The NLRP3 inflammasome plays a critical role in various inflammatory conditions.However,despite extensive research in targeted drug development for NLRP3,including MCC950,clinical success remains elusive.Here,we disco...The NLRP3 inflammasome plays a critical role in various inflammatory conditions.However,despite extensive research in targeted drug development for NLRP3,including MCC950,clinical success remains elusive.Here,we discovered that the activated NLRP3 inflammasome complex(disc-NLRP3)and the activating mutation L351P exhibited resistance to MCC950.Through investigations using the small-molecule compound polydatin,HSP90αwas found to stabilize both the resting(cage-NLRP3)and activated state(disc-NLRP3)of NLRP3 complexes,sustaining its activation.Our mechanistic studies revealed that polydatin specifically targets HSP90α,binding to it directly and subsequently interfering with the HSP90α-NLRP3 interaction.This disruption leads to the dissipation of cage-NLRP3,disc-NLRP3 complexes and NLRP3 L351P.Importantly,genetic and pharmacological inactivation of HSP90αeffectively reduced NLRP3 inflammasome activation and alleviated cerulein-induced acute pancreatitis.These therapeutic effects highlight the clinical potential of HSP90αinhibition.Our findings demonstrate that HSP90αis crucial for the stability of both the resting and activated states of the NLRP3 inflammasome during its sustained activation,and targeting HSP90αrepresents a promising therapeutic strategy for diseases driven by the NLRP3 inflammasome.展开更多
We classify all the indecomposable modules of dimension ≤ 5 over the quantum exterior algebra k(x, y)/(x^2, y^2, xy + qyx) in two variables, and all the indecomposable modules of dimension ≤3 over the quantum comple...We classify all the indecomposable modules of dimension ≤ 5 over the quantum exterior algebra k(x, y)/(x^2, y^2, xy + qyx) in two variables, and all the indecomposable modules of dimension ≤3 over the quantum complete intersection k(x,y)/(x^m,y^n,xy + qyx) in two variables, where m or n ≥3, by giving explicitly their diagram presentations.展开更多
Quantum dynamical maps are defined and studied for quantum statistical physics based on Orlicz spaces.This complements earlier work[26]where we made a strong case for the assertion that statistical physics of regular ...Quantum dynamical maps are defined and studied for quantum statistical physics based on Orlicz spaces.This complements earlier work[26]where we made a strong case for the assertion that statistical physics of regular systems should properly be based on the pair of Orlicz spaces(Lcosh-1,L log(L+1)),since this framework gives a better description of regular observables,and also allows for a well-defined entropy function.In the present paper we"complete"the picture by addressing the issue of the dynamics of such a system,as described by a Markov semigroup corresponding to some Dirichlet form(see[4,13,14]).Specifically,we show that even in the most general non-commutative contexts,completely positive Markov maps satisfying a natural Det ailed Balance condition canonically admit an action on a large class of quantum Orlicz spaces.This is achieved by the development of a new interpolation strategy for extending the action of such maps to the appropriate intermediate spaces of the pair(L∞,L1).As a consequence,we obtain that completely positive quantum Markov dynamics naturally extends to the context proposed in[26].展开更多
The East Kunlun terrain is located on the northern Qinghai—Tibet plateau, composed of the East Kunlun Mountain and the Qaidam Basin and bounded by the Qilian terrain on the north and Bayanhar—Songpan Ganze terrain o...The East Kunlun terrain is located on the northern Qinghai—Tibet plateau, composed of the East Kunlun Mountain and the Qaidam Basin and bounded by the Qilian terrain on the north and Bayanhar—Songpan Ganze terrain on the south. It is regarded as a composite orogenic belt characterized by having developed superimposed ductile tectonic regimes reflecting the collision orogeny during Early Paleozoic and Triassic periods. It has also experienced transformation from ductile to brittle deformation caused by the post orogeny, since Jurassic after the formation of the East Kunlun Mountain and the Qaidam Basin. A Paleozoic subduction complex zone was recently recognized along the north border of the East Kunlun terrain from Da Qaidam to Dulan (Xu,et al, 1 999). It is composed of ophiolite (of Early Paleozoic age?), tectonic melange and very high\|pressure metamorphic rocks with eclogite (\%p\%=2 2GPa, \%t\%=720℃) (Yang,et al.,1998) and garnet\|peridotite (\%p\%=2 5GPa, t =837℃). The Anyemaqin Triassic subduction complex zone trending in NWW\|SEE was developed along the eastern segment of the south border of the East Kunlun terrain. It is mainly composed of ultramafic and mafic rocks, pillow basalt, radiolaria\|bearing clastic rocks, tectonic melange and mylonite. The subduction complex zone contains a series of the southward overthrusting imbricated slices. Instead of this subduction complex zone, a 2 km\|wide sinistral strike\|slip ductile shear zone trending in E\|W was developed along the western segment. On the basis of macroscopic and microscopic studies on a series of structural sections, we divide the East Kunlun Mountain into four tectonic units as follows: (1) North Proterozoic Metamorphic Basement Zone; (2) South Early Paleozoic—Triassic Superimposed Fold Zone; (3) South Triassic Transpression Zone; (4) Anyemaqin Back\|Arc Decollement\|Thrust Zone.展开更多
https://www.sciencedirect.com/journal/applied-energy/vol/291/suppl/C Volume 291,1 June 2021(1) Identification of key performance indicators and complimentary load profiles for 5th generation district energy networks,b...https://www.sciencedirect.com/journal/applied-energy/vol/291/suppl/C Volume 291,1 June 2021(1) Identification of key performance indicators and complimentary load profiles for 5th generation district energy networks,by Michael-Allan Millar,Zhibin Yu,Neil Burnside,Greg Jones,Bruce Elrick,Article 116672.展开更多
In a science class of the second semester on the third grade,I received four silkworms from my science teacher.At first,I looked at the caterpillars like black baby silkworms,and I didn’t dare to touch them.However,w...In a science class of the second semester on the third grade,I received four silkworms from my science teacher.At first,I looked at the caterpillars like black baby silkworms,and I didn’t dare to touch them.However,when I saw them in the humble box I built,not minding the humbleness and the narrow space of the“house”and living hard;when I saw them not afraid of food mulberry leaves in huge contrast of their body size,and tirelessly willing to be“foodie”;when I saw them clumsily crawling forward in spite of their slow footsteps;when I saw their diligent efforts to grow plump at an amazing speed and still not complacent wanting to grow further,I didn’t fear them anymore.I found that they were very cute,and I affectionately called them Silkworm Babies.展开更多
Objective: to analyze the effect of continuous midwifery nursing and routine nursing on vaginal trial labor. Methods: the sample size was 90 cases, all of which were pregnant women with scar uterus. They were randomly...Objective: to analyze the effect of continuous midwifery nursing and routine nursing on vaginal trial labor. Methods: the sample size was 90 cases, all of which were pregnant women with scar uterus. They were randomly divided into control group and observation group. Routine intervention was applied in the control group, and continuous midwifery intervention was applied in the whole process of observation group. Results: observation group were significantly better, P < 0.05. Conclusion: the whole process of continuous midwifery nursing effect is better.展开更多
Let E: C^n→C^n be an exponential system, where C^n is an n-dimensional complex space. By an exponential system we mean that each term in every equation is of the
The operator T=UP on ttilbert space is called ψ-quasi-hyponormal, if it satisfies ψ(P)—U_ψ(P)U=D_ψ≥0. For the invertible ψ-quasi-hyponormal operator T and the scale function ψ satisfying the condition that the...The operator T=UP on ttilbert space is called ψ-quasi-hyponormal, if it satisfies ψ(P)—U_ψ(P)U=D_ψ≥0. For the invertible ψ-quasi-hyponormal operator T and the scale function ψ satisfying the condition that the function t/ψ(t) is展开更多
Case history A 66-year-old woman presented with a 10-month history of gradually increasing fatigue,lethargy,weight gain,constipation,and difficulty coping with the cold winter.She feels like sitting by the fire and do...Case history A 66-year-old woman presented with a 10-month history of gradually increasing fatigue,lethargy,weight gain,constipation,and difficulty coping with the cold winter.She feels like sitting by the fire and doing noth-ing.She tends to sleep excessively.She also complains of chest tightness and shortness of breath on exertion,such as when she hurries to catch a bus.展开更多
"During the 11th Five-Year Plan period,China’s copper processing industry advanced by leaps and bounds,nevertheless it still lagged far behind international standards.The industry was plagued by low industrial c..."During the 11th Five-Year Plan period,China’s copper processing industry advanced by leaps and bounds,nevertheless it still lagged far behind international standards.The industry was plagued by low industrial concentration,fierce competition of similar mid/low-end products and lack of high-speed and high-precision展开更多
On September 9th, 2009, AstraZeneca Chinaheld the ground-breaking ceremony for its newsite in Zhangjiang High-Tech Park, which isalso known as China’s medicine valley. Oncethe construction is completed, AstraZenecawi...On September 9th, 2009, AstraZeneca Chinaheld the ground-breaking ceremony for its newsite in Zhangjiang High-Tech Park, which isalso known as China’s medicine valley. Oncethe construction is completed, AstraZenecawill be based in the Zhangjiang Site and bringthe innovation capabilities of Shanghai’s modernbioengineering and pharmaceutical industryto new heights by its great collaborationtradition and unique strength in展开更多
基金supported by the National Natural Science Foundation of China(82273933,82073856,82230116,and 82473929)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(no.ZYYCXTD-C-202208)Fundamental Research Funds for the Central Universities(020814380199).
文摘The NLRP3 inflammasome plays a critical role in various inflammatory conditions.However,despite extensive research in targeted drug development for NLRP3,including MCC950,clinical success remains elusive.Here,we discovered that the activated NLRP3 inflammasome complex(disc-NLRP3)and the activating mutation L351P exhibited resistance to MCC950.Through investigations using the small-molecule compound polydatin,HSP90αwas found to stabilize both the resting(cage-NLRP3)and activated state(disc-NLRP3)of NLRP3 complexes,sustaining its activation.Our mechanistic studies revealed that polydatin specifically targets HSP90α,binding to it directly and subsequently interfering with the HSP90α-NLRP3 interaction.This disruption leads to the dissipation of cage-NLRP3,disc-NLRP3 complexes and NLRP3 L351P.Importantly,genetic and pharmacological inactivation of HSP90αeffectively reduced NLRP3 inflammasome activation and alleviated cerulein-induced acute pancreatitis.These therapeutic effects highlight the clinical potential of HSP90αinhibition.Our findings demonstrate that HSP90αis crucial for the stability of both the resting and activated states of the NLRP3 inflammasome during its sustained activation,and targeting HSP90αrepresents a promising therapeutic strategy for diseases driven by the NLRP3 inflammasome.
文摘We classify all the indecomposable modules of dimension ≤ 5 over the quantum exterior algebra k(x, y)/(x^2, y^2, xy + qyx) in two variables, and all the indecomposable modules of dimension ≤3 over the quantum complete intersection k(x,y)/(x^m,y^n,xy + qyx) in two variables, where m or n ≥3, by giving explicitly their diagram presentations.
基金supported by the National Research Foundation(IPRR Grant 96128).
文摘Quantum dynamical maps are defined and studied for quantum statistical physics based on Orlicz spaces.This complements earlier work[26]where we made a strong case for the assertion that statistical physics of regular systems should properly be based on the pair of Orlicz spaces(Lcosh-1,L log(L+1)),since this framework gives a better description of regular observables,and also allows for a well-defined entropy function.In the present paper we"complete"the picture by addressing the issue of the dynamics of such a system,as described by a Markov semigroup corresponding to some Dirichlet form(see[4,13,14]).Specifically,we show that even in the most general non-commutative contexts,completely positive Markov maps satisfying a natural Det ailed Balance condition canonically admit an action on a large class of quantum Orlicz spaces.This is achieved by the development of a new interpolation strategy for extending the action of such maps to the appropriate intermediate spaces of the pair(L∞,L1).As a consequence,we obtain that completely positive quantum Markov dynamics naturally extends to the context proposed in[26].
文摘The East Kunlun terrain is located on the northern Qinghai—Tibet plateau, composed of the East Kunlun Mountain and the Qaidam Basin and bounded by the Qilian terrain on the north and Bayanhar—Songpan Ganze terrain on the south. It is regarded as a composite orogenic belt characterized by having developed superimposed ductile tectonic regimes reflecting the collision orogeny during Early Paleozoic and Triassic periods. It has also experienced transformation from ductile to brittle deformation caused by the post orogeny, since Jurassic after the formation of the East Kunlun Mountain and the Qaidam Basin. A Paleozoic subduction complex zone was recently recognized along the north border of the East Kunlun terrain from Da Qaidam to Dulan (Xu,et al, 1 999). It is composed of ophiolite (of Early Paleozoic age?), tectonic melange and very high\|pressure metamorphic rocks with eclogite (\%p\%=2 2GPa, \%t\%=720℃) (Yang,et al.,1998) and garnet\|peridotite (\%p\%=2 5GPa, t =837℃). The Anyemaqin Triassic subduction complex zone trending in NWW\|SEE was developed along the eastern segment of the south border of the East Kunlun terrain. It is mainly composed of ultramafic and mafic rocks, pillow basalt, radiolaria\|bearing clastic rocks, tectonic melange and mylonite. The subduction complex zone contains a series of the southward overthrusting imbricated slices. Instead of this subduction complex zone, a 2 km\|wide sinistral strike\|slip ductile shear zone trending in E\|W was developed along the western segment. On the basis of macroscopic and microscopic studies on a series of structural sections, we divide the East Kunlun Mountain into four tectonic units as follows: (1) North Proterozoic Metamorphic Basement Zone; (2) South Early Paleozoic—Triassic Superimposed Fold Zone; (3) South Triassic Transpression Zone; (4) Anyemaqin Back\|Arc Decollement\|Thrust Zone.
文摘https://www.sciencedirect.com/journal/applied-energy/vol/291/suppl/C Volume 291,1 June 2021(1) Identification of key performance indicators and complimentary load profiles for 5th generation district energy networks,by Michael-Allan Millar,Zhibin Yu,Neil Burnside,Greg Jones,Bruce Elrick,Article 116672.
文摘In a science class of the second semester on the third grade,I received four silkworms from my science teacher.At first,I looked at the caterpillars like black baby silkworms,and I didn’t dare to touch them.However,when I saw them in the humble box I built,not minding the humbleness and the narrow space of the“house”and living hard;when I saw them not afraid of food mulberry leaves in huge contrast of their body size,and tirelessly willing to be“foodie”;when I saw them clumsily crawling forward in spite of their slow footsteps;when I saw their diligent efforts to grow plump at an amazing speed and still not complacent wanting to grow further,I didn’t fear them anymore.I found that they were very cute,and I affectionately called them Silkworm Babies.
文摘Objective: to analyze the effect of continuous midwifery nursing and routine nursing on vaginal trial labor. Methods: the sample size was 90 cases, all of which were pregnant women with scar uterus. They were randomly divided into control group and observation group. Routine intervention was applied in the control group, and continuous midwifery intervention was applied in the whole process of observation group. Results: observation group were significantly better, P < 0.05. Conclusion: the whole process of continuous midwifery nursing effect is better.
文摘Let E: C^n→C^n be an exponential system, where C^n is an n-dimensional complex space. By an exponential system we mean that each term in every equation is of the
文摘The operator T=UP on ttilbert space is called ψ-quasi-hyponormal, if it satisfies ψ(P)—U_ψ(P)U=D_ψ≥0. For the invertible ψ-quasi-hyponormal operator T and the scale function ψ satisfying the condition that the function t/ψ(t) is
文摘Case history A 66-year-old woman presented with a 10-month history of gradually increasing fatigue,lethargy,weight gain,constipation,and difficulty coping with the cold winter.She feels like sitting by the fire and doing noth-ing.She tends to sleep excessively.She also complains of chest tightness and shortness of breath on exertion,such as when she hurries to catch a bus.
文摘"During the 11th Five-Year Plan period,China’s copper processing industry advanced by leaps and bounds,nevertheless it still lagged far behind international standards.The industry was plagued by low industrial concentration,fierce competition of similar mid/low-end products and lack of high-speed and high-precision
文摘On September 9th, 2009, AstraZeneca Chinaheld the ground-breaking ceremony for its newsite in Zhangjiang High-Tech Park, which isalso known as China’s medicine valley. Oncethe construction is completed, AstraZenecawill be based in the Zhangjiang Site and bringthe innovation capabilities of Shanghai’s modernbioengineering and pharmaceutical industryto new heights by its great collaborationtradition and unique strength in
