1 Introduction Single-cell analyses have rapidly emerged as powerful tools for studying cellular heterogeneity,gene regulation,and complex biological processes[1].A key technology of singlecell analyses is single-cell...1 Introduction Single-cell analyses have rapidly emerged as powerful tools for studying cellular heterogeneity,gene regulation,and complex biological processes[1].A key technology of singlecell analyses is single-cell chromatin accessibility sequencing(scCAS)which enables the analysis of chromatin accessibility at the resolution of individual cells[2],providing unprecedented insights into gene regulation,cellular differentiation,and disease mechanisms by profiling key regulatory regions such as transcription factor binding sites,enhancers,and promoters.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.62473212,62203236)the Young Elite Scientists Sponsorship Program by CAST[2023QNRC001].
文摘1 Introduction Single-cell analyses have rapidly emerged as powerful tools for studying cellular heterogeneity,gene regulation,and complex biological processes[1].A key technology of singlecell analyses is single-cell chromatin accessibility sequencing(scCAS)which enables the analysis of chromatin accessibility at the resolution of individual cells[2],providing unprecedented insights into gene regulation,cellular differentiation,and disease mechanisms by profiling key regulatory regions such as transcription factor binding sites,enhancers,and promoters.
