Purpose-This study explores how managerial leadership and organizational innovation interact to enhance resilience and risk management in railway supply chains and how these capabilities contribute to sustained compet...Purpose-This study explores how managerial leadership and organizational innovation interact to enhance resilience and risk management in railway supply chains and how these capabilities contribute to sustained competitive advantage.It emphasizes the strategic importance of resilience in railway systems that face operational complexity,regulatory pressures and increasing exposure to systemic risks.Design/methodology/approach-A mixed-methods design was employed,integrating survey data from 186 railway organizations with six case studies involving railway operators,rolling stock manufacturers and supply chain partners across multiple regions.Constructs were measured using validated scales and hypothesized relationships were tested using Structural Equation Modeling(SEM).Case study interviews were analyzed thematically to provide contextual understanding of leadership practices and innovation strategies.Findings-The results confirm that transformational managerial leadership significantly predicts innovation adoption,which in turn strengthens resilience and risk management capabilities.Resilience emerged as a powerful driver of competitive advantage,reinforcing its role as a strategic capability rather than a reactive response to disruptions.Furthermore,innovation was shown to partially mediate the relationship between leadership and resilience,highlighting its function as the operational channel through which vision translates into capability.Originality/value-This study contributes to the literature by integrating the Resource-Based View(RBV)and Dynamic Capabilities(DC)framework into the context of railway supply chains.It is among the first to empirically validate the mediating role of innovation between leadership and resilience,offering both theoretical advancements and actionable strategies for building resilient and competitive railway systems.展开更多
The differences in the competitive reactions of hydrogarnet and quicklime when reacting with titaniumcontaining and silicon-containing minerals during the Bayer digestion process were investigated.Thermodynamic analys...The differences in the competitive reactions of hydrogarnet and quicklime when reacting with titaniumcontaining and silicon-containing minerals during the Bayer digestion process were investigated.Thermodynamic analysis,artificial mineral experiments,and an evaluation of the digestion effect of natural diasporic bauxite were conducted.The results indicate that hydrogarnet shows a preferential reaction with anatase,and this preference becomes more pronounced as the silicon saturation coefficient increases.In contrast,quicklime participates in non-selective reactions with both anatase and desilication products(DSP).The preference of hydrogarnet for anatase significantly enhances the utilization efficiency of CaO in the high-temperature Bayer digestion process.展开更多
Injecting impure CO_(2)for enhanced gas recovery(CO_(2)-EGR)offers a dual benefit by improving natural gas extraction while enabling CO_(2)sequestration.However,the interactions between CO_(2),N_(2),and CH_(4)under re...Injecting impure CO_(2)for enhanced gas recovery(CO_(2)-EGR)offers a dual benefit by improving natural gas extraction while enabling CO_(2)sequestration.However,the interactions between CO_(2),N_(2),and CH_(4)under reservoir conditions require further investigation.This study employs Grand Canonical Monte Carlo(GCMC)and Molecular Dynamics(MD)simulations to quantify the adsorption and diffusion behaviors of CO_(2),N_(2),and CH_(4)in quartz nanopores over a pressure range of 1-24 MPa under varying water saturations and gas compositions.The results indicate that:(1)CO_(2)exhibits the broadest energy distribution and the strongest adsorption stability,occupying about 20%-30%more adsorption sites than CH_(4)or N_(2)and showing the least sensitivity to water saturation,with only a 30%reduction at 50%saturation,compared to 60%for CH_(4),giving CO_(2)a clear competitive advantage.(2)The adsorption and desorption behaviors are strongly pressure dependent,as increasing pressure reduces the adsorption layer area and shifts gas distribution from adsorption dominated to free phase.Competitive adsorption analysis reveals that while CO_(2)dominates displacement at low pressures,mixtures that contain N_(2)achieve higher CH_(4)desorption efficiency above 13 MPa by mitigating diffusion resistance.(3)A higher N_(2)fraction improves CH_(4)diffusion coefficients,thereby facilitating gas mobility and ensuring superior recovery performance under high-pressure conditions.This study advances the fundamental knowledge of microscale gas behavior in tight sandstones and supports the feasibility of impure CO_(2)injection as a practical strategy for sustainable gas production.展开更多
The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alon...The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.展开更多
Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The...Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The long noncoding RNA growth arrest-specific 5(GAS5) is a member of the 5′-terminal oligopyrimidine gene family that may be involved in neurological disorders, but its role in Alzheimer's disease remains unclear. This study aimed to investigate the function of GAS5 and construct a GAS5-associated competitive endogenous RNA network comprising potential targets. RNA sequencing results showed that GAS5 was upregulated in five familial Alzheimer's disease(5×FAD) mice, APPswe/PSEN1dE9(APP/PS1) mice, Alzheimer's disease-related APPswe cells, and serum from patients with Alzheimer's disease. Functional experiments with targeted overexpression and silencing demonstrated that GAS5 played a role in cognitive dysfunction and multiple Alzheimer's disease-associated pathologies, including tau hyperphosphorylation, amyloid-beta accumulation, and neuronal apoptosis. Mechanistic studies indicated that GAS5 acted as an endogenous sponge by competing for microRNA-23b-3p(miR-23b-3p) binding to regulate its targets glycogen synthase kinase 3beta(GSK-3β) and phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in an Argonaute 2-induced RNA silencing complex(RISC)-dependent manner. GAS5 inhibited miR-23b-3p-mediated GSK-3β and PTEN cascades with a feedforward PTEN/protein kinase B(Akt)/GSK-3β linkage. Furthermore, recovery of GAS5/miR-23b-3p/GSK-3β/PTEN pathways relieved Alzheimer's disease-like symptoms in vivo, indicated by the amelioration of spatial cognition, neuronal degeneration, amyloid-beta load, and tau phosphorylation. Together, these findings suggest that GAS5 promotes Alzheimer's disease pathogenesis. This study establishes the functional convergence of the GAS5/miR-23b-3p/GSK-3β/PTEN pathway on multiple pathologies, suggesting a candidate therapeutic target in Alzheimer's disease.展开更多
Heterogeneous crystallization is a common occurrence during the formation of solidwastes.It leads to the encapsulation of valuable/hazardous metals within the primary phase,presenting significant challenges for waste ...Heterogeneous crystallization is a common occurrence during the formation of solidwastes.It leads to the encapsulation of valuable/hazardous metals within the primary phase,presenting significant challenges for waste treatment andmetal recovery.Herein,we proposed a novel method involving the in-situ formation of a competitive substrate during the precipitation of jarosite waste,which is an essential process for removing iron in zinc hydrometallurgy.We observed that the in-situ-formed competitive substrate effectively inhibits the heterogeneous crystallization of jarosite on the surface of anglesite,a lead-rich phase present in the jarositewaste.As a result,the iron content on the anglesite surface decreases from34.8%to 1.65%.The competitive substrate was identified as schwertmannite,characterized by its loose structure and large surface area.Furthermore,we have elucidated a novel mechanism underlying this inhibition of heterogeneous crystallization,which involves the local supersaturation of jarosite caused by the release of ferric and sulfate ions from the competitive substrate.The local supersaturation promotes the preferential heterogeneous crystallization of jarosite on the competitive substrate.Interestingly,during the formation of jarosite,the competitive substrate gradually vanished through a dissolution-recrystallization process following the Ostwald rule,where a metastable phase slowly transitions to a stable phase.This effectively precluded the introduction of impurities and reduced waste volume.The goal of this study is to provide fresh insights into the mechanism of heterogeneous crystallization control,and to offer practical crystallization strategies conducive to metal separation and recovery from solid waste in industries.展开更多
Quantifying and mapping how ecosystem services impact agricultural competitiveness is crucial for attaining the Sustainable Development Goals of United Nations.However,few study quantified agricultural competitiveness...Quantifying and mapping how ecosystem services impact agricultural competitiveness is crucial for attaining the Sustainable Development Goals of United Nations.However,few study quantified agricultural competitiveness and mapped the effects of ecosystem services on agricultural competitiveness using multiple models.In this study,multi-source data from 2000 to 2020 were utilized to establish the indicator system of agricultural competitiveness;five ecosystem services were quantified using computation models;Geographic Information System(GIS)spatial analysis was used to explore the spatial patterns of agricultural competitiveness and ecosystem services;geographic detector models were applied to investigate the effects and driving mechanisms of ecosystem services on agricultural competitiveness.Shandong Province of China was selected as the case study area.The results demonstrated that:1)there was a significant increase in agricultural competitiveness during the study period,with high levels observed mainly in the east region of the study area.2)The spatial distribution patterns of ecosystem services and agricultural competitiveness primarily exhibited High-High and Low-Low Cluster types.3)Habitat quality emerged as the main driving factor of agricultural competitiveness in 2000 and 2020,while water yield played a substantial role in 2010.4)The coupling of two ecosystem services exerted a greater effect on agricultural competitiveness compared to individual ecosystem service.The innovations of this study are constructing an indicator system to quantify agricultural competitiveness,and exploring the effects of ecosystem services on agricultural competitiveness.This study proposed an indicator system to quantify agricultural competitiveness,which can be applied in other regions,and explored the effects of ecosystem services on agricultural competitiveness.The findings of this study can serve as valuable insights for policymakers to formulate tailored agricultural development policies that take into account the synergistic effects of ecosystem services on agricultural competitiveness.展开更多
Zwitterions(ZIs)are considered as an ideal,novel ionic conductive medium due to their high dipole moment and good solubility of lithium salts.However,the strong interactions between ZIs and Li^(+)severely hinder Li^(+...Zwitterions(ZIs)are considered as an ideal,novel ionic conductive medium due to their high dipole moment and good solubility of lithium salts.However,the strong interactions between ZIs and Li^(+)severely hinder Li^(+)migration.Herein,a quasi-solid electrolyte(MSQSE-2Na)was fabricated by adding sodium bis(fluorosulfonyl)imide(NaFSI)to sulfobetaine methacrylate(SBMA,a ZI)based polymerization system.Na^(+)occupies the–SO_(3)^(-)site in SBMA prior to Li^(+),which weakens the self-crosslinking of SBMA and frees the Li^(+)bound to the polymer segments.Thus,the polymer conformation of MSQSE-2Na changes to a relaxed,homogeneous"sea-island"type.Meanwhile,Na^(+),due to its electron-withdrawing effect,decreases the electron cloud density of the polymer segments,building a weakly coordinated environment in MSQSE-2Na.Consequently,MSQSE-2Na exhibits excellent ionic conductivity of 7.38×10^(-4)S cm^(-1)and a high Li^(+)transference number of 0.632 at 25℃.The(-)Li|MSQSE-2Na|Li(+)cells exhibit super stability,sustaining operation for over 6182h.The(-)Li|MSQSE-2Na|LiFePO_(4)(+)cells demonstrate outstanding charge/discharge reversibility with a Coulombic efficiency exceeding 99.9%over 270 cycles(≈4500 h),with a capacity retention of 70.0%.This work proposes a new design concept for regulating the polymer conformation and charge characteristics through competitive coordination,thereby advancing the application of ZI-based polymer electrolytes in lithium metal batteries.展开更多
Digital technology is the most dynamic frontier of contemporary global scientific and technological advancements,serving as a central driver of today’s technological progress.Ongoing R&D and deployment of digital...Digital technology is the most dynamic frontier of contemporary global scientific and technological advancements,serving as a central driver of today’s technological progress.Ongoing R&D and deployment of digital innovative technologies have rendered international competition and cooperation increasingly complex in both implications and forms.Beyond its role in accelerating technological progress,digital technology enhances state capability by adding a digital dimension to national power.It enables states that possess comparative advantages in digital R&D and deployment to gain greater influence in shaping international discourse,thereby widening the power gap among nations.展开更多
Planting genetically improved,fast-growing tree seedlings is gaining importance as a strategy to enhance forest productivity and reduce labor requirements during plantation establishment.In this study,we evaluated the...Planting genetically improved,fast-growing tree seedlings is gaining importance as a strategy to enhance forest productivity and reduce labor requirements during plantation establishment.In this study,we evaluated the early growth and survival of advanced-generation Cryptomeria japonica seedlings compared to conventional stock,under varying planting densities and cultivation methods.A field experiment was conducted over 5 years using containergrown and bare-root seedlings derived from first-and second-generation plus trees,alongside traditional seedlings.The results showed that advanced-generation seedlings exhibited higher growth in tree height,stem diameter,and crown development than traditional seedlings,particularly when planted as container stock.These seedlings also had higher survival rates,likely due to their rapid initial height growth,which reduced the risks of accidental damage during weeding operations.Wider planting intervals increased the risk of man-made injury and seedling mortality,while faster-growing seedlings were more likely to escape from competing vegetation.Our findings highlight the potential of improved seedling stock to enhance early plantation success and reduce management inputs in the critical establishment phase of forestry.展开更多
Rechargeable batteries have changed human daily life from electronic devices and electric transport to renewable energy systems[1-3].Especially,lithium-ion batteries(LIBs)have dominated the market since their first co...Rechargeable batteries have changed human daily life from electronic devices and electric transport to renewable energy systems[1-3].Especially,lithium-ion batteries(LIBs)have dominated the market since their first commercialization in the 1990s,and the three pioneers(John B.Goodenough,M.Stanley Whittingham,and Akira Yoshino)in the historical development of LIBs were awarded the Novel Prize in chemistry in 2019[4].However,the imbalance between supply and demand during the past few years induced extremely huge fluctuations in lithium resources.The misgivings of lithium resources have promoted the quick development of potential alternative battery technologies.展开更多
In the context of accelerated globalization and the rapid development of the digital economy,the scale of China's import and export trade continues to expand.Enhancing the international competitiveness of China...In the context of accelerated globalization and the rapid development of the digital economy,the scale of China's import and export trade continues to expand.Enhancing the international competitiveness of China's digital service trade is of significant importance.This article will analyze the current state of China's digital service trade development based on relevant theoretical concepts and provide a discussion on proposals for improving the international competitiveness of China's digital service trade,to offer a reference for the development of digital service trade in China.展开更多
With the rapid development of the internet,the dissemination of public opinion in online social networks has become increasingly complex.Existing dissemination models rarely consider group phenomena and the simultaneo...With the rapid development of the internet,the dissemination of public opinion in online social networks has become increasingly complex.Existing dissemination models rarely consider group phenomena and the simultaneous spread of competing public opinion information in online social networks.This paper introduces the UHNPR information dissemination model to study the dynamic spread and interaction of positive and negative public opinion information in hypernetworks.To improve the accuracy of modeling of information dissemination,we revise the traditional assumptions of constant propagation and decay rates by redefining these rates based on factors that influence the spread of public opinion information.Subsequently,we validate the effectiveness of the UHNPR model using numerical simulations and analyze the impact of factors such as authority effect,user intimacy,information content and information timeliness on the spread of public opinion,providing corresponding suggestions for public opinion control.Our research results demonstrate that this model outperforms the SIR,SEIR and SEIDR models in describing public opinion propagation in real social networks.Compared with complex networks,information spreads faster and more extensively in hypernetworks.展开更多
The distribution and competitive behaviors of phosphotungstic acid and ferric chloride in the TBP-HCl-H_(2)O system were investigated by controlling the extractant concentration and the solution environment.The result...The distribution and competitive behaviors of phosphotungstic acid and ferric chloride in the TBP-HCl-H_(2)O system were investigated by controlling the extractant concentration and the solution environment.The results revealed that phosphotungstic acid exhibited a strong affinity for TBP with decreasing TBP concentration.Higher acidity significantly improved the W extraction efficiency with TBP,and the lower Cl^(-)concentration reduced the extraction efficiency of Fe.As the organic phase approached saturation point,phosphotungstic acid competitively displaced Fe to combine with TBP.The hydrogen bond structure(P=O·HO-P-W-O)between phosphotungstic acid and TBP was characterized by FT-IR,and the salting-out effect induced by FeCl_(3) was elucidated.In summary,high acidity is beneficial for exhaustive extraction of W,and an effective W/Fe separation can be achieved by reducing the concentrations of TBP and Cl^(-).展开更多
With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient pur...With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient purchasing channels,and online consultation services.This has put considerable pressure on traditional retail chain pharmacies.This paper provides an overview of the current state of pharmaceutical e-commerce,and analyzes the main challenges faced by retail chain pharmacies,including intense price competition,changes in consumer habits,insufficient digitalization and severe homogenized competition.Drawing on industry practices and case studies,the paper proposes strategies to enhance competitiveness,such as promoting digital transformation and online-offline(O2O)integration,strengthening pharmacist services and health management capabilities,optimizing supply chain management,building differentiated brand advantages,and proactively responding to policy and regulatory requirements.The study argues that,while leveraging their advantages in specialization,community-based operations,service orientation and retail chain pharmacies,should actively embrace digitalization and industrial collaboration in order to achieve sustainable development in the context of e-commerce.This research provides theoretical references for the strategic transformation of retail chain pharmacies and offers practical significance for the high-quality development of the pharmaceutical retail industry.展开更多
An in-depth understanding of the competition mechanism between olefins and different types of sulfides in gasoline is essential to improve the desulfurization selectivity of the adsorption desulfurization process(ADS)...An in-depth understanding of the competition mechanism between olefins and different types of sulfides in gasoline is essential to improve the desulfurization selectivity of the adsorption desulfurization process(ADS).In this study,the competitive adsorption and diffusion mechanism of two systems,diethyl sulfide/cyclohexene and n-butyl mercaptan/cyclohexene,with different adsorption amounts in siliceous faujasite zeolite(FAU) were investigated by Monte Carlo(MC) and molecular dynamics(MD).The systems exhibited a two-stage loading-dependent competitive adsorption and diffusion mechanism,with an inflection point of 32 molecule/UC(moleculers per microcoulomb).Before the inflection point(4-32molecule/UC),the competition mechanism of the two systems was the "optimal-displacement" mechanism.After the inflection point,the mechanism of the diethyl sulfide/cyclohexene changed to "relocation-displacement",while that of the n-butyl mercaptan/cyclohexene system changed to "dominantdisplacement".Compared to ether functional groups,the alcohol functional group has higher polarity and stronger adsorption stability,thus occupying more favorable adsorption sites within the supercages(SCs),while ethyl sulfide shifts outward to other sites within other SCs.In addition,the diffusion performance of adsorbent is related to the adsorption energy.The lower the adsorption energy,the weaker the diffusion ability.Meanwhile,the diffusion performance of adsorbates is better at high temperatures and low adsorption capacity.The effect of temperatu re on the desulfu rization selectivity was determined.A lower temperature is favorable for the adsorption capacity of the two systems and the removal selectivity of sulfides.This study provides fundamental insights into the competitive adsorption and diffusion mechanisms among sulfides,mercaptans and olefins,offering theoretical guidance for adsorbent design and reaction temperature optimization.展开更多
With the continuous development of science and technology,we have already entered the digital age.While big data,artificial intelligence,and digital twin technology provide convenience for various fields of people’s ...With the continuous development of science and technology,we have already entered the digital age.While big data,artificial intelligence,and digital twin technology provide convenience for various fields of people’s lives,they also bring new opportunities for the innovation and development of competitive cheerleading.Especially for the training of aerial techniques in competitive cheerleading,which has high requirements for accuracy,coordination,and safety,the traditional training model has problems such as empiricism and insufficient risk prediction,which directly affect the quality of training.This article discusses the application value and application countermeasures of digital twin technology in the aerial techniques of competitive cheerleading,hoping to provide some reference for relevant personnel.展开更多
BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ us...BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ using the competitive reaction time task(CRTT).Further investigation into the ERP correlates of aggression in SCZ would provide valuable insights into the neural processes involved.AIM To explore the neural mechanism of aggressive behavior in SCZ.METHODS Participants of this study included 40 SCZ patients and 42 healthy controls(HCs).The Reactive Proactive Aggression Questionnaire was used to assess trait of aggression.The Barratt Impulsiveness Scale 11 was used to measure impulsiveness.The Positive and Negative Symptom Scale(PANSS)was used to evaluate psychopathological features and disease severity.All participants were measured with ERP while performing the CRTT.Data of behavior,ERP components(P2,N2,and P3),and feedback-related negativity(FRN)were analyzed.RESULTS Analysis of the behavioral data revealed that compared with HCs,SCZ patients exhibited higher punishment choices.Analysis of ERP components showed that compared with HCs,SCZ patients exhibited higher N2 amplitudes and P2 amplitudes during the decision phase of the CRTT;however,SCZ patients exhibited lower FRN amplitudes and lower P3 amplitudes during the outcome phase of the CRTT.The N2 amplitudes evoked by highintensity provocation were positively related to PANSS-P scores.And the P3 amplitudes evoked in the winning trials were negatively correlated with the PANSS-G scores.CONCLUSION SCZ patients exhibit abnormal ERP characteristics evoked by the CRTT,which suggests the neural correlates of aggressive behavior in SCZ.展开更多
BACKGROUND The use of proton pump inhibitors(PPIs)with the intent of reducing gastric acidity to the desired therapeutic level for treating bleeding peptic ulcer still has several limitations.AIM To compare intravenou...BACKGROUND The use of proton pump inhibitors(PPIs)with the intent of reducing gastric acidity to the desired therapeutic level for treating bleeding peptic ulcer still has several limitations.AIM To compare intravenous PPIs and oral potassium competitive acid blockers(PCABs)administered prior to endoscopic treatment of bleeding peptic ulcers.METHODS This retrospective study involved 105 consecutive patients with non-variceal upper gastrointestinal bleeding(treated August 2023 to February 2024).Prior to emergency endoscopy,patients received either intravenous PPI(pantoprazole 80 mg bolus)or oral PCAB(tegoprazan 50 mg single-dose).Severity of bleeding was assessed using the Glasgow-Blatchford,Rockall,and AIMS65 scoring systems.Patients with severe comorbidities were excluded.Primary outcomes included need for therapeutic endoscopic intervention and occurrence of re-bleeding.Multivariate logistic regression was performed to adjust for potential confounding factors.RESULTS Total of the 105 patients,61 received intravenous PPI injection and 44 received oral PCAB prior to emergency endoscopy.To minimize selection bias,bleeding severity was assessed using the Glasgow-Blatchford,Rockall and AIMS65 scores,with no statistically significant differences observed between the two groups.During emergency endoscopy performed within 48 hours,ulcer bed status was classified according to the Forrest classification.The proportion of lesions graded IIa or higher was significantly lower in the PCAB group(P<0.001),as was the frequency of therapeutic endoscopy intervention(odds ratio=0.272,95%confidence interval:0.111-0.665,P=0.004).The frequency of re-bleeding events was statistically significantly higher in the PPI group(odds ratio=0.141,95%confidence interval:0.024-0.844,P=0.032).CONCLUSION Pre-endoscopic PCAB administration is more effective than PPI injection for upper gastrointestinal bleeding and may reduce ulcer bleeding mortality.展开更多
As India vigorously reclaims its cost advantages in textiles,the apparel trade landscape in South Asia is set for a reshuffle,with Bangladesh,Vietnam,and China becoming key reference points in India's new competit...As India vigorously reclaims its cost advantages in textiles,the apparel trade landscape in South Asia is set for a reshuffle,with Bangladesh,Vietnam,and China becoming key reference points in India's new competitiveness roadmap.According to India's Ministry of Textiles,the government has formulated a fourpoint action plan divided into short-term(two years),medium-term(five years),and two long-term stages.It aims to reduce production costs,enhance labor productivity,and strengthen export competitiveness in the textile sector.The plan seeks to increase India's textile and apparel exports to$100 billion by 2030,a significant leap from the$37.7 billion projected for the 2024-25 fiscal year.The trigger for this plan was the US imposition of 50%tariffs on Indian textiles earlier this year,raising concerns about India's competitiveness relative to Bangladesh,Vietnam,and China.展开更多
文摘Purpose-This study explores how managerial leadership and organizational innovation interact to enhance resilience and risk management in railway supply chains and how these capabilities contribute to sustained competitive advantage.It emphasizes the strategic importance of resilience in railway systems that face operational complexity,regulatory pressures and increasing exposure to systemic risks.Design/methodology/approach-A mixed-methods design was employed,integrating survey data from 186 railway organizations with six case studies involving railway operators,rolling stock manufacturers and supply chain partners across multiple regions.Constructs were measured using validated scales and hypothesized relationships were tested using Structural Equation Modeling(SEM).Case study interviews were analyzed thematically to provide contextual understanding of leadership practices and innovation strategies.Findings-The results confirm that transformational managerial leadership significantly predicts innovation adoption,which in turn strengthens resilience and risk management capabilities.Resilience emerged as a powerful driver of competitive advantage,reinforcing its role as a strategic capability rather than a reactive response to disruptions.Furthermore,innovation was shown to partially mediate the relationship between leadership and resilience,highlighting its function as the operational channel through which vision translates into capability.Originality/value-This study contributes to the literature by integrating the Resource-Based View(RBV)and Dynamic Capabilities(DC)framework into the context of railway supply chains.It is among the first to empirically validate the mediating role of innovation between leadership and resilience,offering both theoretical advancements and actionable strategies for building resilient and competitive railway systems.
基金the financial support from the Natural Science Foundation of Hunan Province,China(No.2022JJ40616)。
文摘The differences in the competitive reactions of hydrogarnet and quicklime when reacting with titaniumcontaining and silicon-containing minerals during the Bayer digestion process were investigated.Thermodynamic analysis,artificial mineral experiments,and an evaluation of the digestion effect of natural diasporic bauxite were conducted.The results indicate that hydrogarnet shows a preferential reaction with anatase,and this preference becomes more pronounced as the silicon saturation coefficient increases.In contrast,quicklime participates in non-selective reactions with both anatase and desilication products(DSP).The preference of hydrogarnet for anatase significantly enhances the utilization efficiency of CaO in the high-temperature Bayer digestion process.
基金supported by the National Natural Science Foundation of China(Grant No.U23A2022)the National Natural Science Foundation of China(Grant No.52474047)+2 种基金the Natural Science Foundation of Chongqing(Grant No.CSTB2024NSCQ-MSX0951)the Natural Science Foundation of Sichuan Province(Grant No.2025ZNSFSC1357)the National Science and Technology Major Project(Grant No.2025ZD1404307).
文摘Injecting impure CO_(2)for enhanced gas recovery(CO_(2)-EGR)offers a dual benefit by improving natural gas extraction while enabling CO_(2)sequestration.However,the interactions between CO_(2),N_(2),and CH_(4)under reservoir conditions require further investigation.This study employs Grand Canonical Monte Carlo(GCMC)and Molecular Dynamics(MD)simulations to quantify the adsorption and diffusion behaviors of CO_(2),N_(2),and CH_(4)in quartz nanopores over a pressure range of 1-24 MPa under varying water saturations and gas compositions.The results indicate that:(1)CO_(2)exhibits the broadest energy distribution and the strongest adsorption stability,occupying about 20%-30%more adsorption sites than CH_(4)or N_(2)and showing the least sensitivity to water saturation,with only a 30%reduction at 50%saturation,compared to 60%for CH_(4),giving CO_(2)a clear competitive advantage.(2)The adsorption and desorption behaviors are strongly pressure dependent,as increasing pressure reduces the adsorption layer area and shifts gas distribution from adsorption dominated to free phase.Competitive adsorption analysis reveals that while CO_(2)dominates displacement at low pressures,mixtures that contain N_(2)achieve higher CH_(4)desorption efficiency above 13 MPa by mitigating diffusion resistance.(3)A higher N_(2)fraction improves CH_(4)diffusion coefficients,thereby facilitating gas mobility and ensuring superior recovery performance under high-pressure conditions.This study advances the fundamental knowledge of microscale gas behavior in tight sandstones and supports the feasibility of impure CO_(2)injection as a practical strategy for sustainable gas production.
基金supported by Major Scientific and Technological Innovation Project of Shandong Province(No.2020CXGC011204)Qingdao Natural Science Foundation(No.23-2-1-234-zyyd-jch).
文摘The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.
基金supported by the National Natural Science Foundation of China,Nos. 82173806 and U1803281Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science,Nos. 2021-I2M-1-030 and 2022-I2M-2-002Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences,No. 2022-JKCS-08 (all to RL)。
文摘Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The long noncoding RNA growth arrest-specific 5(GAS5) is a member of the 5′-terminal oligopyrimidine gene family that may be involved in neurological disorders, but its role in Alzheimer's disease remains unclear. This study aimed to investigate the function of GAS5 and construct a GAS5-associated competitive endogenous RNA network comprising potential targets. RNA sequencing results showed that GAS5 was upregulated in five familial Alzheimer's disease(5×FAD) mice, APPswe/PSEN1dE9(APP/PS1) mice, Alzheimer's disease-related APPswe cells, and serum from patients with Alzheimer's disease. Functional experiments with targeted overexpression and silencing demonstrated that GAS5 played a role in cognitive dysfunction and multiple Alzheimer's disease-associated pathologies, including tau hyperphosphorylation, amyloid-beta accumulation, and neuronal apoptosis. Mechanistic studies indicated that GAS5 acted as an endogenous sponge by competing for microRNA-23b-3p(miR-23b-3p) binding to regulate its targets glycogen synthase kinase 3beta(GSK-3β) and phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in an Argonaute 2-induced RNA silencing complex(RISC)-dependent manner. GAS5 inhibited miR-23b-3p-mediated GSK-3β and PTEN cascades with a feedforward PTEN/protein kinase B(Akt)/GSK-3β linkage. Furthermore, recovery of GAS5/miR-23b-3p/GSK-3β/PTEN pathways relieved Alzheimer's disease-like symptoms in vivo, indicated by the amelioration of spatial cognition, neuronal degeneration, amyloid-beta load, and tau phosphorylation. Together, these findings suggest that GAS5 promotes Alzheimer's disease pathogenesis. This study establishes the functional convergence of the GAS5/miR-23b-3p/GSK-3β/PTEN pathway on multiple pathologies, suggesting a candidate therapeutic target in Alzheimer's disease.
基金supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.52121004)the Major Program Natural Science Foundation of Hunan Province of China(No.2021JC0001)+2 种基金the National Key R&D Programof China(No.2022YFC3900200)the National Natural Science Foundation of China(No.22276218)the Science and Technology Innovation Programof Hunan Province(No.2021RC3013).
文摘Heterogeneous crystallization is a common occurrence during the formation of solidwastes.It leads to the encapsulation of valuable/hazardous metals within the primary phase,presenting significant challenges for waste treatment andmetal recovery.Herein,we proposed a novel method involving the in-situ formation of a competitive substrate during the precipitation of jarosite waste,which is an essential process for removing iron in zinc hydrometallurgy.We observed that the in-situ-formed competitive substrate effectively inhibits the heterogeneous crystallization of jarosite on the surface of anglesite,a lead-rich phase present in the jarositewaste.As a result,the iron content on the anglesite surface decreases from34.8%to 1.65%.The competitive substrate was identified as schwertmannite,characterized by its loose structure and large surface area.Furthermore,we have elucidated a novel mechanism underlying this inhibition of heterogeneous crystallization,which involves the local supersaturation of jarosite caused by the release of ferric and sulfate ions from the competitive substrate.The local supersaturation promotes the preferential heterogeneous crystallization of jarosite on the competitive substrate.Interestingly,during the formation of jarosite,the competitive substrate gradually vanished through a dissolution-recrystallization process following the Ostwald rule,where a metastable phase slowly transitions to a stable phase.This effectively precluded the introduction of impurities and reduced waste volume.The goal of this study is to provide fresh insights into the mechanism of heterogeneous crystallization control,and to offer practical crystallization strategies conducive to metal separation and recovery from solid waste in industries.
基金Under the auspices of the National Key Research and Development Program of China(No.2022YFC3204404)。
文摘Quantifying and mapping how ecosystem services impact agricultural competitiveness is crucial for attaining the Sustainable Development Goals of United Nations.However,few study quantified agricultural competitiveness and mapped the effects of ecosystem services on agricultural competitiveness using multiple models.In this study,multi-source data from 2000 to 2020 were utilized to establish the indicator system of agricultural competitiveness;five ecosystem services were quantified using computation models;Geographic Information System(GIS)spatial analysis was used to explore the spatial patterns of agricultural competitiveness and ecosystem services;geographic detector models were applied to investigate the effects and driving mechanisms of ecosystem services on agricultural competitiveness.Shandong Province of China was selected as the case study area.The results demonstrated that:1)there was a significant increase in agricultural competitiveness during the study period,with high levels observed mainly in the east region of the study area.2)The spatial distribution patterns of ecosystem services and agricultural competitiveness primarily exhibited High-High and Low-Low Cluster types.3)Habitat quality emerged as the main driving factor of agricultural competitiveness in 2000 and 2020,while water yield played a substantial role in 2010.4)The coupling of two ecosystem services exerted a greater effect on agricultural competitiveness compared to individual ecosystem service.The innovations of this study are constructing an indicator system to quantify agricultural competitiveness,and exploring the effects of ecosystem services on agricultural competitiveness.This study proposed an indicator system to quantify agricultural competitiveness,which can be applied in other regions,and explored the effects of ecosystem services on agricultural competitiveness.The findings of this study can serve as valuable insights for policymakers to formulate tailored agricultural development policies that take into account the synergistic effects of ecosystem services on agricultural competitiveness.
基金supported by the National Natural Science Foundation of China(22078228)。
文摘Zwitterions(ZIs)are considered as an ideal,novel ionic conductive medium due to their high dipole moment and good solubility of lithium salts.However,the strong interactions between ZIs and Li^(+)severely hinder Li^(+)migration.Herein,a quasi-solid electrolyte(MSQSE-2Na)was fabricated by adding sodium bis(fluorosulfonyl)imide(NaFSI)to sulfobetaine methacrylate(SBMA,a ZI)based polymerization system.Na^(+)occupies the–SO_(3)^(-)site in SBMA prior to Li^(+),which weakens the self-crosslinking of SBMA and frees the Li^(+)bound to the polymer segments.Thus,the polymer conformation of MSQSE-2Na changes to a relaxed,homogeneous"sea-island"type.Meanwhile,Na^(+),due to its electron-withdrawing effect,decreases the electron cloud density of the polymer segments,building a weakly coordinated environment in MSQSE-2Na.Consequently,MSQSE-2Na exhibits excellent ionic conductivity of 7.38×10^(-4)S cm^(-1)and a high Li^(+)transference number of 0.632 at 25℃.The(-)Li|MSQSE-2Na|Li(+)cells exhibit super stability,sustaining operation for over 6182h.The(-)Li|MSQSE-2Na|LiFePO_(4)(+)cells demonstrate outstanding charge/discharge reversibility with a Coulombic efficiency exceeding 99.9%over 270 cycles(≈4500 h),with a capacity retention of 70.0%.This work proposes a new design concept for regulating the polymer conformation and charge characteristics through competitive coordination,thereby advancing the application of ZI-based polymer electrolytes in lithium metal batteries.
文摘Digital technology is the most dynamic frontier of contemporary global scientific and technological advancements,serving as a central driver of today’s technological progress.Ongoing R&D and deployment of digital innovative technologies have rendered international competition and cooperation increasingly complex in both implications and forms.Beyond its role in accelerating technological progress,digital technology enhances state capability by adding a digital dimension to national power.It enables states that possess comparative advantages in digital R&D and deployment to gain greater influence in shaping international discourse,thereby widening the power gap among nations.
基金supported by FFPRI FTBC Operational Expense Grants。
文摘Planting genetically improved,fast-growing tree seedlings is gaining importance as a strategy to enhance forest productivity and reduce labor requirements during plantation establishment.In this study,we evaluated the early growth and survival of advanced-generation Cryptomeria japonica seedlings compared to conventional stock,under varying planting densities and cultivation methods.A field experiment was conducted over 5 years using containergrown and bare-root seedlings derived from first-and second-generation plus trees,alongside traditional seedlings.The results showed that advanced-generation seedlings exhibited higher growth in tree height,stem diameter,and crown development than traditional seedlings,particularly when planted as container stock.These seedlings also had higher survival rates,likely due to their rapid initial height growth,which reduced the risks of accidental damage during weeding operations.Wider planting intervals increased the risk of man-made injury and seedling mortality,while faster-growing seedlings were more likely to escape from competing vegetation.Our findings highlight the potential of improved seedling stock to enhance early plantation success and reduce management inputs in the critical establishment phase of forestry.
文摘Rechargeable batteries have changed human daily life from electronic devices and electric transport to renewable energy systems[1-3].Especially,lithium-ion batteries(LIBs)have dominated the market since their first commercialization in the 1990s,and the three pioneers(John B.Goodenough,M.Stanley Whittingham,and Akira Yoshino)in the historical development of LIBs were awarded the Novel Prize in chemistry in 2019[4].However,the imbalance between supply and demand during the past few years induced extremely huge fluctuations in lithium resources.The misgivings of lithium resources have promoted the quick development of potential alternative battery technologies.
文摘In the context of accelerated globalization and the rapid development of the digital economy,the scale of China's import and export trade continues to expand.Enhancing the international competitiveness of China's digital service trade is of significant importance.This article will analyze the current state of China's digital service trade development based on relevant theoretical concepts and provide a discussion on proposals for improving the international competitiveness of China's digital service trade,to offer a reference for the development of digital service trade in China.
基金supported by Yunnan High-tech Industry Development Project(Grant No.201606)Yunnan Provincial Major Science and Technology Special Plan Projects(Grant Nos.202103AA080015 and 202002AD080001-5)+1 种基金Yunnan Basic Research Project(Grant No.202001AS070014)Talents and Platform Program of Science and Technology of Yunnan(Grant No.202105AC160018)。
文摘With the rapid development of the internet,the dissemination of public opinion in online social networks has become increasingly complex.Existing dissemination models rarely consider group phenomena and the simultaneous spread of competing public opinion information in online social networks.This paper introduces the UHNPR information dissemination model to study the dynamic spread and interaction of positive and negative public opinion information in hypernetworks.To improve the accuracy of modeling of information dissemination,we revise the traditional assumptions of constant propagation and decay rates by redefining these rates based on factors that influence the spread of public opinion information.Subsequently,we validate the effectiveness of the UHNPR model using numerical simulations and analyze the impact of factors such as authority effect,user intimacy,information content and information timeliness on the spread of public opinion,providing corresponding suggestions for public opinion control.Our research results demonstrate that this model outperforms the SIR,SEIR and SEIDR models in describing public opinion propagation in real social networks.Compared with complex networks,information spreads faster and more extensively in hypernetworks.
基金supported by the National key R&D Program of China(No.2022YFC2905105)the National Natural Science Foundation of China(No.72088101)。
文摘The distribution and competitive behaviors of phosphotungstic acid and ferric chloride in the TBP-HCl-H_(2)O system were investigated by controlling the extractant concentration and the solution environment.The results revealed that phosphotungstic acid exhibited a strong affinity for TBP with decreasing TBP concentration.Higher acidity significantly improved the W extraction efficiency with TBP,and the lower Cl^(-)concentration reduced the extraction efficiency of Fe.As the organic phase approached saturation point,phosphotungstic acid competitively displaced Fe to combine with TBP.The hydrogen bond structure(P=O·HO-P-W-O)between phosphotungstic acid and TBP was characterized by FT-IR,and the salting-out effect induced by FeCl_(3) was elucidated.In summary,high acidity is beneficial for exhaustive extraction of W,and an effective W/Fe separation can be achieved by reducing the concentrations of TBP and Cl^(-).
文摘With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient purchasing channels,and online consultation services.This has put considerable pressure on traditional retail chain pharmacies.This paper provides an overview of the current state of pharmaceutical e-commerce,and analyzes the main challenges faced by retail chain pharmacies,including intense price competition,changes in consumer habits,insufficient digitalization and severe homogenized competition.Drawing on industry practices and case studies,the paper proposes strategies to enhance competitiveness,such as promoting digital transformation and online-offline(O2O)integration,strengthening pharmacist services and health management capabilities,optimizing supply chain management,building differentiated brand advantages,and proactively responding to policy and regulatory requirements.The study argues that,while leveraging their advantages in specialization,community-based operations,service orientation and retail chain pharmacies,should actively embrace digitalization and industrial collaboration in order to achieve sustainable development in the context of e-commerce.This research provides theoretical references for the strategic transformation of retail chain pharmacies and offers practical significance for the high-quality development of the pharmaceutical retail industry.
基金support from the National Natural Science Foundation of China (22325808,U22B20140,22021004)。
文摘An in-depth understanding of the competition mechanism between olefins and different types of sulfides in gasoline is essential to improve the desulfurization selectivity of the adsorption desulfurization process(ADS).In this study,the competitive adsorption and diffusion mechanism of two systems,diethyl sulfide/cyclohexene and n-butyl mercaptan/cyclohexene,with different adsorption amounts in siliceous faujasite zeolite(FAU) were investigated by Monte Carlo(MC) and molecular dynamics(MD).The systems exhibited a two-stage loading-dependent competitive adsorption and diffusion mechanism,with an inflection point of 32 molecule/UC(moleculers per microcoulomb).Before the inflection point(4-32molecule/UC),the competition mechanism of the two systems was the "optimal-displacement" mechanism.After the inflection point,the mechanism of the diethyl sulfide/cyclohexene changed to "relocation-displacement",while that of the n-butyl mercaptan/cyclohexene system changed to "dominantdisplacement".Compared to ether functional groups,the alcohol functional group has higher polarity and stronger adsorption stability,thus occupying more favorable adsorption sites within the supercages(SCs),while ethyl sulfide shifts outward to other sites within other SCs.In addition,the diffusion performance of adsorbent is related to the adsorption energy.The lower the adsorption energy,the weaker the diffusion ability.Meanwhile,the diffusion performance of adsorbates is better at high temperatures and low adsorption capacity.The effect of temperatu re on the desulfu rization selectivity was determined.A lower temperature is favorable for the adsorption capacity of the two systems and the removal selectivity of sulfides.This study provides fundamental insights into the competitive adsorption and diffusion mechanisms among sulfides,mercaptans and olefins,offering theoretical guidance for adsorbent design and reaction temperature optimization.
基金AI-Empowered Practical Course Teaching Project of Zhuhai College of Science and Technology(Project No.:SYSG2025025)。
文摘With the continuous development of science and technology,we have already entered the digital age.While big data,artificial intelligence,and digital twin technology provide convenience for various fields of people’s lives,they also bring new opportunities for the innovation and development of competitive cheerleading.Especially for the training of aerial techniques in competitive cheerleading,which has high requirements for accuracy,coordination,and safety,the traditional training model has problems such as empiricism and insufficient risk prediction,which directly affect the quality of training.This article discusses the application value and application countermeasures of digital twin technology in the aerial techniques of competitive cheerleading,hoping to provide some reference for relevant personnel.
基金Supported by Wuxi Municipal Health Commission Major Project,No.Z202107Wuxi Taihu Talent Project,No.WXTTP 2021.
文摘BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ using the competitive reaction time task(CRTT).Further investigation into the ERP correlates of aggression in SCZ would provide valuable insights into the neural processes involved.AIM To explore the neural mechanism of aggressive behavior in SCZ.METHODS Participants of this study included 40 SCZ patients and 42 healthy controls(HCs).The Reactive Proactive Aggression Questionnaire was used to assess trait of aggression.The Barratt Impulsiveness Scale 11 was used to measure impulsiveness.The Positive and Negative Symptom Scale(PANSS)was used to evaluate psychopathological features and disease severity.All participants were measured with ERP while performing the CRTT.Data of behavior,ERP components(P2,N2,and P3),and feedback-related negativity(FRN)were analyzed.RESULTS Analysis of the behavioral data revealed that compared with HCs,SCZ patients exhibited higher punishment choices.Analysis of ERP components showed that compared with HCs,SCZ patients exhibited higher N2 amplitudes and P2 amplitudes during the decision phase of the CRTT;however,SCZ patients exhibited lower FRN amplitudes and lower P3 amplitudes during the outcome phase of the CRTT.The N2 amplitudes evoked by highintensity provocation were positively related to PANSS-P scores.And the P3 amplitudes evoked in the winning trials were negatively correlated with the PANSS-G scores.CONCLUSION SCZ patients exhibit abnormal ERP characteristics evoked by the CRTT,which suggests the neural correlates of aggressive behavior in SCZ.
文摘BACKGROUND The use of proton pump inhibitors(PPIs)with the intent of reducing gastric acidity to the desired therapeutic level for treating bleeding peptic ulcer still has several limitations.AIM To compare intravenous PPIs and oral potassium competitive acid blockers(PCABs)administered prior to endoscopic treatment of bleeding peptic ulcers.METHODS This retrospective study involved 105 consecutive patients with non-variceal upper gastrointestinal bleeding(treated August 2023 to February 2024).Prior to emergency endoscopy,patients received either intravenous PPI(pantoprazole 80 mg bolus)or oral PCAB(tegoprazan 50 mg single-dose).Severity of bleeding was assessed using the Glasgow-Blatchford,Rockall,and AIMS65 scoring systems.Patients with severe comorbidities were excluded.Primary outcomes included need for therapeutic endoscopic intervention and occurrence of re-bleeding.Multivariate logistic regression was performed to adjust for potential confounding factors.RESULTS Total of the 105 patients,61 received intravenous PPI injection and 44 received oral PCAB prior to emergency endoscopy.To minimize selection bias,bleeding severity was assessed using the Glasgow-Blatchford,Rockall and AIMS65 scores,with no statistically significant differences observed between the two groups.During emergency endoscopy performed within 48 hours,ulcer bed status was classified according to the Forrest classification.The proportion of lesions graded IIa or higher was significantly lower in the PCAB group(P<0.001),as was the frequency of therapeutic endoscopy intervention(odds ratio=0.272,95%confidence interval:0.111-0.665,P=0.004).The frequency of re-bleeding events was statistically significantly higher in the PPI group(odds ratio=0.141,95%confidence interval:0.024-0.844,P=0.032).CONCLUSION Pre-endoscopic PCAB administration is more effective than PPI injection for upper gastrointestinal bleeding and may reduce ulcer bleeding mortality.
文摘As India vigorously reclaims its cost advantages in textiles,the apparel trade landscape in South Asia is set for a reshuffle,with Bangladesh,Vietnam,and China becoming key reference points in India's new competitiveness roadmap.According to India's Ministry of Textiles,the government has formulated a fourpoint action plan divided into short-term(two years),medium-term(five years),and two long-term stages.It aims to reduce production costs,enhance labor productivity,and strengthen export competitiveness in the textile sector.The plan seeks to increase India's textile and apparel exports to$100 billion by 2030,a significant leap from the$37.7 billion projected for the 2024-25 fiscal year.The trigger for this plan was the US imposition of 50%tariffs on Indian textiles earlier this year,raising concerns about India's competitiveness relative to Bangladesh,Vietnam,and China.
