目的探讨对比增强磁共振血管成像(Ce MRA)及流入反转恢复(IFIR)序列对肾动脉及其病变显示的临床应用价值。方法对82例确诊高血压拟诊为肾动脉狭窄者同时行Ce MRA和IFIR检查,对比分析两者副肾动脉、肾动脉分支以及肾动脉狭窄的检出率,并...目的探讨对比增强磁共振血管成像(Ce MRA)及流入反转恢复(IFIR)序列对肾动脉及其病变显示的临床应用价值。方法对82例确诊高血压拟诊为肾动脉狭窄者同时行Ce MRA和IFIR检查,对比分析两者副肾动脉、肾动脉分支以及肾动脉狭窄的检出率,并比较图像质量。结果 Ce MRA显示肾动脉198支(含副肾动脉34支),肾动脉各级分支均显示128支,IFIR显示肾动脉198支(含副肾动脉34支),肾动脉各级分支均显示162支,Ce MRA显示肾静脉8支,而IFIR无肾静脉显示,两种成像方法对肾动脉分支的显示差异有统计学意义(χ2=14.89,P<0.01),对肾动脉主干(198支)及肾动脉狭窄的检出率相同(15/198支)。结论 Ce MRA和IFIR对肾动脉各级分支的显示差异有统计学意义,而对于肾动脉主干及狭窄的显示差异无统计学意义。由于IFIR成像无需注入对比剂,没有对比剂肾病的潜在危险,并且可以短期内重复检查,可以作为肾动脉狭窄的初步筛查手段。展开更多
目的建立同时快速测定六味地黄浓缩丸中没食子酸、马钱苷、芍药苷、丹皮酚成分的体外溶出测定方法,并考查其溶出特点。方法采用桨法,以250 m L 0.1 mol·L-1盐酸为溶出介质,转速100 r·min-1;用HPLC法测定六味地黄浓缩丸中4种...目的建立同时快速测定六味地黄浓缩丸中没食子酸、马钱苷、芍药苷、丹皮酚成分的体外溶出测定方法,并考查其溶出特点。方法采用桨法,以250 m L 0.1 mol·L-1盐酸为溶出介质,转速100 r·min-1;用HPLC法测定六味地黄浓缩丸中4种成分的溶出度,并计算累积溶出度;采用相似因子法对溶出度曲线进行相似性比较。结果没食子酸与马钱苷、芍药苷、丹皮酚的相似因子分别为90.47、74.11、88.36,马钱苷与芍药苷、丹皮酚的相似因子分别为77.77、86.40,芍药苷与丹皮酚的相似因子为73.39。结论所用方法以0.1 mol·L-1盐酸为溶出介质时,六味地黄浓缩丸中的4个成分的溶出度具有同步性,可为其质量标准的制定提供参考。展开更多
OBJECTIVE: To examine whether electric acupuncture can improve the daily life of patients with ischemic cerebral apoplexy at acute stage.METHODS: A stratified-block randomized controlled multicenter trial was designed...OBJECTIVE: To examine whether electric acupuncture can improve the daily life of patients with ischemic cerebral apoplexy at acute stage.METHODS: A stratified-block randomized controlled multicenter trial was designed for this study.Totally 340 patients with acute ischemic cerebral apoplexy were randomly divided into an electric acupuncture group and a control group. In the electric acupuncture group, 170 patients were treated with electric acupuncture and routine therapy, and170 patients in the control group with routine therapy alone. Major indexes for judging curative effect were Barthel index at 3- and 6- months follow-up visits and number of re-hospitalized patients. Mi-nor indexes for judging curative effect were change in the score for nervous dysfunction at 4and 12 weeks follow-up visits and number of patients persisting in rehabilitation treatment with acupuncture during follow-up visit.RESULTS: Baseline data at the time of case selection between the two groups were similar. The odds ratio(OR) was 0.92, and the 95% confidence interval(CI) was 0.49-1.73 in disabled rate and 0.73 and 0.51-1.05 in the number of re-hospitalized patients in the electric acupuncture group at 6-month follow up visit compared with the control group.There was no difference in the score for nervous dysfunction at the end of 12-week follow-up visit between the two groups. The score for nervous dysfunction at the end of 4-week treatment in the electric acupuncture group was significantly higher than that in the control group(P<0.05). The number of patients discharged from hospital who persisted in rehabilitation treatment with acupuncture in the acupuncture group was significantly higher than that in the control group.CONCLUSION: Using electric acupuncture to treat patients with acute ischemic cerebral apoplexy can effectively improve the nervous dysfunction scores after 4-week treatment and their ability to deal with daily life after 6-month follow-up visit. Systematic treatment with acupuncture may also reduce the number of patients with secondary apoplexy.展开更多
文摘目的探讨对比增强磁共振血管成像(Ce MRA)及流入反转恢复(IFIR)序列对肾动脉及其病变显示的临床应用价值。方法对82例确诊高血压拟诊为肾动脉狭窄者同时行Ce MRA和IFIR检查,对比分析两者副肾动脉、肾动脉分支以及肾动脉狭窄的检出率,并比较图像质量。结果 Ce MRA显示肾动脉198支(含副肾动脉34支),肾动脉各级分支均显示128支,IFIR显示肾动脉198支(含副肾动脉34支),肾动脉各级分支均显示162支,Ce MRA显示肾静脉8支,而IFIR无肾静脉显示,两种成像方法对肾动脉分支的显示差异有统计学意义(χ2=14.89,P<0.01),对肾动脉主干(198支)及肾动脉狭窄的检出率相同(15/198支)。结论 Ce MRA和IFIR对肾动脉各级分支的显示差异有统计学意义,而对于肾动脉主干及狭窄的显示差异无统计学意义。由于IFIR成像无需注入对比剂,没有对比剂肾病的潜在危险,并且可以短期内重复检查,可以作为肾动脉狭窄的初步筛查手段。
文摘目的建立同时快速测定六味地黄浓缩丸中没食子酸、马钱苷、芍药苷、丹皮酚成分的体外溶出测定方法,并考查其溶出特点。方法采用桨法,以250 m L 0.1 mol·L-1盐酸为溶出介质,转速100 r·min-1;用HPLC法测定六味地黄浓缩丸中4种成分的溶出度,并计算累积溶出度;采用相似因子法对溶出度曲线进行相似性比较。结果没食子酸与马钱苷、芍药苷、丹皮酚的相似因子分别为90.47、74.11、88.36,马钱苷与芍药苷、丹皮酚的相似因子分别为77.77、86.40,芍药苷与丹皮酚的相似因子为73.39。结论所用方法以0.1 mol·L-1盐酸为溶出介质时,六味地黄浓缩丸中的4个成分的溶出度具有同步性,可为其质量标准的制定提供参考。
基金Chongqing Municipal Planned the Sci-tech Project(#CSTC,No.2011AC5187)
文摘OBJECTIVE: To examine whether electric acupuncture can improve the daily life of patients with ischemic cerebral apoplexy at acute stage.METHODS: A stratified-block randomized controlled multicenter trial was designed for this study.Totally 340 patients with acute ischemic cerebral apoplexy were randomly divided into an electric acupuncture group and a control group. In the electric acupuncture group, 170 patients were treated with electric acupuncture and routine therapy, and170 patients in the control group with routine therapy alone. Major indexes for judging curative effect were Barthel index at 3- and 6- months follow-up visits and number of re-hospitalized patients. Mi-nor indexes for judging curative effect were change in the score for nervous dysfunction at 4and 12 weeks follow-up visits and number of patients persisting in rehabilitation treatment with acupuncture during follow-up visit.RESULTS: Baseline data at the time of case selection between the two groups were similar. The odds ratio(OR) was 0.92, and the 95% confidence interval(CI) was 0.49-1.73 in disabled rate and 0.73 and 0.51-1.05 in the number of re-hospitalized patients in the electric acupuncture group at 6-month follow up visit compared with the control group.There was no difference in the score for nervous dysfunction at the end of 12-week follow-up visit between the two groups. The score for nervous dysfunction at the end of 4-week treatment in the electric acupuncture group was significantly higher than that in the control group(P<0.05). The number of patients discharged from hospital who persisted in rehabilitation treatment with acupuncture in the acupuncture group was significantly higher than that in the control group.CONCLUSION: Using electric acupuncture to treat patients with acute ischemic cerebral apoplexy can effectively improve the nervous dysfunction scores after 4-week treatment and their ability to deal with daily life after 6-month follow-up visit. Systematic treatment with acupuncture may also reduce the number of patients with secondary apoplexy.
