Xia et al.recently reported that during obesity-related psoriasis,saturated fatty acids(SFAs)are increased and promote neutrophil extracellular net(NET)release through the TLR-4-MD2/ROS signaling pathway,which in turn...Xia et al.recently reported that during obesity-related psoriasis,saturated fatty acids(SFAs)are increased and promote neutrophil extracellular net(NET)release through the TLR-4-MD2/ROS signaling pathway,which in turn exacerbates psoriasis progression and diminishes the efficacy of current pharmacological therapies.Hence,this study helps elucidate how obesity exacerbates psoriasis and highlights NET inhibition as a potential complementary therapeutic strategy in obese psoriasis patients.展开更多
文摘Xia et al.recently reported that during obesity-related psoriasis,saturated fatty acids(SFAs)are increased and promote neutrophil extracellular net(NET)release through the TLR-4-MD2/ROS signaling pathway,which in turn exacerbates psoriasis progression and diminishes the efficacy of current pharmacological therapies.Hence,this study helps elucidate how obesity exacerbates psoriasis and highlights NET inhibition as a potential complementary therapeutic strategy in obese psoriasis patients.
