ore and pulverized coal, was investigated by thermogravimetry at the temperature of 1 273-1 673 K. The effects of xC/xO and the atmospheres on the extent of reduction also were investigated. The results indicate that the fractional reaction increased proportionally with temperature increasing and heating temperature is the significant influence factor to the reaction of carbon bearing pellets. The optimum xC/xO is 1.2 and the effect of atmosphere on the reduction of iron oxides is almost negligible. The results can be interpreted that the reaction was initially controlled by a mixed controlled mechanism of carbon gasification and interface chemical reaction, and in the later stage, interface chemical reaction became the rate-controlling step. Apparent activation energy values of reduction at different levels of fractional reaction were calculated. Before F （fraction of reaction）=0.5, the apparent activation energy ranges from 66.39 to 75.64 kJ/mol, while after F=0.5, the apparent activation energy is 80.98 to 85.37 kJ/mol.
基金Supported by the National Natural Science Foundation of China,No.81971943,No.81772196,No.31470264,No.81271820,No.30870789,and No.30300117the Stanley Foundation of United States,No.06R-1366(for Zhu F)the Medical Science Advancement Program(Basic Medical Sciences)of Wuhan University,No.TFJC 2018002.
文摘BACKGROUND Schizophrenia afflicts 1%of the world population.Clinical studies suggest that schizophrenia patients may have an imbalance of mitochondrial energy metabolism via inhibition of mitochondrial complex I activity.Moreover,recent studies have shown that ERVWE1 is also a risk factor for schizophrenia.Nevertheless,there is no available literature concerning the relationship between complex I deficits and ERVWE1 in schizophrenia.Identifying risk factors and blood-based biomarkers for schizophrenia may provide new guidelines for early interventions and prevention programs.AIM To address novel potential risk factors and the underlying mechanisms of mitochondrial complex I deficiency caused by ERVWE1 in schizophrenia.METHODS Quantitative polymerase chain reaction(qPCR)and enzyme-linked immunosorbent assay were used to detect differentially expressed risk factors in blood samples.Clinical statistical analyses were performed by median analyses and Mann-Whitney U analyses.Spearman’s rank correlation was applied to examine the correlation between different risk factors in blood samples.qPCR,western blot analysis,and luciferase assay were performed to confirm the relationship among ERVWE1,cytoplasmic polyadenylation element-binding protein 1(CPEB1),NADH dehydrogenase ubiquinone flavoprotein 2(NDUFV2),and NDUFV2 pseudogene(NDUFV2P1).The complex I enzyme activity microplate assay was carried out to evaluate the complex I activity induced by ERVWE1.RESULTS Herein,we reported decreasing levels of CPEB1 and NDUFV2 in schizophrenia patients.Further studies showed that ERVWE1 was negatively correlated with CPEB1 and NDUFV2 in schizophrenia.Moreover,NDUFV2P1 was increased and demonstrated a significant positive correlation with ERVWE1 and a negative correlation with NDUFV2 in schizophrenia.In vitro experiments disclosed that ERVWE1 suppressed NDUFV2 expression and promoter activity by increasing NDUFV2P1 level.The luciferase assay revealed that ERVWE1 could enhance the promoter activity of NDUFV2P1.Additionally,ERVWE1 downregulated the expression of CPEB1 by suppressing the promoter activity,and the 400 base pair sequence at the 3′terminus of the promoter was the minimum sequence required.Advanced studies showed that CPEB1 participated in regulating the NDUFV2P1/NDUFV2 axis mediated by ERVWE1.Finally,we found that ERVWE1 inhibited complex I activity in SH-SY5Y cells via the CPEB1/NDUFV2P1/NDUFV2 signaling pathway.CONCLUSION In conclusion,CPEB1 and NDUFV2 might be novel potential blood-based biomarkers and pathogenic factors in schizophrenia.Our findings also reveal a novel mechanism of ERVWE1 in the etiology of schizophrenia.
文摘This article chronicles a failed research project.We designed and carried out a psychological intervention aimed at increasing esogastric and lung cancer patients’emotional competencies after treatments.We present the final protocol of the study,a randomized controlled trial in a public hospital,and describe the difficulties encountered and our subsequent reflections,to provide researchers and clinicians with advice for the implementation of such interventions.Firstly,the role of psychology,emotions,and emotional competencies,is still underacknowledged in cancer care.Pedagogical efforts must be made to convince both physicians and patients of the importance of those elements.Secondly and consequently,even distressed patients sure to benefit from such an intervention,do not take it up.In particular,male patients often declined the intervention due to gender stereotypes,and as such creativity is needed to present such interventions in a motivating way for patients.Finally,and most importantly,even if there is a good rationale for a psychological intervention and all favorable conditions are present,it is essential to first conduct a feasibility/pilot study.Indeed,even the most thorough preparation is no guarantee of anticipating all issues due to important gaps between theory and practice.
基金Natural Science Foundation of Beijing (Grant No. 7021001)the Foundation for the Special Program of the Following Novel Candidate Drug by Beijing S&T Committee (Grant No. H20220060190)National Natural Science Foundation (Grant No.30472036)
文摘In our previous study,a novel organic selenium compound Eb was synthesized and found to have significant antitumor activity with much less toxicity compared with the leading compound Ebselen.Unfortunately,Eb was practically insoluble in water （2.57 μg/mL） and had very low oral bioavailability,thus its clinical application was greatly limited.In the present study,the inclusion complex of Eb with 2-hydroxypropyl-β-cyclodextrin （HP-βCD） was prepared and pharmacokinetics of Eb and the inclusion complex were investigated.The water solubility of Eb was dramatically enhanced by inclusion with HP-βCD,which reached 8.4 mg/mL.The pharmacokinetic study showed that the elimination half-life （t 1/2β） of Eb was between 22 h and 30 h and the distribution half-life （t 1/2α） of Eb was 1 h.The results indicated that Eb was rapidly distributed to tissues but slowly eliminated in rats.The absolute bioavailability of Eb/HP-βCD inclusion complex solution through the oral route was 28.3%,and it was 1552% that of Eb in its pure form.In summary,the absorption of Eb in the Eb/HP-βCD inclusion complex was better and faster than that of Eb in its pure form.
基金the National Natural Science Foundation of China:Key Program(81830115)China and Overseas Expertise Project,Ministry of Education of the People’s Republic of China(G20190001122).
文摘Objective:Qualitative research on therapeutic components is necessary to evaluate the efficacy of complex interventions in healthcare.As few qualitative syntheses have been conducted,this study aimed to derive a new conceptual framework for understanding the components of complex interventions and provide evidence for the implementation and evaluation of complex healthcare interventions.Methods:A systematic search of seven databases was conducted to identify qualitative studies that explored components of complex healthcare interventions.Meta-ethnography was used to analyze the data and thematic analysis was used to build the conceptual framework.Results:Of the 35 included studies,most complex interventions were non-pharmacological,with cancer accounting for 22%,mental health for 14%,and stroke for 8%.Half of the studies were conducted in the United Kingdom.Three main categories emerged:what should healthcare workers do?what qualifications should they have?and what should patients do?Five main themes were identified:psychological,biological,cognitive and behavioral,environmental,and social support.Conclusion:This analysis provides a reference for designing components of complex interventions in further studies.
基金Science Foundation of Shenyang Medical College,No.20187076.
文摘BACKGROUND Lisfranc injuries have not received much attention by orthopedic doctors in the past,and there is little related research on the diagnosis and treatment of these injuries.In recent years with the rise in foot and ankle surgery,doctors are now paying more attention to this type of injury.However,there is still a high rate of missed diagnosis due to insufficient attention causing treatment delays or inadequate treatments,which eventually result in greater sequelae;including long-term pain,arthritis,foot deformity etc.In particular,for cases with a mild Lisfranc joint complex injury,the incidence of sequelae is higher.AIM To select an active surgical treatment for an atypical Lisfranc joint complex injury and to evaluate the clinical efficacy of the surgical treatment.METHODS The clinical data of 18 patients,including 10 males and 8 females aged 20-64 years with Lisfranc injuries treated in our department from January 2017 to September 2019 were retrospectively analyzed.All patients were treated with an open reduction and internal fixation method using locking titanium mini-plates and hollow screws or Kirschner wires.X-ray images were taken and follow-up was performed monthly after the operation;the internal fixation was then removed 4-5 mo after the operation;and the American Orthopedic Foot and Ankle Society(AOFAS)score was used for evaluation on the last follow-up.RESULTS All patients were followed up for 6-12 mo.A good/excellent AOFAS score was observed in 88.9%of patients.CONCLUSION For atypical Lisfranc joint complex injuries,active open reduction and internal fixation can be performed to enable patients to obtain a good prognosis and satisfactory functional recovery.
文摘This paper puts forward a complex inner product averaging method for calculating normal form of ODE. Compared with conventional averaging method, the theoretic analytical process has such simple forms as to realize computer program easily. Results can be applied in both autonomous and non-autonomous systems. At last, an example is resolved to verify the method.
文摘Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in association with rotations or radial/ulnar deviations.In order to treat professional athletes,a detailed specific knowledge of the pathology is needed.Moreover,the clinician should fully understand the specific and unique environment and needs of the athletes,their priorities and goals,the type of sport,the time of the season,and the position played.An early diagnosis and appropriate management with the quickest possible recovery time are the uppermost goals for both the athlete and the surgeon.A compromise between conservative vs surgical indications,athletes’needs and expectations,and financial implications should be achieved.Arthroscopic procedures should be timely planned when indicated as they could allow early diagnosis and treatment at the same time.Conservative measures are often used as first line treatment when possible.Peripheral lesions are treated by arthroscopic repair,whilst central lesions are treated by arthroscopic debridement.Further procedures(such as the Wafer procedure,ulnar osteotomies,etc.)have specific indications and great implications with regard to rehabilitation.
基金supported by Sichuan Science and Technology Program(No.2022YFS0622)the Science and Technology Development Fund,Macao SAR(Nos.0036/2020/A1 and 0013/2019/A1).
文摘Metabolic reprogramming,a newly recognized trait of tumor biology,is an intensively studied prospect for oncology medicines.For numerous tumors and cancer cell subpopulations,oxidative phosphorylation(OXPHOS)is essential for their biosynthetic and bioenergetic functions.Cancer cells with mutations in isocitrate dehydrogenase 1(IDH1)exhibit differentiation arrest,epigenetic and transcriptional reprogramming,and sensitivity to mitochondrial OXPHOS inhibitors.In this study,we report that berberine,which is widely used in China to treat intestinal infections,acted solely at the mitochondrial electron transport chain(ETC)complex I,and that its association with IDH1 mutant inhibitor(IDH1^(m)i)AG-120 decreased mitochondrial activity and enhanced antileukemic effect in vitro and in vivo.Our study gives a scientific rationale for the therapy of IDH1 mutant acute myeloid leukemia(AML)patients using combinatory mitochondrial targeted medicines,particularly those who are resistant to or relapsing from IDH1m i.
基金Supported by the National Natural Science Foundation of China(50105006 )National Hi-tech R&D Program of China (2001AA412140 and 2003AA411120)
文摘Since Manufacturing Execution System (MES) is a bridge which links the upper planning system of the enterprise and the control system of the shop floor, various kinds of the information with different characteristics flow through the system. The information environment of MES and its effect on MES scheduling are analyzed. A methodological proposal is given to address the problem of agile scheduling in a complex information environment, based on which a microeconomic market and game theoretic model-based scheduling approach is presented. The future development of this method is also discussed.
文摘The Proterozoic Miaowan Ophiolite Complex is a highly dismembered ophiolitic complex cropping out near the northern margin of the Yangtze Craton(Peng et al.,2012).The rocks of this complex consist of,from bottom
文摘The FT-IR spectra for K_2NbF_7-FLINAK-O^(2-) solution were measured and compared with the spectra of crystalline K_2NbF_7 and K_2NbOF_6.The results show that the niobium fluoro-complex and/or oxyfluoro-complex ions are presented in these solutions.NbF_7^(2-) complex ion is the predominant species in Nb(V)-FLINAK solution(not considering oxide impurity).The influence of O^(2-) on the oxyfluoro-complex ions shows that NbOF_6^(3-) as a stable monooxyfluoro-complex anion presented in FLINAK-O^(2-) systems and the number of NbOF_6^(3-) species are increased with increasing of O^(2-) when molar ratio of O^(2-)/Nb(V) is less than 1.
