Considering the dependence and competitive relation-ship between traumatic failure and degradation,the reliability assessment of products based on competing failure analysis is studied.The hazard rate of traumatic fai...Considering the dependence and competitive relation-ship between traumatic failure and degradation,the reliability assessment of products based on competing failure analysis is studied.The hazard rate of traumatic failure is regarded as a Weibull distribution of the degradation performance,and the Wiener process is used to describe the degradation process.The parameters are estimated with the maximum likelihood estimation（MLE）method.A reliability model based on competing failure analysis is proposed.A case study of the GaAs lasers is given to validate the effectiveness of the model and its solving method.The results indicate that if only the degradation failure is considered,the estimated result will be comparably optimistic.Meanwhile,the correlation between the degradation and traumatic failure has a great influence on the accuracy of reliability assessment.展开更多
In this paper,a class of discrete time non-autonomous competing system with feedback controls is considered.With the help of differential equations with piecewise constant arguments,we first propose a discrete model o...In this paper,a class of discrete time non-autonomous competing system with feedback controls is considered.With the help of differential equations with piecewise constant arguments,we first propose a discrete model of a continuous non-autonomous competing system with feedback controls.Then,using the coincidence degree and the related continuation theorem as well as some priori estimations,a suficient condition for the existence of positive solutions to difference equations is obtained.展开更多
A method for reliability analysis of the competing failure with the probabilistic failure threshold value not the fixed threshold value is presented, which involves the random shocks and the degradation is independent...A method for reliability analysis of the competing failure with the probabilistic failure threshold value not the fixed threshold value is presented, which involves the random shocks and the degradation is independent and dependent respectively. Specifically, for the dependent condition, the effect due to the random shocks on the degradation is considered with a damage factor. In addition, the dependent competing failure model is applied to the reliability analysis of the k-out-of-n systems. Finally, two studied cases are presented to illustrate the proposed method, and the results show the proposed method is reasonable.展开更多
This paper proposes a health evaluation method for degrading systems subject to competing risks of dependent soft and hard failures. To characterize the time-varying degradation rate, the degradation process is determ...This paper proposes a health evaluation method for degrading systems subject to competing risks of dependent soft and hard failures. To characterize the time-varying degradation rate, the degradation process is determined by a non-stationary Gamma process and the soft failure is encountered when it exceeds a predefined critical level. For the hard failure, a Cox’s proportional hazard model is applied to describe the hazard rate of the time to system failure. The dependent relationship is modeled by incorporating the degradation process as a time-varying covariate into the Cox’s proportional hazard model. To facilitate the health characteristics evaluation, a discretization technique is applied both to the degradation process and the monitoring time.All health characteristics can be obtained in the explicit form using the transition probability matrix, which is computationally attractive for practical applications. Finally, a numerical analysis is carried out to show the effectiveness and the performance of the proposed health evaluation method.展开更多
In this paper，we consider the Kolmogorov type n-species competition systems with forced terms．We prove that this system is permanent in the case of which there are positive forced terms in this system;and if there a...In this paper，we consider the Kolmogorov type n-species competition systems with forced terms．We prove that this system is permanent in the case of which there are positive forced terms in this system;and if there are several negative forced terms in this system，it has at least two positive periodic solutions.展开更多
Electrochemical carbon dioxide reduction reaction(CO_(2)RR)converts CO_(2) into valuable chemicals by consuming renewable electricity at mild conditions,making it a promising approach to achieving carbon neutrality.Ho...Electrochemical carbon dioxide reduction reaction(CO_(2)RR)converts CO_(2) into valuable chemicals by consuming renewable electricity at mild conditions,making it a promising approach to achieving carbon neutrality.However,the reaction of CO_(2) with hydroxide ions to form carbonates leads to low carbon utilization and energy efficiency in near-neutral or alkaline CO_(2)RR.The high concentration of protons in acidic media can effectively mitigate carbonate formation and deposition,thereby significantly minimizing carbon loss and energy consumption.Unfortunately,hydrogen evolution reaction(HER)is more kinetically favorable than CO_(2)RR in acidic media.Herein,we comprehensively overview recent progress in acidic CO_(2)RR and propose two strategies derived from the competing reaction pathways of HER and CO_(2)RR:one focuses on regulating the H+mass transport,while the other aims to modulate the intrinsic kinetic activity of CO_(2)RR.The two strategies are designed to compete for the limited active sites on the catalyst surface,inhibit side reactions,and enhance the activity and selectivity of CO_(2)RR.The representative approaches include modulating the interface electric field,constructing a local alkaline environment,and regulating competing adsorption sites.Finally,we also review the technical challenges and future perspectives of acidic CO_(2)RR coupled with membrane electrode assemblies(MEAs).展开更多
Declaration of Competing Interest statements is updated in the published version of the following articles that appeared in issues of Resources Chemicals and Materials.The appropriate updated Declaration of Competing ...Declaration of Competing Interest statements is updated in the published version of the following articles that appeared in issues of Resources Chemicals and Materials.The appropriate updated Declaration of Competing Interest state-ments,provided by the Authors,are included below.展开更多
The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Compe...The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Competing Interest statements,provided by authors,are included below.展开更多
The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Compe...The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Competing Interest statements,provided by authors,are included below.展开更多
The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration of Co...The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration of Competing Interest statements,provided by authors,are included below.展开更多
The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration of Co...The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration of Competing Interest statements,provided by authors,are included below.展开更多
The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Compe...The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Competing Interest statements,provided by authors,are included below.展开更多
Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Journal of Dermatologic Science and Cosmetic Technology.The appropr...Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Journal of Dermatologic Science and Cosmetic Technology.The appropriate Declaration/Competing Interest statements,provided by the Authors,are included below.展开更多
Objectives:Glioblastoma is a prevalent malignant brain tumor,and the actions of the long non-coding RNA HOXA10-AS in its invasion and migration remain unclear.Here,the function of HOXA10-AS in glioblastoma cell invasi...Objectives:Glioblastoma is a prevalent malignant brain tumor,and the actions of the long non-coding RNA HOXA10-AS in its invasion and migration remain unclear.Here,the function of HOXA10-AS in glioblastoma cell invasion and migration and associated mechanisms were investigated.Methods:HOXA10-AS was knocked down in glioblastoma cells,and Transwell and wound healing assays were conducted to elucidate its impacts on cell invasion and migration.Western blotting and quantitative reverse transcription polymerase chain reaction(qRTPCR)assessed HOXA10-AS’s impact on the epithelial-mesenchymal transition(EMT).Microarray analysis identified differentially expressed genes,complemented by bioinformatics approaches to explore potentialmolecular participants and pathways.Rescue experiments validated our findings.Results:HOXA10-AS knockdown significantly inhibits glioblastoma cell migration,invasion,and the EMT process.Specifically,HOXA10-AS siRNA transfection significantly reduced the migratory capacity of A172 cells by 50.5%and U251 cells by 61.4%,as well as their invasive capacities by 33.8%and 58.5%,respectively(all p<0.05).HOXA10-AS acts as anmiR-99a-3p sponge,and pathway analysis identified processes linked to tumorigenesis andmetastasis,alongwith nine hub genes.HOXA10-AS upregulates the expression of integrin subunit beta 5(ITGB5)through a competing endogenous RNAmechanism.Thereduced tumorigenic behavior of glioblastoma cells due toHOXA10-AS knockdown can be rescued by ITGB5 overexpression ormiR-99a-3p inhibitor.Conclusion:These results indicate thatHOXA10-AS promotes tumorigenic behavior in glioblastoma cells by regulating the EMT-like process and functioning as an miR-99a-3p sponge to modulate ITGB5 levels,providing insights into glioblastoma development and potential therapeutic targets.展开更多
Objective:To elucidate the role and clinical potential of the lncRNA DLX6-AS1/miR-26a/PTEN axis in liver fibrosis.Methods:Systematic studies were conducted using cellular and animal models through causal validation,bi...Objective:To elucidate the role and clinical potential of the lncRNA DLX6-AS1/miR-26a/PTEN axis in liver fibrosis.Methods:Systematic studies were conducted using cellular and animal models through causal validation,bivariate experiments,single-cell sequencing,ROC analysis of clinical samples,and humanized mouse models.Results:LncRNA DLX6-AS1 inhibited PTEN by adsorbing miR-26a,promoting hepatic stellate cell activation in a dose/time-dependent manner;the axis demonstrated excellent diagnostic performance(AUC>0.9),and its inhibitors effectively reversed fibrosis in vivo.Conclusion:This study provides new biomarkers and targeted therapeutic strategies for liver fibrosis.展开更多
DDeeaarr EEddiittoorr,,The encoding and retrieval of emotional memories demands intricate interplay within the limbic network,where the network state is subject to significant reconfiguration by learning-induced plast...DDeeaarr EEddiittoorr,,The encoding and retrieval of emotional memories demands intricate interplay within the limbic network,where the network state is subject to significant reconfiguration by learning-induced plasticity,behavioral state,and contextual information[1].展开更多
BACKGROUND Brain-computer interface(BCI)technology is rapidly advancing in psychiatry.Informed consent competency(ICC)assessment among psychiatric patients is a pivotal concern in clinical research.AIM To analyze the ...BACKGROUND Brain-computer interface(BCI)technology is rapidly advancing in psychiatry.Informed consent competency(ICC)assessment among psychiatric patients is a pivotal concern in clinical research.AIM To analyze the assessment of ICC and form a framework with multi-dimensional elements involved in ICC of BCI clinical research among psychiatric disorders.METHODS A systematic review of studies regarding ICC assessments of BCI clinical research in patients with six kinds of psychiatric disorders was conducted.A systematic literature search was performed using PubMed,ScienceDirect,and Web of Science.Peer-reviewed articles and full-text studies were included in the analysis.There were no date restrictions,and all studies published up to February 27,2025,were included.RESULTS A total of 103 studies were selected for this review.Fifty-eight studies included ICC factors,and forty-five were classified in ICC related ethical issues of BCI research in six kinds of psychiatric disorders.Executive function impairment is widely recognized as the most significant factor impacting ICC,and processing speed deficits are observed in schizophrenia,mood disorders,and Alzheimer’s disease.Memory dysfunction,particularly episodic and working memory,contributes to compromised ICC.Five core ethical issues in BCI research should be addressed:BCI specificity,vulnerability,autonomy,dynamic ICC,comprehensiveness,and uncertainty.CONCLUSION A Five-Dimensional evaluative framework,including clinical,ethical,sociocultural,legal,and procedural dimensions,is constructed and proposed for future ICC research in BCI clinical research involving psychiatric disorders.展开更多
BACKGROUND As a non-coding RNA molecule,circular RNAs(circRNAs)have significant specificity,and existing data suggest a close relationship between them and the prognosis of patients with gastric cancer(GC).However,thi...BACKGROUND As a non-coding RNA molecule,circular RNAs(circRNAs)have significant specificity,and existing data suggest a close relationship between them and the prognosis of patients with gastric cancer(GC).However,this mechanism has no evidence yet.This article explores the functions of hsa_circRNA_102415 in the malignant behavior and potential downstream signaling of GC cells.The chosen approach is loss of signal and functional gain.AIM To investigate and analyze the relationship between hsa_circRNA_102415 and GC and explore its specific role.Results provide reference for other researchers to develop targeted treatment plans.METHODS The gene expression omnibus(GEO)database can be used to obtain the microarray dataset GSE83521.Data were analyzed using the GEO2R tool to identify differences in circRNAs between normal and GC samples.Quantitative real-time polymerase chain reaction was used to detect differentially expressed genes in GC tissue samples and adjacent cancer tissue samples.GC cells were transfected with small interfering-hsa_circRNA_104415 and plasmid DNA(pcDNA)-hsa_ircRNA_102415.Multiple detection methods,such as Transwell and cell counting kit 8,were used to evaluate cellular physiological activities,including cell invasion and proliferation.The relationship between Wnt family members 2B,microRNA(miR)-4529-5p,etc.,including argonaute 2-RNA immunoprecipitation and luciferase reporter genes was analyzed.Rescue experiments were conducted to analyze and explore the relationship between the malignant behavior of GC cells and hsa_circRNA_102415.RESULTS GEO2R analysis confirmed that hsa_circRNA_102415 had significantly higher expression levels in disease tissues.hsa_circRNA_102415 and miR-4529-5p showed a negative correlation in disease cells,suggesting that hsa_circRNA_102415 upregulated WNT2B expression in GC cells as a competing endogenous RNA for miR-4529-5p.miR-4529-5p mimic or small interfering-WNT2B reversed the effects of pcDNA-hsa_circRNA_102415 or miR-4529-5p inhibitor on cell malignant functions.CONCLUSION miR-4529-5p was used to successfully activate the potential of WNT2B,clarify the role of hsa_circRNA_102415 in GC cells,and provide reference for other researchers to develop targeted treatment plans.展开更多
This study addresses the limitations of traditional disaster medicine course assessments,including single evaluation formats,delayed feedback mechanisms,and gaps in competency mapping,by developing a diversified asses...This study addresses the limitations of traditional disaster medicine course assessments,including single evaluation formats,delayed feedback mechanisms,and gaps in competency mapping,by developing a diversified assessment system leveraging the Rain Classroom platform.The system incorporates six interconnected evaluation components across the learning cycle:pre-class preparation,pre-class tests,case discussions,skills assessment,post-class tests,and post-class feedback,collectively forming a three-dimensional“cognitive-skill-attitude”assessment framework.In the assessment design,the weighting of practical skill evaluation is elevated to 40%to prioritize the development of students’disaster response competencies.Additionally,an innovative multi-subject evaluation model(“self-peer-teacher”)is implemented within disaster scenario simulations,utilizing standardized scoring rubrics.This methodology not only enables comprehensive performance evaluation but also fosters critical teamwork and reflective practice.Implementation outcomes demonstrated that the system effectively evaluates learning progress through multi-modal assessments,enhances disaster rescue knowledge and skill proficiency,and successfully achieves predefined pedagogical objectives.展开更多
基金The National Natural Science Foundation of China(No.50405021)
文摘Considering the dependence and competitive relation-ship between traumatic failure and degradation,the reliability assessment of products based on competing failure analysis is studied.The hazard rate of traumatic failure is regarded as a Weibull distribution of the degradation performance,and the Wiener process is used to describe the degradation process.The parameters are estimated with the maximum likelihood estimation（MLE）method.A reliability model based on competing failure analysis is proposed.A case study of the GaAs lasers is given to validate the effectiveness of the model and its solving method.The results indicate that if only the degradation failure is considered,the estimated result will be comparably optimistic.Meanwhile,the correlation between the degradation and traumatic failure has a great influence on the accuracy of reliability assessment.
基金supported by National Natural Science Foundation of China(No.10771215)the Scientific Research Initializing Foundation of Hunan Institute of Engineering(0744)
文摘In this paper,a class of discrete time non-autonomous competing system with feedback controls is considered.With the help of differential equations with piecewise constant arguments,we first propose a discrete model of a continuous non-autonomous competing system with feedback controls.Then,using the coincidence degree and the related continuation theorem as well as some priori estimations,a suficient condition for the existence of positive solutions to difference equations is obtained.
基金the Special Research Fund for the National Natural Science Foundation of China(No.11272082)the Fundamental Research Funds for the Central Universities(No.E022050205)the Open Research Fund of Key Laboratory of Fluid and Power Machinery of Xihua University(No.szjj2013-03)
文摘A method for reliability analysis of the competing failure with the probabilistic failure threshold value not the fixed threshold value is presented, which involves the random shocks and the degradation is independent and dependent respectively. Specifically, for the dependent condition, the effect due to the random shocks on the degradation is considered with a damage factor. In addition, the dependent competing failure model is applied to the reliability analysis of the k-out-of-n systems. Finally, two studied cases are presented to illustrate the proposed method, and the results show the proposed method is reasonable.
基金supported by the Aeronautical Science Foundation of China(20155553039)the Natural Sciences and Engineering Research Council of Canada(RGPIN 121384-11)
文摘This paper proposes a health evaluation method for degrading systems subject to competing risks of dependent soft and hard failures. To characterize the time-varying degradation rate, the degradation process is determined by a non-stationary Gamma process and the soft failure is encountered when it exceeds a predefined critical level. For the hard failure, a Cox’s proportional hazard model is applied to describe the hazard rate of the time to system failure. The dependent relationship is modeled by incorporating the degradation process as a time-varying covariate into the Cox’s proportional hazard model. To facilitate the health characteristics evaluation, a discretization technique is applied both to the degradation process and the monitoring time.All health characteristics can be obtained in the explicit form using the transition probability matrix, which is computationally attractive for practical applications. Finally, a numerical analysis is carried out to show the effectiveness and the performance of the proposed health evaluation method.
文摘In this paper，we consider the Kolmogorov type n-species competition systems with forced terms．We prove that this system is permanent in the case of which there are positive forced terms in this system;and if there are several negative forced terms in this system，it has at least two positive periodic solutions.
基金supported by the National Natural Science Foundation of China(52301259 and 22208019)the Research Fund Program for Young Scholars of Beijing Institute of Technology。
文摘Electrochemical carbon dioxide reduction reaction(CO_(2)RR)converts CO_(2) into valuable chemicals by consuming renewable electricity at mild conditions,making it a promising approach to achieving carbon neutrality.However,the reaction of CO_(2) with hydroxide ions to form carbonates leads to low carbon utilization and energy efficiency in near-neutral or alkaline CO_(2)RR.The high concentration of protons in acidic media can effectively mitigate carbonate formation and deposition,thereby significantly minimizing carbon loss and energy consumption.Unfortunately,hydrogen evolution reaction(HER)is more kinetically favorable than CO_(2)RR in acidic media.Herein,we comprehensively overview recent progress in acidic CO_(2)RR and propose two strategies derived from the competing reaction pathways of HER and CO_(2)RR:one focuses on regulating the H+mass transport,while the other aims to modulate the intrinsic kinetic activity of CO_(2)RR.The two strategies are designed to compete for the limited active sites on the catalyst surface,inhibit side reactions,and enhance the activity and selectivity of CO_(2)RR.The representative approaches include modulating the interface electric field,constructing a local alkaline environment,and regulating competing adsorption sites.Finally,we also review the technical challenges and future perspectives of acidic CO_(2)RR coupled with membrane electrode assemblies(MEAs).
文摘Declaration of Competing Interest statements is updated in the published version of the following articles that appeared in issues of Resources Chemicals and Materials.The appropriate updated Declaration of Competing Interest state-ments,provided by the Authors,are included below.
文摘The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Competing Interest statements,provided by authors,are included below.
文摘The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Competing Interest statements,provided by authors,are included below.
文摘The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration of Competing Interest statements,provided by authors,are included below.
文摘The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration of Competing Interest statements,provided by authors,are included below.
文摘The Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Water Science and Engineering.The appropriate Declaration Competing Interest statements,provided by authors,are included below.
文摘Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Journal of Dermatologic Science and Cosmetic Technology.The appropriate Declaration/Competing Interest statements,provided by the Authors,are included below.
基金supported by the National Natural Science Foundation of China(No.82001243).
文摘Objectives:Glioblastoma is a prevalent malignant brain tumor,and the actions of the long non-coding RNA HOXA10-AS in its invasion and migration remain unclear.Here,the function of HOXA10-AS in glioblastoma cell invasion and migration and associated mechanisms were investigated.Methods:HOXA10-AS was knocked down in glioblastoma cells,and Transwell and wound healing assays were conducted to elucidate its impacts on cell invasion and migration.Western blotting and quantitative reverse transcription polymerase chain reaction(qRTPCR)assessed HOXA10-AS’s impact on the epithelial-mesenchymal transition(EMT).Microarray analysis identified differentially expressed genes,complemented by bioinformatics approaches to explore potentialmolecular participants and pathways.Rescue experiments validated our findings.Results:HOXA10-AS knockdown significantly inhibits glioblastoma cell migration,invasion,and the EMT process.Specifically,HOXA10-AS siRNA transfection significantly reduced the migratory capacity of A172 cells by 50.5%and U251 cells by 61.4%,as well as their invasive capacities by 33.8%and 58.5%,respectively(all p<0.05).HOXA10-AS acts as anmiR-99a-3p sponge,and pathway analysis identified processes linked to tumorigenesis andmetastasis,alongwith nine hub genes.HOXA10-AS upregulates the expression of integrin subunit beta 5(ITGB5)through a competing endogenous RNAmechanism.Thereduced tumorigenic behavior of glioblastoma cells due toHOXA10-AS knockdown can be rescued by ITGB5 overexpression ormiR-99a-3p inhibitor.Conclusion:These results indicate thatHOXA10-AS promotes tumorigenic behavior in glioblastoma cells by regulating the EMT-like process and functioning as an miR-99a-3p sponge to modulate ITGB5 levels,providing insights into glioblastoma development and potential therapeutic targets.
基金Study on the Correlation between the Regulation of the miR-26a/PTEN Axis by lncRNA DLX6-AS1 and Post-Hepatitis Liver Fibrosis(Project No.:YKK22233)。
文摘Objective:To elucidate the role and clinical potential of the lncRNA DLX6-AS1/miR-26a/PTEN axis in liver fibrosis.Methods:Systematic studies were conducted using cellular and animal models through causal validation,bivariate experiments,single-cell sequencing,ROC analysis of clinical samples,and humanized mouse models.Results:LncRNA DLX6-AS1 inhibited PTEN by adsorbing miR-26a,promoting hepatic stellate cell activation in a dose/time-dependent manner;the axis demonstrated excellent diagnostic performance(AUC>0.9),and its inhibitors effectively reversed fibrosis in vivo.Conclusion:This study provides new biomarkers and targeted therapeutic strategies for liver fibrosis.
基金supported by the National Natural Science Foundation of China(T2394531)the National Key R&D Program of China(2024YFF1206500)+1 种基金the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)ZJ Lab,and the Shanghai Center for Brain Science and Brain-Inspired Technology,China.
文摘DDeeaarr EEddiittoorr,,The encoding and retrieval of emotional memories demands intricate interplay within the limbic network,where the network state is subject to significant reconfiguration by learning-induced plasticity,behavioral state,and contextual information[1].
基金Supported by the Ministry of Science and Technology of the People's Republic of China(2021ZD0201900)Project 5,No.2021ZD0201905Capital’s Funds for Health Improvement and Research,No.CFH 2022-2-4115.
文摘BACKGROUND Brain-computer interface(BCI)technology is rapidly advancing in psychiatry.Informed consent competency(ICC)assessment among psychiatric patients is a pivotal concern in clinical research.AIM To analyze the assessment of ICC and form a framework with multi-dimensional elements involved in ICC of BCI clinical research among psychiatric disorders.METHODS A systematic review of studies regarding ICC assessments of BCI clinical research in patients with six kinds of psychiatric disorders was conducted.A systematic literature search was performed using PubMed,ScienceDirect,and Web of Science.Peer-reviewed articles and full-text studies were included in the analysis.There were no date restrictions,and all studies published up to February 27,2025,were included.RESULTS A total of 103 studies were selected for this review.Fifty-eight studies included ICC factors,and forty-five were classified in ICC related ethical issues of BCI research in six kinds of psychiatric disorders.Executive function impairment is widely recognized as the most significant factor impacting ICC,and processing speed deficits are observed in schizophrenia,mood disorders,and Alzheimer’s disease.Memory dysfunction,particularly episodic and working memory,contributes to compromised ICC.Five core ethical issues in BCI research should be addressed:BCI specificity,vulnerability,autonomy,dynamic ICC,comprehensiveness,and uncertainty.CONCLUSION A Five-Dimensional evaluative framework,including clinical,ethical,sociocultural,legal,and procedural dimensions,is constructed and proposed for future ICC research in BCI clinical research involving psychiatric disorders.
文摘BACKGROUND As a non-coding RNA molecule,circular RNAs(circRNAs)have significant specificity,and existing data suggest a close relationship between them and the prognosis of patients with gastric cancer(GC).However,this mechanism has no evidence yet.This article explores the functions of hsa_circRNA_102415 in the malignant behavior and potential downstream signaling of GC cells.The chosen approach is loss of signal and functional gain.AIM To investigate and analyze the relationship between hsa_circRNA_102415 and GC and explore its specific role.Results provide reference for other researchers to develop targeted treatment plans.METHODS The gene expression omnibus(GEO)database can be used to obtain the microarray dataset GSE83521.Data were analyzed using the GEO2R tool to identify differences in circRNAs between normal and GC samples.Quantitative real-time polymerase chain reaction was used to detect differentially expressed genes in GC tissue samples and adjacent cancer tissue samples.GC cells were transfected with small interfering-hsa_circRNA_104415 and plasmid DNA(pcDNA)-hsa_ircRNA_102415.Multiple detection methods,such as Transwell and cell counting kit 8,were used to evaluate cellular physiological activities,including cell invasion and proliferation.The relationship between Wnt family members 2B,microRNA(miR)-4529-5p,etc.,including argonaute 2-RNA immunoprecipitation and luciferase reporter genes was analyzed.Rescue experiments were conducted to analyze and explore the relationship between the malignant behavior of GC cells and hsa_circRNA_102415.RESULTS GEO2R analysis confirmed that hsa_circRNA_102415 had significantly higher expression levels in disease tissues.hsa_circRNA_102415 and miR-4529-5p showed a negative correlation in disease cells,suggesting that hsa_circRNA_102415 upregulated WNT2B expression in GC cells as a competing endogenous RNA for miR-4529-5p.miR-4529-5p mimic or small interfering-WNT2B reversed the effects of pcDNA-hsa_circRNA_102415 or miR-4529-5p inhibitor on cell malignant functions.CONCLUSION miR-4529-5p was used to successfully activate the potential of WNT2B,clarify the role of hsa_circRNA_102415 in GC cells,and provide reference for other researchers to develop targeted treatment plans.
基金supported by the Anesthesiology Department Teaching Development Foundation of Naval Medical University under grant(2024MZQN02 and 2024MZQN03).
文摘This study addresses the limitations of traditional disaster medicine course assessments,including single evaluation formats,delayed feedback mechanisms,and gaps in competency mapping,by developing a diversified assessment system leveraging the Rain Classroom platform.The system incorporates six interconnected evaluation components across the learning cycle:pre-class preparation,pre-class tests,case discussions,skills assessment,post-class tests,and post-class feedback,collectively forming a three-dimensional“cognitive-skill-attitude”assessment framework.In the assessment design,the weighting of practical skill evaluation is elevated to 40%to prioritize the development of students’disaster response competencies.Additionally,an innovative multi-subject evaluation model(“self-peer-teacher”)is implemented within disaster scenario simulations,utilizing standardized scoring rubrics.This methodology not only enables comprehensive performance evaluation but also fosters critical teamwork and reflective practice.Implementation outcomes demonstrated that the system effectively evaluates learning progress through multi-modal assessments,enhances disaster rescue knowledge and skill proficiency,and successfully achieves predefined pedagogical objectives.
